Search Results (28)

Background: Effective triage of women testing positive for high-risk HPV DNA is essential to reduce unnecessary colposcopies while preserving cancer prevention. Cytology, the current standard, has limited specificity and reproducibility. The genotype-specific 7-type HPV E6/E7 mRNA test (PreTect HPV-Proofer’7), targeting HPV types 16, 18, 31, 33, 45, 52, and 58, detects transcriptionally active infections and may enhance risk stratification. Methods: Between 2019 and 2023, 34,721 women aged 25–69 underwent primary HPV DNA screening with the Cobas 4800 assay at the University Hospital of North Norway, within the national screening program. Of these, 1896 HPV DNA-positive women were triaged with liquid-based cytology with atypical squamous cells of undetermined significance or worse (≥ASC-US) and the 7-type HPV mRNA test. Histological outcomes were followed through October 2024. Diagnostic performance for CIN2+ was evaluated overall and by genotype. Results: CIN2+ prevalence was 13.3%. The mRNA test reduced test positivity from 50.3% to 33.4% while maintaining comparable sensitivity (70.6% vs. 72.2%) and improving specificity (72.3% vs. 53.0%) and PPV (28.1% vs. 19.1%). Genotype-specific PPVs were highest for HPV16 mRNA (47.7%), followed by HPV33 (39.2%) and HPV31 (32.2%), all exceeding corresponding DNA-based estimates. Conclusion: Genotype-specific HPV mRNA triage offers superior risk discrimination compared to cytology, supporting more targeted, efficient, and accessible cervical cancer screening. Full article

An increasing trend towards the installation of photovoltaic (PV) solar energy generation capacity is driven by several factors including the desire for greater energy independence and, especially, the desire to decarbonize industrial economies. While large ‘solar farms’ can be installed in relatively open areas, urban environments also offer scope for significant energy generation, although the heterogeneous nature of the surface of the urban fabric complicates the task of forming an area-wide view of this potential. In this study, we investigate the potential offered by publicly available airborne LiDAR data, augmented using data from OpenStreetMap (OSM), to estimate rooftop PV generation capacities from individual buildings and regionalized across an entire small city. We focus on the island of Tromsøya in the city of Tromsø, Norway, which is located north (69.6° N) of the Arctic Circle, covers about 13.8 km², and has a population of approximately 42,800. A total of 16,377 buildings were analyzed. Local PV generation potential was estimated between 120 and 180 kWh m⁻² per year for suitable roof areas, with a total estimated generation potential of approximately 200 GWh per year, or approximately 30% of the city’s current total consumption. Regional averages within the city show significant variations in potential energy generation, highlighting the importance of roof orientation and building density, and suggesting that rooftop PV could play a much more substantial role in local energy supply than is commonly assumed at such high latitudes. The analysis method developed here is rapid, relatively simple, and easily adaptable to other locations. Full article

Chinese-style greenhouses (CSGs), characterized by a distinct geometric shape compared to traditional greenhouses, are extensively utilized in China. In this study, this type of greenhouse was modeled using TRNSYS software version 18 and experimentally validated. The model can transiently determine the indoor conditions of the greenhouse and the requirement for additional heating. It calculates the heat loss due to plant evapotranspiration as well as all the heat gains and losses from the surfaces. The application of this greenhouse has been investigated from the southernmost to the northernmost regions of Europe. For this purpose, cities located at different latitudes (between 32.63° N and 69.65° N) were entered into the model, and the results were obtained and compared. The analysis conducted over the entire year demonstrated that the CSG indoor temperature is more dependent on solar energy during the day and on outdoor temperature at night. The two southernmost cities in our survey, Funchal, Portugal (32.63° N) and Luqa, Malta (35.83° N), had no winter heating requirement. The thermal covering was sufficient to minimize night heat loss and maintain a suitable indoor temperature. In northern cities, the heating requirement was relatively high due to the lower outdoor temperature and solar radiation. Consequently, the duration of the heating season increases towards the north. In the northernmost city, Tromso, Norway (69.65° N), the heating season was determined to last 12 months. In the absence of solar energy, the transparent surface of the greenhouse is covered with thermal insulation to prevent heat loss. It has been shown that with the appropriate selection of this thermal covering, which is controlled based on the presence of instantaneous solar energy, up to 80% savings can be achieved from additional heating in southern cities. In the north, this rate can be increased up to a maximum of 70% by increasing the thermal covering thickness. Full article

