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  • Article
  • Open Access
9 Citations
5,794 Views
15 Pages

Expression of Transcript Variants of PTGS1 and PTGS2 Genes among Patients with Chronic Rhinosinusitis with Nasal Polyps

  • Wioletta Pietruszewska,
  • Wojciech Fendler,
  • Marta Podwysocka,
  • Adam J. Białas,
  • Piotr Kuna,
  • Izabela Kupryś-Lipińska and
  • Maciej Borowiec

To date, there has been no reliable test to identify unfavorable course of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP), especially in aspirin intolerant patients. The research aimed to analyze the expression of transcript variants of PTGS1 and...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
10 Citations
3,915 Views
21 Pages

PTSD and PTG in French and American Firefighters: A Comparative Study

  • Charlotte Henson,
  • Didier Truchot and
  • Amy Canevello

Studies show that experiencing traumatic events can lead to positive psychological change, or posttraumatic growth (PTG). In the hope of promoting PTG, authors have been focusing on identifying the factors that may foster PTG. Despite these attempts,...

(This article belongs to the Special Issue Mental Health Disorders and Healthcare after Potentially Traumatic Events)
  • Article
  • Open Access
22 Citations
5,323 Views
16 Pages

Evaluation of Glycosylated PTGS2 in Colorectal Cancer for NSAIDS-Based Adjuvant Therapy

  • Roberta Venè,
  • Delfina Costa,
  • Raffaella Augugliaro,
  • Sebastiano Carlone,
  • Stefano Scabini,
  • Gianmaria Casoni Pattacini,
  • Maurizio Boggio,
  • Simonetta Zupo,
  • Federica Grillo and
  • Roberto Benelli
  • + 8 authors

11 March 2020

Observational/retrospective studies indicate that prostaglandin-endoperoxide synthase-2 (PTGS2) inhibitors could positively affect colorectal cancer (CRC) patients’ survival after diagnosis. To obtain an acceptable cost/benefit balance, the inc...

(This article belongs to the Special Issue Micro- and Macro-Environmental Factors in Solid Cancers)
  • Review
  • Open Access
51 Citations
16,784 Views
15 Pages

The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer

  • Dingzhi Wang,
  • Dianren Xia and
  • Raymond N. DuBois

14 October 2011

Colorectal cancer (CRC) is now the second-leading cause of cancer deaths in the USA. Colorectal cancer progression and metastasis depends on the orchestration of the aberrant signaling pathways that control tumor cell proliferation, survival and migr...

(This article belongs to the Special Issue Exploring Inflammation in Cancers)
  • Article
  • Open Access
4 Citations
3,335 Views
12 Pages

6 March 2021

Osteoporosis, characterized by reduced bone mass and increased bone fragility, is a disease prevalent in women. Likewise, breast cancer is a multifactorial disease and considered the major cause of mortality in premenopausal and postmenopausal women...

(This article belongs to the Section Human Genomics and Genetic Diseases)
  • Article
  • Open Access
34 Citations
3,914 Views
18 Pages

21 January 2023

Promotion of angiogenesis and restoration of the blood flow in the ischemic penumbra is an effective treatment for patients with ischemic stroke (IS). Radix astragali-safflower (AS), a classic herbal pair for accelerating blood circulation and disper...

(This article belongs to the Section Molecular Pharmacology)
  • Review
  • Open Access
7 Citations
6,069 Views
12 Pages

26 November 2022

Protein phosphorylation and dephosphorylation are widely considered to be the key regulatory factors of cell function, and are often referred to as “molecular switches” in the regulation of cell metabolic processes. A large number of stud...

