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17 pages, 1647 KB  
Article
Novel Genetic Diversity and Geographic Structures of Aspergillus fumigatus (Order Eurotiales, Family Aspergillaceae) in the Karst Regions of Guizhou, China
by Duanyong Zhou, Yixian Liu, Qifeng Zhang, Ying Zhang and Jianping Xu
Microorganisms 2026, 14(1), 237; https://doi.org/10.3390/microorganisms14010237 (registering DOI) - 20 Jan 2026
Abstract
Aspergillus fumigatus is the primary pathogen causing aspergillosis. Recent molecular population genetic studies have demonstrated that A. fumigatus exhibits high local genetic diversity, with evidence for limited differentiation among geographic populations. However, research on the impacts of geomorphological factors on shaping the population [...] Read more.
Aspergillus fumigatus is the primary pathogen causing aspergillosis. Recent molecular population genetic studies have demonstrated that A. fumigatus exhibits high local genetic diversity, with evidence for limited differentiation among geographic populations. However, research on the impacts of geomorphological factors on shaping the population genetic diversity patterns of this species remains scarce. In this study, large-scale sampling and in-depth population genetic analysis were performed on soil-derived A. fumigatus from Guizhou Province, a representative karst landscape in southern China. This area is dominated by plateaus and mountains (accounting for 92.5% of the total area) and represents a classic example of conical karst landscapes. A total of 206 A. fumigatus strains were isolated from 9 sampling sites across Guizhou. Genetic diversity, genetic differentiation, and population structure of these strains were analyzed based on short tandem repeats (STRs) at 9 loci. The results revealed that A. fumigatus in the karst region of Guizhou harbors abundant novel alleles and genotypes, with high genetic diversity. Gene flow among geographical populations was infrequent, and significant genetic differentiation was detected between 30 of the 36 pairs of geographical populations where mountain ranges played a very important role, with the overall regional genetic differentiation reaching PhiPT = 0.061 (p = 0.001). Furthermore, the Guizhou populations showed significant differences from those reported in other regions worldwide. Surprisingly, only one of the 206 (0.49%) A. fumigatus isolates from this region exhibited resistance to the two medical triazoles commonly used for treating aspergillosis, and this resistance frequency was far lower than those reported in previous studies from other regions. We discuss the implications of our results for evolution and environmental antifungal resistance management in this important human fungal pathogen. Full article
(This article belongs to the Special Issue Ecology and Genetics of Medically Important Fungi)
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24 pages, 707 KB  
Review
Obesity and Its Clinical Implications in End-Stage Kidney Disease
by Kristina Petruliene, Alanta Zilinskiene, Ruta Vaiciuniene, Kestutis Vaiciunas, Inga Arune Bumblyte and Egle Dalinkeviciene
Medicina 2026, 62(1), 211; https://doi.org/10.3390/medicina62010211 (registering DOI) - 20 Jan 2026
Abstract
Both obesity and chronic kidney disease (CKD) are increasingly recognized as global epidemics. Their escalating incidence and far-reaching health implications highlight the urgent need for comprehensive prevention and management strategies. This review aims to clarify how obesity interacts with end-stage kidney disease (ESKD) [...] Read more.
Both obesity and chronic kidney disease (CKD) are increasingly recognized as global epidemics. Their escalating incidence and far-reaching health implications highlight the urgent need for comprehensive prevention and management strategies. This review aims to clarify how obesity interacts with end-stage kidney disease (ESKD) and how to improve the management of obese patients receiving kidney replacement therapy. It also explores underlying mechanisms, current treatments, future directions, and ongoing controversies. By highlighting this intricate relationship, the review seeks to enhance clinical practice and promote further research toward more personalized care for this vulnerable population. Obesity is frequent in dialysis patients and creates challenges related to body composition, metabolism, and treatment. While higher body mass index (BMI) may appear to improve survival, this paradox does not offset the cardiovascular and functional risks of visceral and sarcopenic obesity. Obesity also increases post-transplant complications and can limit access to transplantation. Lifestyle changes rarely achieve lasting weight loss, whereas bariatric surgery—especially sleeve gastrectomy—can improve transplant eligibility with fewer complications. Weight-loss medications may be used before transplantation but remain insufficiently studied in ESKD. After transplantation, weight-reduction efforts should continue, with pharmacotherapy preferred over bariatric surgery. Comprehensive assessment strategies and individualized management approaches in ESKD patients are essential to optimize outcomes in this growing patient population. Full article
(This article belongs to the Special Issue End-Stage Kidney Disease (ESKD))
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32 pages, 521 KB  
Review
Vineyard Design, Cultural Practices and Physical Methods for Controlling Grapevine Pests and Disease Vectors in Europe: A Review
by Francesco Pavan, Elena Cargnus and Pietro Zandigiacomo
Insects 2026, 17(1), 113; https://doi.org/10.3390/insects17010113 (registering DOI) - 20 Jan 2026
Abstract
In Europe, due to reduced availability and efficacy of active ingredients, strategies against grapevine pests based on alternative tools to synthetic pesticides need to be developed. So far, attention has been mainly focused on biological control (arthropod natural enemies and entomopathogens) and mating [...] Read more.
