Search Results (251)

Background and Clinical Significance: Cryotherapy, particularly with the CryoBalloon Focal Ablation System (CbFAS), has emerged as a minimally invasive modality delivering targeted ablation through liquid nitrous oxide. While its role in treating Barrett’s esophagus and dysplasia is well established, its application in early esophageal adenocarcinoma (EAC) salvage treatment remains limited. Case Presentation: We report the case of an 84-year-old male with Barrett’s esophagus and multiple comorbidities who underwent endoscopic submucosal dissection (ESD) for a 3 cm esophageal adenocarcinoma (pT1bN0M0). Histology revealed deep submucosal invasion, perivascular infiltration, and positive margins, rendering the resection non-curative. Given surgical ineligibility, the patient underwent cryoballoon ablation six months later for recurrent intramucosal carcinoma proximal to the ESD scar. At three months, surveillance endoscopy showed residual Barrett’s esophagus with low-grade dysplasia. Conclusions: This case highlights the feasibility and safety of cryoballoon ablation as salvage therapy after non-curative ESD in inoperable EAC. To our knowledge, this represents the first report of salvage CbFAS in T1bN0M0 EAC, underscoring the need for further studies to define its role in the multimodal management of EAC. Full article

Global glacier models (GGMs) are effective tools for assessing changes in water resources in mountainous regions and studying glacier degradation. Moreover, with the rapid development and increasing complexity of Earth System Models (ESMs), the incorporation of mountain glaciation parametrizations into ESMs is only a matter of time. GGMs, being computationally efficient and physically well-founded, provide a solid basis for such parametrizations. In this study, we present a new global glacier model, IGRICE. Its dynamic core is based on the Oerlemans minimal model, and surface mass balance (SMB) is explicitly simulated, accounting for orographic precipitation, radiation redistribution on the glacier surface, turbulent heat fluxes, and snow cover evolution on ice. The model is tested on glaciers situated in climatically and topographically contrasting regions—the Caucasus and Svalbard—using observational data for validation. The model is forced with ERA5 reanalysis data and employs morphometric glacial and topographic parameters. The simulated components of the surface energy and mass balance, as well as glacier dynamics over the period of 1984–2021, are presented. The model results demonstrate good agreement with observations, with correlation coefficients for accumulation, ablation, and total SMB ranging from 0.6 to 0.9. The primary driver of glacier retreat in the Caucasus is identified as an increase in net shortwave radiation balance caused by reduced cloudiness and albedo. In contrast, rapid glacier degradation in Svalbard is linked to an increased fraction of liquid precipitation and an extended snow-free period, leading to a sharp decrease in albedo. Full article

We report the fabrication of nanoscale MoS₂ (nMoS₂) via laser ablation in liquid and its application in electrochemical sensing. The laser ablation process fragments microscale MoS₂ sheets into ~5 nm dots with stable aqueous dispersibility. Electrochemical analysis reveals that nMoS₂ possesses multiple reversible redox states, enabling it to participate in redox cycling reactions that can amplify electrochemical signals. When the nMoS₂ is embedded in an electrochemically inert matrix, a chitosan layer, and subsequently incorporated within a nanostructured Au electrode, the nMoS₂-participating redox cycling reactions are further enhanced by the nanoconfinement effect, leading to synergistic signal amplification. As a model system, this hybrid nMoS₂-in-nanoporous Au electrode demonstrates a 9-fold increase in sensitivity for detecting pyocyanin, a biomarker of Pseudomonas aeruginosa infection, compared with a flat electrode without nMoS₂ loading. This study not only elucidates the redox characteristics of laser-fabricated zero-dimensional transition metal dichalcogenides but also presents a strategy to integrate semiconducting nanomaterials with metallic nanostructures for high-performance electrochemical sensing. Full article

