Search Results (13,575)

This article describes the design, methods, and baseline characteristics of the social needs assessment (SNA) of participants enrolled in an ongoing randomized clinical trial implementing a comprehensive approach to improving diabetes self-management and providing an intensive Diabetes Self-Management Education and Support (iDSMES) Program at St. Vincent’s House Clinic, a primary care practice serving resource-challenged diverse populations in Galveston, Texas. Standardized SNA was conducted to collect information on financial needs, psychosocial well-being, and other chronic health conditions. Based on their identified needs, participants were referred to non-medical existing community resources. A series of in-depth interviews were conducted with a subset of participants. A team member independently categorized these SNA narratives and aggregated them into two overarching groups: medical and social needs. Fifty-nine participants (with a mean age of 53 years and equal representation of men and women) completed an SNA. Most (71%) did not have health insurance. Among 12 potential social needs surveyed, the most frequently requested resources were occupational therapy (78%), utility assistance (73%), and food pantry services (71%). SNA provided data with the potential to address barriers that may hinder participation, retention, and outcomes in diabetes self-management. SNA findings may serve as tertiary prevention to mitigate diabetes-related complications and disparities. Full article

A novel stainless steel with high Mn and Mo content (much higher than traditional stainless steel), designated CH241SS, was developed as a potential replacement for Cr-Mo-V alloy steel in the cold forging applications of precision industry. Through carbon reduction in an environmentally friendly manner and a two-stage heat treatment process, the hardness of as-cast CH241 was tailored from HRC 37 to HRC 29, thereby meeting the industrial specifications of cold-forged steel (≤HRC 30). X-ray diffraction analysis of the as-cast microstructure revealed the presence of a small amount of ferrite, martensite, austenite, and alloy carbides. After heat treatment, CH241 exhibited a dual-phase microstructure consisting of ferrite and martensite with dispersed Cr(Ni-Mo) alloy carbides. The CH241 alloy demonstrated excellent high-temperature stability. No noticeable softening occurred after 72 h for the second-stage heat treatment. Based on the mechanical and room-temperature tensile fatigue properties of CH241-F (forging material) and CH241-ST (soft-tough heat treatment), it was demonstrated that the CH241 stainless steel was superior to the traditional stainless steel 4xx in terms of strength and fatigue life. Therefore, CH241 stainless steel can be introduced into cold forging and can be used in precision fatigue application. The relevant data include composition design and heat treatment properties. This study is an important milestone in assisting the upgrading of the vehicle and aerospace industries. Full article

This study investigates changes in Near-Surface Air Temperature (NSAT) over the South African region using weather station data, reanalysis products, and Coupled Model Intercomparison Project Phase 6 (CMIP6) model outputs. It is shown that, based on ERA5 reanalysis, the average NSAT increase in the region (45–10° S, 0–50° E) for the period 1940–2023 was 0.11 ± 0.04 °C. Weak multi-decadal changes in NSAT were observed from 1940 to the mid-1970s, followed by a rapid warming trend starting in the mid-1970s. Weather station data generally confirm these results, although they exhibit considerable inter-station variability. An ensemble of 33 CMIP6 models also reproduces these multi-decadal NSAT change characteristics. Specifically, the average model-simulated NSAT values for the region increased by 0.63 ± 0.12 °C between the periods 1940–1969 and 1994–2023. Based on the results of the comparison between weather station observations, reanalysis, and models, we utilize projections of NSAT changes from the analyzed ensemble of 33 CMIP6 models until the end of the 21st century under various Shared Socioeconomic Pathway (SSP) scenarios. These projections indicate that the average NSAT of the South African region will increase between 1994–2023 and 2070–2099 by 0.92 ± 0.36 °C under the SSP1-2.6 scenario, by 1.73 ± 0.44 °C under SSP2-4.5, by 2.52 ± 0.50 °C under SSP3-7.0, and by 3.17 ± 0.68 °C under SSP5-8.5. Between 1994–2023 and 2025–2054, the increase in average NSAT for the studied region, considering inter-model spread, will be 0.49–1.15 °C, depending on the SSP scenario. Furthermore, climate warming in South Africa, both in the next 30 years and by the end of the 21st century, is projected to occur according to all 33 CMIP6 models under all considered SSP scenarios. The main spatial feature of this warming is a more significant increase in NSAT over the landmass of the studied region compared to its surrounding waters, due to the stabilizing role of the ocean. Full article