In Europe, due to reduced availability and efficacy of active ingredients, strategies against grapevine pests based on alternative tools to synthetic pesticides need to be developed. So far, attention has been mainly focused on biological control (arthropod natural enemies and entomopathogens) and mating disruption, but other means can also help keep pests below economic injury levels. This paper aims to review information on the direct effects of farmers’ choices on grapevine pest populations, ranging from vineyard design (e.g., growing habitat, grapevine cultivar, and training system) to annual agronomic practices (e.g., fertilization, irrigation, and pruning), and specific cultural and physical methods. Information was based on the CABI Digital Library, websites and books on grapevine pests. The data presentation is based on control strategies rather than pests, as it was considered more important to focus on the mode of action of different practices and to know which pests they affect simultaneously. The widespread availability of insecticides has long led to the neglect of the potential of cultural practices, which can effectively integrate other pest control tools. Full article
(This article belongs to the Special Issue Insects Ecology and Biological Control Applications)
21 pages, 4114 KB  
Article
Energy Evolution of Far-Field Surrounding Rock Under True Triaxial Compression Conditions: Taking Fissured Sandstone as an Example
by Fan Feng, Yuanpu Li, Chenglin Li, Jiadong Qiu, Tong Zhang and Shaojie Chen
Processes 2026, 14(2), 356; https://doi.org/10.3390/pr14020356 - 20 Jan 2026
Abstract
Fissured rock masses are widespread in deep underground mining engineering, and they are prone to inducing instability and failure during excavation activities. Borehole pressure relief is one of the most effective measures with which to control dynamic disaster in high-stress roadways. After pressure [...] Read more.
Fissured rock masses are widespread in deep underground mining engineering, and they are prone to inducing instability and failure during excavation activities. Borehole pressure relief is one of the most effective measures with which to control dynamic disaster in high-stress roadways. After pressure relief, redistribution of stress leads to stress concentration in the far-field surrounding rock (far away from working face), which can be represented by true triaxial compression state. However, current research on the energy evolution behavior of fissured rock masses under far-field conditions remains relatively limited. This study analyzes the energy evolution process, peak energy characteristics, and laws of energy storage and dissipation in fractured sandstone under different fissure dip angles (θ, 30°, 45°, 60°, 90°), with intermediate principal stresses (σ2, 10, 20, … 120 MPa) and minimum principal stresses (σ3, 10, 20, … 50 MPa). The results indicate that the curve of dissipated energy ratio versus maximum principal strain becomes more distinctly concave as θ increases under true triaxial compression. The growth rate of the dissipated energy ratio and dissipated energy with maximum principal strain gradually decreases when σ3 is high, and the fissured sandstone is prone to exhibiting ductile failure, leading to a reduced energy dissipation rate. The peak elastic strain energy of fissured sandstone increases gradually with increasing σ2 and shows a linear characteristic. The energy storage and dissipation law is nonlinear with increasing peak total energy for the fissured sandstone with different values of θ. However, the law exhibits a linear trend under varying σ2 and σ3. This study provides a new approach and insight into the failure characteristics of deep fissured sandstone and aims to offer theoretical guidance for the layout and construction safety of roadways or mining panels in far-field surrounding rock in future engineering practices. Full article
(This article belongs to the Section Energy Systems)
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20 pages, 1726 KB  
Review
CILP2: From ECM Component to a Pleiotropic Modulator in Metabolic Dysfunction, Cancer, and Beyond
by Zheqiong Tan, Suotian Liu and Zhongxin Lu
Biomolecules 2026, 16(1), 167; https://doi.org/10.3390/biom16010167 - 19 Jan 2026
Abstract
Initially characterized as a component of the extracellular matrix (ECM) in cartilage, cartilage intermediate layer protein 2 (CILP2) is now recognized as a pleiotropic secretory protein with far-reaching roles in physiology and disease. This review synthesizes evidence establishing CILP2 as a key modulator [...] Read more.
