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Article

22 Citations

2,428 Views

25 Pages

The Mayo Clinic Florida Microdosimetric Kinetic Model of Clonogenic Survival: Application to Various Repair-Competent Rodent and Human Cell Lines

Alessio Parisi,
Chris J. Beltran and
Keith M. Furutani

Int. J. Mol. Sci.2022, 23(20), 12491;https://doi.org/10.3390/ijms232012491

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18 October 2022

The relative biological effectiveness (RBE) calculations used during the planning of ion therapy treatments are generally based on the microdosimetric kinetic model (MKM) and the local effect model (LEM). The Mayo Clinic Florida MKM (MCF MKM) was rec...

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Article

10 Citations

4,682 Views

22 Pages

Clonogenic Survival RBE Calculations in Carbon Ion Therapy: The Importance of the Absolute Values of α and β in the Photon Dose-Response Curve and a Strategy to Mitigate Their Anticorrelation

Alessio Parisi,
Chris J. Beltran and
Keith M. Furutani

Quantum Beam Sci.2023, 7(1), 3;https://doi.org/10.3390/qubs7010003

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28 January 2023

The computation of the relative biological effectiveness (RBE) is a fundamental step in the planning of cancer radiotherapy treatments with accelerated ions. Numerical parameters derived analyzing the dose response of the chosen cell line after irrad...

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