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Article

2 Citations

2,528 Views

15 Pages

Onchocerciasis Drug Discovery: In Vitro Evaluation of FDA-Approved Drugs against Onchocerca gutturosa in Gambia

Suzanne Gokool,
Simon Townson,
Andrew Freeman,
Jadzia Siemienski-Kleyn,
Jakub Zubrzycki,
Senyo Tagboto,
Marc P. Hübner and
Ivan Scandale

Pharmaceutics2024, 16(2), 210;https://doi.org/10.3390/pharmaceutics16020210

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31 January 2024

Onchocerciasis treatment and control relies mainly on the use of ivermectin which has high activity against the microfilarial stage of Onchocerca volvulus but limited activity against the long-lived, tissue dwelling adult nematodes. As this neglected...

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Review

23 Citations

9,238 Views

17 Pages

Zoonotic Implications of Onchocerca Species on Human Health

Maria Cambra-Pellejà,
Javier Gandasegui,
Rafael Balaña-Fouce,
José Muñoz and
María Martínez-Valladares

Pathogens2020, 9(9), 761;https://doi.org/10.3390/pathogens9090761

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17 September 2020

The genus Onchocerca includes several species associated with ungulates as hosts, although some have been identified in canids, felids, and humans. Onchocerca species have a wide geographical distribution, and the disease they produce, onchocerciasis...

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