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MDPIMDPI

7 Results Found

  • Article
  • Open Access
10 Citations
7,596 Views
16 Pages
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EGF Receptor-Dependent Mechanism May be Involved in the Tamm–Horsfall Glycoprotein-Enhanced PMN Phagocytosis via Activating Rho Family and MAPK Signaling Pathway

  • Ko-Jen Li,
  • Sue-Cien Siao,
  • Cheng-Han Wu,
  • Chieh-Yu Shen,
  • Tsai-Hung Wu,
  • Chang-Youh Tsai,
  • Song-Chou Hsieh and
  • Chia-Li Yu
Molecules2014, 19(1), 1328-1343;https://doi.org/10.3390/molecules19011328

21 January 2014

Our previous studies showed that urinary Tamm–Horsfall glycoprotein (THP) potently enhanced polymorphonuclear neutrophil (PMN) phagocytosis. However, the domain structure(s), signaling pathway and the intracellular events responsible for THP-enhanced...

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  • Article
  • Open Access
9 Citations
7,755 Views
12 Pages
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The Binding Affinity and Molecular Basis of the Structure-Binding Relationship between Urinary Tamm-Horsfall Glycoprotein and Tumor Necrosis Factor-α

  • Cheng-Han Wu,
  • Ko-Jen Li,
  • Sue-Cien Siao,
  • Yu-Hsuan Chen,
  • Tsai-Hung Wu,
  • Chang-Youh Tsai and
  • Chia-Li Yu
Molecules2012, 17(10), 11978-11989;https://doi.org/10.3390/molecules171011978

11 October 2012

In a previous study we noted significant THP binding to TNF-α, but did not explore the molecular basis of the structure-binding relationship. In this study, we used lectin-binding ELISA to assess the carbohydrate compositions of THP, BSA, IgG, TNF-α,...

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  • Article
  • Open Access
20 Citations
11,164 Views
16 Pages
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Tamm-Horsfall Glycoprotein Enhances PMN Phagocytosis by Binding to Cell Surface-Expressed Lactoferrin and Cathepsin G That Activates MAP Kinase Pathway

  • Syue-Cian Siao,
  • Ko-Jen Li,
  • Song-Chou Hsieh,
  • Cheng-Han Wu,
  • Ming-Chi Lu,
  • Chang-Youh Tsai and
  • Chia-Li Yu
Molecules2011, 16(3), 2119-2134;https://doi.org/10.3390/molecules16032119

3 March 2011

The molecular basis of polymorphonuclear neutrophil (PMN) phagocytosis-enhancing activity (PEA) by human purified urinary Tamm-Horsfall glyco- protein (THP) has not been elucidated. In this study, we found human THP bound to lactoferrin (LF) and cath...

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  • Review
  • Open Access
2,160 Views
14 Pages
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The Role of the Sda Carbohydrate Antigen and That of Its Cognate Glycosyltransferase B4GALNT2 in Health and Disease

  • Martina Duca,
  • Nadia Malagolini and
  • Fabio Dall’Olio
SynBio2025, 3(1), 6;https://doi.org/10.3390/synbio3010006

3 March 2025

The carbohydrate antigen Sda is expressed on the cells and secretions of the vast majority of Caucasians. The epitope is formed by a terminal GalNAc residue β4-linked to an α3-sialylated galactose. Different carbohydrate chains N- or O-lin...

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  • Article
  • Open Access
2 Citations
2,757 Views
11 Pages
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Longitudinal Changes in Serum Creatinine Levels and Urinary Biomarkers in Late Preterm Infants during the First Postnatal Week: Association with Acute Kidney Injury and Treatment with Aminoglycoside

  • Sang-Yoon Lee,
  • Jung-Eun Moon and
  • Sook-Hyun Park
Children2021, 8(10), 896;https://doi.org/10.3390/children8100896

9 October 2021

We aimed to determine the incidence of acute kidney injury (AKI) and longitudinal changes in SCr levels and urinary biomarkers associated with AKI and aminoglycoside (AG) medication during the first week of life of late preterm infants. Urine biomark...

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  • Article
  • Open Access
29 Citations
8,178 Views
18 Pages
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Fructus Gardenia Extract Ameliorates Oxonate-Induced Hyperuricemia with Renal Dysfunction in Mice by Regulating Organic Ion Transporters and mOIT3

  • Qing-Hua Hu,
  • Ji-Xiao Zhu,
  • Jing Ji,
  • Lin-Lin Wei,
  • Ming-Xing Miao and
  • Hui Ji
Molecules2013, 18(8), 8976-8993;https://doi.org/10.3390/molecules18088976

29 July 2013

The potent anti-hyperuricemia activities of Fructus Gardenia Extract (FGE) have been well reported. The aim of this study was to evaluate the uricosuric and nephro-protective effects of FGE and explore its possible mechanisms of action in oxonate-ind...

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  • Review
  • Open Access
45 Citations
25,715 Views
14 Pages
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Tamm–Horsfall Protein is a Potent Immunomodulatory Molecule and a Disease Biomarker in the Urinary System

  • Tsai-Hung Wu,
  • Ko-Jen Li,
  • Chia-Li Yu and
  • Chang-Youh Tsai
Molecules2018, 23(1), 200;https://doi.org/10.3390/molecules23010200

22 January 2018

Tamm–Horsfall protein (THP), or uromodulin (UMOD), is an 80–90-kDa phosphatidylinositol-anchored glycoprotein produced exclusively by the renal tubular cells in the thick ascending limb of the loop of Henle. Physiologically, THP is implicated in rena...

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