Initially characterized as a component of the extracellular matrix (ECM) in cartilage, cartilage intermediate layer protein 2 (CILP2) is now recognized as a pleiotropic secretory protein with far-reaching roles in physiology and disease. This review synthesizes evidence establishing CILP2 as a key modulator at the nexus of metabolic dysfunction, cancer, and other pathologies. Genomic studies have firmly established the NCAN-CILP2 locus as a hotspot for genetic variants influencing dyslipidemia and cardiovascular risk. Functionally, CILP2 is upregulated by metabolic stress, including high glucose and oxidatively modified LDL (oxLDL), and actively contributes to pathologies such as dyslipidemia, diabetes, and sarcopenia by impairing glucose metabolism and mitochondrial function. Its role extends to fibrosis and neurodevelopment, promoting hypertrophic scar formation and neurogenesis through interactions with ATP citrate lyase (ACLY) and Wnt3a, respectively. More recently, CILP2 has emerged as an oncoprotein, overexpressed in multiple cancers, including pancreatic ductal adenocarcinoma and colorectal cancer. It drives tumor proliferation and metastasis and correlates with tumor microenvironment remodeling through mechanisms involving Akt/EMT signaling and immune infiltration. The dysregulation of CILP2 in patient serum and its correlation with disease severity and poor prognosis highlight it as a promising biomarker and a compelling therapeutic target across a spectrum of human diseases. Full article
(This article belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
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13 pages, 1686 KB  
Article
Ocean Chlorophyll-a Concentration and the Extension of the Migration of Franklin’s Gulls (Leucophaeus pipixcan) in Southern South America
by María P. Acuña-Ruz, Julian F. Quintero-Galvis, Angélica M. Vukasovic, Jonathan Hodge and Cristián F. Estades
Animals 2026, 16(2), 301; https://doi.org/10.3390/ani16020301 (registering DOI) - 19 Jan 2026
Abstract
Although many long-distance migratory birds choose stable wintering sites and staging posts, irruptive migrants may exhibit considerable interannual variability in their migratory patterns, often depending on food availability. The Franklin’s gull (Leucophaeus pipixcan) is a common long-distance migrant along Chile’s coast [...] Read more.
Although many long-distance migratory birds choose stable wintering sites and staging posts, irruptive migrants may exhibit considerable interannual variability in their migratory patterns, often depending on food availability. The Franklin’s gull (Leucophaeus pipixcan) is a common long-distance migrant along Chile’s coast during the austral summer. Using census data from three estuaries in central Chile (2006–2023), we analyzed variation in summer populations in relation to chlorophyll-a (chl-a) concentration along the migration route, used as a proxy for food availability. The best model predicting the number of gulls reaching Chile included a negative effect of chl-a concentration on the Peruvian coast (0–10° S) during winter (June–July). Considering the time lag associated with the transformation of phytoplankton into seagull food, this result suggests that primary productivity along the route may influence how far south these birds migrate in search of food. We also found a negative correlation between the summer abundance of Franklin’s gulls in Chile and an eBird index for the species in Peru during the same period, suggesting redistribution of individuals between the two countries in response to resource availability. Models such as ours provide a useful tool for understanding and managing populations of migratory waterbirds. Full article
(This article belongs to the Section Ecology and Conservation)
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23 pages, 6909 KB  
Article
Experimental and Numerical Assessment of Fiber Orientation Effects in Biaxial Glass/Vinyl Ester Laminates
by Sultan Ullah, Arvydas Palevicius, Almontas Vilutis, Raul Fangueiro and Giedrius Janusas
Polymers 2026, 18(2), 265; https://doi.org/10.3390/polym18020265 - 19 Jan 2026
Abstract
This study analyzes the mechanical behavior of a quasi-isotropic biaxial glass fiber–vinyl ester composite in a multiaxial stress condition and the effect of the orientation of the fibers. A ply structure was created through the process of vacuum infusion using six layers of [...] Read more.