(This article belongs to the Section Biomacromolecules: Carbohydrates)
  • Article
  • Open Access
6 Citations
2,843 Views
23 Pages

The Mechanism of Ferroptosis Regulating Granulosa Cell Apoptosis and Oxidative Stress Through the NF-κB/PTGS2 Axis in Porcine Atretic Follicles

  • Yiting Yang,
  • Yuxu He,
  • Mailin Gan,
  • Xue Zhao,
  • Tianci Liao,
  • Yuhang Lei,
  • Lei Chen,
  • Lili Niu,
  • Ye Zhao and
  • Li Zhu
  • + 3 authors

1 September 2025

Ferroptosis is a new mode of cell death, which is characterized by inducing the accumulation of lipid peroxides dependent on iron ions and reactive oxygen species. It has been found that ferroptosis can lead to follicle atresia by promoting granulosa...

(This article belongs to the Special Issue Recent Advances in Applications of Antioxidants in Livestock Health and Reproduction)
  • Article
  • Open Access
13 Citations
4,150 Views
17 Pages

MAEL Augments Cancer Stemness Properties and Resistance to Sorafenib in Hepatocellular Carcinoma through the PTGS2/AKT/STAT3 Axis

  • Chaoran Shi,
  • Dora Lai-Wan Kwong,
  • Xue Li,
  • Xia Wang,
  • Xiaona Fang,
  • Liangzhan Sun,
  • Ying Tang,
  • Xin-Yuan Guan and
  • Shan-Shan Li

10 June 2022

Cancer stem cells (CSCs) are responsible for tumorigenesis, therapeutic resistance, and metastasis in hepatocellular cancer (HCC). Cancer/testis antigen Maelstrom (MAEL) is implicated in the formation of CSC phenotypes, while the exact role and under...

(This article belongs to the Topic Molecular Profiling and Identification of Molecular Signatures Associated with Tissue Development, Tumorigenesis, and Anticancer Agents’ Action)
  • Article
  • Open Access
8 Citations
2,576 Views
14 Pages

Elsholtzia bodinieri Vaniot Ameliorated Acute Lung Injury by NQO1, BCL2 and PTGS2 In Silico and In Vitro Analyses

  • Jin Sun,
  • Xiaoqian Jiang,
  • Yuxu Chen,
  • Shancheng Guo,
  • Zhiye Zhao,
  • Jianxin Cao,
  • Yaping Liu,
  • Guiguang Cheng,
  • Ye Li and
  • Lei Tian

9 December 2022

Acute lung injury (ALI) is a clinical respiratory disease caused by various factors, which lacks effective pharmacotherapy to reduce the mortality rate. Elsholtzia bodinieri Vaniot is an annual herbaceous plant used as a traditional herbal tea and fo...

(This article belongs to the Section Bioactives and Nutraceuticals)
  • Article
  • Open Access
419 Views
19 Pages

A RUBY-Based Visual Hairy Root Transformation and CRISPR-PTG Genome-Editing System in Eucommia ulmoides

  • Linqing Xu,
  • Yani Zhou,
  • Yongfeng Sun,
  • Yating Dong,
  • Rong Kang,
  • Nan Yao and
  • Xia Cai

11 September 2026

Eucommia ulmoides Oliv. is a woody plant with significant medicinal and industrial value. However, the lack of an efficient genetic transformation and gene-editing system has seriously hindered the research on its functional genes and the progress of...

(This article belongs to the Special Issue Applications of Plant Biotechnology: In Vitro Propagation and Plant Transformations—2nd Edition)
  • Article
  • Open Access
2 Citations
1,537 Views
17 Pages

LncRNA LOC610012 Inhibits Canine Mammary Tumor Activity via the PTGS2/EP3 and GSK3β Signaling Pathways

  • Bohan Zhang,
  • Lixin He,
  • Xiao Wang,
  • Wenjing Liu,
  • Yuxin Li,
  • Yinan Wang,
  • Huili Feng,
  • Wenxuan Li and
  • Changwei Qiu

25 June 2025

Canine mammary tumors (CMTs) are the common tumors in female dogs, and approximately 50% of CMTs are malignant tumors, with abnormal regulation of non-coding RNAs being a critical factor in disease progression. Currently, research on long non-coding...

