Search Results (449)

The American Cancer Society estimates that over 152,000 new cases of colorectal cancer (CRC) were diagnosed in 2024, with more than 105,000 cases affecting the colon and 46,000 involving the rectum. CRC remains the second leading cause of cancer-related deaths in the United States, with an estimated 53,010 deaths in 2024. In the era of precision medicine, which incorporates molecular and environmental information into clinical decision-making, identifying patients harboring a deficiency in Deoxyribonucleic acid (DNA) repair allowed for targeted immunotherapies and significantly reduced CRC-related mortality. A significant advancement in this domain is the application of liquid biopsy, which has emerged as a promising tool for prognostication, guiding therapy, and monitoring treatment response in CRC. This review aims to comprehensively explore the role of liquid biopsy in colorectal malignancies, describing its practical applications, prognostic significance, and potential to revolutionize CRC management in the future. At the end, we also aim to show a schematic representation of showing integration of Circulating Tumor (Ct) DNA in routine clinical management of CRC. The highlight of this article is the structured and evidence-based schematic framework and its integration into future practice. The schematic pathway is designed to optimize ctDNA utilization across various stages of colorectal cancer management. Full article

The report examines food availability and demand in the Anthropocene era, exploring the connections between global population growth and carrying capacity through an extended version of Cohen’s Condorcet concept. It recalls the super-Malthus and Verhulst-type scalings, matched with the recently introduced analytic relative growth rate. It focuses particularly on the ongoing Fifth Industrial Revolution (IR) and its interaction with the concept of a sustainable civilization. In this context, the significance of innovative food preservation technologies that can yield high-quality foods with health-promoting features, while simultaneously increasing food quantities and reducing adverse environmental impacts, is discussed. To achieve this, high-pressure preservation and processing (HPP) can play a dominant role. High-pressure ‘cold pasteurization’, related to room-temperature processing, has already achieved a global scale. Its superior features are notable and are fairly correlated with social expectations of a sustainable society and the technological tasks of the Fifth Industrial Revolution. The discussion is based on the authors’ experiences in HPP-related research and applications. The next breakthrough could be HPP-related sterilization. The innovative HPP path, supported by the colossal barocaloric effect, is presented. The mass implementation of pressure-related sterilization could lead to milestone societal, pro-health, environmental, and economic benefits. Full article

This paper examines the epistemological transformation prompted by the integration of generative artificial intelligence technologies into social science research, proposing the “adaptive epistemology” paradigm. In today’s post-digital era—characterized by pervasive infrastructures and non-human agents endowed with generative capabilities—traditional research approaches have become inadequate. Through a critical review of historical and discursive paradigms (positivism, interpretivism, critical realism, pragmatism, transformative paradigms, mixed and digital methods), here I show how the advent of digital platforms and large language models reconfigures the boundaries between data collection, analysis, and interpretation. Employing a theoretical–conceptual framework that draws on sociotechnical systems theory, platform studies, and the philosophy of action, the core features of adaptive epistemology are identified: dynamism, co-construction of meaning between researcher and system, and the capacity to generate methodological solutions in response to rapidly evolving contexts. The findings demonstrate the need for reasoning in terms of an adaptive epistemology that could offer a robust theoretical and methodological framework for guiding social science research in the post-digital society, emphasizing flexibility, reflexivity, and ethical sensitivity in the deployment of generative tools. Full article

The quality of living environments for older adults represents a critical component of social sustainability in an ageing society. Among various housing options, nursing homes are the most institutionalised form of elderly care and demand special attention regarding architectural design. This paper explores the impact of architectural and open space features on social sustainability in living environments for older adults. A comparative analysis of three Slovenian nursing homes is presented. The first two, built in the post-war period, were based on elevated architectural criteria inspired by Swedish human-centred housing design. The third was completed in 2021 in the post-COVID-19 era, which revealed the vulnerability of such housing typologies. An integrated methodological framework was developed by applying two complementary assessment tools: the Safe and Connected, developed by the authors to evaluate the spatial, health, and social resilience of nursing home environments, and the Well-being and Integration, addressing the role of open space with a particular emphasis on the identification of older adults with their environment and the facilitation of social resilience. Both tools evaluate indicators linked to the social dimension of quality of life for older adults. The results show a gradual improvement in architectural quality from the 1960s to the 1980s, followed by a partial decline in the contemporary case. The Swedish example scored highest across both tools. In contrast, the newest Slovenian facility scored surprisingly low in social integration, highlighting critical gaps in current nursing home design. This study demonstrates the value of applying interdisciplinary, tool-based evaluations in identifying design strategies that foster resilient and inclusive LTC environments, and the proposed framework may serve as a decision-making aid for architects, planners, and policymakers. This research highlights the importance of reintroducing human-oriented design principles to support socially sustainable nursing home environments. Full article