This study analyzes the mechanical behavior of a quasi-isotropic biaxial glass fiber–vinyl ester composite in a multiaxial stress condition and the effect of the orientation of the fibers. A ply structure was created through the process of vacuum infusion using six layers of biaxial fabric that were oriented to 15°. Tensile samples were isolated at 0, 15, 30, 45 and 90 degrees relative to the warp direction. It was found that strength and stiffness strongly depend on orientation, with maximum tensile strengths of 157.2 MPa at 90° and 125 MPa at 0°, and minimum tensile strengths 59.6 MPa at 15°, showing fiber and shear failures, respectively. MAT_124 underwent finite element analysis in LS-DYNA, and the results were excellent, with a difference of less than 1.5%. Three-point bending and Charpy impact tests indicated that flexural properties were lower at 15° and 90°, whereas off-axis orientations were generally better at impact energy absorption, although at 45°, binding sites were few and far between. The results have important implications for the design of laminates subjected to complicated loads. Full article
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11 pages, 1564 KB  
Article
On Possibility of Converting Electricity Generation System Based on Fossil Fuels to Fully Renewable—Polish Case
by Andrzej Szlęk
Energies 2026, 19(2), 483; https://doi.org/10.3390/en19020483 - 19 Jan 2026
Abstract
The energy sector in all countries around the world is undergoing a transformation, with the main trend being the increasing share of renewable sources. Some countries, such as those in the European Union, have set themselves the goal of completely phasing out fossil [...] Read more.
The energy sector in all countries around the world is undergoing a transformation, with the main trend being the increasing share of renewable sources. Some countries, such as those in the European Union, have set themselves the goal of completely phasing out fossil fuels by 2050. Currently, the energy systems of European countries are far from this goal, and fossil fuels play a key role in balancing energy systems. This article presents a one-year simulation of a hypothetical Polish energy system based solely on renewable sources and utilizing biomethane, synthetic ammonia, and solid biomass as sources to ensure energy supply in the event of unfavorable weather conditions, which means a lack of wind and solar radiation. Six variants of these systems were analyzed, demonstrating the feasibility of such a system using only biogas as a stabilizing fuel. The required generating capacities of wind turbines, photovoltaic panels, and installations for converting biomethane, ammonia, and solid biomass into electricity were determined. Calculations were based on historical data recorded in 2024 in the Polish energy system. It was found that by increasing currently installed PV and wind turbines by a factor of 4.8 and installing 24 GW of ICE engines fueled with biomethane and an additional 10 GW of ORC modules, current electricity demand would be covered 100% by renewable energy sources. The same goal can be achieved without ORC modules by increasing the installed power of PV and wind turbines by a factor of 6.8. The novelty of this research is the application of the fully renewable concept of electricity generation systems to Polish reality using real-life data. Full article
(This article belongs to the Section A: Sustainable Energy)
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23 pages, 4786 KB  
Article
Potassium Fertilization as a Steering Tool for Sustainable Valorization of Cereal Straw in Circular Bioeconomy Value Chains
by Dario Iljkić, Ivana Varga, Paulina Krolo and Ivan Kraus
Sustainability 2026, 18(2), 984; https://doi.org/10.3390/su18020984 (registering DOI) - 18 Jan 2026
Viewed by 48
Abstract
Potassium (K) fertilization plays a key role in regulating stem morphology, particularly stem diameter, yet the influence of different K fertilizer formulations on stem structure and tensile strength remains insufficiently understood. Cereal straw is a key lignocellulosic by-product with growing importance in the [...] Read more.
