Search Results (157)

The growing need to improve the management of end-of-life vehicle (ELV) waste and mitigate its environmental impact is a global concern. One promising approach to enhancing the recyclability of these vehicles is leveraging synergies between the automotive and construction industries as part of a circular economy strategy. In this context, ELV waste emerges as a valuable source of secondary raw materials, enabling the development of sustainable innovations that capitalize on its physical and mechanical properties. This paper aims to develop and evaluate construction industry composites incorporating waste from ELV carpets, with a focus on maintaining or enhancing performance compared to conventional materials. To achieve this, an experimental program was designed to assess cementitious composites, specifically subfloor mortars, incorporating automotive carpet waste (ACW). The results demonstrate that, beyond the physical and mechanical properties of the developed composites, the dynamic stiffness significantly improved across all tested waste incorporation levels. This finding highlights the potential of these composites as an alternative material for impact noise insulation in flooring systems. From an academic perspective, this research advances knowledge on the application of ACW in cement-based composites for construction. In terms of managerial contributions, two key market opportunities emerge: (1) the commercial exploitation of composites produced with ELV carpet waste and (2) the development of a network of environmental service providers to ensure a stable waste supply chain for innovative and sustainable products. Both strategies contribute to reducing landfill disposal and mitigating the environmental impact of ELV waste, reinforcing the principles of the circular economy. Full article

Influenza A virus (IAV) poses a significant threat to animal and public health due to its wide host range and potential for interspecies transmission. This study aimed to conduct a comprehensive survey of IAV in a wide range of wildlife in the Orinoco flooded savannas of Colombia, a region of high biodiversity and a strategic location for monitoring viral transmission. Sampling was conducted during both dry and rainy seasons in two localities. ELISA and qPCR targeted 2028 individuals from 173 bird, mammal, and reptile species, 124 of them without previously published reports. There were positive results for 54 species, with 34 representing first-time world reports. Of the qPCR, 13.4% were positive from birds, and 2.9% were from mammals. Seropositivity was identified in 5.7% of birds, 2.7% of mammals, and 1.3% of reptiles. These findings underscore the potential role of these diverse species as reservoirs or incidental hosts in the transmission cycle of IAV, emphasizing the need for expanded research on less-studied taxa and their ecological interactions. The results also contribute to our understanding of the epidemiology of IAV in the Neotropics and can inform future surveillance and mitigation strategies. Full article

Background/Objective: Cancer stem cells (CSCs) are a self-renewing subpopulation within tumors that contribute to heterogeneity and resistance to conventional cancer therapies, including chemotherapy and radiotherapy. Despite growing interest in CSCs as therapeutic targets, effective compounds against these cells remain limited. This systematic review aims to assess the potential of metal-based coordination complexes as anti-CSC agents in preclinical models. Methods: A systematic literature search was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Twenty-seven original in vitro studies were included, all evaluating the cytotoxic effects of metal-based compounds on cancer cell lines enriched with CSC subpopulations. To ensure methodological rigor, all articles underwent a critical appraisal by independent reviewers who resolved discrepancies through consensus, and only studies meeting predefined quality criteria were included. Results: Several metal complexes, particularly copper-based compounds, demonstrated significant cytotoxicity toward CSCs, mainly through the induction of apoptosis. Breast cancer was the most frequently studied tumor type. Many studies reported modulation of CSC-related markers, including EPCAM, CD44, CD133, CD24, SOX2, KLF4, Oct4, NOTCH1, ALDH1, CXCR4, and HES1, suggesting effects on CSC maintenance pathways. Most studies were conducted in the United Kingdom and relied on in vitro models. Conclusions: Metal coordination complexes, especially those containing copper, show promise as therapeutic agents targeting CSCs. However, further in vivo studies and mechanistic investigations are essential to advance their translational potential. Full article

Tectonic activity in the Mediterranean region has been driven by the convergence of the confining plates (Nubia, Arabia and Eurasia). This convergence has been accommodated by the consumption of the oceanic domains that were present in the late Oligocene. It is suggested that this process has been enabled by the lateral escape of orogenic belts in response to constrictional contexts. Where this condition was not present, subduction did not occur. This interpretation can plausibly and coherently account for the very complex pattern of tectonic processes in the whole area since the early Miocene. It is also suggested, by providing some examples, that the geodynamic context proposed here might help us to recognize the connection between the ongoing tectonic processes and the spatio-temporal distribution of past major earthquakes. A discussion is then reported about the incompatibilities of the main alternative geodynamic interpretation (slab pull) with the observed deformation pattern. Full article

