Lipid Peroxidation and Cancer
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 December 2025
Special Issue Editors
Interests: lipid peroxidation; oxidative stress; cancer; chemoresistance; resistance to targeted therappies; melanoma; nanomedicine
Special Issues, Collections and Topics in MDPI journals
Interests: tissue regenerations; biocompatibility and bioactivity of materials for medical devices; molecular aspects of osseointegration of dental implants; chemical and physical stimulation of implant integration; nanoparticles for theranostics in cancer; oncology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Lipid metabolism reprogramming occurs during cancer development and progression and grants cancer cells a phenotype more favorable to proliferation and survival. Changes in fatty acid amount and profile affect several structural and biochemical characteristics of cancer cells. Alterations in the relative amounts of saturated, monounsaturated, and polyunsaturated fatty acids are known to vary the susceptibility of tumor cells to lipid peroxidation, to the effects of lipid peroxidation products and to lipid peroxidation-induced cell death indicated as ferroptosis.
In particular, the intracellular amount of polyunsaturated fatty acids (PUFAs), the lipid peroxidation substrates, their incorporation into the membrane phospholipids, and the antioxidant availability are key regulators of cancer cell proliferation/survival and of cancer progression, including the acquisition of resistance to antitumoral drugs. Moreover, the end products of lipid peroxidation, such as 4-hydroxynonenal (HNE) or malondialdehyde (MDA), have been reported to play a role in cancerogenesis and cancer progression.
All the above observations suggest that modulating lipid peroxidation in cancer is a promising approach for identifying new targetable molecular pathways.
This Special Issue aims to further deepen our understanding of the correlations among lipid peroxidation, cancer progression, and the onset of drug resistance, paving the way for the design of new therapeutic approaches. All types of "omics" investigations will contribute to attaining the principal aim of the Special Issue.
Original research articles, reviews, and clinical studies investigating the following aspects are welcome:
- Lipidomic characterization of lipid profiles specifically associated with the various types of cancer and with their progression;
- Correlation among the intracellular content of PUFA, susceptibility to lipid peroxidation, and proneness to ferroptosis in cancer cell lines and in vivo models;
- Deciphering the contribution of end-products of lipid peroxidation in the hallmarks of cancer;
- Evaluation of the possibility of modulating tumor progression by targeting lipid metabolism reprogramming and its consequences by new molecular or pharmacological strategies, including drug repurposing.
The Special Issue and the resulting discoveries may benefit from the involvement of researchers from various disciplines, from basic research to the clinical field.
Dr. Stefania Pizzimenti
Dr. Giuliana Muzio
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- lipid peroxidation
- fatty acid metabolism
- 4-hydroxynonenal (HNE)
- malondialdehyde (MDA)
- ferroptosis
- carcinogenesis
- cancer progression
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
