Search Results (21,858)

Background: Head and neck squamous cell carcinoma remains a highly aggressive malignancy with limited predictive biomarkers for prognosis and radiotherapy response. Increasing evidence indicates that pseudogenes are functionally active regulators of cancer biology, yet their clinical relevance in HNSCC is poorly defined. Methods: Using transcriptomic and clinical data from The Cancer Genome Atlas, we analyzed the expression and clinical significance of two pseudogenes, ANXA2P2 and PA2G4P4, in HNSCC. Associations with clinicopathological features, HPV status, tumor subtypes, survival, genomic instability, radiotherapy response, and immune landscape were assessed using bioinformatic tools. Results: Both pseudogenes were significantly upregulated in HNSCC compared to normal tissues. Higher expression levels correlated with adverse clinicopathological features, increased tumor proliferation and wound-healing capacity, and unfavorable TCGA molecular subtypes. High ANXA2P2 and PA2G4P4 expression was associated with reduced overall survival, while their combined low-expression signature identified patients with significantly improved overall and disease-free survival. Notably, lower expression of both pseudogenes was observed in patients responding to radiotherapy, whereas higher expression was linked to genomic instability parameters and enrichment of oncogenic pathways, including MYC, PI3K/AKT/mTOR, cell cycle regulation, and DNA repair. ANXA2P2 expression differed significantly by HPV status, showing reduced levels in HPV-positive tumors. Furthermore, pseudogene expression stratified distinct immune profiles, including immune subtypes, stromal and immune scores, and specific immune cell populations. Conclusions:ANXA2P2 and PA2G4P4 are clinically relevant pseudogenes associated with tumor aggressiveness, immune modulation, and radiotherapy response in HNSCC. These findings support their potential utility as prognostic and predictive biomarkers and provide a rationale for further functional validation in experimental models. Full article

High electrostrain, excellent thermal stability, and low hysteresis are critical requirements for advanced high-precision actuators. However, simultaneously achieving these synergistic properties in lead-free ferroelectric ceramics remains a significant challenge. In this work, a targeted B-site doping strategy was employed to develop novel lead-free (0.99-x)BaTiO₃-xBaZrO₃-0.01Bi(Zn_2/3Nb_1/3)O₃ (BT-xBZ-BZN, x = 0–0.2) ceramics. Systematic investigation identified optimal Zr⁴⁺ substitution at x = 0.1, which yielded an outstanding combination of electromechanical properties. For this optimal composition, a high unipolar electrostrain (S_max = 0.11%) was achieved at 50 kV/cm, accompanied by an ultra-low hysteresis (H_S = 1.9%). Concurrently, a large electrostrictive coefficient (Q₃₃ = 0.0405 m⁴/C²) was determined, demonstrating excellent thermal robustness with less than 10% variation across a broad temperature range of 30–120 °C. This superior comprehensive performance is attributed to a composition-driven evolution from a long-range ferroelectric to a pseudocubic relaxor state. In this state, the dominant electrostrictive effect, propelled by reversible dynamics of polar nanoregions (PNRs), minimizes irreversible domain switching. These findings not only present BT-xBZ-BZN (x = 0.1) as a highly promising lead-free candidate for high-precision, low-loss actuator devices, but also provide a viable design strategy for developing high-performance electrostrictive materials with synergistic large strain and superior thermal stability. Full article

