Next Article in Journal
Antiviral Activity of Bacillus sp. Isolated from the Marine Sponge Petromica citrina against Bovine Viral Diarrhea Virus, a Surrogate Model of the Hepatitis C Virus
Next Article in Special Issue
Biochemical and Functional Interactions of Human Papillomavirus Proteins with Polycomb Group Proteins
Previous Article in Journal
Small Ruminant Lentiviruses: Genetic Variability, Tropism and Diagnosis
Previous Article in Special Issue
Deregulation of Epigenetic Mechanisms by the Hepatitis B Virus X Protein in Hepatocarcinogenesis
Article Menu

Export Article

Open AccessReview
Viruses 2013, 5(5), 1208-1218;

The Role of the CoREST/REST Repressor Complex in Herpes Simplex Virus 1 Productive Infection and in Latency

Marjorie B. Kovler Viral Oncology Laboratories, The University of Chicago, 910 East 58th Street, Chicago, IL 60637, USA
Author to whom correspondence should be addressed.
Received: 11 March 2013 / Revised: 21 April 2013 / Accepted: 23 April 2013 / Published: 29 April 2013
(This article belongs to the Special Issue Chromatin Control of Viral Infection)
Full-Text   |   PDF [298 KB, uploaded 12 May 2015]   |  


REST is a key component of the HDAC1 or 2, CoREST, LSD1, REST (HCLR) repressor complex. The primary function of the HCLR complex is to silence neuronal genes in non-neuronal cells. HCLR plays a role in regulating the expression of viral genes in productive infections as a donor of LDS1 for expression of α genes and as a repressor of genes expressed later in infection. In sensory neurons the HCLR complex is involved in the silencing of viral genome in the course of establishment of latency. The thesis of this article is that (a) sensory neurons evolved a mechanism to respond to the presence and suppress the transmission of infectious agents from the periphery to the CNS and (b) HSV evolved subservience to the HCLR with at least two objectives: to maintain a level of replication consistent with maximal person-to-person spread and to enable it to take advantage of neuronal innate immune responses to survive and be available for reactivation shielded from adaptive immune responses of the host. View Full-Text
Keywords: HCLR; herpes viruses; productive infection; latency HCLR; herpes viruses; productive infection; latency

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Zhou, G.; Du, T.; Roizman, B. The Role of the CoREST/REST Repressor Complex in Herpes Simplex Virus 1 Productive Infection and in Latency. Viruses 2013, 5, 1208-1218.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top