Potassium (K) fertilization plays a key role in regulating stem morphology, particularly stem diameter, yet the influence of different K fertilizer formulations on stem structure and tensile strength remains insufficiently understood. Cereal straw is a key lignocellulosic by-product with growing importance in the circular bioeconomy. Thus, the aim of this study was to determine the links between potassium nutrition, stem structure, and mechanical behavior for four cereal species: wheat, barley, rye, and oats. There were three potassium fertilization levels (0, 60, and 120 kg K ha−1) conducted in a field experiment in eastern Croatia (2021/2022). At maturity, stem morphology, macroelements (Ca, K, P, C, N), acid detergent fiber (ADF), neutral detergent fiber (NDF), and uniaxial tensile properties (maximum force, tensile strength, Young’s modulus) were determined. Cereal species was the dominant source of variation (p < 0.0001) for all traits, whereas the main effect of K was generally weak and significant only for stem diameter at the midpoint and N concentration, although K × species interactions were frequent. Oats and rye showed the most vigorous biomass production, whereas wheat exhibited by far the highest tensile strength (about 120 MPa) and stiffness (6.23 GPa), together with the highest ADF, while barley had the greatest NDF. Oat stems had the lowest ADF and NDF, indicating less lignified, more digestible tissues but mechanically weaker straw. Mechanical traits were tightly and positively correlated with ADF, NDF, and CN ratio, whereas P showed weak or negative associations with plant size and strength. Therefore, for targeted straw valorization, cereal species selection is paramount, with potassium fertilization playing a secondary, species-dependent role. Full article
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16 pages, 6513 KB  
Article
Assessment of Antibiotic Sensitivity in Biofilms Using GelMA Hydrogel Microspheres
by Junchi Zhu, Wenqi Chen, Zhenzhi Shi, Yiming Liu, Lulu Shi and Jiafei Xi
Gels 2026, 12(1), 85; https://doi.org/10.3390/gels12010085 - 18 Jan 2026
Viewed by 40
Abstract
Conventional antibiotic susceptibility testing (AST) primarily assesses planktonic bacteria. However, the three-dimensional architecture and barrier properties of biofilms mean that the minimum inhibitory concentration (MIC) for planktonic cells is typically far lower than the antibiotic exposure required for biofilm eradication. In this study, [...] Read more.
Conventional antibiotic susceptibility testing (AST) primarily assesses planktonic bacteria. However, the three-dimensional architecture and barrier properties of biofilms mean that the minimum inhibitory concentration (MIC) for planktonic cells is typically far lower than the antibiotic exposure required for biofilm eradication. In this study, gelatin methacryloyl (GelMA) microspheres were used to create a three-dimensional biofilm microenvironment for the quantitative evaluation of biofilm tolerance. Escherichia coli K-12 MG1655 was immersed in GelMA microspheres and subjected to a series of antibiotic concentration gradients. Bacterial viability was inferred from time-dependent changes in microsphere diameter. The results demonstrated substantial tolerance of the resulting biofilms to ampicillin, ciprofloxacin, and ceftriaxone, with biofilm antibiotic tolerance values exceeding 200 μg/mL, 10–50 μg/mL, and 20–50 μg/mL, respectively. Relative to planktonic MICs, these tolerance levels are elevated by one to two orders of magnitude and surpass the standard clinical breakpoint thresholds. This methodology includes a high-throughput platform, involving only several hundred microspheres and achieving completion within 24 h, thereby offering a useful platform for investigating biofilm resistance mechanisms and guiding antibiotic treatment strategies. Full article
(This article belongs to the Section Gel Chemistry and Physics)
15 pages, 461 KB  
Article
Effects of Cannabis on Multiple Visual Parameters and Self-Perceived Eyesight: A Cross-Sectional Study in Cannabis Users in Morocco
by Karima Raoui, Elmhedi Wakrim, Abdelmounaim Baslam, René Combe, Sarah Michaud, Hajar Gebrati, Mohamed Cherkaoui and Chait Abderrahman
Psychoactives 2026, 5(1), 3; https://doi.org/10.3390/psychoactives5010003 - 18 Jan 2026
Viewed by 61
Abstract
Cannabis is one of the most common intoxicants used worldwide. Cannabis is widely consumed worldwide and can lead to visual alterations. However, most of the available information on its effects comes from studies conducted in developed countries, while data remain limited in developing [...] Read more.
