Search Results (667)

Food policies that respond to shocks and support nutritious diets for vulnerable populations can enhance resilience, support social equity, and reduce environmental damage. Using a simulation model, we evaluated the effectiveness of two food redistribution policies—Nourish New York, a program providing funds to food rescue organizations to purchase food directly from farmers, and the Food Donation and Food Scraps Recycling Law (an organics “waste ban”)—in response to a shock such as the COVID-19 pandemic. We assessed policy based on recovered food and life cycle carbon and water footprints over 10 years. Both policies improved produce donations during post-shock. The waste ban increased waste at feeding organizations; diverting unavoidable food waste to composting and anaerobic digestion mitigated its carbon footprint. Enhanced coordination and partnerships within the food redistribution network were crucial for ensuring that produce reached those in need, ultimately reducing long-term environmental impacts. Implementing multiple strategies that enhance recovery from farms and retail, while strengthening the organizational capacity of the food redistribution network, can simultaneously advance food security and environmental goals. Full article

TwinArray Sort is a non-comparison integer sorting algorithm designed for non-negative integers with relatively dense key ranges, offering competitive runtime performance and reduced memory usage relative to other counting-based methods. The algorithm introduces a conditional distinct-array verification mechanism that adapts the reconstruction strategy based on data characteristics while maintaining worst-case time and space complexity of O(n + k). Comprehensive experimental evaluations were conducted on datasets containing up to 10⁸ elements across multiple data distributions, including random, reverse-sorted, nearly sorted, and their unique variants. The results demonstrate consistent performance improvements compared with established algorithms such as Counting Sort, Pigeonhole Sort, MSD Radix Sort, Spreadsort, Flash Sort, Bucket Sort, and Quicksort. TwinArray Sort achieved execution times up to 2.7 times faster and reduced memory usage by up to 50%, with particularly strong performance observed for unique and reverse-sorted datasets. The algorithm exhibits good scalability for large datasets and key ranges, with performance degradation occurring primarily in extreme cases where the key range significantly exceeds the input size due to auxiliary array requirements. These findings indicate that TwinArray Sort is a competitive solution for in-memory sorting in high-performance and distributed computing environments. Future work will focus on optimizing performance for wide key ranges and developing parallel implementations for multi-core and GPU architectures. Full article

In this paper, we investigate the lexicographic and colexicographic orderings of m-ary vectors of length n, as well as the mirror (left-recursive) reflected Gray code, complementing the classical m-ary reflected Gray code. We present efficient algorithms for generating vectors in each of these orders, each achieving constant amortized time per vector. Additionally, we propose algorithms implementing the four fundamental functions in generating combinatorial objects—successor, predecessor, rank, and unrank—each with time complexity $\Theta \left(n\right)$. The properties and the relationships between these orderings and the set of integers $\{0,1,\dots ,m^n-1\}$ are examined in detail. We define explicit transformations between the different orders and illustrate them as a digraph very close to the complete symmetric digraph. In this way, we provide a unified framework for understanding ranking, unranking, and order conversion. Our approach, based on emulating the execution of nested loops, proves powerful and flexible, leading to elegant and efficient algorithms that can be extended to the generation of submultisets, the generation of numbers in mixed-radix number systems, and related problems. The mirror m-ary Gray code introduced here has potential applications in coding theory and related areas. By providing an alternative perspective on m-ary Gray codes, we aim to inspire further research and applications in combinatorial generation and coding theory. Full article

Bupleuri radix has demonstrated therapeutic potential in treating liver disorders, and polysaccharides are one of its main bioactive components; however, the effects of Bupleuri radix polysaccharides (BRP) on metabolic dysfunction-associated steatotic liver disease (MASLD) remain unclear. This study aimed to identify the BRP fractions with anti-MASLD activity and elucidate their underlying mechanisms. We prepared BRP and characterized its physicochemical properties. It markedly alleviated liver injury and restored intestinal barrier function in MASLD. The correlation analysis between transcriptomics and targeted metabolomics showed that BRP restored intestinal acetic acid and propionic acid, with acetic acid activating AMPK and propionic acid promoting cholesterol efflux and metabolism in the liver, thereby reducing lipid accumulation in hepatocytes. Mechanistically, 16S RNA sequencing and diversity analysis indicated that BRP enriched short chain fatty acids (SCFAs)-producing bacteria, such as the genus Muribaculaceae, and inhibited pro-inflammatory microbiota. Interestingly, Paramuribaculum intestinale (P. intestinale), a representative species in the genus Muribaculaceae, synergistically enhanced BRP in improving liver and colonic mucosal damage in MASLD. In conclusion, our findings revealed that BRP improved MASLD by regulating Muribaculaceae-derived SCFAs in the gut–liver axis and could be used in combination with probiotics as a novel therapeutic strategy for MASLD. Full article