Amidst the ongoing global energy crisis, environmental deterioration, and the exacerbation of climate change, the development of renewable energy, particularly solar energy, has become a central topic in the global energy transition. This study investigates a solar photovoltaic thermal (PVT) heat pump system that utilizes an expanded honeycomb-channel PVT module to enhance the comprehensive utilization efficiency of solar energy. A simulation platform for the solar PVT heat pump system was established using Aspen Plus software (V12), and the system’s performance impact mechanisms and engineering applications were researched. The results indicate that solar irradiance and the circulating water temperature within the PVT module are the primary factors affecting system performance: for every 100 W/m² increase in solar irradiance, the coefficient of performance for heating (COP_h) increases by 13.7%, the thermoelectric comprehensive performance coefficient (COP_co) increases by 14.9%, and the electrical efficiency of the PVT array decreases by 0.05%; for every 1 °C increase in circulating water temperature, the COP_h and COP_co increase by 11.8% and 12.3%, respectively, and the electrical efficiency of the PVT array decreases by 0.03%. In practical application, the system achieves an annual heating capacity of 24,000 GJ and electricity generation of 1.1 million kWh, with average annual COP_h and COP_co values of 5.30 and 7.60, respectively. The Life Cycle Cost (LCC) is 13.2% lower than that of the air-source heat pump system, the dynamic investment payback period is 4–6 years, and the annual carbon emissions are reduced by 94.6%, demonstrating significant economic and environmental benefits. This research provides an effective solution for the efficient and comprehensive utilization of solar energy, utilizing the low-global-warming-potential refrigerant R290, and is particularly suitable for combined heat and power applications in regions with high solar irradiance. Full article

Currently, research on the hydrodynamic characteristics of artificial reef deployment still faces challenges such as insufficient environmental coupling, but accurate simulation of the deployment process holds significant engineering importance for optimizing deployment efficiency and ensuring reef stability. This study employs the Smoothed Particle Hydrodynamics (SPH) method to establish a 3D numerical model, focusing on the influence of key parameters—inflow velocity and water entry angle—on the hydrodynamic characteristics of cubic artificial reef deployment. The results indicate that under flow velocities of 0.4–0.5 m/s, pressure fluctuations are relatively minor, with peak pressure gradients below 15 kPa/m, exhibiting a gradual trend, while particle concentration remains high, and drag gradually increases. At flow velocities of 0.6–0.8 m/s, the maximum pressure at the bottom reaches up to 35 kPa, with low-pressure areas at the tail dropping to −10 kPa; particle concentration decreases compared to conditions at 0.4–0.5 m/s; settling time extends from 8.4 s to 12 s, representing a 42% increase. Under different water entry angles, drag varies nonlinearly with the angle, reaching its maximum at 20° and its minimum at 25°, with a reduction of approximately 47% compared to the maximum. The anti-sliding safety factor and anti-overturning safety factor are used to assess the stability of the cubic reef placed on the seabed. Across different inflow velocities, the anti-sliding safety factor of the cubic artificial reef significantly exceeds 1.2, whereas the anti-overturning safety factor is below 1.2 at 0.4 m/s but exceeds 1.2 at velocities of 0.5 m/s and above, indicating that the reef maintains stability under the majority of these flow conditions. Our findings provide a scientific basis for the deployment process, site selection, and geometric design of cubic artificial reefs, offering valuable insights for the precise deployment and structural optimization of artificial reefs in marine ranching construction. Full article

The misuse of antibacterial agents has contributed to the growing prevalence of antibiotic resistance, highlighting an urgent need to explore alternative anti-infection therapeutic strategies. Antimicrobial peptides (AMPs) are naturally occurring molecules. They exhibit broad-spectrum antimicrobial activity and represent promising candidates for the development of novel therapeutics. A cysteine-rich antimicrobial peptide was identified and characterized from the genome of Tigriopus japonicus and designated “TjRcys1”. The precursor form of TjRcys1 comprises 96 amino acids. Structural analyses of TjRcys1 revealed random coils, two α-helices, and two β-strands. Recombinant TjRcys1 had inhibitory effects upon Staphylococcus aureus and Bacillus sp. T2, with a minimum inhibitory concentration of 64 μM for both. TjRcys1 did not show complete inhibition against Vibrio alginolyticus, Klebsiella pneumoniae, or Aeromonas hydrophila at 64 μM, but it did slow their growth rate. TjRcys1 could disrupt the permeability of the cell membrane of S. aureus. Transcriptomic analyses indicated that TjRcys1 could interfere with the ribosome biosynthesis and nucleotide metabolism of K. pneumoniae. Our results provide a valuable reference for the development of new AMPs and optimization of their design. Full article

