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Search Results (581)

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Keywords = Revelation 14:1–5

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9 pages, 159 KiB  
Article
The Mask and the Giant: Shakespearean Acting and Reputation Management
by Darren Tunstall
Humanities 2025, 14(8), 159; https://doi.org/10.3390/h14080159 - 31 Jul 2025
Viewed by 101
Abstract
I use Shakespeare to teach acting to students. A key to my work is impression management: what Shakespeare called reputation. I view the management of reputation as a route into Shakespearean character, which I present to students as a mask attuned to sacred [...] Read more.
I use Shakespeare to teach acting to students. A key to my work is impression management: what Shakespeare called reputation. I view the management of reputation as a route into Shakespearean character, which I present to students as a mask attuned to sacred values. The physical basis from which the actor can discover the mask is what Hamlet calls ‘smoothness’, which I explain with an acting exercise. We discover the force of sacred values by noticing the ubiquity of keywords in the text such as honor, virtue, reason, shame and faith. By holding characters to the fire of their sacred values, I shift the actor’s attention from an individualist idea of authentic representation towards a sense of character as a battleground of mind-shaping. The resulting performance work is scaled up to a more expansive and energized degree than the actor may be used to delivering in a social media-saturated environment in which what is often prioritized is a quasi-confessional self-revelation. The revelation of an inner life then emerges through a committed exploration of antithetical relations, a strategy basic both to mask work and to Shakespeare’s poetics. The actor finds their personal connection to the material by facing the contradiction between the objective standards of behavior demanded of the character and the character’s attempt to control their status, that is, how they are seen. The final value of the performance work is that the actor learns how to manage their reputation so that they come to appear like a giant who is seen from a distance. Full article
31 pages, 3754 KiB  
Review
Artificial Gametogenesis and In Vitro Spermatogenesis: Emerging Strategies for the Treatment of Male Infertility
by Aris Kaltsas, Maria-Anna Kyrgiafini, Eleftheria Markou, Andreas Koumenis, Zissis Mamuris, Fotios Dimitriadis, Athanasios Zachariou, Michael Chrisofos and Nikolaos Sofikitis
Int. J. Mol. Sci. 2025, 26(15), 7383; https://doi.org/10.3390/ijms26157383 - 30 Jul 2025
Viewed by 324
Abstract
Male-factor infertility accounts for approxiamately half of all infertility cases globally, yet therapeutic options remain limited for individuals with no retrievable spermatozoa, such as those with non-obstructive azoospermia (NOA). In recent years, artificial gametogenesis has emerged as a promising avenue for fertility restoration, [...] Read more.
Male-factor infertility accounts for approxiamately half of all infertility cases globally, yet therapeutic options remain limited for individuals with no retrievable spermatozoa, such as those with non-obstructive azoospermia (NOA). In recent years, artificial gametogenesis has emerged as a promising avenue for fertility restoration, driven by advances in two complementary strategies: organotypic in vitro spermatogenesis (IVS), which aims to complete spermatogenesis ex vivo using native testicular tissue, and in vitro gametogenesis (IVG), which seeks to generate male gametes de novo from pluripotent or reprogrammed somatic stem cells. To evaluate the current landscape and future potential of these approaches, a narrative, semi-systematic literature search was conducted in PubMed and Scopus for the period January 2010 to February 2025. Additionally, landmark studies published prior to 2010 that contributed foundational knowledge in spermatogenesis and testicular tissue modeling were reviewed to provide historical context. This narrative review synthesizes multidisciplinary evidence from cell biology, tissue engineering, and translational medicine to benchmark IVS and IVG technologies against species-specific developmental milestones, ranging from rodent models to non-human primates and emerging human systems. Key challenges—such as the reconstitution of the blood–testis barrier, stage-specific endocrine signaling, and epigenetic reprogramming—are discussed alongside critical performance metrics of various platforms, including air–liquid interface slice cultures, three-dimensional organoids, microfluidic “testis-on-chip” devices, and stem cell-derived gametogenic protocols. Particular attention is given to clinical applicability in contexts such as NOA, oncofertility preservation in prepubertal patients, genetic syndromes, and reprocutive scenarios involving same-sex or unpartnered individuals. Safety, regulatory, and ethical considerations are critically appraised, and a translational framework is outlined that emphasizes biomimetic scaffold design, multi-omics-guided media optimization, and rigorous genomic and epigenomic quality control. While the generation of functionally mature sperm in vitro remains unachieved, converging progress in animal models and early human systems suggests that clinically revelant IVS and IVG applications are approaching feasibility, offering a paradigm shift in reproductive medicine. Full article
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13 pages, 339 KiB  
Article
Babel and New Jerusalem: Two Urban Expressions of Theological Contrast
by Bret David Fearrien
Religions 2025, 16(8), 982; https://doi.org/10.3390/rel16080982 - 29 Jul 2025
Viewed by 230
Abstract
Numerous researchers have linked the description of the New Jerusalem in Rev 21 to Fallen Babylon in Rev 18 in order to establish intertextual opportunities for comparison and contrast. However, the New Jerusalem is seldom linked to the Tower of Babel in Gen [...] Read more.
