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Article

26 Citations

5,367 Views

20 Pages

Zebrafish-Based Discovery of Antiseizure Compounds from the North Sea: Isoquinoline Alkaloids TMC-120A and TMC-120B

Daniëlle Copmans,
Sara Kildgaard,
Silas A. Rasmussen,
Monika Ślęzak,
Nina Dirkx,
Michèle Partoens,
Camila V. Esguerra,
Alexander D. Crawford,
Thomas O. Larsen and
Peter A. M. de Witte

Mar. Drugs2019, 17(11), 607;https://doi.org/10.3390/md17110607

25 October 2019

There is a high need for the development of new and improved antiseizure drugs (ASDs) to treat epilepsy. Despite the potential of marine natural products (MNPs), the EU marine biodiscovery consortium PharmaSea has made the only effort to date to perf...

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Article

11 Citations

5,577 Views

26 Pages

From the North Sea to Drug Repurposing, the Antiseizure Activity of Halimide and Plinabulin

Daniëlle Copmans,
Sara Kildgaard,
Emma Roux,
Michèle Partoens,
Gert Steurs,
Xinhui Wang,
Wim M. De Borggraeve,
Camila V. Esguerra,
Alexander D. Crawford and
Peter A. M. de Witte

Pharmaceuticals2022, 15(2), 247;https://doi.org/10.3390/ph15020247

18 February 2022

PharmaSea performed large-scale in vivo screening of marine natural product (MNP) extracts, using zebrafish embryos and larvae, to identify compounds with the potential to treat epilepsy. In this study, we report the discovery of two new antiseizure...

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Abstract

1,555 Views

2 Pages

Remote Monitoring of Ship Pharmacy: An Experience of Maritime Telepharmacy

Giulio Nittari,
Antonio Arcese and
Francesco Amenta

Med. Sci. Forum2022, 13(1), 10;https://doi.org/10.3390/msf2022013010

28 November 2022

The ship is not only a workplace [...]

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Article

11 Citations

4,407 Views

15 Pages

Sustainable Low-Volume Analysis of Environmental Samples by Semi-Automated Prioritization of Extracts for Natural Product Research (SeaPEPR)

Riyanti,
Michael Marner,
Christoph Hartwig,
Maria A. Patras,
Stevy I. M. Wodi,
Frets J. Rieuwpassa,
Frans G. Ijong,
Walter Balansa and
Till F. Schäberle

Mar. Drugs2020, 18(12), 649;https://doi.org/10.3390/md18120649

17 December 2020

The discovery of novel natural products (NPs) that will serve as lead structures has to be an ongoing effort to fill the respective development pipelines. However, identification of NPs, which possess a potential for application in e.g., the pharma o...

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