Background: The treatment of soft tissue vascular anomalies is a challenge in materials science, requiring injectable biomaterials that can conform to complex lesion architectures while providing controlled drug delivery. Conventional liquid sclerosants fail due to poor localization. This study reports on the formulation and clinical performance of an in situ-forming, drug-eluting composite foam designed to overcome these limitations. Methods: A multicomponent composite foam was formulated from a liquid phase containing bleomycin and polidocanol and a gaseous phase of room air using a standardized Tessari emulsification technique. The therapeutic performance of this composite was evaluated retrospectively in 14 patients with high-risk airway venous malformations (AVMs) by quantifying lesion volume reduction on magnetic resonance imaging (MRI) and assessing clinical outcomes. Biocompatibility was determined by monitoring adverse tissue reactions. Results: The injectable composite foam demonstrated superior clinical performance with a 100% therapeutic response rate. Full target lesion ablation, defined as a complete response, was achieved in 10 of 14 cases (71.4%), demonstrating the composite’s high efficacy. The material exhibited excellent biocompatibility, with adverse events limited to minor, localized mucosal necrosis (21.4%) that resolved without intervention, indicating predictable material-tissue interaction. Conclusions: The bleomycin-polidocanol composite foam is an effective, therapeutic biomaterial whose performance is directly linked to its unique physicochemical structure. This work validates a material-based strategy for treating complex vascular lesions and highlights the potential for further optimization of such injectable composites by enhancing their long-term stability. Full article

Sensing represents one of the most rapidly developing areas of modern life sciences, spreading from the detection of pathogenic microorganisms in living systems, food, and beverages to hazardous substances in liquid and gaseous environments. However, the development of efficient and low-cost multimodal sensors with easy-to-read functionality is still very challenging. In this paper, stable aqueous colloidal suspensions (ζ-potential was between −30 and −40 mV) of ultrasmall (~7 nm) plasmonic Si-Au and SiC-Au nanocomposites were formed. Two variants of pulsed laser ablation in liquids (PLAL)—direct ablation and laser co-fragmentation—were used for this purpose. The co-fragmentation approach led to a considerable decrease in hydrodynamic diameter (~78 nm) and bandgap widening to approximately 1.6 eV. All plasmonic nanocomposites exhibited efficient multi-band blue emission peaking at ~430 nm upon Xe lamp excitation. Co-fragmentation route considerably (~1 order of magnitude) increased the PL efficiency of the nanocomposites in comparison with the laser-ablated ones, accompanied by a negligible amount of dangling bonds. These silicon-based nanostructures significantly affected the optical response of rhodamine 6G, depending on the synthesis route. In particular, directly ablated nanoparticles revealed a stronger influence on the optical response of dye molecules. The observed findings suggest using such types of semiconductor-plasmonic nanocomposites for multimodal plasmonic and colorimetric sensing integrated with luminescent detection capability. Full article

Pulsed liquid-based nanoparticle synthesis has emerged as a versatile and environmentally friendly approach for producing a wide range of nanomaterials with tunable properties. Unlike conventional chemical methods, pulsed techniques—such as pulsed laser ablation in liquids (PLAL), electrical discharge, and other energy-pulsing methods—enable the synthesis of high-purity nanoparticles without the need for toxic precursors or stabilizing agents. This review provides a comprehensive overview of the fundamental mechanisms driving nanoparticle formation under pulsed conditions, including plasma–liquid interactions, cavitation, and shockwave dynamics. We discuss the influence of key synthesis parameters, explore different pulsed energy sources, and highlight the resulting effects on nanoparticle size, shape, and composition. The review also surveys a broad spectrum of material systems and outlines advanced characterization techniques for analyzing synthesized nanostructures. Furthermore, we examine current and emerging applications in biomedicine, catalysis, sensing, energy, and environmental remediation. Finally, we address critical challenges such as scalability, reproducibility, and mechanistic complexity, and propose future directions for advancing the field through hybrid synthesis strategies, real-time diagnostics, and machine learning integration. By bridging mechanistic insights with practical applications, this review aims to guide researchers toward more controlled, sustainable, and innovative nanoparticle synthesis approaches. Full article