Numerous researchers have linked the description of the New Jerusalem in Rev 21 to Fallen Babylon in Rev 18 in order to establish intertextual opportunities for comparison and contrast. However, the New Jerusalem is seldom linked to the Tower of Babel in Gen 11—essentially, the urban archetype of Babylon in the Old Testament. Exploring these two urban metaphors—from a largely canonical, theological perspective—it appears that the New Jerusalem and the Tower of Babel stand out as two urban expressions of theological contrast. The two city metaphors contrast each other as they relate to themes of builders, unity/diversity, and temple language when describing divine and human activities. Full article
(This article belongs to the Section Religions and Theologies)
17 pages, 284 KiB  
Article
Becoming God in Life and Nature: Watchman Nee and Witness Lee on Sanctification, Union with Christ, and Deification
by Michael M. C. Reardon and Brian Siu Kit Chiu
Religions 2025, 16(7), 933; https://doi.org/10.3390/rel16070933 - 18 Jul 2025
Viewed by 695
Abstract
This article examines the theological trajectories of Watchman Nee (1903–1972) and Witness Lee (1905–1997) on sanctification, union with Christ, and deification, situating their contributions within recent reappraisals of the doctrine of theosis in the academy. Though deification was universally affirmed by the early [...] Read more.
This article examines the theological trajectories of Watchman Nee (1903–1972) and Witness Lee (1905–1997) on sanctification, union with Christ, and deification, situating their contributions within recent reappraisals of the doctrine of theosis in the academy. Though deification was universally affirmed by the early church and retained in various forms in medieval and early Protestant theology, post-Reformation Western Christianity marginalized this theme in favor of juridical and forensic soteriological categories. Against this backdrop, Nee and Lee offer a theologically rich, biblically grounded, and experientially oriented articulation of deification that warrants greater scholarly attention. Drawing from the Keswick Holiness tradition, patristic sources, and Christian mysticism, Nee developed a soteriology that integrates justification, sanctification, and glorification within an organic model of progressive union with God. Though he does not explicitly use the term “deification”, the language he employs regarding union and participation closely mirrors classical expressions of Christian theosis. For Nee, sanctification is not merely moral improvement but the transformative increase of the divine life, culminating in conformity to Christ’s image. Lee builds upon and expands Nee’s participatory soteriology into a comprehensive theology of deification, explicitly referring to it as “the high peak of the divine revelation” in the Holy Scriptures. For Lee, humans become God “in life and nature but not in the Godhead”. By employing the phrase “not in the Godhead”, Lee upholds the Creator–creature distinction—i.e., humans never participate in the ontological Trinity or God’s incommunicable attributes. Yet, in the first portion of his description, he affirms that human beings undergo an organic, transformative process by which they become God in deeply significant ways. His framework structures sanctification as a seven-stage process, culminating in the believer’s transformation and incorporation into the Body of Christ to become a constituent of a corporate God-man. This corporate dimension—often overlooked in Western accounts—lies at the heart of Lee’s ecclesiology, which he sees as being consummated in the eschatological New Jerusalem. Ultimately, this study argues that Nee and Lee provide a coherent, non-speculative model of deification that integrates biblical exegesis, theological tradition, and practical spirituality, and thus, present a compelling alternative to individualistic and forensic soteriologies while also highlighting the need for deeper engagement across global theological discourse on sanctification, union with Christ, and the Triune God. Full article
(This article belongs to the Special Issue Christian Theologies of Deification)
41 pages, 424 KiB  
Article
Rationalising the First Crusade (1095–1099): Rupert of Deutz, the Roman Conquest of Jerusalem, and the Twists of Salvation History
by Alexander Marx
Religions 2025, 16(7), 919; https://doi.org/10.3390/rel16070919 - 16 Jul 2025
Viewed by 290
Abstract
Many contemporaries considered the crusader conquest of Jerusalem in 1099 as a significant moment in Salvation History. This article investigates how the reception of the Roman conquest of the city (70 CE) contributed to such an understanding. The important Benedictine exegete Rupert of [...] Read more.