Cannabis is one of the most common intoxicants used worldwide. Cannabis is widely consumed worldwide and can lead to visual alterations. However, most of the available information on its effects comes from studies conducted in developed countries, while data remain limited in developing regions such as Morocco, despite its significant role in cannabis cultivation. The aim of this study was to explore multiple visual parameters and self-perceived eyesight in cannabis users in Morocco. A cross-sectional study was conducted between March 2022 and April 2023 in Marrakesh, Morocco, in cannabis consumers. Data collection was performed in two phases. First a hetero-administrated questionnaire was used to collect socio-demographics, intoxicant consumption habit information, and eye health information. Then, several visual acuity tests were performed, including a preliminary examination, a visual function assessment, and an eye health assessment. Ninety-five cannabis users participated in this study. The majority were single (62.1%) males (87.4%). All lived in the Marrakesh-Safi region (100%), and most had daily activities such as having a job or being a student (77.9%). Most had vision conditions like astigmatism or myopia (83.4%). The majority had multiple addictions (66.5%), mainly to tobacco (43.7%). Hashish was the main cannabis type used (57.9%), and smoked cannabis was the principal mode of consumption (94.7%). Many had a family history of cannabis addiction (58.9%). Day light sensitivity (66.3%) and appearance of eye symptoms after cannabis use (90.5%) were declared by the majority. In most cases, no impact on far or near vision or vision impairment due to cannabis use were declared. Our results showed that using cannabis could have significant adverse effects on visual functions. Full article
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20 pages, 3827 KB  
Article
Development and Experimental Validation of a Physics-Based Digital Twin for Railway Freight Wagon Monitoring
by Alessio Cascino, Leandro Nencioni, Laurens Lanzillo, Francesco Mazzeo, Salvatore Strano, Mario Terzo, Simone Delle Monache and Enrico Meli
Sensors 2026, 26(2), 643; https://doi.org/10.3390/s26020643 - 18 Jan 2026
Viewed by 64
Abstract
The development of digital twins for railway freight vehicles represents a key step toward more efficient, data-driven maintenance and safety assessment. This study focuses on the creation of a digital twin of the T3000 articulated freight wagon, one of the most widespread intermodal [...] Read more.
The development of digital twins for railway freight vehicles represents a key step toward more efficient, data-driven maintenance and safety assessment. This study focuses on the creation of a digital twin of the T3000 articulated freight wagon, one of the most widespread intermodal transport solutions in Europe. Despite its relevance, the dynamic behavior of this vehicle type has been scarcely investigated so far in scientific literature. A dedicated onboard measurement layout was defined to enable comprehensive monitoring of vehicle dynamics and the interactions between adjacent wagons within the train. The experimental setup integrates inertial sensors and a 3D vision system, allowing for detailed analysis of both rigid-body and vibrational responses under real operating conditions. A high-fidelity multibody model of the articulated wagon was developed and tuned using the acquired data, achieving optimal agreement with experimental measurements in both straight and curved track segments. The resulting model constitutes a reliable and scalable digital twin of the T3000 wagon, suitable for predictive simulations and virtual testing. Future developments will focus on a deeper investigation of the buffer interaction through an additional experimental campaign, further extending the digital twin’s capability to represent the full dynamic behavior of articulated freight trains. Full article
(This article belongs to the Section Vehicular Sensing)
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17 pages, 1596 KB  
Article
Whole-Genome Sequencing and Genomic Features of Vagococcus sp. JNUCC 83 Isolated from Camellia japonica Flowers
by Kyung-A Hyun, Ji-Hyun Kim, Min Nyeong Ko and Chang-Gu Hyun
Microbiol. Res. 2026, 17(1), 23; https://doi.org/10.3390/microbiolres17010023 - 18 Jan 2026
Viewed by 45
Abstract
Vagococcus species have been isolated from diverse environments, including aquatic, terrestrial, food-associated, and clinical sources; however, plant- and flower-associated representatives remain poorly characterized at the genomic level. In this study, we report the complete genomic sequence and analysis of Vagococcus sp. JNUCC 83, [...] Read more.