Leishmaniasis is a significant public health concern, affecting millions and causing substantial mortality, thus urgently requiring more effective and safer treatments. This study explored the potential of 33 novel N-acylhydrazone-derived compounds against Leishmania amazonensis parasites, focusing on their inhibition of the Leishmania arginase enzyme and promastigote growth. Compounds 8 and 18 showed over 90% inhibitory activity against promastigote cultures after 72 h of treatment. Compound 8 showed an IC₅₀ of 10.5 µM (9.4–11.8 µM), while compound 18 exhibited an IC₅₀ of 42.8 µM (41.3–44.4 µM). The antipromastigote effects of these compounds highlight their potential for further new drug design. These findings offer a promising starting point for addressing the pressing need for new therapeutic options against leishmaniasis. In addition, we used web-based tools to predict the compounds’ toxicity and pharmacokinetic parameters. Despite the lack of inhibition against the L. amazonensis arginase enzyme, further investigation into the mechanisms of action of these compounds and in vivo efficacy could contribute to the development of safer and more effective treatments for this neglected tropical disease. Full article

This study evaluated the effect of soil and foliar fertilization with nitrogen (N), molybdenum (Mo), zinc (Zn), and their combination (Zn-Mo) on nutrition, enzymatic activity, photosynthetic pigments, and productive parameters in the Western Schley pecan tree. An orthogonal Taguchi L16 design was used with differentiated soil and foliar nitrate concentrations, reaching an average of 1557.7 mg kg⁻¹, and increasing up to 1907 mg kg⁻¹ depending on the fertilization dose. Nitrate reductase activity (NRNO₃⁻) significantly increased with N and Mo applications, reaching a maximum of 13.62 µmol. Among photosynthetic pigments, chlorophyll a was the only variable with a significant response, highlighting the role of Mo in its enhancement. Positive effects were also observed on pomological traits such as yield (up to 425 kg ha⁻¹), nut weight, and kernel percentage with increased doses of N and Mo. In conclusion, combined fertilization improved the nutritional status, physiological responses, and productivity of pecan trees, emphasizing the importance of balanced nutrient management to avoid nutritional antagonisms and to optimize both yield and fruit quality. Full article

Awake Bruxism (AB) is defined as masticatory muscle activity during wakefulness, characterized by repetitive or sustained tooth contact and/or the bracing or thrusting of the mandible. AB remains less understood than Sleep Bruxism (SB), and its identification remains a methodological challenge. The aim of this study was to introduce the Awake Bruxism Identification Tool (ABIT), developed for children and adolescents aged 8 to 12 years, to facilitate the identification of AB. The tool integrates data from self-reports, clinical examinations, and the Ecological Momentary Assessment (EMA). It comprises questionnaires using a five-point Likert scale, an analog EMA component involving color-based responses, and a clinical inspection. The tool adopts the concept of an “AB Spectrum”, as it generates individualized scores based on the combined outcomes of these multiple assessment components. The ABIT was piloted with ten families to evaluate its comprehensibility, applicability, and reliability. The results demonstrated that the participants found the questions understandable, that the tool had a minimal impact on daily family routines, and that it required approximately 5–10 min to complete. Additionally, the test–retest reliability indicated temporal stability. In terms of identification, four children were classified within the “AB identified by report and self-report,” while three were identified through the “report, self-report, and EMA.” Based on participant feedback, adjustments were made to the instrument, including the addition of an item addressing Sleep Bruxism. Although the ABIT is being applied for the first time in a research setting, it presents a promising, clinically relevant approach grounded in the self-perception of children and their caregivers. Full article

Mycelium-based composites (MBCs) have emerged as eco-friendly alternatives, utilizing fungal mycelium as a natural binder for agro-industrial residues. This study focuses on developing an MBC based on abundant waste in Colombia, pith Arboloco (A) (Montanoa quadrangularis), a plant endemic to the Colombian–Venezuelan Andes with outstanding insulating properties, and natural fiber of Kikuyu grass (G) (Cenchrus clandestinus), utilizing Ganoderma lucidum as an agent to form a mycelium network in the MBC. Three formulations, T (100% A), F1 (70% A/30% G), and F2 (30% A/70% G), were evaluated under two different Arboloco particle size ranges (1.0 to 5.6 mm) for their physical, mechanical, and thermal properties. The Arboloco particle sizes did not show significant differences in the MBC properties. An increase in Kikuyu grass proportion (F2) demonstrated superior density (60.4 ± 4.5 kg/m³), lower water absorption (56.6 ± 18.4%), and better compressive strength (0.1686 MPa at 50% deformation). Both mixing formulations (F1–F2) achieved promising average thermal conductivity and specific heat capacity values of 0.047 ± 0.002 W m⁻¹ K⁻¹ and 1714 ± 105 J kg⁻¹ K⁻¹, comparable to commercial insulation materials. However, significant shrinkage (up to 53.6%) and high water absorption limit their scalability for broader applications. These findings enhance the understanding of MBC’s potential for non-structural building materials made of regional lignocellulosic waste, promoting a circular economy in waste management for developing countries. Full article