Organic phase change materials show potential for thermal energy storage, but their scalable implementation is limited by fixed phase change temperatures, molten leakage, and low thermal conductivity. To address the temperature constraint, a binary eutectic system of 1-tetradecanol and 1,10-decanediol is prepared, expanding the operational temperature range for building thermal management. Compositing the eutectic with expanded graphite yields a composite material that exhibits a low leakage and a markedly improved thermal conductivity of 4.642 W/(m·K), which is approximately 12 times that of the pure eutectic. The composite maintains distinct phase transition properties, with melting and solidification temperatures of 37.77 °C and 29.38 °C and corresponding latent heats of 218.80 J/g and 216.66 J/g. It also demonstrates a good cycling stability, retaining over 87% of the original latent heat after 2000 thermal cycles. While these findings remain valid under controlled conditions, further studies are required to evaluate their practical feasibility and long-term durability in real-world scenarios. This work establishes a systematic approach for fabricating composite phase change materials and provides a promising candidate for building thermal management applications. Full article

Background/Objectives: We investigated the association between leisure-time physical activity (LTPA) and liver fibrosis, and whether this relationship differs by obesity and diabetes status. Methods: We conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) 2017–March 2020 cycle. LTPA was assessed using the Global Physical Activity Questionnaire (GPAQ) and classified as physically active if engaging in ≥600 metabolic equivalent (MET)-minutes per week of moderate-to-vigorous activity, or inactive. Clinically significant liver fibrosis was defined as liver stiffness measurement (LSM) ≥ 8.0 kPa on transient elastography. Multivariable logistic and linear regression models estimated adjusted odds ratios (ORs) for significant liver fibrosis, with additional subgroup analyses according to obesity and diabetes status. Results: In 7662 U.S. adults, physically active participants (n = 2721) had a lower prevalence of significant fibrosis than inactive individuals (5.4% vs. 11.4%, p < 0.001). In multivariable analysis, Participants who were physically active were associated with 42% lower odds of having fibrosis (OR 0.58, 95% confidence interval [CI] 0.41–0.82; p = 0.004). This association remained consistent in subgroup analyses stratified by obesity and diabetes status, even in the non-obese subgroup with body mass index (BMI) < 30 kg/m² (OR 0.54, 95% CI 0.32–0.91; p = 0.022) and the non-diabetic subgroup (OR 0.59, 95% CI 0.39–0.90; p = 0.016). Conclusions: Regular moderate-to-vigorous LTPA was independently associated with lower likelihood of clinically significant liver fibrosis. This beneficial association was significant regardless of obesity or diabetes status, suggesting that LTPA may play a clinically meaningful role in populations at high risk for progressive liver disease. Full article

During on-site welding operations, the sealant coated on anchor bolt surfaces can be ignited by hot particles or localized sparks, potentially triggering a fire hazard. This combustion process involves a complex multi-physics coupling among sealant combustion, convective and radiative heat transfer, and three-dimensional heat conduction in solids. To resolve this coupling, a simulation strategy is proposed that correspondingly integrates the Fire Dynamics Simulator (FDS, version 6.7.6) for modeling combustion and radiation with ABAQUS (2024) for simulating conductive heat transfer in solids. The proposed method is validated against experimental measurements, showing close agreement in temperature evolution. It also demonstrates robustness across varying geometric scales, thereby confirming its reliability for predicting thermal response. Using this validated method, simulations are performed to analyze the fire behavior of an anchor rod-sealant system. Results show that the burning sealant can raise anchor rod temperatures above 900 °C and lead to rapid flame spread between adjacent rods. Furthermore, a sensitivity analysis of thermophysical parameters identifies critical thresholds for fire safety optimization: sealants with an ignition temperature > 280 °C and thermal conductivity ≥ 0.26 W/(m·K) demonstrate effective self-extinguishing properties, while specific heat capacity can retard flame growth. These findings provide a robust numerical framework and quantitative guidelines for the fire-safe design of bridge anchorage systems. Full article