Ozone micro–nano bubbles (OMNBs) are an emerging preservation technology. However, there are few reports regarding their application in controlling postharvest diseases of agricultural products. Radix astragali, as a medicinal and edible plant, is particularly vulnerable to pathogenic microorganisms during postharvest storage, which leads to diminishing the quality and commercial value. In this study, fresh R. astragali inoculated with Penicillium polonicum was treated with different concentrations (2, 3, 4, 5, 6, 8 mg/L) of OMNBs and stored at room temperature for 28 days. The results indicate that 3 mg/L OMNBs application for 8 min effectively inhibited the development of blue mold in fresh R. astragali and preserved its quality. Then, we compared the three different treatments of micro–nano bubbles (MNBs), 3 mg/L O₃, and 3 mg/L OMNBs on physiological and pathological parameters of un-inoculated fresh R. astragali during storage and analyzed the changes in the active ingredients by liquid chromatography and metabolomics. The results indicate that the 3 mg/L OMNBs treatment effectively inhibited the decline in weight loss rate, respiratory rate, firmness, browning index, and ABTS and DPPH radical-scavenging rates, as well as reduced the incidence rate and disease index of fresh R. astragali during storage. The metabolomics results suggest that the 3 mg/L OMNBs application activated the mevalonate pathway (MVA), the methylerythritol phosphate pathway (MEP), and the phenylpropanoid biosynthesis pathway to maintain the content of active ingredients such as terpenoids and flavonoids, and these findings are consistent with the results of HPLC-MS analysis. Full article

The incidence of kidney diseases has been increasing due to changes in modern lifestyles and the ecological environment. The progression of kidney disease is characterized by ongoing renal damage and a gradual decline in renal function, ultimately leading to end-stage renal disease. The limitations of present medications have brought many disadvantages to patients. Consequently, identifying bioactive molecules has emerged as a critical strategy in the development of novel therapies for kidney diseases, particularly those derived from natural medicinal resources. This review presents a comprehensive analysis of renoprotective effects and underlying mechanisms of the medicinal plant Scutellaria baicalensis Georgi based on evidence retrieved from multiple databases, including Web of Science, PubMed, and CNKI. Flavonoids from S. baicalensis have been demonstrated to have good renoprotective properties by mitigating inflammation and oxidative stress, inhibiting cell apoptosis, reducing renal fibrosis, etc. Baicalein, wogonin, baicalin, and wogonoside are considered as the main bioactive components of the renoprotective effect of S. baicalensis. Further research on candidate molecules derived from S. baicalensis represents a promising strategy for the development of novel therapeutic agents targeting kidney diseases. Full article

This study systematically analyzed commercially available traditional Chinese medicines for As, Hg, Pb, Cd, and Cu, classifying them into roots and rhizomes (underground parts), stems and leaves, whole herbs, flowers, fruits and seeds (aboveground parts), and animal-derived decoction pieces. The concentration ranges of five elements in underground parts were 0~7.09, 0~0.29, 0~4.1, 0~1.1 and 0~49.2 mg/kg, with exceedance rates of 0–2.3%. Aboveground parts showed ranges of 0~1.54, 0~1.02, 0~13, 0~0.96 and 0~43.4 mg/kg, with exceedance rates of 0–8.8%. Animal-derived decoction pieces showed ranges of 0.07~27.18, 0~1, 0~55, 0~4.11 and 0.23~43.9 mg/kg, with exceedance rates of 6.7–41.3%. Principal component and cluster analyses indicated distinct contamination sources between animal-derived and plant-derived materials. The pollution index showed that animal-derived materials required special attention. Among plant-derived materials, Notoginseng Radix et Rhizoma, and Artemisiae Argyi Folium were also of concern. Health risk assessment indicated low non-carcinogenic risks across all categories (HI < 1), and uncertainty analysis showed a 0% probability of HI > 1. The 95th percentile carcinogenic risk for all categories was <1 × 10⁻⁴. Sensitivity analysis identified metal concentrations and daily intake as key uncertainty contributors. The findings underscore distinct contamination patterns between material types, highlighting the need for targeted control strategies, including strengthened source management and standardized dosing. Full article

