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Article

13 Pages

Phenylketonuria Alters the Prefrontal Cortex Genome-Wide Expression Profile Regardless of the Mouse Genetic Background

Elena Fiori,
Serafina Manila Guzzo,
Luisa Lo Iacono,
Cristina Orsini,
Simona Cabib,
Diego Andolina,
Luigia Rossi,
Francesca Nardecchia,
Vincenzo Leuzzi and
Tiziana Pascucci

Cells2026, 15(3), 227;https://doi.org/10.3390/cells15030227
(registering DOI)

24 January 2026

Mouse models of genetic diseases are important research tools. However, the genetic background of the mouse strain can significantly influence how a genetic mutation is expressed. Studies on preclinical models of phenylketonuria (PKU), an inherited m...

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Article

796 Views

22 Pages

Chronic Stress Segregates Mice into Distinct Behavioral Phenotypes Based on Glucocorticoid Sensitivity

Polina Ritter,
Rasha Salman,
Yuliya Ryabushkina and
Natalya Bondar

Int. J. Mol. Sci.2025, 26(23), 11436;https://doi.org/10.3390/ijms262311436

26 November 2025

Chronic stress alters hypothalamic–pituitary–adrenal (HPA) axis function, affecting corticosterone regulation and adaptive responses. Understanding individual variability in stress adaptation requires identifying distinct HPA axis respons...

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Review

24 Pages

Sensory Deprivation and the Brain: Neurobiological Mechanisms, Psychological Effects, and Clinical Implications

Donatella Marazziti,
Gerardo Russomanno,
Matteo Gambini,
Francesca Rita Digiuseppe,
Enrico Fazio and
Riccardo Gurrieri

Brain Sci.2026, 16(2), 122;https://doi.org/10.3390/brainsci16020122

23 January 2026

Background/Objectives: Sensory deprivation, defined as a reduction or absence of external sensory input across one or more modalities, has long been investigated in extreme and experimental settings. More recently, its relevance has expanded to clini...

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Article

14 Citations

3,391 Views

27 Pages

The Role of Microglia in the (Mal)adaptive Response to Traumatic Experience in an Animal Model of PTSD

Kesem Nahum,
Doron Todder,
Joseph Zohar and
Hagit Cohen

Int. J. Mol. Sci.2022, 23(13), 7185;https://doi.org/10.3390/ijms23137185

28 June 2022

The present study investigates whether predator scent-stress (PSS) shifts the microglia from a quiescent to a chronically activated state and whether morphological alterations in microglial activation differ between individuals displaying resilient v...

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