Posterior capsule opacification (PCO), a frequent complication of cataract surgery, arises from dysregulated wound healing and fibrotic transformation of residual lens epithelial cells. While transcriptomic and machine learning (ML) approaches have elucidated fibrosis-related pathways in other tissues, the molecular divergence between regenerative and fibrotic outcomes in the lens remains unclear. Here, we used an ex vivo chick lens injury model to simulate post-surgical conditions, collecting RNA from lenses undergoing either regenerative wound healing or fibrosis between days 1–3 post-injury. Bulk RNA sequencing data were normalized, log-transformed, and subjected to univariate filtering prior to training LASSO, SVM, and RF ML models to identify discriminatory gene signatures. Each model was independently validated using a held-out test set. Distinct gene sets were identified, including fibrosis-associated genes (VGLL3, CEBPD, MXRA7, LMNA, gga-miR-143, RF00072) and wound-healing-associated genes (HS3ST2, ID1), with several achieving perfect classification. Gene Set Enrichment Analysis revealed divergent pathway activation, including extracellular matrix remodeling, DNA replication, and spliceosome associated with fibrosis. RT-PCR in independent explants confirmed key differential expression levels. These findings demonstrate the utility of supervised ML for discovering lens-specific fibrotic and regenerative gene features and nominate biomarkers for targeted intervention to mitigate PCO. Full article

As the electromagnetic spectrum is a limited and valuable resource, auctions have emerged as an effective tool for promoting efficient allocation and generating revenue. This article proposes a theoretical review of the most commonly used auction formats for spectrum auctions, highlighting the primary strengths and weaknesses of each format. Additionally, comparisons are made between the revenue generated by different auction formats and the corresponding countries in North and South America during the 21st century. The conclusion drawn is that the Combinatorial Clock Auction format is the preferred choice, as it consistently leads to more efficient allocation, as measured by the revenue generated from each auction. Full article

A multidisciplinary study was conducted to reconstruct the paleoenvironmental evolution of Maladroxia Bay, one of the principal bays of the islet of Sant’Antioco in southwestern Sardinia, over the past eight millennia. As part of an archaeological landscape project, this study explores the paleogeography and environment of the bay from a diachronic perspective to gain insights into the Holocene relative sea level history, shoreline displacements, and the environmental conditions during different phases. This study is based on an analysis of four sediment cores in conjunction with a chronological model that is based on radiocarbon dates. Four relative sea level indicators were produced. These are the first such indicators from the early and middle Holocene for the island of Sant’Antioco. The results indicate that in the early Holocene, the area was a terrestrial, fluvial environment without marine influence. In the 6th millennium BCE, the rising sea level and marine transgression resulted in the formation of a shallow inner lagoon. It reached its maximum extent in the middle of the 5th millennium BCE. Afterwards, a gradual transition from lagoon to floodplain, and a seaward shift of the shoreline occurred. The lagoon potentially served as a valuable source of food and resources during the middle Holocene. During the Nuragic period (2nd to 1st millennium BCE), the Bay of Maladroxia was very similar to how it is today. Its location was ideal for use as an anchorage, due to the calm and sheltered conditions that prevailed. Full article