Aluminum powder is the most commonly used metal fuel in the industry of explosives and propellants. The research progress in preparation technology, reactivity and application of nano-aluminum in explosives and propellants is systematically reviewed in this paper. The preparation technology of nano-aluminum powder includes mechanical pulverization technology (such as the ball milling method and ultrasonic ablation method, etc.), evaporation condensation technology (such as the laser induction composite heating method, high-frequency induction method, arc method, pulsed laser ablation method, resistance heating condensation method, gas-phase pyrolysis method, wire explosion pulverization method, etc.), chemical reduction technology (such as the solid-phase reduction method, solution reduction method, etc.) and the ionic liquid electrodeposition method, each of which has its own advantages. Some new preparation methods have emerged, providing important reference value for the large-scale production of high-purity, high-quality nano-aluminum powder. The reactivity differences between nano-aluminum powder and micro-aluminum powder are compared in the thesis. It is clear that the reactivity of nano-aluminum powder is much higher than that of micro-aluminum powder in terms of ignition performance, combustion performance and reaction completeness, and it has a stronger influence on the detonation performance of mixed explosives and the combustion performance of propellants. Nano-aluminum powder is highly prone to oxidation, which seriously affects its application efficiency. In addition, when aluminum powder oxidizes or burns, a surface oxide layer will be formed, which hinders the continued reaction of internal aluminum powder. In addition, nano-aluminum powder may deteriorate the preparation process of explosives or propellants. To improve these shortcomings, appropriate coating or modification treatment is required. The application of nano-aluminum powder in mixed explosives can improve many properties of mixed explosives, such as detonation velocity, detonation heat, peak value of shock wave overpressure, etc. Applying nano-aluminum powder to propellants can significantly increase the burning rate and improve the properties of combustion products. It is pointed out that the high reactivity of nano-aluminum powder makes the preparation and storage of high-purity nano-aluminum powder extremely difficult. It is recommended to increase research on the preparation and storage technology of high-purity nano-aluminum powder. Full article

Using the method of laser ablation in liquid, submicron-sized particles of zero-valent amorphous selenium (Se SMPs) were created. A number of composite polymer materials were manufactured based on polyurea and Se SMPs at concentrations ranging 0.1–2.5 wt.%. The manufactured materials showed no significant surface or internal defects at either the macro or micro level. It was found that the Se SMPs were not uniformly distributed inside the polymer, but formed ordered areas with slightly higher and lower concentrations of the particles. It was demonstrated that the manufactured materials did not generate a significant amount of active oxygen species, which could damage biological objects such as protein molecules and DNA, while also exhibiting pronounced bacteriostatic properties without significantly affecting the growth and reproduction of mammalian cells. Materials containing 0.25 and 1% Se SMPs, when added to soil, improved the morphometric parameters of radish plants (Raphanus sativus var. sativus). These polymer composite materials based on polyurea with the addition of Se SMPs are promising functional materials for agriculture due to their antibacterial activity. Full article

This study presents a flame detection model that is based on real experimental data that were collected during turbopump hot-fire tests of a liquid rocket engine. In these tests, a MEMRECAM ACS-1 M40 high-speed camera—serving as an optical sensor within the test instrumentation system—captured plume images for analysis. To detect abnormal flame phenomena in the plume, a Gaussian support vector machine (SVM) model was developed using image features that were derived from both color and gradient information. Six representative frames containing visible flames were selected from a single test failure video. These images were segmented in the YCbCr color space using the k-means clustering algorithm to distinguish flame and non-flame pixels. A 10-dimensional feature vector was constructed for each pixel and then reduced to five dimensions using the Maximum Relevance Minimum Redundancy (mRMR) method. The reduced vectors were used to train the Gaussian SVM model. The model achieved a 97.6% detection accuracy despite being trained on a limited dataset. It has been successfully applied in multiple subsequent engine tests, and it has proven effective in detecting ablation-related anomalies. By combining real-world sensor data acquisition with intelligent image-based analysis, this work enhances the monitoring capabilities in rocket engine development. Full article

Chitosan is a natural biopolymer with intrinsic antimicrobial properties and strong metal ion chelating properties, making it an ideal matrix for the development of bioactive composites. In this study, silver and copper nanoparticles were synthesized using laser ablation in liquid (LAL) by the ablation of metallic targets into commercial chitosan (Cs) and chitosan produced from Hermetia illucens pupal exuviae (CsE) solutions, avoiding the use of chemical precursors or stabilizing agents. The nanocomposites obtained were characterized by UV–vis spectroscopy, TEM microscopy and FTIR spectroscopy in order to evaluate the size of the nanoparticles and the interactions between the polymer and metal nanoparticles. Antibacterial tests demonstrated the efficacy of Ag-based composites with a minimum inhibitory concentration (MIC) of 0.006 g/L, and Cu-based composites with a MIC of 0.003 g/L against both Escherichia coli and Micrococcus flavus. While the silver composites show antibacterial activity in both colloidal and film forms, the copper composites present antibacterial activity only in colloidal form. Swelling tests indicated that all films maintained a high water absorption capacity, with a swelling index over 200%, unaffected by nanoparticle integration. The results highlight the potential of LAL-synthesized metal–chitosan composites, particularly those based on insect chitosan, as sustainable and effective antimicrobial materials for biomedical and environmental applications. Full article