  • Article
  • Open Access
22 Citations
5,019 Views
25 Pages

MicroRNA Sequencing Analysis in Obstructive Sleep Apnea and Depression: Anti-Oxidant and MAOA-Inhibiting Effects of miR-15b-5p and miR-92b-3p through Targeting PTGS1-NF-κB-SP1 Signaling

  • Yung-Che Chen,
  • Po-Yuan Hsu,
  • Mao-Chang Su,
  • Ting-Wen Chen,
  • Chang-Chun Hsiao,
  • Chien-Hung Chin,
  • Chia-Wei Liou,
  • Po-Wen Wang,
  • Ting-Ya Wang and
  • Meng-Chih Lin
  • + 2 authors

22 November 2021

The aim of this study was to identify novel microRNAs related to obstructive sleep apnea (OSA) characterized by intermittent hypoxia with re-oxygenation (IHR) injury. Illumina MiSeq was used to identify OSA-associated microRNAs, which were validated...

  • Article
  • Open Access
4 Citations
1,646 Views
16 Pages

5 September 2024

This article presents a detailed analysis of the energy availability of a 15 kW hybrid wind–solar photovoltaic microplant, designed to supply the electricity demand of the power-to-gas (PtG) pilot plant located at the University of La Guajira,...

(This article belongs to the Section Energy Systems)
  • Article
  • Open Access
1,512 Views
25 Pages

A Comparative Analysis of Gremlin-1 (GREM1), Hyaluronic Acid Synthetase-2 (HAS2), and Prostaglandin-Endoperoxide Synthase-2 (PTGS2) Expression in Cumulus Cells Among Women with Diminished Ovarian Reserve Following Rescue In Vitro Maturation (r-IVM)

  • Mohd Faizal Ahmad,
  • Marjanu Hikmah Elias,
  • Norazilah Mat Jin,
  • Muhammad Azrai Abu,
  • Saiful Effendi Syafruddin,
  • Ani Amelia Zainuddin,
  • Shah Shamsul Azhar,
  • Nao Suzuki and
  • Abdul Kadir Abdul Karim

16 October 2025

Managing women with diminished ovarian reserve for in vitro fertilization (IVF) is challenging, often resulting in low oocyte yield and cycle failures. We hypothesize that coupling in vitro fertilization (IVF) with rescue in vitro maturation (r-IVM)...

(This article belongs to the Section Reproductive and Developmental Biology)
  • Article
  • Open Access
6 Citations
3,629 Views
12 Pages

Association between Vitamin Intake and Chronic Kidney Disease According to a Variant Located Upstream of the PTGS1 Gene: A Cross-Sectional Analysis of Shika Study

  • Kim-Oanh Pham,
  • Akinori Hara,
  • Hiromasa Tsujiguchi,
  • Keita Suzuki,
  • Fumihiko Suzuki,
  • Sakae Miyagi,
  • Takayuki Kannon,
  • Takehiro Sato,
  • Kazuyoshi Hosomichi and
  • Hiroyuki Nakamura
  • + 11 authors

16 May 2022

Chronic kidney disease (CKD) patients have been advised to take vitamins; however, the effects have been controversial. The individual differences in developing CKD might involve genetic variants of inflammation, including variant rs883484 located up...

(This article belongs to the Section Micronutrients and Human Health)
  • Article
  • Open Access
17 Citations
9,242 Views
20 Pages

Suffering intimate partner violence (IPV) is a devastating personal experience and post-traumatic growth (PTG) is a positive, psychological change in a person, following trauma such as IPV. There is a gap in the literature when it comes to theories o...

(This article belongs to the Special Issue Influence of Domestic Violence on Mental Health)
  • Article
  • Open Access
32 Citations
10,544 Views
18 Pages

Post-traumatic growth (PTG) is a positive psychological change following trauma. Intimate partner violence (IPV) is one such trauma. The aim of this phenomenological study was to explore PTG from the perspective of women who have survived IPV as well...

