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Review

29 Citations

9,216 Views

15 Pages

Deregulation of Epigenetic Mechanisms by the Hepatitis B Virus X Protein in Hepatocarcinogenesis

Ourania M. Andrisani

Viruses2013, 5(3), 858-872;https://doi.org/10.3390/v5030858

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18 March 2013

This review focuses on the significance of deregulation of epigenetic mechanisms by the hepatitis B virus (HBV) X protein in hepatocarcinogenesis and HBV replication. Epigenetic mechanisms, DNA methylation, and specific histone modifications, e.g., t...

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Review

24 Citations

9,363 Views

11 Pages

The Role of the CoREST/REST Repressor Complex in Herpes Simplex Virus 1 Productive Infection and in Latency

Guoying Zhou,
Te Du and
Bernard Roizman

Viruses2013, 5(5), 1208-1218;https://doi.org/10.3390/v5051208

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29 April 2013

REST is a key component of the HDAC1 or 2, CoREST, LSD1, REST (HCLR) repressor complex. The primary function of the HCLR complex is to silence neuronal genes in non-neuronal cells. HCLR plays a role in regulating the expression of viral genes in prod...

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Article

16 Citations

4,534 Views

20 Pages

Activation of ABCC Genes by Cisplatin Depends on the CoREST Occurrence at Their Promoters in A549 and MDA-MB-231 Cell Lines

Maciej Sobczak,
Magdalena Strachowska,
Karolina Gronkowska and
Agnieszka Robaszkiewicz

Cancers2022, 14(4), 894;https://doi.org/10.3390/cancers14040894

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11 February 2022

Although cisplatin-based therapies are common among anticancer approaches, they are often associated with the development of cancer drug resistance. This phenomenon is, among others, caused by the overexpression of ATP-binding cassette, membrane-anch...

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