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Review

13 Citations

6,972 Views

13 Pages

CK2 Molecular Targeting—Tumor Cell-Specific Delivery of RNAi in Various Models of Cancer

Janeen H. Trembley,
Betsy T. Kren,
Md. Joynal Abedin,
Rachel I. Vogel,
Claire M. Cannon,
Gretchen M. Unger and
Khalil Ahmed

Pharmaceuticals2017, 10(1), 25;https://doi.org/10.3390/ph10010025

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21 February 2017

Protein kinase CK2 demonstrates increased protein expression relative to non-transformed cells in the majority of cancers that have been examined. The elevated levels of CK2 are involved in promoting not only continued proliferation of cancer cells b...

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Article

18 Citations

5,618 Views

22 Pages

CK2 Pro-Survival Role in Prostate Cancer Is Mediated via Maintenance and Promotion of Androgen Receptor and NFκB p65 Expression

Janeen H. Trembley,
Betsy T. Kren,
Md. J. Abedin,
Daniel P. Shaughnessy,
Yingming Li,
Scott M. Dehm and
Khalil Ahmed

Pharmaceuticals2019, 12(2), 89;https://doi.org/10.3390/ph12020089

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14 June 2019

The prosurvival protein kinase CK2, androgen receptor (AR), and nuclear factor kappa B (NFκB) interact in the function of prostate cells, and there is evidence of crosstalk between these signals in the pathobiology of prostate cancer (PCa). As...

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