The Storegga slide tsunami (SST) at ca. 8100 ± 100–250 cal BP is known to be the largest tsunami that affected the North Sea during the entire Holocene. Geological traces of tsunami landfall were discovered along the coasts of Norway, Scotland, England, Denmark, the Faroes and Shetland Islands. So far, the German North Sea coast has been considered as being well protected due to the wide continental shelf and predominant shallow water depths, both assumed to dissipate tsunami wave energy significantly, thus hindering SST propagation dynamics. The objective of our research was to clarify if the SST reached the German Bight and if corresponding sediment markers can be found. Our research was based on the in-depth investigation of a 5 m long section of the research core Garding-2 from Eiderstedt Peninsula near Garding in North Frisia known from a previous study. For this, we newly recovered sediment core Garding-2A at exactly the same coring location as core Garding-2. Additionally, high-resolution Direct Push sensing data were collected to gain undisturbed stratigraphic information. Multi-proxy analyses of sediment material (grain size, geochemical, geochronological and microfaunal data) were carried out to reconstruct palaeoenvironmental and palaeogeographical conditions. We identified a high-energy event layer with sedimentological (e.g., erosional unconformity, rip-up clasts, fining-upward), microfaunal (e.g., strongly mixed foraminiferal assemblage) and other features typical of tsunami influence and identical in age with the SST, dated to ca. 8.15 ka cal BP. The event layer was deposited at or maximum ca. 1–1.5 m below the local contemporary relative sea level and several tens of kilometers inland from the coastline within the palaeo-Eider estuarine system beyond the reach of storm surges. Tsunami facies and geochronological data correspond well with SST signatures identified on the nearby island of Rømø. SST candidate deposits identified at Garding represent the southernmost indications of this event in the southeastern North Sea. They give evidence, for the first time, of high-energy tsunami landfall along the German North Sea coast and tsunami impact related to the Storegga slide. SST deposits seem to have been subsequently reworked and redeposited over centuries until the site was affected by the Holocene marine transgression around 7 ka cal BP (7.3–6.5 ka cal BP). Moreover, the transgression initiated energetically and ecologically stable shallow marine conditions within an Eider-related tidal channel, lasting several millennia. It is suggested that the SST was not essentially weakened across the shallow continental shelf of the North Sea, but rather caused tsunami run-up of several meters (Rømø Island) or largely intruded estuarine systems tens of kilometers inland (North Frisia, this study). We, therefore, assume that the southern North Sea coast was generally affected by the SST but sedimentary signals have not yet been identified or have been misinterpreted. Our findings suggest that the German North Sea coast is not protected from tsunami events, as assumed so far, but that tsunamis are also a phenomenon in this region. Full article

This paper presents some features of apple production in Norway, the northernmost apple-growing country in the world. Acceptable growing conditions prevail along the fjords in western Norway and around the lakes in eastern Norway at 60° north. These specific mesic climate conditions are associated with very long summer days (18 h daylight mid-summer) and short winter days (6 h daylight), with frost rarely occurring in the spring along the fjord areas. The present apple-growing technique in Norway is similar to that of other developed apple-growing countries, taking into account that all local growing phases involve a considerable delay in progress (1.5–2 months). Therefore, high-density planting systems based on the use of dwarf rootstocks (mainly M.9) with imported early maturing international apple cultivars are used in most orchards. The most common soil type has high organic matter content (2–18%), which persists due to the cool climate and low mineralization, and a clay content of <15%, which results from the formation of the soil from bedrock. The increase in average temperatures caused by current climatic changes leads to a complex combination of different physiological effects on apples, which can have positive or negative effects on the phenology of the trees. The main advantage of Norwegian apple production is that the quality and aroma of the fruit meet the current demands of the local market. Full article