In this contribution, we propose and study long-time behaviors of a new class of N-dimensional delayed Kirchhoff–Carrier-type problems with variable transfer coefficients involving a logarithmic nonlinearity. We take into account the dependence of diffusion and damping coefficients on the position and direction, as well as the presence of different types of delays. This class of nonlocal anisotropic and nonlinear wave-type equations with multiple time-varying mixed delays and dampings, of a fairly general form, containing several arbitrary functions and free parameters, is of the following form: ${\displaystyle \frac{{\partial }^{2}u}{\partial t^2}-{div\left(\mathcal{K}\right(\Vert \sigma \nabla u\Vert }_{L^2\left(\Omega \right)}^2)A_{\sigma }{\left(\mathbf{x}\right)\nabla u)+\mathcal{M}(\Vert u\Vert }_{L^2\left(\Omega \right)}^2)u-div(\zeta \left(t\right)A_{\sigma }\left(\mathbf{x}\right)\nabla \frac{\partial u}{\partial t})+d_0\left(t\right)\frac{\partial u}{\partial t}+{\mathbb{D}}_r(\mathbf{x},t;\frac{\partial u}{\partial t})=\mathbb{G}\left(u\right),}$ where $u(\mathbf{x},t)$ is the state function, $\mathcal{M}$ and $\mathcal{K}$ are the nonlocal Kirchhoff operators and the nonlinear operator $\mathbb{G}\left(u\right)$ corresponds to a logarithmic source term. The symmetric tensor $A_{\sigma }$ describes the anisotropic behavior and processes of the system, and the operator ${\mathbb{D}}_r$ represents the multiple time-varying mixed delays related to velocity ${\displaystyle \frac{\partial u}{\partial t}}$. Our problem, which encompasses numerous equations already studied in the literature, is relevant to a wide range of practical and concrete applications. It not only considers anisotropy in diffusion, but it also assumes that the strong damping can be totally anisotropic (a phenomenon that has received very little mathematical attention in the literature). We begin with the reformulation of the problem into a nonlinear system coupling a nonlocal wave-type equation with ordinary differential equations, with the help of auxiliary functions. Afterward, we study the local existence and some necessary regularity results of the solutions by using the Faedo–Galerkin approximation, combining some energy estimates and the logarithmic Sobolev inequality. Next, by virtue of the potential well method combined with the Nehari manifold, conditions for global in-time existence are given. Finally, subject to certain conditions, the exponential decay of global solutions is established by applying a perturbed energy method. Many of the obtained results can be extended to the case of other nonlinear source terms. Full article

Agrivoltaics—the co-location of photovoltaic energy production with agriculture—offers a promising pathway to address growing pressures on land, food, and clean energy resources. This study evaluates the first agrivoltaic pilot installation in Jordan, located in Amman (935 m above sea level; hot-summer Mediterranean climate), during its first operational year. Two 11.1 kWp bifacial photovoltaic (PV) systems were compared: (i) a south-facing array tilted at 10°, and (ii) a vertical east–west “fence” configuration. The tilted system achieved an annual specific yield of 1962 kWh/kWp, approximately 35% higher than the 1288 kWh/kWp obtained from the vertical array. Seasonal variation was observed, with the performance gap widening to ~45% during winter and narrowing to ~22% in June. As expected, the vertical system exhibited more uniform diurnal output, enhanced early-morning and late-afternoon generation, and lower soiling losses. The light profiles measured for the year indicate that vertical systems barely impede the light requirements of crops, while the tilted system splits into distinct profiles for the intra-row area (akin to the vertical system) and sub-panel area, which is likely to support only low-light requirement crops. This configuration increases the levelized cost of electricity (LCOE) by roughly 88% compared to a conventional ground-mounted system due to elevated structural costs. In contrast, the vertical east–west system provides an energy yield equivalent to about 33% of the land area at the tested configuration but achieves this without increasing the LCOE. These results highlight a fundamental trade-off: elevated tilted systems offer greater land-use efficiency but at higher cost, whereas vertical systems preserve cost parity at the expense of lower energy density. Full article

