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Article

26 Citations

5,502 Views

12 Pages

Anti-Inflammatory and Reactive Oxygen Species Suppression through Aspirin Pretreatment to Treat Hyperoxia-Induced Acute Lung Injury in NF-κB–Luciferase Inducible Transgenic Mice

Chuan-Mu Chen,
Yu-Tang Tung,
Chi-Hsuan Wei,
Po-Ying Lee and
Wei Chen

Antioxidants2020, 9(5), 429;https://doi.org/10.3390/antiox9050429

15 May 2020

Acute lung injury (ALI), a common cause of morbidity and mortality in intensive care units, results from either direct intra-alveolar injury or indirect injury following systemic inflammation and oxidative stress. Adequate tissue oxygenation often re...

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Article

13 Citations

2,720 Views

18 Pages

Novel Kefir Exopolysaccharides (KEPS) Mitigate Lipopolysaccharide (LPS)-Induced Systemic Inflammation in Luciferase Transgenic Mice through Inhibition of the NF-κB Pathway

Chun-Huei Liao,
Chih-Ching Yen,
Hsiao-Ling Chen,
Yu-Hsien Liu,
Yu-Hsuan Chen,
Ying-Wei Lan,
Ke-Rong Chen,
Wei Chen and
Chuan-Mu Chen

Antioxidants2023, 12(9), 1724;https://doi.org/10.3390/antiox12091724

5 September 2023

A novel kefir exopolysaccharides (KEPS) derived from kefir grain fermentation were found to have a small molecular weight (12 kDa) compared to the traditionally high molecular weight (12,000 kDa) of kefiran (KE). KE has been shown to possess antioxid...

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Article

90 Citations

8,988 Views

17 Pages

Dietary Apigenin Exerts Immune-Regulatory Activity in Vivo by Reducing NF-κB Activity, Halting Leukocyte Infiltration and Restoring Normal Metabolic Function

Horacio Cardenas,
Daniel Arango,
Courtney Nicholas,
Silvia Duarte,
Gerard J. Nuovo,
Wei He,
Oliver H. Voss,
M. Elba Gonzalez-Mejia,
Denis C. Guttridge and
Erich Grotewold
+ 1 author

Int. J. Mol. Sci.2016, 17(3), 323;https://doi.org/10.3390/ijms17030323

1 March 2016

The increasing prevalence of inflammatory diseases and the adverse effects associated with the long-term use of current anti-inflammatory therapies prompt the identification of alternative approaches to reestablish immune balance. Apigenin, an abunda...

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Article

19 Citations

4,491 Views

20 Pages

Role of microRNA 690 in Mediating Angiotensin II Effects on Inflammation and Endoplasmic Reticulum Stress

Kalhara R. Menikdiwela,
Latha Ramalingam,
Mostafa M. Abbas,
Halima Bensmail,
Shane Scoggin,
Nishan S. Kalupahana,
Asha Palat,
Preethi Gunaratne and
Naima Moustaid-Moussa

Cells2020, 9(6), 1327;https://doi.org/10.3390/cells9061327

26 May 2020

Overactivation of the renin–angiotensin system (RAS) during obesity disrupts adipocyte metabolic homeostasis and induces endoplasmic reticulum (ER) stress and inflammation; however, underlying mechanisms are not well known. We propose that over...

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