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Article

21 Citations

5,914 Views

13 Pages

EpCAM- and EGFR-Specific Antibody Drug Conjugates for Triple-Negative Breast Cancer Treatment

Chaoyu Zhang,
Wenjie Sheng,
Marwah Al-Rawe,
T. M. Mohiuddin,
Marcus Niebert,
Felix Zeppernick,
Ivo Meinhold-Heerlein and
Ahmad Fawzi Hussain

Int. J. Mol. Sci.2022, 23(11), 6122;https://doi.org/10.3390/ijms23116122

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30 May 2022

Triple-negative breast cancer (TNBC) is a group of heterogeneous and refractory breast cancers with the absence of estrogen receptor (ER), progesterone receptor (PgR) and epidermal growth factor receptor 2 (HER2). Over the past decade, antibody drug...

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Article

1 Citations

4,180 Views

21 Pages

Development of SNAP-Tag Based Nanobodies as Secondary Antibody Mimics for Indirect Immunofluorescence Assays

Wenjie Sheng,
Chaoyu Zhang,
T. M. Mohiuddin,
Marwah Al-Rawe,
Roland Schmitz,
Marcus Niebert,
Lutz Konrad,
Steffen Wagner,
Felix Zeppernick and
Ivo Meinhold-Heerlein
+ 1 author

Cells2025, 14(10), 691;https://doi.org/10.3390/cells14100691

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10 May 2025

The immunofluorescence assay is widely used for cellular biology and diagnosis applications. Such an antigen–antibody detection system enables the assessment and visualization of the expression and localization of target proteins. In the classi...

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Article

20 Citations

9,018 Views

15 Pages

Immobilization of Ferrocene-Modified SNAP-Fusion Proteins

Dorothee Wasserberg,
Dana A. Uhlenheuer,
Pauline Neirynck,
Jordi Cabanas-Danés,
Jan Hendrik Schenkel,
Bart Jan Ravoo,
Qi An,
Jurriaan Huskens,
Lech-Gustav Milroy and
Luc Brunsveld
+ 1 author

Int. J. Mol. Sci.2013, 14(2), 4066-4080;https://doi.org/10.3390/ijms14024066

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18 February 2013

The supramolecular assembly of proteins on surfaces has been investigated via the site-selective incorporation of a supramolecular moiety on proteins. To this end, fluorescent proteins have been site-selectively labeled with ferrocenes, as supramolec...

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