This study investigated the effect of mechanical activation on the physicochemical properties of lepidolite and the leaching behavior of mechanically activated samples in sulfuric acid (H₂SO₄). Lepidolite was mechanically activated using a high-energy planetary ball mill (PBM) at 400 RPM with a 20:1 ball-to-feed weight ratio (BFR, g:g) and the samples activated for different durations were characterized for amorphous phase content, particle size, and morphology using various solid analyses. X-ray diffraction (XRD) revealed the progressive amorphization of lepidolite, with the amorphous fraction increased from 34.1% (unactivated) to 81.4% after 60 min of mechanical activation. Scanning electron microscopy (SEM) showed that mechanically activated particles became fluffy and rounded, whereas unactivated particles retained lamellar and angular shapes. The reactivity of minerals after mechanical activation was evaluated through a 2 M H₂SO₄ leaching test at different leaching temperatures (25–80 °C) and time periods (30–180 min). Although the leaching efficiencies of Li and Al slightly improved at higher leaching temperatures and longer leaching times, the leaching of these metals was primarily governed by the mechanical activation time. The highest Li and Al leaching efficiencies—87.0% for Li and 79.4% for Al—were obtained from lepidolite that was mechanically activated for 60 min under leaching conditions of 80 °C and a 10% (w/v) solid/liquid (S/L) ratio for 30 min. The elemental mapping images of leaching feed and residue produced via energy dispersive spectroscopy (EDS) indicated that unactivated particles in the leaching residue had much higher metal content than mechanically activated particles. Kinetic analysis further suggested that leaching predominantly occurs at mechanically activated sites and the apparent activation energies calculated in this study (<3.1 kJ·mol⁻¹) indicate diffusion-controlled behavior with weak temperature dependence. This result confirmed that mechanical activation significantly improves reactivity and that the residual unleached fraction can be attributed to unactivated particles. Full article

CeO₂ doping is a well-established strategy for enhancing the properties of zirconia (ZrO₂) ceramics, with the prior literature indicating an optimal doping range of around 10–15 wt.% for specific attributes. Building upon this foundation, this study provides a systematic investigation into the concurrent evolution of mechanical, tribological, and thermophysical properties across a broad compositional spectrum (0–20 wt.% CeO₂). The primary novelty lies in the holistic correlation of these often separately examined properties, revealing their interdependent trade-offs governed by microstructural development. The 15Ce-ZrO₂ composition, consistent with the established optimal range, achieved a synergistic balance: hardness increased by 27.6% to 310 HV₁, the friction coefficient was minimized to 0.205, and the wear rate was reduced to 1.81 × 10⁻³ mm³/(N m). Thermally, it exhibited a 72.2% reduction in the thermal expansion coefficient magnitude at 1200 °C and a low thermal conductivity of 0.612 W/(m·K). The enhancement mechanisms are consistent with solid solution strengthening, grain refinement, and likely enhanced phonon scattering, potentially from point defects such as oxygen vacancies commonly associated with aliovalent doping in oxide ceramics, while performance degradation beyond 15 wt.% is linked to CeO₂ agglomeration and duplex microstructure formation. This work provides a relatively comprehensive insight into the dataset and mechanism, which is conducive to the fine design of multifunctional ZrO₂ bulk ceramics. It is not limited to determining the optimal doping level, but also aims to clarify the comprehensive performance map, providing reference significance for the development of advanced ceramic materials with synergistically optimized hardness, wear resistance, and thermal properties. Full article