Many contemporaries considered the crusader conquest of Jerusalem in 1099 as a significant moment in Salvation History. This article investigates how the reception of the Roman conquest of the city (70 CE) contributed to such an understanding. The important Benedictine exegete Rupert of Deutz (c. 1070–1129) refers to the Roman conquest in 79 passages within his opus, notably in his various biblical commentaries. This case study shows how the past event provided a rationale, exegetical and providential in nature, to understand three dimensions: (a) the role of the Jews, especially that it had been necessary to deprive them of the Holy Land; (b) the current situation of and purpose of Christians in the Holy Land; and (c) the End of Time, which was expected in Jerusalem, and which Rupert anchored already significantly in his own present. His commentary on John’s Revelation even asserted that the Roman conquest had opened the sixth of seven seals (Rev. 6:12). Therefore, the Apocalypse had been ongoing since 70 CE—but only in the Holy Land, a fact that made it necessary for Christians to travel there. The article thus demonstrates that biblical commentaries are potent sources for both crusade studies and historical research in general. Full article
18 pages, 639 KiB  
Article
Predictors of Macro Socio-Ecological Factors Affecting Minority-Muslims and Majority Non-Muslim Anglo Communities’ Perceptions of Each Other
by Abe Ata and David T. Teh
Religions 2025, 16(7), 913; https://doi.org/10.3390/rel16070913 - 16 Jul 2025
Viewed by 505
Abstract
This study was carried out to determine if macro-level factors (namely, demographic and ecological factors) influence self-perceived social distance and actual social practice with individuals of different faith communities among tertiary students in Australian universities. The response drew several critical revelations, including 2 [...] Read more.
This study was carried out to determine if macro-level factors (namely, demographic and ecological factors) influence self-perceived social distance and actual social practice with individuals of different faith communities among tertiary students in Australian universities. The response drew several critical revelations, including 2 key findings: 1. Muslim and non-Muslim respondents largely befriend individuals of similar faith backgrounds, although non-Muslims were far more likely to be indifferent towards the religious beliefs of their immediate social circle. 2. Respondents with highly religious social circles reported a clear preference against befriending individuals of different faiths. Muslims were mainly reluctant to befriend non-Muslims, whereas non-Muslims were slightly less apprehensive. The findings presented in this study demonstrate the complexity and dynamism of intergroup contact, traditionally termed social distance, that has distinct implications for social integration. Whereas negative attitudes provide insight into the affective evaluation of a particular group, measures of social distance directly assess the impact of contact on the structural integration of groups. Given its inherently relational focus, this is an important direction for work on intergroup contact. Full article
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16 pages, 494 KiB  
Article
Kaddish and Other Millin Setimin: Esoteric Languages in Jewish–American Narratives
by Ofra Amihay
Humanities 2025, 14(7), 149; https://doi.org/10.3390/h14070149 - 15 Jul 2025
Viewed by 271
Abstract
In this article, I analyze the use of Hebrew, Yiddish, and Aramaic texts—and the Kaddish in particular—as esoteric tongues in Jewish–American narratives, including poems, plays, television shows, and films. I suggest that by doing so, the creators of these works evoke the Lurianic [...] Read more.
In this article, I analyze the use of Hebrew, Yiddish, and Aramaic texts—and the Kaddish in particular—as esoteric tongues in Jewish–American narratives, including poems, plays, television shows, and films. I suggest that by doing so, the creators of these works evoke the Lurianic notion of millin setimin or “secreted words”—utterances that transcend the communicative function of everyday speech and partake in some profound revelations. I hope to show that from Allen Ginsberg, through Tony Kushner, to the Coen Brothers and beyond, Jewish–American creators have been evoking Jewish tongues both as symbols of a lost past and as millin setimin that aspire to restore the connection to that past, within the Jewish–American community and beyond. Full article
(This article belongs to the Special Issue Comparative Jewish Literatures)
25 pages, 8705 KiB  
Review
A Systems Perspective on Material Stocks Research: From Quantification to Sustainability
by Tiejun Dai, Zhongchun Yue, Xufeng Zhang and Yuanying Chi
Systems 2025, 13(7), 587; https://doi.org/10.3390/systems13070587 - 15 Jul 2025
Viewed by 375
Abstract
Material stocks (MS) serve as essential physical foundations for socio–economic systems, reflecting the accumulation, transformation, and consumption of resources over time and space. Positioned at the intersection of environmental and socio–economic systems, MS are increasingly recognized as leverage points for advancing sustainability. However, [...] Read more.