Division remains one of the most computationally demanding operations in digital arithmetic. Traditional algorithms, such as restoring, non-restoring, and SRT (Sweeney–Robertson–Tocher) division, are limited by sequential dependencies that reduce throughput in hardware implementations. To overcome these constraints, this work proposes a pipelined integer divider architecture that employs precomputed divisor multiples and comparator-based logic to eliminate the need for full binary adders in the quotient selection stages. The proposed design consists of a three-stage pipeline, where each stage compares the shifted partial remainder with stored multiples of the divisor (B, 2B, 3B) to generate two quotient bits per clock cycle. This approach achieves a 2× reduction in the number of computation stages compared with conventional radix-2 dividers and ensures continuous operation after an initial pipeline latency. The architecture was described in Verilog hardware description language (HDL) and implemented on a Xilinx Artix-7 (XC7A100T-1CSG324C) field-programmable gate array (FPGA) using the Xilinx ISE Design Suite 14.4. Post-synthesis simulation confirmed correct quotient and remainder generation with a maximum operating frequency of 208 MHz. The implementation occupied less than 0.3% the look-up table (LUT) resources, achieving over a twofold performance improvement compared with a non-pipelined baseline. These results demonstrate that the proposed divider provides an efficient trade-off between speed and hardware cost, making it suitable for digital signal processing and embedded computation systems. Full article

Chinese herbal medicine (CHM) residues represent a promising and sustainable category of silage additives, with the potential to modulate fermentation and enhance nutrient preservation. This study investigated the effects of two CHMs, Astragalus membranaceus L. (Astragali Radix, AR) and Inula helenium L. (Inulae Radix, IR), on the fermentation profile, nutritional composition, and bacterial community structure in barley silage. The forage was ensiled without additive (control, CK), or with 1% or 2% (w/w) of AR or IR for 75 days. The results showed that all additive treatments significantly improved fermentation quality, as evidenced by lower pH and reduced ammonia-nitrogen (NH₃-N) content compared to CK. The 2% IR treatment was most effective in promoting homolactic fermentation, yielding the highest lactic acid content and lactic acid-to-acetic acid ratio. Nutritionally, additives significantly increased dry matter, starch, and water-soluble carbohydrates, while decreasing neutral and acid detergent fiber contents. High-throughput sequencing of the 16S rRNA gene revealed that both herbal additives profoundly reshaped the microbial community. They suppressed undesirable bacteria and significantly enriched beneficial Lactobacillus species. Principal component analysis confirmed a distinct separation in microbial community structure between control and treated silages. These findings underscore the potential of these herbal residues as natural modulators of the silage microbiome for improved forage conservation. Full article

Polygalae Radix, a traditional Chinese medicine for insomnia and memory disorders, is highly susceptible to fungal contamination and mycotoxin production (especially by Aspergillus flavus) during storage, compromising its safety and efficacy. Therefore, in this study, high-throughput sequencing was employed to evaluate the dynamic changes in fungal communities during the storage of Polygalae Radix and to analyze common mycotoxin-producing genera. Furthermore, the inhibitory effects of peppermint essential oil (PEO) on A. flavus were assessed through fumigation treatments, combined with colony counting and quantification of aflatoxins. Results showed the following: (1) Storage for 1–3 months significantly altered the fungal structure, promoting saprophytic and pathogenic fungi (e.g., Wallemia, Paraphoma, Didymella, Cladosporium…) and increasing the relative abundance of mycotoxin producers like Penicillium, Aspergillus, and Fusarium (notably, Penicillium increased from 0.28–2.33% to 5.39–80.43%). Additionally, A. flavus, capable of producing aflatoxins, was detected in samples stored for two months (RM2). (2) Antifungal tests demonstrated that PEO significantly inhibited the common fungi in Polygalae Radix. At 10 μL/g, it suppressed fungal growth and significantly reduced aflatoxin B₁ (AFB₁) and total aflatoxins (AFT, including AFB₁, AFB₂, AFG₁, and AFG₂) levels (p < 0.05). At 10 μL/g, AFB₁ and AFT were reduced to undetectable levels. PEO can serve as a green and effective protective strategy to inhibit A. flavus during the storage of Polygalae Radix and control aflatoxin contamination. Full article