Straw returning (ST) significantly improves soil quality and profoundly impacts soil microorganisms. However, the effects of different ST application amounts on the soil bacterial community remain unclear, and more studies on optimal ST application amounts are warranted. This study aimed to investigate the bacterial diversity and composition, as well as physicochemical properties, of soil in a corn field with 5-year ST amounts of 0, 3, 4.5, 5, and 6 t/hm², respectively. The results indicated that ST significantly reduced soil bulk density and increased soil pH and nutrients. Meanwhile, ST had a significant effect on the bacterial composition, and the bacterial diversity increased significantly after ST. The relative abundance of Proteobacteria and Acidobacteria increased dramatically, whereas that of Actinobacteria significantly decreased after ST. The amount of ST had threshold effects on soil physicochemical properties and the dominant bacterial phyla. Moreover, the co-occurrence networks indicated that bacterial stability first increased and then decreased with the increase in ST amounts. Soil organic carbon and total nitrogen concentrations were the main drivers of bacterial diversity, whereas soil pH and total nitrogen concentrations were the main drivers of bacterial composition. This study strengthens the fact that ST amounts have threshold effects on the soil physicochemical properties and soil microorganisms, and ST amounts of 3–5 t/hm² were appropriate. Full article

Non-agricultural business activity of farmers is crucial not only for stabilizing farm income but also for the multifunctional development of rural areas. Capturing changes in the level and nature of this activity supports the development of sustainable agricultural and rural policy. In this context, this study aimed to identify the scale and types of non-agricultural business activity and to recognize the main determinants of such business activities undertaken by farmers in Poland between 2002 and 2022. Sectoral-level data from the Agricultural Censuses and cyclical studies of the structure of farms and household budgets were used to approximate underlying motivations for running non-agricultural business (opportunity vs. necessity entrepreneurship). The findings indicate that, in Poland, the impact of regressive factors remains strong, pushing farmers to take on additional business activity due to the large share of small and very small farms. However, during the 21st century, a gradual spread of opportunity entrepreneurship among Polish farmers has been observed. This study highlights the rationale for supporting non-agriculture business activity motivated by progressive factors to increase the income resilience of farmer households and the sustainable development of agriculture. The article indicates the need for further research on the motives for undertaking non-agricultural economic activities by farmers and the impact of this activity on the allocation of farm resources. Full article

Plastic waste accumulation is one of the most pressing environmental challenges of the 21st century, owing to the widespread use of synthetic polymers and the limitations of conventional recycling methods. Among available strategies, chemical upcycling via depolymerization has emerged as a promising circular approach that converts plastic waste back into valuable monomers and chemical feedstocks. This article provides an in-depth narrative review of recent progress in the upcycling of major plastic types such as PET, PU, PS, and engineering plastics through thermal, chemical, catalytic, biological, and mechanochemical depolymerization methods. Each method is critically assessed in terms of efficiency, scalability, energy input, and environmental impact. Special attention is given to innovative catalyst systems, such as microsized MgO/SiO₂ and Co/CaO composites, and emerging enzymatic systems like engineered PETases and whole-cell biocatalysts that enable low-temperature, selective depolymerization. Furthermore, the conversion pathways of depolymerized products into high-purity monomers such as BHET, TPA, vanillin, and bisphenols are discussed with supporting case studies. The review also examines life cycle assessment (LCA) data, techno-economic analyses, and policy frameworks supporting the adoption of depolymerization-based recycling systems. Collectively, this work outlines the technical viability and sustainability benefits of depolymerization as a core pillar of plastic circularity and monomer recovery, offering a path forward for high-value material recirculation and waste minimization. Full article

