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Article

35 Citations

7,063 Views

20 Pages

Bovine Herpesvirus Type 4 (BoHV-4) Vector Delivering Nucleocapsid Protein of Crimean-Congo Hemorrhagic Fever Virus Induces Comparable Protective Immunity against Lethal Challenge in IFNα/β/γR−/− Mice Models

Touraj Aligholipour Farzani,
Katalin Földes,
Alireza Hanifehnezhad,
Burcu Yener Ilce,
Seval Bilge Dagalp,
Neda Amirzadeh Khiabani,
Koray Ergünay,
Feray Alkan,
Taner Karaoglu and
Aykut Ozkul
+ 1 author

Viruses2019, 11(3), 237;https://doi.org/10.3390/v11030237

9 March 2019

Crimean-Congo hemorrhagic fever virus (CCHFV) is the causative agent of a tick-borne infection with a significant mortality rate of up to 40% in endemic areas, with evidence of geographical expansion. Due to a lack of effective therapeutics and contr...

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Article

43 Citations

8,706 Views

17 Pages

Immunological Analysis of a CCHFV mRNA Vaccine Candidate in Mouse Models

Touraj Aligholipour Farzani,
Katalin Földes,
Koray Ergünay,
Hakan Gurdal,
Aliye Bastug and
Aykut Ozkul

Vaccines2019, 7(3), 115;https://doi.org/10.3390/vaccines7030115

16 September 2019

Development of new vaccine platforms against viral diseases is considered urgent. In recent years, mRNA constructs have attracted great interest in this field due to unique advantages over conventional gene transfer platforms. In the present study, w...

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Article

5 Citations

3,880 Views

16 Pages

Combined TLR-3/TLR-8 Signaling in the Presence of α-Type-1 Cytokines Represents a Novel and Potent Dendritic Cell Type-1, Anti-Cancer Maturation Protocol

Tadej Fevžer,
Primož Poženel,
Kaja Zajc,
Nataša Tešić and
Urban Švajger

Cells2022, 11(5), 835;https://doi.org/10.3390/cells11050835

28 February 2022

During the ex vivo generation of anti-cancer dendritic cell (DC)-based vaccines, their maturation still represents one of the most crucial steps of the manufacturing process. A superior DC vaccine should: possess extensive expression of co-stimulator...

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Article

26 Citations

4,586 Views

11 Pages

Plasmacytoid Dendritic Cells Contribute to the Production of IFN-β via TLR7-MyD88-Dependent Pathway and CTL Priming during Respiratory Syncytial Virus Infection

Tae Hoon Kim,
Dong Sun Oh,
Hi Eun Jung,
Jun Chang and
Heung Kyu Lee

Viruses2019, 11(8), 730;https://doi.org/10.3390/v11080730

8 August 2019

Respiratory syncytial virus (RSV) is the leading cause of respiratory viral infection in infants and children, yet little is known about the antiviral response of plasmacytoid dendritic cells (pDCs) to RSV infection. We tracked the cellular source of...

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