Introduction. Mesotherapy is a widely used technique around the world. However, there is currently no internationally recognized, evidence-based standard for its various clinical applications. To address this gap, we have reviewed the current state of the art, critically evaluated its clinical benefits and limitations, and proposed a set of standards including procedural steps, recommended actions, and practical instructions in the form of protocols, guidelines, and expert recommendations. Methods. A team of researchers conducted a comprehensive literature review, selecting studies published between 1976 and 2023. Drawing on the available evidence and the needs expressed by patient associations, 23 clinical questions were developed and presented to a panel of experts. Through multiple rounds of evaluation, evidence-based recommendations were formulated and subsequently submitted for structured evaluation and voting by a broad, multidisciplinary panel of international experts, representing numerous national and international scientific societies. Results. The recommendations outlined in this guideline support the use of mesotherapy across diverse clinical and organizational settings, providing a standardized framework that ensures both efficacy and patient safety in osteoarticular pain, rehabilitation, and dermatological fields. Conclusions. The era of mesotherapy based on personal beliefs now gives way to evidence-based practice. The limitations underscore the need for continued high-quality research and scheduled guideline updates. Full article

Sixteenth-century Spanish accounts of the invasions of the Americas claimed that Indigenous peoples found horseback riding so shocking that they mistook cavalry for centaurs. Drawing a one-to-one connection between sixteenth-century Mesoamericans and ancient Europeans, a nineteenth-century historian claimed that this must have happened in ancient Greece also, inspiring the centaur myth in the first place. A closer examination of Classical textual and archaeological sources and of the ethnohistory of the contact-era Americas shows this to be wishful thinking by Iberian writers desirous to believe that awestruck American societies saw them as gods or monsters. However, a closer examination of the centaur myth and the responses by contact-era American societies to horses reveals a more complicated reality behind a simple mythology of conquest. Full article

In the digital age, the mechanisms of power and control have evolved beyond Foucault’s disciplinary societies, giving rise to a new paradigm of algorithmic governance. This study critically reinterprets Foucault’s concept of the human subject in light of contemporary digital surveillance, big data analytics, and algorithmic decision-making. The paper looks at how technology, biopolitics, and subject formation interact. It says that algorithmic control changes people’s choices in ways that have never been seen before through predictive modeling and real-time behavioral modulation. The study starts with a comparison of early Foucauldian frameworks and more recent theories of digital governance. It uses a method that combines philosophy, media studies, and political theory. The results show that while disciplinary societies relied on institutionalized norms and body regulation, algorithmic control works through data-driven anticipatory mechanisms, which make subjectivity less clear and more broken up. This shift raises ethical and ontological questions about autonomy, resistance, and the very notion of the self in a hyper-connected society. The study concludes that rethinking Foucault’s insights in the digital era is essential for understanding and contesting the pervasive influence of algorithmic power on human subjectivity. Full article

In recent years, land degradation has become a major challenge for human society, with negative impacts on the natural habitat, the economy, and human well-being. A variety of anthropogenic and natural factors are exacerbating the processes of land degradation in the era of climate change. Land restoration is an important and proactive strategy to combat this negative situation. Among the many approaches, the use of vegetation plays a central role in restoring soil health, preventing erosion, promoting biodiversity, and improving water retention. Therefore, the identification of new plant species that have the properties to contribute to land restoration is a necessity today. The plant proposed in this conceptual review for land restoration is the cup plant (Silphium perfoliatum L.). After a brief presentation of the agronomy, adaptability, and multiple uses of this plant species, its potential to provide important ecosystem services useful for land restoration to combat land degradation is herein emphasized. Recent studies have shown that this plant has great potential for phytoremediation of soils contaminated with heavy metals (Zn, Pb, Cr, Cd, Ni, Hg, and Co), especially in post-mining areas where pollution exceeds ecological limits. Most studies have shown that the accumulation of heavy metals is higher at the lamina stage. There is also some evidence that the cup plant thrives in flood-prone areas and contributes to their restoration. Cup plant cultivation can also reduce greenhouse gasses and increase the organic carbon content of the soil. Another method of land restoration related to the establishment of the cup plant in a given area is the suppression of weeds, particularly the prevention of the invasion of exotic weed species. Further research under different soil–climatic conditions is needed to investigate cup plant cultivation as a promising strategy for land restoration in a time when the climate is constantly changing. Full article