Background/Objectives: Acute lung injury (ALI) is a severe condition driven largely by inflammation and has limited therapeutic options. Although saikosaponin B1 (SSB1), a primary bioactive saponin from Bupleurum Radix, has demonstrated anti-inflammatory properties, its efficacy against ALI and its corresponding molecular mechanisms remain largely unexplored. This study employed an integrated approach combining network pharmacology, transcriptomics, and metabolomics to decipher the protective mechanisms of SSB1 against ALI. Methods: Potential targets were identified via network pharmacology, and core targets were validated through molecular docking, dynamics simulations, and independent GEO transcriptomic datasets. Experimental validation was performed in an LPS-induced murine ALI model, combining histopathology, ELISA, and integrated transcriptomic and metabolomic analyses. Results: Integrated analyses identified IL1B, TNF, and IL6 as core targets through which SSB1 exerts its anti-ALI effects. These targets were validated by high-affinity binding in simulations, confirmed in independent GEO transcriptomic datasets, and shown to be normalized by SSB1 treatment in vivo. Mechanistically, SSB1 appears to modulate the NOD-like receptor and cGAS-STING signaling pathways and rectify the key metabolic pathways orchestrated by these targets, including glycerophospholipid, arachidonic acid, and linoleic acid metabolism. Conclusions: This study systematically investigates the therapeutic effects of SSB1 against ALI by identifying its potential targets and underlying pathways. These results provide crucial mechanistic insights and robust experimental support, thereby paving the way for the clinical translation of SSB1. Full article

Herein, a co-adsorption modification based on ZIF-8 was introduced with the contribution of polyethylene glycol package to enhance the antioxidant potency of the Hedysari Radix disperse particles. In the solution system containing ethanol, the rough surface of the original Hedysari Radix disperse particles was improved by the typical co-adsorption modification with ZIF-8 and further smoothed by the package. The co-adsorption modifications, including ZIF-8 only, polyethylene glycol only, and ZIF-8 with polyethylene glycol, were all studied in the solution system. In particular, the modification that combined both the polyethylene glycol package and a suitable amount of ZIF-8 achieved the most significant enhancement of the catalase activity as well as the total antioxidant capacity value. The obtained hit platform alleviated the oxidative stress upon Caenorhabditis elegans and extended the survival time. This work suggested that meaningful co-adsorption modification could improve the potency of medicinal plant resources. Full article

Background: Mandibular third molars (MTMs) are the most frequently impacted teeth and a common indication for oral surgery. Anatomical root variations can complicate extractions and increase intra- and postoperative risks. Methods: This narrative review analyzes the most frequent MTM root anomalies—supernumerary roots, fusion, taurodontism, C-shaped canals, hypercementosis, and apical dilacerations—focusing on their clinical implications and the diagnostic role of cone-beam computed tomography (CBCT). Results: Root anomalies markedly influence surgical complexity. Supernumerary roots and fusions may hinder elevator use and require modified sectioning. Taurodontism and hypercementosis prolong procedures and increase incomplete extraction risk. C-shaped canals and severe apical curvatures raise the likelihood of root fracture, displacement, or nerve injury. Panoramic radiographs, though common, provide limited two-dimensional detail and may underestimate anomalies. CBCT, by contrast, offers three-dimensional visualization, enhancing diagnosis, planning, and safety. Conclusions: Knowledge of MTM root anomalies, combined with selective CBCT use, is essential for optimizing surgical strategies, minimizing complications, and improving outcomes. Full article

Inflammatory diseases are a type of disease caused by multiple factors, which are characterized by local or systemic tissue inflammatory reactions, commonly including atherosclerosis, osteoarthritis, non-alcoholic fatty liver, chronic kidney diseases, acute pancreatitis, and tumors. The prevalence of the above diseases is globally high and a growing threat to human health, as well as a huge healthcare burden. In recent years, Chinese herbal medicines have become an important reservoir for the discovery of new drugs and applications due to their unique molecular structures and potential biotherapeutic effects. Numerous studies have confirmed the beneficial effects of natural products in the prevention and treatment of different diseases. Scientific studies on the therapeutic potential of natural products have become a hot topic nowadays, especially regarding the active ingredients of herbs. Calycosin is a kind of isoflavonoid extracted from the root of Radix astragali, exhibiting anti-inflammatory, antioxidant, anti-cancer, cardioprotective, hepatoprotective, and neuroprotective activities. Therefore, this review aims to discuss the emerging roles, molecular mechanisms and therapeutic potential of calycosin in resolving inflammatory diseases. Full article