The sustainable management of organic waste is a global priority due to its environmental impact and the increasing pressure on urban and rural systems, particularly in regions with limited technological infrastructure. This study introduces and validates a comprehensive methodology based on Digital Twins (DTs) to optimize production and service systems in organic waste management. The methodology includes contextual and propositional phases and is built on a modular three-layer architecture (physical, cloud, and virtual) that enables real-time monitoring, simulation, and feedback. It was validated through a field implementation in a composting facility in Cajamarca, Colombia. The results showed a 10% increase in composting efficiency and a monthly gain of 1200 kg of compost. A statistical analysis confirmed a significant increase in process efficiency (p < 0.001) and a reduction in performance variability (p < 0.01). The return on investment reached 18,957.6% using low-cost technology. These findings demonstrate the viability and adaptability of the proposed methodology for low-tech environments and support its potential for scaling in circular economy applications across waste management and agriculture. Full article

The Nubia Sandstone in the Gulf of Suez, Egypt, is a well-known unclassified sediment. Palynology is considered the most effective tool for dealing with this problem. Miospore assemblages from the Lowermost Carboniferous (Tournaisian) have been discovered from the J62-86 and the J62-64 AST1 wells located in the July Field of the Gulf of Suez, Egypt. Spores are moderately to poorly preserved, suggesting a stratigraphical position within Lowermost Carboniferous ages. The studied sediments include poorly preserved conodont fragments and present significant identification challenges due to the drilling methodologies’ complexities. Spore assemblage consists of 31 genera with 56 species. The dominant spores include zonate genera Vallatisporites, Densosporites, and Archaeozonotriletes, camerate genera Grandispora, Geminospora, apiculate genera Apiculiretusispora, and laevigate trilete genus Punctatisporites and megaspores of the Lagenoisporites type are recorded. Marine microphytoplankton including Schizocystia bicornuta, Lophosphaeridium, Leiosphaerida, and some filamentous green algae of unknown affinity are recorded. The dispersed spore assemblage is associated with carbonized plant fragments. The palynological data have effectively dated the lower intervals of the Nubia Sandstone from the Nubia “B,” indicating a Lowermost Carboniferous (Tournaisian) age, i.e., Vallatisporites vallatus–Retustriletes incohatus palynozone (VI). The stratigraphic differentiation of the Nubia Sandstone is crucial for subsequent correlating subsurface wells in the Gulf of Suez within the context of geology and hydrocarbon exploration, particularly given the scarcity of other fossil groups. Full article

Oxidative stress is involved in pathophysiological mechanisms associated with a myriad of liver diseases. Bergamot (Citrus bergamia) leaves yield a high level of antioxidant polyphenolic compounds that may hinder the development of liver diseases, while their potential is yet to be fully explored. Thus, the aim of the study was to test the effects of bergamot leaf extract (BLE) on hepatic and mitochondrial oxidative stress in different models. In vivo study: Wistar rats were distributed into two groups: control diet (C) and high-sugar–fat diet (HSF) for twenty weeks. Afterward, the animals were redivided to initiate a ten-week treatment with BLE: C, HSF, and HSF+BLE. In vitro study: Rat hepatic mitochondria were isolated by differential centrifugation and used to assess safety and efficacy of the BLE. Hepatocyte monolayer and spheroids were applied to evaluate the safety of physiologically plausible BLE concentrations and their effects on hydrogen peroxide-induced cytotoxicity. The results showed that BLE improved metabolic parameters, reduced hepatic triglyceride levels, malondialdehyde, and increased catalase activity in vivo. In vitro, BLE decreased lipid peroxidation and increased the ratio of reduced and oxidized glutathione in chemically challenged mitochondria. BLE did not exert cytotoxicity in the hepatocyte monolayer and spheroids, while attenuated oxidative stress-induced cytotoxicity. Data indicate that in vivo and in vitro hepatic oxidative stress is modulated by BLE, reinforcing that BLE may act as an agent against chronic liver diseases. Full article