Background: Heat therapy (HT) and electroacupuncture (EA) are widely utilized pain relief methods, but the analgesic mechanisms of their combined application remain unclear. Methods: In acetic acid (AA)-induced writhing test and complete Freund’s adjuvant (CFA)-induced inflammatory pain tests, mice received one of three treatments: EA at bilateral ST36, HT via a 45 °C heating pad, or the combination (EA + HT). To probe underlying pathways, separate groups were pretreated with caffeine, DPCPX (a selective adenosine A₁ receptor antagonist), or naloxone (an opioid receptor antagonist). Spinal expression of glial fibrillary acidic protein (GFAP) and phosphorylated p38 (p-p38) was examined by Western blot and immunofluorescence. Results: Both EA and HT individually reduced AA-induced writhing, with the combination (EA + HT) exhibiting the greatest analgesic effect. EA’s analgesic effect was reversed by caffeine and DPCPX and partially by naloxone, while HT’s effect was reversed by caffeine and DPCPX but was unaffected by naloxone. AA injection elevated spinal p-p38 and GFAP expression, which were attenuated by either EA or HT, with the most substantial suppression observed in the EA + HT group. In the CFA model, both treatments alleviated mechanical allodynia, while the combined treatment resulted in significantly greater analgesia compared to either treatment alone. Conclusions: EA combined with HT synergistically enhances analgesia in both AA and CFA pain models, accompanied by reduced spinal inflammation and astrocyte activation. EA’s analgesic effects appear to involve adenosine A₁ receptor pathways and, to a lesser extent, opioid receptor mechanisms, whereas HT’s effects involve adenosine A₁ receptor pathways. Full article

Orthognathic surgery (OS) is a complex procedure commonly used to treat dentofacial deformities (DFDs). These conditions, related to jaw position or size and often involving malocclusion, affect approximately 15% of the population. Due to the complexity of OS, accurate planning is essential. Digital assessment using computer-aided design (CAD) and computer-aided manufacturing (CAM) tools enhances surgical predictability. However, limitations in soft tissue simulation often require surgeon input to optimize aesthetic results and minimize surgical impact. This study aimed to evaluate the accuracy of virtual surgery planning (VSP) by analyzing the relationship between planning deviations and surgical satisfaction. A single-center, retrospective study was conducted on 16 patients who underwent OS at San Pedro University Hospital of La Rioja. VSP was based on CT scans using Dolphin Imaging software (v12.0, Patterson Dental, St. Paul, MN, USA) and surgeries were guided by VSP-designed occlusal splints. Outcomes were assessed using the Orthognathic Quality of Life (OQOL) questionnaire and deviations were measured through pre- and postoperative imaging. The results showed high satisfaction scores and good overall outcomes, despite moderate deviations from the virtual plan in many cases, particularly among Class II patients. A total of 63% of patients required VSP modifications due to poor soft tissue fitting, with 72% of these being Class II DFDs. Most deviations involved less maxillary advancement than planned, while maintaining optimal occlusion. This suggests that VSP may overestimate advancement needs, especially in Class II cases. No significant differences in satisfaction were observed between patients with low (<2 mm) and high (>2 mm) deviations. These findings support the use of VSP as a valuable planning tool for OS. However, surgeon experience remains essential, especially in managing soft tissue behavior. Improvements in soft tissue prediction are needed to enhance accuracy, particularly for Class II DFDs. Full article

This study investigates the synergistic modification of cement–soil using waste brick powder (WBP) and polyvinyl alcohol (PVA) fibers to address the growing demand for sustainable construction materials and recycling of demolition waste. An orthogonal experimental design was employed with 5% WBP (by mass) and PVA fiber content (0–1%), evaluating mechanical properties based on unconfined compressive strength (UCS) and splitting tensile strength (STS) and microstructure via scanning electron microscopy (SEM) across 3–28 days of curing. The results demonstrate that 0.75% PVA optimizes performance, enhancing UCS by 28.3% (6.87 MPa) and STS by 34.6% (0.93 MPa) at 28 days compared to unmodified cement–soil. SEM analysis revealed that PVA fibers bridged microcracks, suppressing propagation, while WBP triggered pozzolanic reactions to densify the matrix. This dual mechanism concurrently improves mechanical durability and valorizes construction waste, offering a pathway to reduce reliance on virgin materials. This study establishes empirically validated mix ratios for eco-efficient cement–soil composites, advancing scalable solutions for low-carbon geotechnical applications. By aligning material innovation with circular economy principles, this work directly supports global de-carbonization targets in the construction sector. Full article

