Search Results (158)

This study presents the design and validation of an integrated fire safety system that leverages edge AI, hybrid sensing, and precision suppression to overcome the latency and collateral limitations of conventional smoke detection and sprinkler systems. The proposed platform features a dual-mode sensor array for early fire recognition, motorized ventilation units for rapid smoke extraction, and a 360° directional nozzle for targeted agent discharge using a residue-free clean extinguishing agent. Experimental trials demonstrated an average fire detection time of 5.8 s and complete flame suppression within 13.2 s, with 90% smoke clearance achieved in under 95 s. No false positives were recorded during non-fire simulations, and the system remained fully functional under simulated cloud communication failure, confirming its edge-resilient architecture. A probabilistic risk analysis based on ISO 31000 and NFPA 551 frameworks showed risk reductions of 75.6% in life safety, 58.0% in property damage, and 67.1% in business disruption. The system achieved a composite risk reduction of approximately 73%, shifting the operational risk level into the ALARP region. These findings demonstrate the system’s capacity to provide proactive, energy-efficient, and spatially targeted fire response suitable for high-value infrastructure. The modular design and SmartThings Edge integration further support scalable deployment and real-time system intelligence, establishing a strong foundation for future adaptive fire protection frameworks. Full article

The suppressive regulator of cell fusion, suppressyn, is specifically expressed in the human placenta and is thought to play a crucial role in trophoblast fusion or syncytialization. Previous studies have suggested that alterations in its expression are associated with aberrant placental development, such as the immature placental morphology observed in Down syndrome, and may contribute to the pathogenesis of fetal growth restriction. While syncytialization in trophoblasts is an essential process for normal placental development, the precise molecular causes of its dysregulation remain poorly understood. In the present study, we aimed to elucidate the potential contribution of genomic variation to the loss of suppressyn function, extending previous analyses of expression abnormalities in perinatal disorders. Through sequence analysis, (1) we identified six polymorphisms within the coding region of the suppressyn gene, and (2) discovered that certain deletions and specific amino acid substitutions result in a complete loss of suppressyn-mediated inhibition of cell fusion. Although these mutations have not yet been reported in disease-associated genomic databases, our findings suggest that comprehensive genomic studies of perinatal and other disorders may reveal pathogenic variants of suppressyn, thereby uncovering novel genetic contributions to placental dysfunction. It is also anticipated that these findings might direct the development of therapeutic strategies targeting loss-of-function mutations. Full article

Zimbabwe’s economy has experienced extreme exchange rate fluctuations over the past decades, driven by persistent macroeconomic instability and episodes of hyperinflation. The instability in exchange rates can significantly impact trade balances, inflation rates, and overall economic resilience. Understanding the impact of exchange rate volatility (ERV) on international trade is crucial in such a context. This study investigates the impact of exchange rate volatility (ERV) on international trade in Zimbabwe, addressing a literature gap related to its unique economic challenges and hyperinflation. Using the Generalized Autoregressive Conditional Heteroscedasticity (GARCH) model on data from 1990 to 2023, the study finds a negative relationship between ERV and international trade. The analysis suggests that inflation reduces imports, but foreign direct investment (FDI) and balance of payments (BOP) increase export uncertainties. This study recommends optimal fiscal and monetary management to mitigate ERV and enhance trade stability, offering insights for policymakers to strengthen Zimbabwe’s trade resilience amid exchange rate fluctuations. Full article

Murine leukemia viruses (MuLVs) are retroviruses that cause various diseases in mice and have served as a model for retrovirus replication and pathogenesis. MuLVs are separated into infectious exogenous retroviruses (XRVs) and endogenous retroviruses (ERVs) that are remnants of ancient infectious XRVs. Detection of XRVs in the original host cells has some difficulties because of the high similarity in sequence between ERVs and XRVs and expression of some ERV genes. There are some techniques available for monitoring retroviral replication, but each comes with limitations in terms of labor intensity, detection range, cost, and phases after infection. This study developed a novel quantitative PCR (qPCR) method for assessing replication of Moloney MuLV (M-MuLV) in mouse cells. The method amplified the region in packaging signal and gag and distinguished exogenous M-MuLV from ERVs with mouse SC-1 cells. The qPCR system could quantify viral sequences in infected cells from 16 to 72 h post-infection, with a 3-log range of difference. This was compared with the traditional infectivity assay, focal immunofluorescence assay. In conclusion, the developed qPCR system provides a rapid, sensitive, and scalable alternative for quantifying M-MuLV infectivity, with potential for broader applications in MuLV research. Full article