Value engineering (VE), as a conceptual approach and management technique, has allowed enterprises to capture value through mass production and market expansion during the industrial economic era. The VE method has enabled companies to produce products that meet user needs at a lower cost, leading to success. However, as the complexity of society and industry development increases, the lack of theoretical expansion in VE has limited its application in today’s more complex and macro management systems. With the development and evolution of vehicle–road collaborative intelligence, the intelligent automotive industry has become a complex system with multiple entities and interwoven values across different dimensions. Intelligent connected vehicles (ICVs), along with the external intelligent environment, will jointly participate in the realization of system functions. It is no longer sufficient to apply VE methods to analyze ICVs from a single product perspective. The pursuit of “maximizing value” is always the core driving force of industrial development. This study, building on the fundamental ideas of VE, expands and extends the connotation and theory of VE in three aspects: research objects, value dimensions, and associated entities, to adapt to the current situation. It also provides a new analysis process for the VE theory to better address systemic and complex issues. Taking the intelligent automotive industry as a case study, this study analyzes it based on the expanded VE theory. It considers not only the cost of system function realization and the product value of ICVs but also the external benefits of the system across different dimensions. The social value, user value, enterprise value are introduced in entity value analysis, and the relevant indicators are organized. This approach can better guide the collaboration and division of labor among multiple participating entities such as governments, enterprises, and users, achieving overall value maximization. Full article

The Sierra de las Navajas is a Late Pliocene volcanic complex with a rhyolitic composition and peralkaline affinity. It is located on the northeastern edge of the Trans-Mexican Volcanic Belt in the state of Hidalgo. Within this rocky massif lies Cerro de las Navajas, the site of the most intensively exploited archaeological obsidian deposit in Mesoamerica. Obsidian extraction in this area has been carried out through open-pit mining and unique underground mining. The geological identity of the deposit encompasses the origin, distribution, and petrological characteristics of the obsidian from Cerro de las Navajas, determined through detailed geological mapping, petrographic study, and geochemical analysis. The results reveal the obsidian deposit’s style as well as its temporal and spatial position within the eruptive evolution of the region. The deposit originated from a local explosive eruptive mechanism associated with the partial collapse of a lava dome, forming a Block and Ash Flow Deposit (BAFD). The obsidian blocks, exploited by different cultures, correspond to the pyroclastic blocks within this deposit, which can reach up to 1 m in diameter and are embedded in a weakly consolidated ash matrix. The BAFD was later buried by (a) subsequent volcanic events, (b) structural adjustments of the volcanic edifice, and (c) soils derived from the erosion of other volcanic units. This obsidian deposit was mined underground from the Early Formative period to the Colonial era by the cultures of the Central Highlands and colonized societies. Interest in the vitreous quality and exotic nature of obsidian lithics from the BAFD led to the development of a complex exploitation system, which was generationally refined by the Teotihuacan, Toltec, and Aztec states. Full article

The global transition to a digital era is crucial for society, as most daily activities are driven by digital technologies aimed at enhancing productivity and efficiency in the production of food, fibers, and bioenergy. However, the segregation of digital techniques and equipment in both rural and urban areas poses significant obstacles to technological efforts aimed at combating hunger, ensuring sustainable agriculture, and fostering innovations aligned with the United Nations Sustainable Development Goals (SDGs 02 and 09). Rural regions, which are often less connected to technological advancements, require digital transformation to shift from subsistence farming to market-integrated production. Recent efforts to expand digitalization in these areas have shown promising results. Digital agriculture encompasses terms such as artificial intelligence (AI), the Internet of Things (IoT), big data, and precision agriculture integrating information and communication with geospatial and satellite technologies to manage and visualize natural resources and agricultural production. This digitalization involves both internal and external property management through data analysis related to location, climate, phytosanitary status, and consumption. By utilizing sensors integrated into unmanned aerial vehicles (UAVs) and connected to mobile devices and machinery, farmers can monitor animals, soil, water, and plants, facilitating informed decision-making. An important limitation in studies on nutritional diagnostics is the lack of accuracy validation based on plant responses, particularly in terms of yield. This issue is observed even in conventional leaf tissue analysis methods. The absence of such validation raises concerns about the reliability of digital tools under real field conditions. To ensure the effectiveness of spectral reflectance-based diagnostics, it is essential to conduct additional studies in commercial fields across different regions. These studies are crucial to confirm the accuracy of these methods and to strengthen the development of digital and precision agriculture. Full article