Global warming results in increasingly widespread wildfires, mostly in Siberia, but also in North America and Europe, which are responsible for the uncontrollable emission of pollutants, also to the High Arctic region. This study examines 11 samples of rainfall collected in August in a coastal area of southern Bellsund (Svalbard, Norway). It covers detailed analysis of major ions (i.e., Cl⁻, NO₃⁻, and SO₄²⁻) and elements (i.e., Cu, Fe, Mn, Pb, and Zn) to Hybrid Single-Particle Langrarian Integrated Trajectory( HYSPLIT) backward air mass trajectories. The research of wildfires, volcanic activities, and dust storms in the Northern Hemisphere has permitted the assessment of their relations to the fluctuations and origins of elements. We distinguished at least 2 days (27 and 28 August) with evident influence of volcanic activity in the Aleutian and Kuril–Kamchatka trenches. Volcanic activity was also observed in the case of the Siberian wildfires, as confirmed by air mass trajectories. Based on the presence of non-sea K (nsK), non-sea sulphates (nss), and Ca (the soil factor of burned areas), the continuous influence of wildfires on rainfall chemistry was also found. Moreover, dust storms in Eurasia were mainly responsible for the transport of Zn, Pb, and Cd to Svalbard. Global warming may lead to the increased deposition of mixed-origin pollutants in the summer season in the Arctic. Full article

The high-resolution long-term hydrometeorological “COSMO-CLM Russian Arctic hindcast” based on nonhydrostatic regional atmospheric model COSMO-CLM v.5.06 for the 1980–2016 period covering the North Atlantic, Barents, and Kara and Laptev Seas with ~12 km grid size was utilized to estimate climatological trends of extreme wind speed. In this study, we used the 10 m wind speed data from 95 Russian weather stations inside the hindcast domain. Trends in mean, maximal, 0.90, 0.95, 0.99 quantiles wind speed values, and occurrences of wind speed above 20, 25, 30, and 33 m/s were calculated for all stations and corresponding nearest model grids for yearly data and data from four months of the calendar year (January, April, July, and October). Yearly mean wind speed and quantiles values were observed to increase over the northern Kara Sea, while decreases were observed over the western Barents Sea and northern Atlantic. Extreme wind speeds were observed to increase in January in the eastern Evenkia and northern Yakutia, while declining was observed over north-eastern European Russia. The 0.99 quantile values increased in July near the Gyda peninsula coastline, but decreased over polar regions, the Pechora Sea, and the White Sea coastline. Maximal wind speed declined in October over north-western European Russia, eastern Taymyr, and the Norway Sea, but grew over the Eastern Siberian Sea. Full article

Aquaculture of the lumpfish (Cyclopterus lumpus L.) has become a large, lucrative industry owing to the escalating demand for “cleaner fish” to minimise sea lice infestations in Atlantic salmon mariculture farms. We used over 10K genome-wide single nucleotide polymorphisms (SNPs) to investigate the spatial patterns of genomic variation in the lumpfish along the coast of Norway and across the North Atlantic. Moreover, we applied three genome scans for outliers and two genotype–environment association tests to assess the signatures and patterns of local adaptation under extensive gene flow. With our ‘global’ sampling regime, we found two major genetic groups of lumpfish, i.e., the western and eastern Atlantic. Regionally in Norway, we found marginal evidence of population structure, where the population genomic analysis revealed a small portion of individuals with a different genetic ancestry. Nevertheless, we found strong support for local adaption under high gene flow in the Norwegian lumpfish and identified over 380 high-confidence environment-associated loci linked to gene sets with a key role in biological processes associated with environmental pressures and embryonic development. Our results bridge population genetic/genomics studies with seascape genomics studies and will facilitate genome-enabled monitoring of the genetic impacts of escapees and allow for genetic-informed broodstock selection and management in Norway. Full article