Retroviruses insert DNA copies of themselves into the chromosomes of their hosts forming proviruses that can synthesize new transmissible viruses. Exogenous retroviruses (XRVs) insert into the DNA of somatic cells and are transmitted infectiously. Endogenous retroviruses (ERVs) become inserted in the DNA of germline cells and are transmitted genetically. ERVs can spread through the genome by transposition. ERVs originate from an initial copy of an XRV inserted into the genome of an organism infected by the XRV. Many XRVs are transmitted maternally as well as horizontally; therefore, we consider the effect of maternal transmission on the evolution of virulence of an XRV. Our model shows that the XRV either evolves high virulence with low maternal transmission, or vice versa. We then consider the spread of ERV genes in conjunction with the infectious spread of an XRV. Beginning from a single copy of an ERV, we calculate the probability that it spreads to fixation (i.e., the state where all individuals contain ERV genes). This depends on its virulence and transposition rate. If the XRV is present, the fixation probability also depends on the virulence of the XRV and whether the ERV provides resistance to the XRV. An ERV with only a small deleterious effect on host fitness has a high fixation probability, particularly if it provides resistance to the XRV. We also show that, if an ERV does not spread to fixation, it can still cause elimination of the XRV, with the end result that the population is cleared of both XRV and ERV. Full article

The goal of the study is to reveal the reasons (strategies) behind the use of “virtual masks” (fake profiles and altered identities) by real (human) users of social media networks (SMNs) within a cultural context, specifically in Armenia. Applying Erving Goffman’s Dramaturgical Theory and concepts of virtual identity, the research explores how users construct their online personas, either reflecting their real identities or modifying them to achieve specific communicative goals. A statistical analysis of the most popular SMNs in Armenia, combined with semi-structured interviews with 400 users, reveals diverse approaches to virtual communication. While SMNs facilitate news consumption, socializing, and professional networking, many users deliberately conceal personal information or engage in deceptive practices. Approximately 35% prefer anonymity when following others, and 24% of men and 11% of women admit to posting false information. Additionally, 26% of men and 12% of women alter their online appearance to enhance attractiveness. The study also highlights the role of anonymity in expressing controversial opinions, particularly in political discussions. Men are more inclined than women to create fake accounts and manipulate information to avoid social repercussions. Ultimately, the study highlights how “virtual masks” in Armenia reflect both cultural attitudes and broader global digital communication trends. Full article

Chitin synthase 3 complex assembly begins at the endoplasmic reticulum where the formation of a Chs3/Chs7 complex facilitates its exit from the ER and its transport along the secretory route. In the present study, our work shows that orphan molecules of Chs7 can exit the ER and are later recycled from the early Golgi by coat protein I (COPI) machinery via the adaptor complex Erv41/Erv46. Moreover, an eventual excess of the protein in the Golgi is recognized by the GGA complex and targeted to the vacuole for degradation through the ESCRT machinery. Non-oligomerizable versions of Chs3 can also exit the ER individually and follow a similar route to that of Chs7. We therefore demonstrate the traffic of unassembled CS3 subunits and describe the cellular mechanisms that guarantee the correct assembly of this protein complex at the ER while providing a default traffic route to the vacuole in case of its failure. This traffic route is shared with canonical ER adaptors, such as Erv29 and Erv14, and other components of protein complexes. The comparative analysis of their traffic allows us to discern a cellular program that combines COPI recycling, proteasomal degradation, and vacuolar disposal for maintaining protein homeostasis at the ER. Full article