This paper presents a novel, multi-stage modelling approach for integrating Generative AI (GenAI) tools into design-based STEM education, promoting sustainability and 21st-century problem-solving skills. The proposed methodology includes (i) a conceptual model that defines structural aspects of the domain at a high abstraction level; (ii) a contextual model for defining the internal context; (iii) a GenAI-based model for solving the STEM task, which consists of a generic model for integrating GenAI tools into STEM-driven education and a process model, presenting learning/design processes using those tools. A case study involving the design of an autonomous folkrace robot illustrates the implementation of the approach. Based on Likert-scale evaluations, quantitative results demonstrate a significant impact of GenAI tools in enhancing critical thinking, conceptual understanding, creativity, and engineering practices, particularly during the prototyping and testing phases. This paper concludes that the structured integration of GenAI tools supports personalized, inquiry-based, and sustainable STEM education, while also raising new challenges in prompt engineering and ethical use. This approach provides educators with a systematic pathway for leveraging AI to develop STEM-based skills essential for future sustainable development. Full article

This study aimed to compare isometric strength, range of motion (RoM), and strength ratios of shoulder internal and external rotators between female volleyball and hand ball players Twenty-five volleyball players (age = 21.8 ± 4.8 years, height = 178.5 ± 7.1 cm, mass = 69.3 ± 7.7 kg) and twenty-four handball players (age = 19.5 ± 2.9 years, height = 169.7 ± 6.4 cm, mass = 67.6 ± 8.4 kg), all competing in the Slovenian 1st national league, participated. Maximal isometric strength and passive RoM of internal and external rotation were measured bilaterally using a handheld dynamometer and goniometer, respectively. A significant group × side interaction was observed for internal rotation RoM (F = 5.41; p = 0.024; η² = 0.10), with volleyball players showing lower RoM on the dominant side (p = 0.001; d = 0.89), but this was not the case for handball players (p = 0.304). External rotation strength also showed a significant interaction (F = 9.34; p = 0.004; η² = 0.17); volleyball players were stronger in the non-dominant arm (p = 0.033), while handball players were stronger in the dominant arm (p = 0.041). The external-to-internal rotation strength ratio was significantly lower on the dominant side in volleyball players compared to handball players (p = 0.047; d = 0.59). Findings suggest sport-specific adaptations and asymmetries in shoulder function, emphasizing the need for sport-specific and individually tailored injury prevention strategies. Volleyball players, in particular, may benefit from targeted strengthening of external rotators and flexibility training to address imbalances. Full article

Background and Objectives: Rumors, disinformation, and fake news are problems of contemporary society. We live in a world where the truth no longer holds much importance, and the line that divides the truth from lies, between real news and disinformation, becomes increasingly blurred and difficult to identify. The purpose of this study is to describe this concept, to draw attention to one of the “pandemics” of the 21st-century world, and to find methods by which we can defend ourselves against them. Materials and methods. A cross-sectional study was conducted based on a sample of 442 respondents. Results. For 77.8% of the people surveyed, the concept of “fake news” is important in Romania. Regarding trust in the mass media, a clear dominance (72.4%) was observed among participants who have little trust in the mass media. Although 98.2% of participants detect false information found on the internet, 78.5% are occasionally deceived by the information provided. Of the participants, 47.3% acknowledged their vulnerability to disinformation. The main source of disinformation is the internet, as 59% of the interviewed subjects believed. As the best measure against disinformation, the study group was divided almost equally according to the three possible answers, all of which were considered to be equally important: imposing legal restrictions and blocking the posting of certain news (35.4%), imposing stricter measures for authors (33.9%), and increasing vigilance among people (30.5%). Conclusions. According to the statistics based on the participants’ responses, the main purposes of disinformation are propaganda, manipulation, distracting attention from the truth, making money, and misleading the population. It can be observed that the main intention of disinformation, in the perception of the study participants, is manipulation. Full article