This paper synthesizes lessons learned from drilling a CO₂-storage stratigraphic well in the San Juan Basin (New Mexico, USA) to clarify drivers of operational incidents and to inform future well planning. A literature review of regional drilling problems was combined with pre-drill engineering based on offset-well history and a geomechanical model, including casing, cementing, and hydraulics designs developed in commercial software; these designs were compared with field execution to extract incident-specific lessons. The most frequent problems observed are lost circulation, stuck pipe, and poor control of drilling parameters, consistent with complex lithology and reservoir pressure depletion that reduces fracture pressure below anticipated values. Based on the lessons learned, three mitigations are proposed as follows: (1) update the geomechanical model with the latest pore, fracture pressure estimates; (2) apply underbalanced drilling using nitrified mud by injecting nitrogen through a parasite string while drilling intermediate and production sections; and (3) maintain operating limits (weight on bit < 44.5 kN, top-drive rotation < 45 rpm, and pump rate < 1.32 m³/min) to improve fluid returns through low-fracture-pressure intervals. Simulation results support the applicability of the proposed solutions. Full article

Background: H3K27-altered diffuse midline glioma (DMG) is a highly aggressive central nervous system malignancy with limited therapeutic options and poor prognosis. Precision medicine strategies that integrate molecular profiling with individualized treatment selection represent a critical avenue for improving outcomes. Case presentation: We describe a 31-year-old woman with H3K27-altered DMG who, after standard chemoradiotherapy, was treated with a personalized, mechanism-guided combination regimen based on her tumor’s molecular profile. Next-generation sequencing identified pathogenic alterations in ATRX, H3F3A, and NF1, with a high NF1 mutation allelic fraction indicating RAS/MAPK pathway activation. Immunohistochemistry demonstrated elevated phosphorylated mTOR consistent with PI3K/AKT/mTOR pathway upregulation. The individualized regimen comprised trametinib and everolimus for dual pathway inhibition, the tissue-agnostic agent dordaviprone (ONC201), metabolic modulation with 2-deoxy-D-glucose, and electric field-based therapy. At seven months, MRI showed approximately a 60% volumetric reduction in the enhancing tumor component, accompanied by marked T2-weighted signal regression. Clinically, the patient remained neurologically intact with a Karnofsky Performance Score of 100%. Conclusions: This case illustrates the potential clinical value of a genomics-guided, multimodal treatment strategy in H3K27-altered DMG. The systematic integration of comprehensive molecular profiling with mechanistically rational treatment selection may contribute to meaningful radiological and clinical benefit in this otherwise uniformly fatal disease. These observations support further investigation of individualized, pathway-targeted approaches in prospective studies and N-of-1 trial frameworks. Full article

Triply Periodic Minimal Surface (TPMS) structures, with their zero average curvature, excellent energy absorption properties, high specific strength and high surface-to-volume ratio, could be used in a wide range of applications, such as the creation of lightweight and durable structures, grafts and implants. In this study, an internal TPMS structure inspiring trabecular bone and an external TPMS structure inspiring cortical bone were combined with infill density and topologically functionally graded to obtain hybrid structures. The aim of the study was to investigate the effects of functional grading on mechanical properties, energy absorption capacity and surface/volume (S/V) ratio and to determine the best combination. The novelty of the study is to obtain hybrid structures close to bone structures with a functional grading approach. The experimental design of the study was performed using the Design of Experiment (DoE) approach and the Taguchi method. Specimens were created according to the established experimental design and fabricated using a Masked Stereolithography (mSLA)-type 3D printer with bio-resin. The fabricated structures were subjected to compression tests; the results were examined in terms of deformation behavior, first peak, maximum force, energy absorption, specific energy absorption and S/V ratio. The optimal structures for defined input parameters were determined using signal-to-noise (S/N) ratios and ANOVA results. Deformations for diamond and primitive specimens began as shear band formation. Deformations for Neovius structures were mostly as brittle fracture. The highest first peak of 18.96 kN was obtained with the DN specimens, while the highest maximum force of 23.77 kN was obtained with the ND specimens. The best energy absorption property was also obtained with ND. The highest S/V ratio was 5.65 in the GP specimens. The statistical analyses were in accordance with the experimental results. Infill density increases decreased the S/V ratio while increasing all other parameters. This demonstrated the importance of mechanical-strength/porosity optimization for bone scaffold surrogate applications in this study. Full article