Indoor air quality (IAQ) impacts human health, productivity, and well-being. As buildings become more energy-efficient and tightly sealed, the need for effective ventilation systems that maintain adequate IAQ grows. Energy Recovery Ventilators (ERVs) ensure adequate IAQ by bringing fresh outdoor air indoors while minimizing costly energy wastage. ERVs provide major economic, health, and well-being benefits and are a critical technology in the fight against climate change. However, little is known about the impact of ERV operation on the generation and fate of particulate and gaseous indoor air pollutants, including toxic, carcinogenic, allergenic, and infectious air pollutants. Specifically, the air pollutant crossover, aerosol deposition within ERVs, the chemical identity and composition of aerosols and volatile organic compounds emitted by ERVs themselves and by the accumulated pollutants within them, and the effects on bioaerosols must be investigated. To fill these research gaps, both field and laboratory-based experimental research that closely mimics real-life conditions within a controlled environment is needed to explore critical aspects of ERVs’ effects on indoor air pollution. Filling the research gaps identified herein is urgently needed to alert and inform the industry about how to optimize ERVs to help prevent air pollutant generation and recirculation from these systems and enhance their function of pollutant removal from residential and commercial buildings. Addressing these knowledge gaps related to ERV design and operation will enable evidence-based recommendations and generate valuable insights for engineers, policymakers, and heating, ventilation and air conditioning (HVAC) professionals to create healthier indoor environments. Full article

The temperature frequency method is used to analyze the energy savings of the wall-type energy recovery fresh air ventilator in three different typical regions, namely Guangzhou, with a tropical monsoon climate; the sub-temperate Wuhan; and Beijing, with a temperate monsoon climate, throughout the year. The influence of different temperature efficiencies and resistance levels of the energy recovery ventilator (ERV) on annual energy efficiency is also analyzed. The control temperature of the auxiliary heating device used in the winter is discussed, and the indoor temperature variation trend in the inter-wall-type energy recovery fresh air ventilator operating 24 h on four typical days of the year under different control modes is analyzed in the tropical monsoon climate of Guangzhou. The conclusions obtained can provide a reference for the application and selection of inter-wall-type energy recovery fresh air ventilators. Full article

After the COVID-19 pandemic in South Korea, residential buildings are equipped with an energy recovery ventilator for ventilation and building energy efficiency. During summer, it is required to operate both the ERV system and air conditioners to maintain thermal comfort as well as ensure indoor air quality. The ventilation efficiency of the ERV system can be varied by various layouts of the inlet and outlet vents. Moreover, cooling can be wasted through the exhaust of the ERV system. Considering this, the present study assessed thermal comfort by applying various layouts of the supply and exhaust of ERV systems with different supply air temperatures and air volumes of the air conditioners. Using CFD (computational fluid dynamics) simulation, the ventilation and thermal performance with the PMV (predicted mean vote) were analyzed. As a result, the PMV was highly affected by the supply air temperature and ventilation flow rates of the air conditioners. While additional installations of the inlet or outlet vents showed improved ventilation performance, the PMV index presented “slightly cold” or “cold”. Considering energy saving, this proves that it can provide an opportunity to reduce cooling energy consumption through the intermittent operation mode of the air conditioners. Full article

Improving indoor air quality (IAQ) in daycare centers is essential due to children’s vulnerability to pollutants and prolonged indoor exposure. To address these challenges, energy recovery ventilators (ERVs) with varying filtration efficiencies were evaluated through field measurements and CONTAM simulations. Baseline assessments of CO₂ and PM_2.5 levels revealed significant impacts from outdoor pollutant infiltration. ERVs successfully reduced CO₂ concentrations, maintaining levels below 1000 ppm during most occupancy periods. However, low-efficiency filters (MERV 8 or lower) permitted outdoor particulate matter infiltration, increasing indoor PM_2.5 levels. High-performance filters (MERV 13 or higher) reduced indoor PM_2.5 concentrations by up to 50%, significantly improving air quality. Findings emphasize the necessity of combining high-efficiency filtration with ERVs to mitigate pollutant infiltration and ensure healthy indoor environments. Policymakers and practitioners are urged to implement ventilation systems equipped with MERV 13 or higher filters, particularly in regions with high outdoor pollution. These strategies are critical for safeguarding children’s health and meeting IAQ standards in daycare facilities. Full article

