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Article

2,017 Views

12 Pages

An Epidemic of Parvovirus B19-Induced Aplastic Crises in Pediatric Patients with Hereditary Spherocytosis Following the COVID-19 Pandemic: A Single-Center Retrospective Study

Paola Giordano,
Valentina Palladino,
Giuseppe Lassandro,
Stella Spina and
Giovanni Carlo Del Vecchio

Children2025, 12(6), 772;https://doi.org/10.3390/children12060772

13 June 2025

Background: Parvovirus B19 is the major cause of transient aplastic crisis in children with hereditary spherocytosis (HS) inhibiting erythropoiesis and leading to a severe drop in hemoglobin levels, requiring hospitalization and transfusional support...

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Article

4 Citations

3,810 Views

13 Pages

Novel Surrogate Neutralizing Assay Supports Parvovirus B19 Vaccine Development for Children with Sickle Cell Disease

Rhiannon R. Penkert,
Sumana Chandramouli,
Philip R. Dormitzer,
Ethan C. Settembre,
Robert E. Sealy,
Susan Wong,
Neal S. Young,
Yilun Sun,
Li Tang and
Alyssa Cotton
+ 4 authors

Vaccines2021, 9(8), 860;https://doi.org/10.3390/vaccines9080860

4 August 2021

Children with sickle cell disease (SCD) suffer life-threatening transient aplastic crisis (TAC) when infected with parvovirus B19. In utero, infection of healthy fetuses may result in anemia, hydrops, and death. Unfortunately, although promising vacc...

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Review

57 Citations

10,529 Views

12 Pages

Chloramphenicol Resurrected: A Journey from Antibiotic Resistance in Eye Infections to Biofilm and Ocular Microbiota

Lorenzo Drago

Microorganisms2019, 7(9), 278;https://doi.org/10.3390/microorganisms7090278

21 August 2019

The advent of multidrug resistance among pathogenic bacteria is devastating the worth of antibiotics and changing the way of their administration, as well as the approach to use new or old drugs. The crisis of antimicrobial resistance is also due to...

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Article

11 Citations

4,372 Views

18 Pages

Structural Dynamics and Activity of B19V VP1u during the pHs of Cell Entry and Endosomal Trafficking

Renuk V. Lakshmanan,
Joshua A. Hull,
Luke Berry,
Matthew Burg,
Brian Bothner,
Robert McKenna and
Mavis Agbandje-McKenna

Viruses2022, 14(9), 1922;https://doi.org/10.3390/v14091922

30 August 2022

Parvovirus B19 (B19V) is a human pathogen that is the causative agent of fifth disease in children. It is also known to cause hydrops in fetuses, anemia in AIDS patients, and transient aplastic crisis in patients with sickle cell disease. The unique...

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Case Report

8 Citations

5,362 Views

10 Pages

Clinical Presentation of Parvovirus B19 Infection in Adults Living with HIV/AIDS: A Case Series

Daniela P. Mendes-de-Almeida,
Joanna Paes Barreto Bokel,
Arthur Daniel Rocha Alves,
Alexandre G. Vizzoni,
Isabel Cristina Ferreira Tavares,
Mayara Secco Torres Silva,
Juliana dos Santos Barbosa Netto,
Beatriz Gilda Jegerhorn Grinsztejn and
Luciane Almeida Amado Leon

Viruses2023, 15(5), 1124;https://doi.org/10.3390/v15051124

8 May 2023

Parvovirus B19 (B19V) infection varies clinically depending on the host’s immune status. Due to red blood cell precursors tropism, B19V can cause chronic anemia and transient aplastic crisis in patients with immunosuppression or chronic hemolys...

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Article

4 Citations

3,291 Views

14 Pages

Recombinant Virus-like Particles of Human Parvovirus B19 with the Internal Location of VP1 Unique Region Produced by Hansenula polymorpha

Shuai Shao,
Qingqing Wang,
Yuqin Jin,
Xuefeng Zhang,
Zhaoming Liu,
Shi Chen,
Hailan Wu,
Sensen Yang,
Fang Tang and
Jiguo Su
+ 3 authors

Viruses2022, 14(11), 2410;https://doi.org/10.3390/v14112410

30 October 2022

Human parvovirus B19 (HPV B19) is pathogenic to human, which can cause fifth disease, transient aplastic crisis, arthritis, myocarditis, autoimmune disorders, hydrops fetalis, and so on. Currently, no approved vaccines or antiviral drugs are availabl...

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