Material stocks (MS) serve as essential physical foundations for socio–economic systems, reflecting the accumulation, transformation, and consumption of resources over time and space. Positioned at the intersection of environmental and socio–economic systems, MS are increasingly recognized as leverage points for advancing sustainability. However, there is currently a lack of comprehensive overview, making it difficult to fully capture the latest developments and cutting–edge research. We adopt a systems perspective to conduct a comprehensive bibliometric and thematic review of 602 scholarly publications on MS research. The results showed that MS research encompasses has three development periods: preliminary exploration (before 2007), rapid development (2007–2016), and expansion and deepening (after 2016). MS research continues to deepen, gathering multiple teams and differentiating into diverse topics. MS research has evolved from simple accounting to intersection with socio–economic, resources, and environmental systems, and shifted from relying on statistical data to integrating high–spatio–temporal–resolution geographic big data. MS research is shifting from problem revelation to problem solving, constantly achieving new developments and improvements. In the future, it is still necessary to refine MS spatio–temporal distribution, reveal MS’s evolution mechanism, establish standardized databases, strengthen interaction with other systems, enhance problem–solving abilities, and provide powerful guidance for the formulation of dematerialization and decarbonization policies to achieve sustainable development. Full article
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15 pages, 4108 KiB  
Article
A Multidisciplinary Non-Invasive Approach for the Examination of a Wooden Panel Painting
by Georgia T. Varfi, Spyridoula Farmaki, Georgios P. Mastrotheodoros, Dimitrios A. Exarchos, Anastasios Asvestas, Dimitrios F. Anagnostopoulos and Theodore E. Matikas
Heritage 2025, 8(7), 271; https://doi.org/10.3390/heritage8070271 - 9 Jul 2025
Viewed by 269
Abstract
In this article, a multidisciplinary methodological approach for studying a wooden panel painting is applied. The theoretical framework, within which this research has arisen, is the application of state-of-the-art non-destructive techniques for addressing issues concerning the constituting parts and composing materials of the [...] Read more.
In this article, a multidisciplinary methodological approach for studying a wooden panel painting is applied. The theoretical framework, within which this research has arisen, is the application of state-of-the-art non-destructive techniques for addressing issues concerning the constituting parts and composing materials of the artwork. Hereby, a post-Byzantine icon was studied, which was dated back to 1836. It is a painting executed on a wooden panel, with a decorated wooden frame attached. The artifact was thoroughly investigated through the application of infrared thermography (IRT), multispectral imaging (MSI), and macroscopic X-ray fluorescence spectrometry (MA-XRF). These analyses provided crucial information about the verso of the painting (i.e., the wooden panel and the frame) and allowed for the revelation of important details of the recto of the painting, which were not visible due to the presence of an old, decayed varnish. Additionally, through the detailed mapping of the distribution of various chemical elements on the recto of the painting and the frame, it was possible to identify the materials used and techniques employed. It is therefore shown that, when combined, the non-destructive methodologies in consideration can provide adequate information referring to the materiality and state of preservation of panel paintings, permitting the conservator to proceed to a tailored conservation treatment. Full article
(This article belongs to the Special Issue Recent Progress in Cultural Heritage Diagnostics)
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33 pages, 8285 KiB  
Article
TrustShare: Secure and Trusted Blockchain Framework for Threat Intelligence Sharing
by Hisham Ali, William J. Buchanan, Jawad Ahmad, Marwan Abubakar, Muhammad Shahbaz Khan and Isam Wadhaj
Future Internet 2025, 17(7), 289; https://doi.org/10.3390/fi17070289 - 27 Jun 2025
Viewed by 444
Abstract
We introduce TrustShare, a novel blockchain-based framework designed to enable secure, privacy-preserving, and trust-aware cyber threat intelligence (CTI) sharing across organizational boundaries. Leveraging Hyperledger Fabric, the architecture supports fine-grained access control and immutability through smart contract-enforced trust policies. The system combines Ciphertext-Policy [...] Read more.