Background/Objectives: Postoperative atrial fibrillation (POAF) is the most frequent arrhythmic complication following cardiac surgery and is associated with increased morbidity and prolonged recovery. This study aimed to evaluate the impact of an enhanced recovery after surgery (ERAS) program on the incidence of POAF and broader perioperative outcomes. Methods: In this monocentric, observational cohort study, we compared a retrospective pre-ERAS cohort (n = 162) with a prospective ERAS cohort (n = 321). The primary outcome was the incidence of POAF, assessed using two definitions: (1) the American Association for Thoracic Surgery (AATS) 2014 clinical definition, identifying POAF as atrial fibrillation requiring treatment; and (2) the European Society of Cardiology (ESC) 2024 definition, describing new-onset atrial fibrillation occurring immediately after surgery. Secondary outcomes included compliance with POAF prophylaxis measures, length of hospital stay, and the occurrence of postoperative complications. Statistical analyses included propensity score matching and multivariate logistic regression to identify independent predictors of POAF. Results: ERAS implementation was associated with a significant reduction in POAF incidence across both definitions. According to the AATS 2014 definition, POAF occurred in 20% of ERAS patients vs. 39% in the pre-ERAS group (p = 0.001), and 23% vs. 39% in the matched cohort (p = 0.004). Using the ESC 2024 definition, POAF was observed in 21% vs. 37% (p = 0.001) in unmatched and 20% vs. 36% (p = 0.005) in matched populations. Compliance with POAF prophylaxis improved markedly in the ERAS group (70% vs. 21%, p = 0.001). ERAS patients also experienced shorter hospital stays and fewer postoperative complications (26% vs. 38% in the matched cohort, p = 0.033). Conclusions: The implementation of a structured ERAS protocol significantly reduced POAF incidence, improved compliance with preventive strategies, and enhanced key aspects of postoperative recovery. Full article

Artificial intelligence (AI) is a field of strategic interest for both the European Union (EU) and its member states, which are making significant efforts to develop and implement AI in a way that is economically and socially beneficial, as well as ethical and secure. This paper analyzes the importance of AI and its impact on the economy and society, highlighting the strategic and regulatory aspects agreed upon at the EU and Romanian levels, given this state’s status as an EU member. Based on the latest specialized literature, the first part addresses the concept of AI and emphasizes its role as a key driver of innovation and economic growth. Subsequently, we examine the EU’s institutional concerns, outlining the key guidelines and steps in harnessing AI opportunities, as well as the strategic and regulatory milestones that govern AI implementation within the EU. In this context, we focus on the complexities involved in the transition to the AI Era, recent developments, the process of drafting and adopting the EU AI Act, and the significance of the AI Pact. Our study fully reflects that Romania is also taking significant strategic and regulatory measures to align with the demands of the AI Era, with particular attention given to improving the legislative framework regarding the ethical implications of AI implementation and preventing deepfakes. Full article

Current modern attention and concern about (human-driven) climate change has prompted much focus on the historical/archaeological relevance and role of (natural) climate change in the past. The topic is both relevant and important—and especially those short(er)-term events that perhaps helped trigger historically substantive change episodes. But, at the same time, initial, somewhat naïve enthusiasm has now run headlong into the limitations of the available data sources before the early modern era, and the many complications of establishing actual causal associations. These need to be, first, closely defined in terms of timing and effects, and then also, second, established as relevant to the specific human societies/civilizations and contexts in question. This paper seeks to highlight the need for appropriate care and rigorous method when seeking to associate climate and environmental events with the available ancient historical and archaeological evidence, and investigates three illustrative, problematic, cases from the Classical Mediterranean world. Full article

Two key pillars of human-centered AI (HCAI) approaches are “control” and “autonomy”. To date, little is known about professional translators’ attitudes towards these concepts in the AI era. This paper explores this issue through a survey study of US-based professional translators in mid-2024. Methodologically, this paper presents a qualitative analysis of open-ended questions through thematic coding to identify themes related to (1) present conceptualizations of control and autonomy over translation technologies, (2) future attitudes towards control and autonomy in the AI era, (3) main threats and challenges, and (4) recommendations to developers to enhance perceptions of control and autonomy. The results show that professionals perceive control and autonomy differently in both the present and the future. The main themes are usability, the ability to turn on and off technologies or reject jobs that require specific technologies, collaboration with developers, and differences in working with LSPs versus private clients. In terms of future attitudes, the most frequent ones are post-editing, quality, communicating or informing clients, LSPs or society at large, and creativity or rates. Overall, the study helps identify how professionals conceptualize control and autonomy and what specific issues could help foster the development of truly human-centered AI in the translation profession. Full article