(This article belongs to the Special Issue Environment and Behavior)
  • Article
  • Open Access
15 Citations
5,617 Views
19 Pages

In this study, we identified 14 obstacles experienced by female survivors of intimate partner violence who had, nonetheless, reached post-traumatic growth (PTG), which is a positive psychological change by a person following serious difficulties or t...

(This article belongs to the Special Issue Violence against Women as an Interdisciplinary Challenge in Public Health)
  • Article
  • Open Access
1,200 Views
15 Pages

6 March 2026

Public health emergencies can trigger posttraumatic stress disorder (PTSD) and posttraumatic growth (PTG) in adolescents. However, few studies have explored the distinct and common processes of these outcomes in adolescents from the perspective of so...

(This article belongs to the Section Social Psychology)
  • Article
  • Open Access
24 Citations
5,429 Views
9 Pages

ABE8e with Polycistronic tRNA-gRNA Expression Cassette Sig-Nificantly Improves Adenine Base Editing Efficiency in Nicotiana benthamiana

  • Zupeng Wang,
  • Xiaoying Liu,
  • Xiaodong Xie,
  • Lei Deng,
  • Hao Zheng,
  • Hui Pan,
  • Dawei Li,
  • Li Li and
  • Caihong Zhong

Adenine base editor containing TadA8e (ABE8e) has been reported in rice. However, the application of ABE8e in other plant species has not been described, and the comparison between ABE8e and ABE7.10, which is widely used in plants, has also been poor...

(This article belongs to the Section Molecular Genetics and Genomics)
  • Article
  • Open Access
26 Citations
5,507 Views
12 Pages

Nursing students, who need to reflect on self, secure their identity, and be prepared as would-be nurses, can make a good use of post-traumatic growth (PTG) that can function as a catalyst for positive change even amidst this COVID-19 crisis. Emotion...

  • Article
  • Open Access
40 Citations
5,764 Views
13 Pages

Post-Traumatic Growth in Women with Breast Cancer: Intensity and Predictors

  • Justyna Michalczyk,
  • Joanna Dmochowska,
  • Anna Aftyka and
  • Joanna Milanowska

Experiencing a traumatic situation such as breast cancer can, beside negative consequences, have a positive impact, described as post-traumatic growth (PTG). A factor that facilitates psychological recovery when coping with stressful events is psycho...

(This article belongs to the Special Issue Work and Health in Cancer Survivors)
  • Article
  • Open Access
21 Citations
2,745 Views
5 Pages

Posttraumatic Growth in Adolescent Survivors of Earthquake, Tsunami, and Liquefaction in Palu Indonesia: A Phenomenological Study

  • Siti Hajar Salawali,
  • Herni Susanti,
  • Novy Helena Catharina Daulima and
  • Arcellia Farosyah Putri

25 June 2020

Exploration of posttraumatic growth (PTG) experiences in adolescent survivors of earthquakes, tsunamis, or liquefaction are needed by nurses to maximize the potential for recovery and growth of adolescents from trauma after natural disasters. The stu...

  • Article
  • Open Access
518 Views
15 Pages

Androgenetic alopecia (AGA) is associated with follicular miniaturization, oxidative stress, and microinflammation. Hydroxytyrosol (HT) has antioxidant and anti-inflammatory activities, but its mechanisms in AGA remain unclear. Differentially express...

(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
  • Article
  • Open Access
26 Citations
4,293 Views
19 Pages

Phloretin Transfersomes for Transdermal Delivery: Design, Optimization, and In Vivo Evaluation

  • Jiawen Wang,
  • Yuanyuan Zhao,
  • Bingtao Zhai,
  • Jiangxue Cheng,
  • Jing Sun,
  • Xiaofei Zhang and
  • Dongyan Guo

24 September 2023

Background: Phloretin (Phl) is a flavonoid compound that contains multiple phenolic hydroxyl groups. It is found in many plants, such as apple leaves, lychee pericarp, and begonia, and has various biological activities, such as antioxidant and antica...