We introduce TrustShare, a novel blockchain-based framework designed to enable secure, privacy-preserving, and trust-aware cyber threat intelligence (CTI) sharing across organizational boundaries. Leveraging Hyperledger Fabric, the architecture supports fine-grained access control and immutability through smart contract-enforced trust policies. The system combines Ciphertext-Policy Attribute-Based Encryption (CP-ABE) with temporal, spatial, and controlled revelation constraints to grant data owners precise control over shared intelligence. To ensure scalable decentralized storage, encrypted CTI is distributed via the IPFS, with blockchain-anchored references ensuring verifiability and traceability. Using STIX for structuring and TAXII for exchange, the framework complies with the GDPR requirements, embedding revocation and the right to be forgotten through certificate authorities. The experimental validation demonstrates that TrustShare achieves low-latency retrieval, efficient encryption performance, and robust scalability in containerized deployments. By unifying decentralized technologies with cryptographic enforcement and regulatory compliance, TrustShare sets a foundation for the next generation of sovereign and trustworthy threat intelligence collaboration. Full article
(This article belongs to the Special Issue Distributed Machine Learning and Federated Edge Computing for IoT)
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12 pages, 239 KiB  
Article
What Is Scripture for Thomas Aquinas?
by Piotr Roszak and Krzysztof Krzemiński
Religions 2025, 16(7), 845; https://doi.org/10.3390/rel16070845 - 26 Jun 2025
Viewed by 249
Abstract
St. Thomas Aquinas defines theology (sacra doctrina) as the communication of wisdom that comes from God and leads to Him. What is important here, according to Thomas, is to read the Bible as a whole and not as a cluster of random books. [...] Read more.
St. Thomas Aquinas defines theology (sacra doctrina) as the communication of wisdom that comes from God and leads to Him. What is important here, according to Thomas, is to read the Bible as a whole and not as a cluster of random books. Revelation, and the testimony of it which is the Bible, cannot be reduced to a mere literal communication of divine truth. More fundamental than the biblical words (verba) themselves is the reality (res) to which they refer: the salvific truth communicated by God. The Thomistic approach to Scripture in theology is shaped by four complementary dimensions: auctoritas (power of authority), sensus (meaning), finis (purpose), and documentum (testimony). In this light, Scripture functions as the “alphabet” of theology—the foundational semantic structure through which revealed truth is expressed and transmitted. Full article
18 pages, 232 KiB  
Article
Reason and Revelation in Ibn Taymiyyah’s Critique of Philosophical Theology: A Contribution to Contemporary Islamic Philosophy of Religion
by Adeeb Obaid Alsuhaymi and Fouad Ahmed Atallah
Religions 2025, 16(7), 809; https://doi.org/10.3390/rel16070809 - 20 Jun 2025
Viewed by 1274
Abstract
This paper addresses the longstanding tension between reason and revelation in Islamic religious epistemology, with a focus on the thought of Ibn Taymiyyah (d. 728/1328). It aims to reassess his critique of philosophical theology (falsafa and kalām) and explore his constructive alternative to [...] Read more.
This paper addresses the longstanding tension between reason and revelation in Islamic religious epistemology, with a focus on the thought of Ibn Taymiyyah (d. 728/1328). It aims to reassess his critique of philosophical theology (falsafa and kalām) and explore his constructive alternative to rationalist metaphysics. The study adopts a descriptive–analytical methodology, combining close textual reading of Darʾ Taʿāruḍ al-ʿAql wa al-Naql and Naqd al-Manṭiq with conceptual analysis informed by contemporary religious epistemology and philosophy of religion. The findings reveal that Ibn Taymiyyah advances a triadic epistemological model centered on revelation (naql), reason (ʿaql), and innate disposition (fiṭrah). He refutes the autonomy of reason, redefines logic as a tool rather than a judge, and repositions fiṭrah as an intuitive foundation for belief. His approach emphasizes the harmony of sound reason with authentic revelation and challenges the epistemic assumptions of speculative theology. By presenting a comparative table of rationalist and Taymiyyan epistemologies, the study demonstrates how Ibn Taymiyyah’s framework anticipates key themes in Reformed Epistemology and the cognitive science of religion. The conclusions suggest that his vision offers a coherent, theocentric paradigm for religious knowledge that is highly relevant to the contemporary philosophy of religion and Islamic theology. Full article
(This article belongs to the Special Issue Problems in Contemporary Islamic Philosophy of Religion)
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16 pages, 340 KiB  
Article
“Circulations” and Self-Transcendence: A Comparative Study of Emerson and Zhuangzi
by Meng Jia
Religions 2025, 16(6), 702; https://doi.org/10.3390/rel16060702 - 29 May 2025
Cited by 1 | Viewed by 404
Abstract
In this article, I begin with the topic of “circulations”, conducting a comparative analysis of the similarities and differences in Emerson’s and Zhuangzi’s philosophies regarding “circulations” as the mode of cosmic generation and operation, as well as the relationship between “circulations” and self-transcendence. [...] Read more.
