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9 Results Found

  • Review
  • Open Access
22 Citations
6,345 Views
14 Pages

Diagnosis of Mitral Valve Prolapse: Much More than Simple Prolapse. Multimodality Approach to Risk Stratification and Therapeutic Management

  • Ali Alenazy,
  • Abdalla Eltayeb,
  • Muteb K. Alotaibi,
  • Muhammah Kashif Anwar,
  • Norah Mulafikh,
  • Mohammed Aladmawi and
  • Olga Vriz

17 January 2022

Mitral valve prolapse (MVP) is the most common valvular disease with a prevalence of 2%. It has generally a benign course; however, recent findings suggested an association between MVP and complex arrhythmias and eventually cardiac arrest and for thi...

  • Review
  • Open Access
100 Citations
16,978 Views
20 Pages

The Global Burden of Valvular Heart Disease: From Clinical Epidemiology to Management

  • Gloria Santangelo,
  • Francesca Bursi,
  • Andrea Faggiano,
  • Silvia Moscardelli,
  • Pasquale Simone Simeoli,
  • Marco Guazzi,
  • Roberto Lorusso,
  • Stefano Carugo and
  • Pompilio Faggiano

10 March 2023

Valvular heart disease is a leading cause of cardiovascular morbidity and mortality and a major contributor of symptoms and functional disability. Knowledge of valvular heart disease epidemiology and a deep comprehension of the geographical and tempo...

  • Review
  • Open Access
1 Citations
2,122 Views
16 Pages

Mitral Valve Prolapse and Sudden Cardiac Death—A Puzzle with Missing Pieces: Review of the Literature and Case Report

  • Diana Roxana Opris,
  • Marius Mihai Harpa,
  • David-Emanuel Anitei,
  • Paul Calburean and
  • Roxana Rudzik

10 September 2025

Background: Mitral valve prolapse is a common valvular heart disorder, usually associated with a benign prognosis in the absence of significant mitral regurgitation. However, a subset of patients is at increased risk for complex ventricular arrhythmi...

  • Article
  • Open Access
4 Citations
3,488 Views
11 Pages

Does Anatomic Phenotype of Mitral Annular Disjunction Impact Survival? An Autopsy-Based Retrospective Study

  • Nan Zhou,
  • Qianhao Zhao,
  • Rui Li,
  • Da Zheng,
  • Yuxi Xiao,
  • Danmi Mao,
  • Yunyi Wang,
  • Jiacheng Yue,
  • Kai Zhang and
  • Jianding Cheng
  • + 1 author

Controversies have been raised regarding the prevalence and potential clinical significance of mitral annular disjunction (MAD). We aim to address the anatomic characteristics of MAD and their association, if any, on survival. We retrospectively revi...

  • Feature Paper
  • Review
  • Open Access
30 Citations
10,035 Views
15 Pages

The morphological changes that occur in myxomatous mitral valve disease (MMVD) involve various components, ultimately leading to the impairment of mitral valve (MV) function. In this context, intrinsic mitral annular abnormalities are increasingly re...

  • Review
  • Open Access
2 Citations
2,221 Views
14 Pages

Mitral Annular Disjunction: Epidemiology, Diagnostic Methods, Prognosis, and Novel Implications

  • Vasileios Tsimpiris,
  • Georgia Kousourna,
  • Aristi Boulmpou,
  • Magdalini Petridou,
  • Chalil Tsavousoglou,
  • Dimitrios Kotzadamis,
  • Christodoulos Papadopoulos,
  • Dimitrios Ntelios,
  • Theodoros Moysiadis and
  • Efstathios Pagourelias
  • + 1 author

Mitral annular disjunction (MAD) is an increasingly recognized structural abnormality of the mitral valve apparatus, often associated with mitral valve prolapse and a heightened risk of ventricular arrhythmias and sudden cardiac death. It is defined...

  • Review
  • Open Access
44 Views
23 Pages

The Arrhythmogenic Spectrum of Mitral Valve Disease: Pathophysiology, Risk Stratification, and Surgical Management

  • Mariagrazia Piscione,
  • Barbara Pala,
  • Francesco Cribari,
  • Walter Vignaroli,
  • Jad Mroue,
  • Vivek Mehta,
  • Fadi Matar and
  • Marco Alfonso Perrone

21 January 2026

Mitral valve prolapse (MVP) is generally associated with excellent long-term outcomes when MR is absent or mild. Nonetheless, a small proportion of patients exhibit a distinct arrhythmogenic susceptibility, characterized by complex ventricular ectopy...

  • Case Report
  • Open Access
2 Citations
771 Views
13 Pages

Does Preliminary Chest Shape Assessment Improve the Prognostic Risk Stratification of Individuals with Mitral Annular Disjunction? A Case Report and Narrative Review

  • Andrea Sonaglioni,
  • Gian Luigi Nicolosi,
  • Giovanna Elsa Ute Muti-Schünemann,
  • Gaetana Anna Rispoli,
  • Michele Lombardo and
  • Paola Muti

26 March 2025

Background: Mitral annular disjunction (MAD), a mitral annular abnormality involving the whole mitral valve annulus circumference, commonly detected in individuals with mitral valve prolapse (MVP), has been recently recognized as a potential risk fac...

  • Systematic Review
  • Open Access
5 Citations
2,638 Views
19 Pages

The Prevalence, Pathophysiological Role and Determinants of Mitral Annular Disjunction Among Patients with Mitral Valve Prolapse: A Systematic Review

  • Andrea Sonaglioni,
  • Gian Luigi Nicolosi,
  • Giovanna Elsa Ute Muti-Schünemann,
  • Michele Lombardo and
  • Paola Muti

20 February 2025

Background: Over the last two decades, a number of imaging studies have evaluated the characteristics and clinical implications of mitral annular disjunction (MAD) among patients with mitral valve prolapse (MVP). The present systematic review has bee...