  • Article
  • Open Access
2 Citations
1,969 Views
14 Pages

A Practical Pole-to-Ground Fault Current Calculation Method for Symmetrical Monopole DC Grids

  • Ying Xu,
  • Wei Kuang,
  • Baohong Li,
  • Xiaopeng Li,
  • Tierui Zou,
  • Qin Jiang and
  • Yiping Luo

29 October 2024

At present, DC grid fault current analyses are usually based on numerical analyses and/or simulations. To make fault current analyses more practical and convenient, this study proposes a fast fault current level assessment methodology that is applica...

(This article belongs to the Section Industrial Electronics)
  • Article
  • Open Access
12 Citations
4,412 Views
15 Pages

24 January 2022

Alphasatellites, which encode only a replication-associated protein (alpha-Rep), are frequently found to be non-essential satellite components associated with begomovirus/betasatellite complexes, and their presence can modulate disease symptoms and/o...

(This article belongs to the Section Viruses of Plants, Fungi and Protozoa)
  • Article
  • Open Access
6 Citations
3,246 Views
20 Pages

Beet Curly Top Iran Virus Rep and V2 Suppress Post-Transcriptional Gene Silencing via Distinct Modes of Action

  • Saeideh Ebrahimi,
  • Omid Eini,
  • Alexandra Baßler,
  • Arvid Hanke,
  • Zeynep Yildirim,
  • Michael Wassenegger,
  • Gabi Krczal and
  • Veli Vural Uslu

26 September 2023

Beet curly top Iran virus (BCTIV) is a yield-limiting geminivirus belonging to the becurtovirus genus. The genome organization of BCTIV is unique such that the complementary strand of BCTIV resembles Mastrevirus, whereas the virion strand organizatio...

(This article belongs to the Section Viruses of Plants, Fungi and Protozoa)
  • Article
  • Open Access
896 Views
18 Pages

Gene Expression Profiles in the Optic Nerve of Mice with Systemic Acanthamoebiasis

  • Ignacy Marcin Wiliński,
  • Patrycja Tomasiak,
  • Michał Czerewaty,
  • Natalia Łanocha-Arendarczyk,
  • Danuta Kosik-Bogacka and
  • Karolina Kot

Systemic infection with Acanthamoeba spp. can induce inflammatory responses within the visual axis, yet the underlying molecular mechanisms in the optic nerve remain poorly understood. The aim of the study was to determine the gene expression of Nlrp...

(This article belongs to the Special Issue Molecular Advances in Pathogen Interaction and Host Immunity)
  • Article
  • Open Access
4 Citations
1,487 Views
30 Pages

Integrative Network Pharmacology and Molecular Docking Analysis Uncovers Multi-Target Mechanisms of Alpha-Mangostin Against Acute Kidney Injury

  • Moragot Chatatikun,
  • Aman Tedasen,
  • Chutima Jansakun,
  • Passakorn Poolbua,
  • Jason C. Huang,
  • Jongkonnee Thanasai,
  • Wiyada Kwanhian Klangbud and
  • Atthaphong Phongphithakchai

7 April 2026

Alpha-mangostin (AM), a xanthone from Garcinia mangostana, has shown promising nephroprotective properties, but its mechanisms in acute kidney injury (AKI) remain incompletely defined. In this study, we applied an integrative network pharmacology pip...

(This article belongs to the Special Issue Bioactive Food Components in Metabolic Health and Disease Prevention: From Functional Insights to Therapeutic Potential)
  • Article
  • Open Access
3 Citations
2,210 Views
32 Pages

Preparation and Characterization of Ru-Based Catalyst for Power to Gas Applications

  • Leonardo Colelli,
  • Alberto Grancini,
  • Enrico Mattei,
  • Claudia Bassano and
  • Giorgio Vilardi

11 February 2025

Heterogeneous catalysis plays a crucial role in various industrial processes, representing a key aspect also in the energy transition for the development of new technologies. Among them, Power to Gas (PtG), belonging to the e-fuels category, requires...