The cultivation of table grapes in Brazil is economically significant, with production influenced by edaphoclimatic factors and rootstock selection. The cultivar ‘BRS Núbia’ (Vitis vinifera L. x Vitis labrusca L.) is a promising alternative; however, its phenological behavior, thermal requirements, and compatibility with different rootstocks under subtropical conditions require further evaluation. This study aimed to assess the duration of phenological stages, thermal requirement, and ripening dynamics of ‘BRS Núbia’ grapevines grafted onto the rootstocks ‘IAC 572 Jales’, ‘IAC 766 Campinas’, and ‘Paulsen 1103’. The experiment was conducted in São Manuel, São Paulo, Brazil during the 2021 and 2022 production cycles using a split-plot experimental design (3 × 2). Evaluations included the duration of phenological stages from pruning to budburst, flowering, fruit set, onset of ripening, and harvest, as well as the ripening curve and thermal accumulation from pruning to harvest. Rootstocks did not significantly affect (p > 0.05) the duration of phenological stages; however, differences were observed between production cycles. The 2022 cycle was longer (167.7 days) compared to 2021 (142.6 days), with greater thermal accumulation (1871.7 GDDs vs. 1743.4 GDDs). The analysis of phenological stages revealed that, across both production cycles evaluated, the ‘BRS Núbia’ cultivar required an average accumulation of 1807.5 growing degree days from pruning to harvest. Soluble solids content ranged from 17.43 to 18.50°Brix, and titratable acidity decreased throughout maturation. The maturation index was highest in vines grafted onto ‘Paulsen 1103’, indicating its positive influence on fruit quality. The ‘BRS Núbia’ grapevine exhibited a mean thermal requirement of 1807.5 growing degree days (GDDs) to complete its phenological cycle, which lasted approximately 150 days under subtropical conditions. Full article

This paper presents a robust control strategy for a synchronous Zeta converter using feedback linearization combined with a PI controller. The control design is based on a state-averaged model, but it is implemented and evaluated in a digitally switched system using PSIM simulations. To ensure consistency between the averaged and switched models, the duty cycle is computed at the beginning of each period, and a centered PWM scheme is applied. This study identifies critical factors that affect stability, including the sampling period and the PWM edge selection, both of which can destabilize the switched system even when the averaged model remains stable. This study analyzes the difference in stability ranges between the averaged and switched models under variations in load and reference voltage, revealing significant discrepancies between them. Results show that the proposed control achieves robust performance, low stabilization time, and good tracking behavior across a wide range of conditions. Full article

Background/objectives: Schistosomiasis is caused by flatworms of the genus Schistosoma, for which mollusks of the genus Biomphalaria are intermediate hosts. Niclosamide (NCL) is a molluscicide recommended by the World Health Organization (WHO) for control of Biomphalaria. Although effective, it is expensive and environmentally toxic, which raises concerns regarding its widespread use. As a result, we explored new synthetic substances as alternative strategies for controlling Biomphalaria glabrata. We evaluated the molluscicidal activity of 2-(1H-py-razol-1-yl)-1,3,4-thiadiazole and 2-(4,5-dihydro-1H-pyrazol-1-yl)-1,3,4-thiadiazole derivatives against B. glabrata snails and embryos, as well as Schistosoma cercariae (infective larvae). Methods: Adult and young snails were added to 24-well plates containing 20 synthetic compounds from the PDAN series for initial screening over 96 h at a concentration of 100 ppm. Water and NCL (2 ppm) were used as the negative and positive controls, respectively. Active compounds in the adult B. glabrata assay were selected for the tests vs. embryos and cercariae. Results: In the initial screen, only PDAN 52 (63 ± 4%) and 79 (12 ± 3%) showed molluscicidal activity at a concentration of 100 ppm up to 48 h. Consequently, we selected only PDAN 52. The LC₅₀ value found in the tests on embryos after 24 h of treatment was 20 ± 2 ppm and, after 48 h, it was 4 ± 0.5 ppm. Against cercariae, we measured an LC₅₀ value of 68 ± 5 ppm after 4 h of treatment. PDAN 52 did not induce marked toxicity against a second mollusk, Physella acuta, after 48 h of exposure. Conclusions: We highlight the promising molluscicidal activity of PDAN 52 against different developmental stages of the mollusk, B. glabrata, as well the infective larvae of Schistosoma mansoni. Full article

This paper is focused on some algebraic and combinatorial properties of a TMTO (Time–Memory Trade-Off) for a chosen plaintext attack against a cryptosystem with a perfect secrecy property. TMTO attacks aim to retrieve the preimage of a given one-way function more efficiently than an exhaustive search and with less memory than a dictionary attack. TMTOs for chosen plaintext attacks against cryptosystems with a perfect secrecy property are associated with some directed graphs, which can be defined by suitable collections of multisets called Brauer configurations. Such configurations induce so-called Brauer configuration algebras, the algebraic and combinatorial invariant analysis of which is said to be a Brauer analysis. In this line, this paper proposes formulas for dimensions of Brauer configuration algebras (and their centers) induced by directed graphs defined by TMTO attacks. These results are used to provide some set-theoretical solutions for the Yang–Baxter equation. Full article