Background: Abdominal wall endometriosis (AWE) is a rare but debilitating condition, often occurring in surgical scars after Caesarean sections. It is characterized by cyclic pain and a palpable mass, significantly impacting patients’ quality of life. Traditional treatments, including hormonal therapy and surgery, have limitations, prompting interest in minimally invasive techniques such as cryoablation. This study evaluates the efficacy and safety of percutaneous image-guided single-probe cryoablation using liquid nitrogen for symptomatic AWE. Purpose: To evaluate the effectiveness and safety of percutaneous image-guided single-probe cryoablation using liquid nitrogen in treating symptomatic AWE lesions, with a primary objective to assess pain relief using the Visual Analog Scale (VAS). Materials and Methods: This retrospective, single-center study included 14 patients (23 lesions) treated with percutaneous cryoablation between September 2022 and April 2025. Clinical, imaging (MRI and ultrasound), and procedural data were analyzed. Pain scores (VAS scale) were assessed before treatment and at 3-month follow-up. Hydro- and/or carbo-dissection were used to protect adjacent structures. Response to treatment was evaluated with MRI and clinical follow-up. Statistical analysis was performed using median, range, and percentage calculations, with comparisons made using the Mann–Whitney test. Results: A total of 23 AWE lesions were treated in 14 patients (mean age: 39.6 years). The median lesion volume was 3546 mm³, with a range from 331 mm³ (8 × 4.6 × 9 mm) to 45,448 mm³ (46 × 26 × 38 mm). Most of the lesions were located in the muscle (69.6%, n = 16), while 17.4% (n = 4) involved both muscle and subcutaneous tissue, and 13.0% (n = 3) were purely subcutaneous. Among the 23 treated lesions, 8.7% (n = 2) appeared as purely hemorrhagic, 13.0% (n = 3) as fibrotic, and 78.3% (n = 18) were classified as mixed, based on imaging characteristics. Procedures were performed under general anesthesia in 65% of cases and under sedation in 35%. Hydrodissection was used in 48% of lesions, carbo-dissection in 4%, and combined hydro–carbo-dissection in 26%. A single 13G cryoprobe was used in 83% of cases, and a 10G probe in 17%. The median ablation time was 15 min (range: 6–28 min), and the median total procedure time was 93 min (range: 22–240 min). Pain scores significantly decreased from a median of 8/10 (range: 6–10) before treatment to 0/10 (range: 0–2) at follow-up (p < 0.0001). MRI follow-up confirmed complete coverage of the ablation zone and disappearance of hemorrhagic inclusions in all cases. Two patients (14%) required re-treatment, both with satisfactory outcomes. No peri- or post-procedural complications were observed, and no visible scars were noted. Conclusions: Percutaneous cryoablation using a single probe with liquid nitrogen is a safe and effective treatment for AWE, offering significant pain relief, minimal morbidity, and excellent cosmetic outcomes. It should be considered as part of multidisciplinary care. Further prospective studies with longer follow-up are warranted to confirm these findings. Full article