(This article belongs to the Section F: Electrical Engineering)
  • Article
  • Open Access
9 Citations
4,677 Views
20 Pages

Superinfection by PHYVV Alters the Recovery Process in PepGMV-Infected Pepper Plants

  • Myriam G. Rodríguez-Gandarilla,
  • Edgar A. Rodríguez-Negrete and
  • Rafael F. Rivera-Bustamante

5 March 2020

Geminiviruses are important plant pathogens that affect crops around the world. In some geminivirus–host interactions, infected plants show recovery, a phenomenon characterized by symptom disappearance in newly emerging leaves. In pepper–...

(This article belongs to the Section Viruses of Plants, Fungi and Protozoa)
  • Article
  • Open Access
54 Citations
14,455 Views
15 Pages

Methanation of CO2 on Ni/Al2O3 in a Structured Fixed-Bed Reactor—A Scale-Up Study

  • Daniel Türks,
  • Hesham Mena,
  • Udo Armbruster and
  • Andreas Martin

15 May 2017

Due to the ongoing change of energy supply, the availability of a reliable high-capacity storage technology becomes increasingly important. While conventional large-scale facilities are either limited in capacity respective supply time or their exten...

(This article belongs to the Special Issue Commemorative Issue in Honor of Professor Emeritus Calvin H. Bartholomew in Anticipation of His 75th Birthday)
  • Article
  • Open Access
2 Citations
2,640 Views
15 Pages

Oryza sativa L. Indica Seed Coat Ameliorated Concanavalin A—Induced Acute Hepatitis in Mice via MDM2/p53 and PKCα/MAPK1 Signaling Pathways

  • Zhiye Zhao,
  • Ye Li,
  • Shancheng Guo,
  • Yuxu Chen,
  • Haiaolong Yin,
  • Yaxian Li,
  • Guiguang Cheng and
  • Lei Tian

25 September 2023

Acute hepatitis (AH) is a common liver disease with an increasing number of patients each year, requiring the development of new treatments. Hence, our work aimed to evaluate the therapeutic effect of Oryza sativa L. indica (purple rice) seed coat on...

(This article belongs to the Collection Feature Papers in Molecular Pathology, Diagnostics, and Therapeutics)
  • Review
  • Open Access
21 Citations
8,589 Views
15 Pages

Biological Correlates of Post-Traumatic Growth (PTG): A Literature Review

  • Liliana Dell’Osso,
  • Barbara Carpita,
  • Benedetta Nardi,
  • Chiara Bonelli,
  • Martina Calvaruso and
  • Ivan Mirko Cremone

10 February 2023

Since the beginning of medical science, much research have focused on the psychopathological effects of traumatic experiences. Despite in past centuries the scientific literature on mental health has been mainly focused on the harmful effects of trau...

(This article belongs to the Section Neuropsychiatry)
  • Article
  • Open Access
4 Citations
3,452 Views
11 Pages

Relationship between Thought Style, Emotional Response, Post-Traumatic Growth (PTG), and Biomarkers in Cancer Patients

  • Mariana Sierra-Murguía,
  • Martha L. Guevara-Sanginés,
  • Gabriela Navarro-Contreras,
  • Guillermo Peralta-Castillo,
  • Amalia Padilla-Rico,
  • Lucía González-Alcocer and
  • Ferrán Padrós-Blázquez

(1) Introduction: Cancer diagnosis has been related to depression, anxiety, and distress, as well as to post-traumatic growth (PTG). One of the mediating variables for emotional response is thought style (rumination, cognitive avoidance, and cognitiv...