In this article, I begin with the topic of “circulations”, conducting a comparative analysis of the similarities and differences in Emerson’s and Zhuangzi’s philosophies regarding “circulations” as the mode of cosmic generation and operation, as well as the relationship between “circulations” and self-transcendence. Furthermore, I explore the practical paths to achieve self-transcendence via circulations based on these two aspects. Specifically, both Emerson and Zhuangzi regard “circulations” as the fundamental way of cosmic generation and operation. However, Emerson emphasizes the directionality of “circulations”, where God generates all things through “emanation”, and all things return to God through “ascent”. In contrast, Zhuangzi emphasizes the characteristics of the Dao in generating all things, including its “cyclic repetition” (xun huan wang fu 循环往复) and “creating myriad forms” (zhi qi wan shu 制器万殊). The “Dao” that generates these “circulations” itself does not possess morality or divinity. Both of them believe that individuals can achieve self-transcendence by aligning with “circulations”. Regarding the specific practical paths, Emerson suggests that we can return to God through revelation, specifically via nature, poets, art, and vocation. On the other hand, Zhuangzi believes that we can achieve unity with the Dao by “following the Dao”, specifically through the life-nurturing method of “following the Du as a principle” (yuan du yi wei jing 缘督以为经) and the spiritual cultivation methods of “emptiness of mind-heart and selflessness” (xinzhai 心斋) and “sitting in oblivion” (zuowang 坐忘). Full article
14 pages, 228 KiB  
Article
Monogenism Revisited: New Perspectives on a Classical Controversy
by Wojciech Piotr Grygiel and Olaf Lizak
Religions 2025, 16(6), 694; https://doi.org/10.3390/rel16060694 - 28 May 2025
Viewed by 429
Abstract
Recent attempts to reconcile the doctrine of original sin with evolutionary theory have sought scientific validation for the historicity of Adam and Eve, particularly through arguments for a single ancestral pair. This paper critically examines such efforts, arguing that they constitute a disguised [...] Read more.
Recent attempts to reconcile the doctrine of original sin with evolutionary theory have sought scientific validation for the historicity of Adam and Eve, particularly through arguments for a single ancestral pair. This paper critically examines such efforts, arguing that they constitute a disguised form of creation science, selectively engaging with evolution to preserve classical Christian anthropology. Through biblical exegesis, theological hermeneutics, and biological research, this study demonstrates that these approaches rest on uncertain scientific and theological premises. Genesis 1–11 is sapiential rather than historical, and genetic evidence biological evidence points to population-oriented emergence of our species. Theological attempts to preserve a literal Adam and Eve rest on an outdated view of revelation as mere information transfer, leading to conceptual confusion and misinterpretation. The pursuit of a historical Adam and Eve as a scientific reality ultimately distorts both theology and science, reducing theology to ideology and fundamentalism while undermining its engagement with mystery and transcendence. Full article
(This article belongs to the Special Issue Images of the World in the Dialogue between Science and Religion)
20 pages, 786 KiB  
Review
Phase Separation in Chromatin Organization and Human Diseases
by Ziwei Zhai, Fei Meng, Junqi Kuang and Duanqing Pei
Int. J. Mol. Sci. 2025, 26(11), 5156; https://doi.org/10.3390/ijms26115156 - 28 May 2025
Viewed by 1070
Abstract
Understanding how the genome is organized into multi-level chromatin structures within cells and how these chromatin structures regulate gene transcription influencing animal development and human diseases has long been a major goal in genetics and cell biology. Recent evidence suggests that chromatin structure [...] Read more.
Understanding how the genome is organized into multi-level chromatin structures within cells and how these chromatin structures regulate gene transcription influencing animal development and human diseases has long been a major goal in genetics and cell biology. Recent evidence suggests that chromatin structure formation and remodeling is regulated not only by chromatin loop extrusion but also by phase-separated condensates. Here, we discuss recent findings on the mechanisms of chromatin organization mediated by phase separation, with a focus on the roles of phase-separated condensates in chromatin structural dysregulation in human diseases. Indeed, these mechanistic revelations herald promising therapeutic strategies targeting phase-separated condensates—leveraging their intrinsic biophysical susceptibilities to restore chromatin structure dysregulated by aberrant phase separation. Full article
(This article belongs to the Special Issue Recent Advances in Chromatin Structure and Dynamics)
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