Because the interfacial Cu⁰/Cu⁺ in Cu-based electrocatalyst promotes CO₂ electroreduction activity, it would be highly desirable to physically separate Cu-based nanoparticles through coating shells and load them onto porous carriers. Herein, multilayered graphene-coated Cu (Cu@G) nanoparticles with tailorable core diameters (28.2–24.2 nm) and shell thicknesses (7.8–3.0 layers) were fabricated via lased ablation in liquid. A thin Cu₂O layer was confirmed between the interface of the Cu core and the graphene shell, providing an interfacial Cu⁰/Cu⁺. Cu@G cross-linked biochars (Cu@G/Bs) with developed porosity (31.8–155.9 m²/g) were synthesized. Morphology, crystalline structure, porosity, and elemental chemical states of Cu@G and Cu@G/Bs were characterized. Cu@G/Bs captured CO₂ with a maximum sorption capacity of 107.03 mg/g at 0 °C. Furthermore, 95.3–97.1% capture capacity remained after 10 cycles. Cu@G/Bs exhibited the most superior performance with 40.7% of FE_C2H4 and 21.7 mA/cm² of current density at −1.08 V vs. RHE, which was 1.7 and 2.7 times higher than Cu@G. Synergistic integration of developed porosity for efficient CO₂ capture and the fast charge transfer rate of interfacial Cu₂O/Cu enabled this improvement. Favorable long-term stability of the phase/structure and CO₂ electroreduction activity were present. This work provides new insight for integrating Cu@G and a biochar platform to efficiently capture and electro-reduce CO₂. Full article

To investigate the effect of liquid-phase laser ablation on the hardness of WC-Co cemented carbide, this study performed hardness testing, elemental distribution analysis, and XRD phase analysis. The influence of ablation times on the hardness, elemental distribution, and phase composition of WC-Co cemented carbide was examined, and a model describing the hardness evolution mechanism under liquid-phase laser ablation was proposed. The results demonstrated that the hardness of WC-Co cemented carbide increased with the number of ablations. After 14 ablation times, the maximum hardness reached 2800 HV, representing an increase of 51%–56% compared to the matrix hardness. As the number of ablations increased, the content of ditungsten carbide (W₂C) and tungsten carbide (WC) in the cemented carbide increased, the WC grain size decreased, the dislocation density increased, and the distribution became more uniform. The refinement of WC grains and the elevated dislocation density facilitated stronger intergranular bonding, thereby significantly enhancing the material’s hardness. This study provides theoretical guidance for improving the surface mechanical properties of WC-Co cemented carbide tools through liquid-phase laser ablation. Full article

Achieving targeted nanoparticle (NP) size and concentration combinations in Pulsed Laser Ablation in Liquid (PLAL) remains a challenge due to the highly nonlinear relationships between laser processing parameters and NP properties. Despite the promise of PLAL as a surfactant-free, scalable synthesis method, its industrial adoption is hindered by empirical trial-and-error approaches and the lack of predictive tools. The current literature offers limited application of machine learning (ML), particularly recommender systems, in PLAL optimization and automation. This study addresses this gap by introducing a ML-based recommender system trained on a 3 × 3 design of experiments with three replicates covering variables, such as fluence (1.83–1.91 J/cm²), ablation time (5–25 min), and laser scan speed (3000–3500 mm/s), in producing magnesium nanoparticles from powders. Multiple ML models were evaluated, including K-Nearest Neighbors (KNN), Extreme Gradient Boosting (XGBoost), Random Forest, and Decision trees. The DT model achieved the best performance for predicting the NP size with a mean percentage error (MPE) of 10%. The XGBoost model was optimal for predicting the NP concentration attaining a competitive MPE of 2%. KNN and Cosine similarity recommender systems were developed based on a database generated by the ML predictions. This intelligent, data-driven framework demonstrates the potential of ML-guided PLAL for scalable, precise NP fabrication in industrial applications. Full article

In this study, we describe the preparation of carbon dots (CDs) from natural charcoal by laser ablation in a liquid. A continuum wave (CW) laser diode operating at a wavelength of 450 nm, hitting a solid carbon target placed into a biocompatible liquid, constituted of a phosphate-buffered saline (PBS) solution and distilled water, was used for the generation of the CDs suspension. Exploring the practical applications of carbon dots, it was observed that the luminescence of the produced CDs can be used as bioimaging in living organisms, environmental monitoring, chemical analysis, targeted drug delivery, disease diagnosis, therapy, and others. The CDs’ luminescence can be induced by UV irradiation and, as demonstrated in this study, by energetic MeV proton beams. The fluorescence was revealed mainly at 480 nm when UV illuminated the CDs, and also in the region at 514–642 nm when the CDs were irradiated by energetic proton ions. Atomic force microscopy (AFM) of the CD films revealed their spherical shape with a size of about 10 nm. The significance of the manuscript lies in the use of CDs produced by laser ablation exhibiting luminescence under irradiation of an energetic proton beam. Full article