(This article belongs to the Special Issue Cancer Causes and Control)
  • Article
  • Open Access
11 Citations
3,851 Views
18 Pages

Identification and Validation of PTGS2 Gene as an Oxidative Stress-Related Biomarker for Arteriovenous Fistula Failure

  • Ke Hu,
  • Yi Guo,
  • Yuxuan Li,
  • Shunchang Zhou,
  • Chanjun Lu,
  • Chuanqi Cai,
  • Hongjun Yang,
  • Yiqing Li and
  • Weici Wang

19 December 2023

(1) Background: Arteriovenous fistulas (AVFs) are the preferred site for hemodialysis. Unfortunately, approximately 60% of patients suffer from AVF failure within one year. Oxidative stress plays an important role in the occurrence and development of...

  • Article
  • Open Access
262 Views
18 Pages

PARP1 Deficiency Attenuates Cisplatin Nephrotoxicity and Renal COX-2/PGE2 Response

  • Theophilus Bhatti,
  • Jia-Bin Yu,
  • Ji-Yeong Bae and
  • Jinu Kim

3 October 2026

Cisplatin is a widely used chemotherapeutic agent whose clinical utility is limited by nephrotoxicity, characterized by tubular injury and renal inflammation. Poly(ADP-ribose) polymerase 1 (PARP1) contributes to cisplatin-induced kidney injury and in...

(This article belongs to the Special Issue Kidney Disease: The Role of Cellular Mechanisms in Renal Pathology)
  • Concept Paper
  • Open Access
12 Citations
6,844 Views
10 Pages

28 August 2018

This theoretical paper explores the need to use posttraumatic growth (PTG) as a framework when studying sexual minority women (SMW) who are survivors of intimate partner violence (IPV) to examine the relationship between risk factors such as stress,...

  • Review
  • Open Access
3 Citations
2,448 Views
30 Pages

Gene Inactivation in Transgenic Plants—A Unique Model for Studying Epigenetic Regulation of Gene Expression

  • Tatyana V. Marenkova,
  • Alla A. Zagorskaya,
  • Igor V. Deyneko and
  • Elena V. Deineko

13 January 2026

The phenomenon of transgene silencing was first observed shortly after the generation of the initial transgenic plants. The vast body of experimental data accumulated since then constitutes an invaluable resource for dissecting the mechanisms of epig...

(This article belongs to the Section Plant Genetics, Genomics and Biotechnology)
  • Article
  • Open Access
8 Citations
3,997 Views
18 Pages

Molecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer

  • Juliana Prado Gusson-Zanetoni,
  • Luana Pereira Cardoso,
  • Stefanie Oliveira de Sousa,
  • Laura Luciana de Melo Moreira Silva,
  • Júlia de Oliveira Martinho,
  • Tiago Henrique,
  • Eloiza Helena Tajara,
  • Sonia Maria Oliani and
  • Flávia Cristina Rodrigues-Lisoni

Piperine, an active plant alkaloid from black pepper (Piper nigrum), has several pharmacological effects, namely antioxidant, anti-inflammatory and immunomodulatory effects, which involve inhibiting molecular events associated with various stages of...

(This article belongs to the Special Issue Natural Compounds in Cancer Therapy and Prevention, 2nd Edition)
  • Article
  • Open Access
4 Citations
3,915 Views
24 Pages

Green hydrogen is increasingly recognized as a sustainable energy vector, offering significant potential for the industrial sector, buildings, and sustainable transport. As countries work to establish infrastructure for hydrogen production, transport...

  • Article
  • Open Access
32 Citations
5,309 Views
11 Pages

Inhibitors of Oxidative Phosphorylation Modulate Astrocyte Inflammatory Responses through AMPK-Dependent Ptgs2 mRNA Stabilization

  • Alina Astakhova,
  • Dmitry Chistyakov,
  • Dominique Thomas,
  • Gerd Geisslinger,
  • Bernhard Brüne,
  • Marina Sergeeva and
  • Dmitry Namgaladze

1 October 2019

Inflammatory activation of astroglia adds to the pathology of various neurological diseases. Astrocytes respond to microglia-derived cytokines such as interleukin-1α (IL-1α) with enhanced inflammatory signaling. This provokes pro-inflamma...