Vagococcus species have been isolated from diverse environments, including aquatic, terrestrial, food-associated, and clinical sources; however, plant- and flower-associated representatives remain poorly characterized at the genomic level. In this study, we report the complete genomic sequence and analysis of Vagococcus sp. JNUCC 83, isolated from flowers of Camellia japonica collected on Jeju Island, Republic of Korea. The genome comprises a single circular chromosome of 2,472,896 bp with a GC content of 33.5 mol% and was assembled at high depth (555.43×), resulting in a high-quality complete genome. Genome-based phylogenomic analysis using the Type (Strain) Genome Server (TYGS) showed that strain JNUCC 83 forms a distinct lineage within the genus Vagococcus. Digital DNA–DNA hybridization (dDDH) values were far below the 70% species threshold, and 16S rRNA gene-based phylogeny consistently supported its independent placement, suggesting that JNUCC 83 represents a previously undescribed genomic species. Functional annotation based on EggNOG/COG analysis indicated the enrichment of genes involved in core metabolism and genome maintenance, while antiSMASH analysis identified a terpene-precursor-type biosynthetic locus encoding a polyprenyl synthase. Overall, this study expands the genomic understanding of flower-associated Vagococcus lineages and provides a foundation for future investigations into their ecological roles and potential applications as plant-derived microbial resources. Full article
(This article belongs to the Special Issue Advances in Plant–Pathogen Interactions)
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24 pages, 10697 KB  
Article
Molecular Strategies of Carbohydrate Binding to Intrinsically Disordered Regions in Bacterial Transcription Factors
by Yuri A. Purtov and Olga N. Ozoline
Int. J. Mol. Sci. 2026, 27(2), 941; https://doi.org/10.3390/ijms27020941 - 17 Jan 2026
Viewed by 97
Abstract
Intrinsically disordered regions enable transcription factors (TFs) to undergo structural changes upon ligand binding, facilitating the transduction of environmental signals into gene expression. In this study, we applied molecular modeling methods to explore the hypothesis that unstructured inter-domain and subdomain linkers in bacterial [...] Read more.
Intrinsically disordered regions enable transcription factors (TFs) to undergo structural changes upon ligand binding, facilitating the transduction of environmental signals into gene expression. In this study, we applied molecular modeling methods to explore the hypothesis that unstructured inter-domain and subdomain linkers in bacterial TFs can function as sensors for carbohydrate signaling molecules. We combined molecular dynamics simulations and carbohydrate docking to analyze six repressors with GntR-type DNA-binding domains, including UxuR, GntR and FarR from Escherichia coli, as well as AraR, NagR and YydK from Bacillus subtilis. Protein models obtained from different time points of the dynamic simulations were subjected to sequential carbohydrate docking. We found that the inter-domain linker of the UxuR monomer binds D-fructuronate, D-galacturonate, D-glucose, and D-glucuronate with an affinity comparable to nonspecific interactions. However, these ligands formed multimolecular clusters, a feature absent in the UxuR dimer, suggesting that protein dimerization may depend on linker occupancy by cellular carbohydrates. D-glucose interacted with linkers connecting subdomains of the LacI/GalR-type E-domains in GntR and AraR, forming hydrogen bonds that connected distant structural modules of the proteins, while in NagR, FarR and YydK, it bridged the inter-domain linkers and a β-sheet within the HutC-type E-domains. Hence, our results establish flexible linkers as pivotal metabolic sensors that directly integrate nutritional cues to alter gene expression in bacteria. Full article
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16 pages, 6489 KB  
Article
LIF-VSR: A Lightweight Framework for Video Super-Resolution with Implicit Alignment and Attentional Fusion
by Songyi Zhang, Hailin Zhang, Xiaolin Wang, Kailei Song, Zhizhuo Han, Zhitao Zhang and Wenchi Cheng
Sensors 2026, 26(2), 637; https://doi.org/10.3390/s26020637 - 17 Jan 2026
Viewed by 196
Abstract
Video super-resolution (VSR) has advanced rapidly in enhancing video quality and restoring compressed content, yet leading methods often remain too costly for real-world use. We present LIF-VSR, a lightweight, near-real-time framework built with an efficiency-first philosophy, comprising economical temporal propagation, a new neighboring-frame [...] Read more.
Video super-resolution (VSR) has advanced rapidly in enhancing video quality and restoring compressed content, yet leading methods often remain too costly for real-world use. We present LIF-VSR, a lightweight, near-real-time framework built with an efficiency-first philosophy, comprising economical temporal propagation, a new neighboring-frame fusion strategy, and three streamlined core modules. For temporal propagation, a uni-directional recurrent architecture transfers context through a compact inter-frame memory unit, avoiding the heavy compute and memory of multi-frame parallel inputs. For fusion and alignment, we discard 3D convolutions and optical flow, instead using (i) a deformable convolution module for implicit feature-space alignment, and (ii) a sparse attention fusion module that aggregates adjacent-frame information via learned sparse key sampling points, sidestepping dense global computation. For feature enhancement, a cross-attention mechanism selectively calibrates temporal features at far lower cost than global self-attention. Across public benchmarks, LIF-VSR achieves competitive results with only 3.06 M parameters and a very low computational footprint, reaching 27.65 dB on Vid4 and 31.61 dB on SPMCs. Full article
(This article belongs to the Section Intelligent Sensors)
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