This paper presents a comprehensive study of winter temperatures in Norway and northern Sweden, covering a period of 50 to 70 years. The analysis utilizes Singular Spectrum Analysis (SSA) to investigate temperature trends at six selected locations. The results demonstrate an overall long-term rise in temperatures, which can be attributed to global warming. However, when investigating variations in highest, lowest, and average temperatures for December, January, and February, 50% of the cases exhibit a significant decrease in recent years, indicating colder winters, especially in December. The study also explores the variations in Atlantic Meridional Overturning Circulation (AMOC) variations as a crucial climate factor over the last 15 years, estimating a possible 20% decrease/slowdown within the first half of the 21st century. Subsequently, the study investigates potential similarities between winter AMOC and winter temperatures in the mid to high latitudes over the chosen locations. Additionally, the study examines another important climatic index, the North Atlantic Oscillation (NAO), and explores possible similarities between the winter NAO index and winter temperatures. The findings reveal a moderate observed lagged correlation for AMOC-smoothed temperatures, particularly in December, along the coastal areas of Norway. Conversely, a stronger lagged correlation is observed between the winter NAO index and temperatures in northwest Sweden and coastal areas of Norway. Thus, NAO may influence both AMOC and winter temperatures (NAO drives both AMOC and temperatures). Furthermore, the paper investigates the impact of colder winters, whether caused by AMOC, NAO, or other factors like winds or sea ice changes, on electrical power and energy systems, highlighting potential challenges such as reduced electricity generation, increased electricity consumption, and the vulnerability of power grids to winter storms. The study concludes by emphasizing the importance of enhancing the knowledge of electrical engineering researchers regarding important climate indices, AMOC and NAO, the possible associations between them and winter temperatures, and addressing the challenges posed by the likelihood of colder winters in power systems. Full article

Commercial fruit production in Norway is located at around latitude 60° north, demanding a careful choice of adapted cultivars. The most comprehensive collection of apple genetic resources in Norway is being kept in the Norwegian Apple Collection (NAC) at the Njøs Fruit and Berry Centre (NJØS). The collection contains around 350 accessions and was recently genotyped with a single nucleotide polymorphism (SNP) array. Curated SNP data were used for the assessment of structure and diversity, pedigree confirmation, and core collection development. In the following SNP analysis, we identified several duplicates and parent-child relationships. Across the geographic regions represented, the collection was equally diverse. Different methods for analyzing population structure were applied. K-means clustering and a Bayesian modeling approach with prior assumptions of the data revealed five subpopulations associated with geographic breeding centers. The collection has a distinct genetic structure and low relatedness among the accessions; hence, two core collections with 100 accessions in each were created. These new core collections will allow breeders and researchers to use the NAC efficiently. The results from this study suggest that several of the accessions in the Norwegian Apple Collection could be of high importance for breeding purposes. Full article

Background: A plethora of data supports HPV-based screening to be the preferred strategy for cervical cancer prevention. The shift to a more sensitive first-line test brings the need of effective triage up for discussion. Currently, most algorithms apply cytology as a triage of HPV-DNA positive women. This study compared the performance of a 7-type HPV-mRNA test to cytology. Methods: From 1 January 2019 until 31 December 2021, cervical samples from 58,029 women were examined at the University Hospital of North Norway. A total of 30.5% (17,684/58,029) fulfilled the criteria for HPV-DNA primary screening. All positive samples were triaged by cytology and followed-up according to national guidelines through 2022. Additionally, a 7-type HPV-mRNA test was applied. The study endpoint was a histologically confirmed high-grade lesion (CIN2+). Results: A total of 5.6% (990/17,684) had positive HPV-DNA test, 97.2% (962/990) with valid HPV-mRNA results. A total of 55.5% (534/962) had abnormal cytology (ASC-US+), and 35.1% (338/962) had a positive HPV-mRNA test. A total of 13.9% (134/962) had CIN2+. The sensitivity (CIN2+) of cytology versus the HPV-mRNA test was 76.1% (102/134) versus 73.1% (98/134), p = 0.67. The specificity was 47.8% (396/828) versus 71.0% (588/624), p < 0.001. PPV was 19.1% (102/534) and 29.0% (98/338), p < 0.001, respectively. The number of colposcopies per CIN2+ detected by cytology and HPV-mRNA test was 5.2 and 3.1. Conclusion: The 7-type HPV mRNA test was significantly more specific than cervical cytology in a triage of HPV-DNA positive women. Using this biomarker as the threshold for colposcopy may better balance the benefits and harms of screening. Full article