(This article belongs to the Special Issue Study around Neuroinflammation)
  • Article
  • Open Access
22 Citations
6,401 Views
20 Pages

PTG-PLM: Predicting Post-Translational Glycosylation and Glycation Sites Using Protein Language Models and Deep Learning

  • Alhasan Alkuhlani,
  • Walaa Gad,
  • Mohamed Roushdy,
  • Michael Gr. Voskoglou and
  • Abdel-badeeh M. Salem

14 September 2022

Post-translational glycosylation and glycation are common types of protein post-translational modifications (PTMs) in which glycan binds to protein enzymatically or nonenzymatically, respectively. They are associated with various diseases such as cor...

(This article belongs to the Section Mathematical Analysis)
  • Article
  • Open Access
113 Citations
14,341 Views
24 Pages

19 February 2017

Concerns about climate change and increasing emission costs are drivers for new sources of fuels for Europe. Sustainable hydrocarbons can be produced synthetically by power-to-gas (PtG) and power-to-liquids (PtL) facilities, for sectors with low dire...

(This article belongs to the Section Environmental Sustainability and Applications)
  • Article
  • Open Access
1,430 Views
17 Pages

3 February 2026

Background/Objectives: Traumatic experiences may lead to both negative and positive outcomes. Positive psychological changes following trauma are commonly referred to as posttraumatic growth (PTG). The present study aims to examine factors associated...

(This article belongs to the Special Issue Stress, Traumatic Events and Political Violence: Implications for Mental Health Care)
  • Review
  • Open Access
2 Citations
3,163 Views
21 Pages

Epigenetic and Epitranscriptomic Antiviral Responses in Plants for Disease Management

  • Islam Hamim,
  • Sadman Jawad Sakib,
  • Md. Readoy Hossain,
  • Jaima Noor Hia,
  • Maria Hasan,
  • Alvi Al Muhimine and
  • John S. Hu

22 December 2025

Plant viral diseases cause significant agricultural losses worldwide and are shaped by complex virus-host and virus-virus interactions. Unlike fungal or bacterial pathogens, viruses cannot be directly controlled with chemicals, and their management r...

(This article belongs to the Special Issue Diversity and Coinfections of Plant or Fungal Viruses, 3rd Edition)
  • Article
  • Open Access
37 Citations
5,721 Views
17 Pages

Spaceflight Modulates the Expression of Key Oxidative Stress and Cell Cycle Related Genes in Heart

  • Akhilesh Kumar,
  • Candice G. T. Tahimic,
  • Eduardo A. C. Almeida and
  • Ruth K. Globus

23 August 2021

Spaceflight causes cardiovascular changes due to microgravity-induced redistribution of body fluids and musculoskeletal unloading. Cardiac deconditioning and atrophy on Earth are associated with altered Trp53 and oxidative stress-related pathways, bu...

(This article belongs to the Special Issue Dysregulation of Human Molecular and Metabolic Mechanisms Resulting in Oxidative Stress and Damage Generation in the Space Environment)
  • Feature Paper
  • Article
  • Open Access
47 Citations
8,211 Views
19 Pages

CRISPR-Mediated Reactivation of DKK3 Expression Attenuates TGF-β Signaling in Prostate Cancer

  • Hoda Kardooni,
  • Estela Gonzalez-Gualda,
  • Emmanouil Stylianakis,
  • Sina Saffaran,
  • Jonathan Waxman and
  • Robert M. Kypta

28 May 2018

The DKK3 gene encodes a secreted protein, Dkk-3, that inhibits prostate tumor growth and metastasis. DKK3 is downregulated by promoter methylation in many types of cancer, including prostate cancer. Gene silencing studies have shown that Dkk-3 mainta...

(This article belongs to the Special Issue TGF-Beta Signaling in Cancer)

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