This study investigates the thermal performance of various counterflow air-to-air heat exchangers under unbalanced flow conditions, aiming to enhance the efficiency of heat recovery systems. Mechanical ventilation with heat recovery is critical in energy-efficient buildings to reduce heat loss, which can reach up to 60% in air exchange processes. This research focuses on the effects of flow imbalance on the heat transfer efficiency of three specific heat exchangers: two commercially available models (Recair Sensitive RS160 and Core ERV366) and a custom 3D-printed prototype (GV PROTO). Experimental tests measured temperature efficiency under both balanced and unbalanced flow conditions, with results indicating that flow imbalance significantly impacts thermal efficiency. Among the exchangers, the RS160 displayed the highest temperature efficiency, maintaining performance better than the others as flow rates increased. The results of the study show that even small differences in the thermal efficiency of different heat exchangers under balanced airflow conditions transform into significant differences under unbalanced conditions. These findings contribute to a better understanding of how real-world ventilation imbalances affect heat exchanger performance, offering insights to optimize energy efficiency in ventilation systems. Full article

Airborne inverse synthetic aperture radar (ISAR) imaging of maneuvering targets is important for maritime surveillance. Long coherent processing intervals (CPIs) can bring better resolution and signal-to-clutter-plus-noise ratio (SCNR). Due to the change in the effective rotation vector (ERV), the conventional Range-Doppler (RD) algorithm is not appropriate for producing a well-focused image. To resolve the above issue, we propose a long CPI imaging algorithm through ERV estimation and data resampling. This algorithm estimates the Doppler length of the sub-aperture image by complex signal kurtosis (CSK) at first. Then, the change in the ERV can be estimated because the ship Doppler length is always proportional to the ERV. Finally, the echo is resampled according to the estimation of the time-varying ERV to obtain the echo from a constant ERV. Computer simulation experiments and measured data have verified the effectiveness of the proposed method. Experimental results demonstrate that the proposed method can achieve ISAR imaging with longer CPIs at low SNR and inhomogeneous clutter. Full article

Today, reducing vehicle energy consumption is a crucial topic. For electric vehicles, reducing energy consumption is essential to address some of the most critical issues associated with this type of vehicle, such as the limited range of electric powertrains and the long battery recharging times. To lower the environmental impact during the vehicle’s use phase and reduce energy consumption, vehicle mass reduction (lightweighting) is an effective strategy. The objective of this work is to analyze the vehicle parameters that influence lightweighting outcomes on a real driving cycle, representative of the home-to-work travel in northern Italy. In particular, a previous work carried out on standard driving cycles is repeated in order to observe whether it is possible to draw the same conclusions regarding the variability in the lightweighting outcome. This study was conducted using two opposite vehicle models, a compact car and an N1 vehicle, simulated through a well-established vehicle simulation tool for energy consumption estimation. To conduct this analysis, several simulations with variable vehicle mass, and with different vehicle parameters, such as aerodynamics and rolling resistance, were performed to estimate energy consumption across a real-world driving cycle, acquired via GPS on board the vehicle during a home-to-work journey in northern Italy. This study reveals that even for the real driving cycle, as for the WLTC and US06 standards, the parameters that most influence the outcome of the lightening are the rolling resistance, the characteristics of the battery pack, the aerodynamic coefficients, and the efficiency of the transmission. Finally, the standard cycle that best fits with the real one considered in this study is the Artemis Urban Cycle. Full article

Homologous recombination events take place between the 5′ and 3′ long terminal repeats (LTRs) of ERVs, resulting in the generation of solo-LTR, which can cause solo-LTR-associated polymorphism across different genomes. In the current study, specific criteria were established for the filtration of solo-LTRs, resulting in an average of 5630 solo-LTRs being identified in 21 genomes. Subsequently, a protocol was developed for detecting solo-LTR polymorphisms in the pig genomes, resulting in the discovery of 927 predicted solo-LTR polymorphic sites. Following verification and filtration processes, 603 highly reliable solo-LTR polymorphic sites were retained, involving 446 solo-LTR presence sites (solo-LTR⁺) and 157 solo-LTR absence sites (solo-LTR⁻) relative to the reference genome. Intersection analysis with gene/functional regions revealed that 248 solo-LTR⁻ sites and 23 solo-LTR⁺ sites overlapped with genes or were in the vicinity of genes or functional regions, impacting a diverse range of gene structures. Moreover, through the utilization of 156 solo-LTR polymorphic sites for population genetic analysis, it was observed that these solo-LTR loci effectively clustered various breeds together, aligning with expectations and underscoring their practical utility. This study successfully established a methodology for detecting solo-LTR polymorphic sites. By applying these methods, a total of 603 high-reliability solo-LTR polymorphic sites were pinpointed, with nearly half of them being linked to genes or functional regions. Full article