Norway is at the forefront of monitoring ice patches and glaciers for archaeological remains, and thousands of artifacts have been recovered over the past two decades due to accelerating melting. The majority of finds stem from the lower latitudes of the country and relatively little is known about the glacial archaeology of Norway’s far north. We use historical maps and high-resolution LiDAR derived elevation models to monitor ice flow and melt. We employ a terrain ruggedness index to map areas of non-moving ice which possibly contain well-preserved archaeological finds, and model least cost paths to understand the accessibility for humans and animals of an archaeologically unexplored landscape. We then conduct a sailboat supported exploratory survey on the arctic island of Seiland. While we fail to locate archaeologically productive ice, we identify and date a so far unknown type of archaeological stone structure likely related to sheltering and reindeer hunting/herding activities. Full article

Microalgae are the richest source of natural carotenoids, which are valuable pigments with a high share of benefits. Often, carotenoid-producing algae inhabit specific biotopes with unfavorable or even extremal conditions. Such biotopes, including alpine snow fields and hypersaline ponds, are widely distributed in Europe. They can serve as a source of new strains for biotechnology. The number of algal species used for obtaining these compounds on an industrial scale is limited. The data on them are poor. Moreover, some of them have been reported in non-English local scientific articles and theses. This review aims to summarize existing data on microalgal species, which are known as potential carotenoid producers in biotechnology. These include Haematococcus and Dunaliella, both well-known to the scientific community, as well as less-elucidated representatives. Their distribution will be covered throughout Europe: from the Greek Mediterranean coast in the south to the snow valleys in Norway in the north, and from the ponds in Amieiro (Portugal) in the west to the saline lakes and mountains in Crimea (Ukraine) in the east. A wide spectrum of algal secondary carotenoids is reviewed: β-carotene, astaxanthin, canthaxanthin, echinenone, adonixanthin, and adonirubin. For convenience, the main concepts of biology of carotenoid-producing algae are briefly explained. Full article

A knotwood of coniferous trees containing large amounts of polyphenolic extractives is considered a promising industrial-scale source of lignans possessing antioxidant properties and other bioactivities. The present study is aimed at a detailed characterization of the chemical composition and antioxidant activity of lignan-rich extractives obtained from the knotwood of the Norway spruce, Scotch pine, Siberian fir, and Siberian larch growing in the European North of Russia as a region with a highly developed forest industry. To achieve this, a comprehensive approach based on a combination of two-dimensional NMR spectroscopy with high-performance liquid chromatography—high-resolution Orbitrap mass spectrometry, and the determination of antioxidant activity by the three complementary methods were proposed. The studied knotwood samples contained from 3.9 to 17% of extractive substances and were comparable to Trolox’s antioxidant activity in the single-electron transfer processes and superoxide radical scavenging, which is associated with the predominance of polyphenolic compounds. The latter was represented by 12 tentatively identified monolignans and 27 oligolignans containing 3–5 phenylpropane units in their structure. The extracts were characterized by an identical set of lignans and differed only in the ratios of their individual compounds. Other components of the knotwood were flavonoids taxifolin, quercetin (Siberian larch), and three stilbenes (pinosylvin, its methyl ester, and pterostilbene), which were identified in the Scotch pine extractives. Sesquiterpene juvabione and its derivatives were found in extracts of Siberian larch knotwood. Full article

Grand fir (Abies grandis/Dougl. ex D. Don/Lindl.) represents the North American species that has the potential to replace and complement to some extent several commercial European species, in particular, Norway spruce and silver fir. This is not only due to its high production potential but also because of its favorable effect on the soil compared to spruce or pine. We tested sample trees from these tree species growing in the same location for physical and mechanical wood properties and evaluated the effect of the thermal treatment (180 °C and 200 °C) on their wood. Wood density, swelling, surface properties, strength, and stiffness were the properties used to find the differences among species. Grand fir obtained higher values for density and compressive strength compared to silver fir. For the remaining properties, these tree species are comparable, except for toughness, which was significantly lower for grand fir. Grand fir wood was even comparable with Norway spruce in the case of density and compressive strength. The thermal treatment resulted in a decrease in density, swelling, wettability, modulus of rupture, and toughness while increasing compressive strength. The effect of the thermal treatment was similar for all tested species. From this perspective, grand fir represents a potential substitute for the timber of endangered European commercial conifers. Full article