Search Results (34)

Foot hyperpronation is a common anatomical misalignment that may contribute to the development of both localized and distant musculoskeletal overuse injuries. Advancements in modern technology may enable the detection of biomechanical changes in dynamic conditions that cannot be captured through conventional foot alignment assessments. This study aimed to investigate potential differences in spatiotemporal, dynamic, and center of pressure (COP)-related gait parameters, between individuals with foot hyperpronation (n = 21) and those with a neutral foot type (n = 21) under various walking conditions, using an instrumented treadmill. These conditions included walking downhill at −20% slope at 3.5 km·h⁻¹, and at −10% slope at 5.0 km·h⁻¹, level (0%) at 5.0 km·h⁻¹, and uphill at +10% slope at 3.5 km·h⁻¹ and +20% slope at 2.5 km·h⁻¹, each lasting five minutes. The results showed no significant differences in stride length and time, foot rotation, step width, cadence, or gait phase durations between the two groups. However, individuals with hyperpronated feet exhibited a more forward and mediolaterally displaced COP, higher vertical ground reaction forces (vGRFs) at the midfoot, and lower vGRFs at the lateral forefoot. Instrumented treadmills enable clinicians and sports scientists to detect specific traits in individuals with foot hyperpronation, which would otherwise go undetected through static assessments. Full article

As part of its plan to transition to an energy secure and environmentally sustainable future, Canada has had a national carbon pricing system since 2019. When first introduced, the $20 (‘$’ refer to Canadian dollars (CAD) in this paper) per tonne price was widely accepted by most Canadians and seen as a way of helping Canada meet its emissions reduction pledges made at the 2015 United Nations Climate Change Conference (COP 21) in Paris. The Canadian system is novel in that it both charges consumers for their emissions and reimburses them for their expected emissions; this is intended to raise awareness of their emissions and encourage those who can afford to opt for lower-emissions energy services to do so. By 2023, the combination of the carbon price reaching $65 per tonne and the post-pandemic economic slowdown was seized on by numerous politicians as a way of pushing back against the carbon pricing system, with most demanding the entire system be scrapped. The debate intensified in late 2023 and into 2024, when the federal government removed the carbon tax on home heating oil because the reimbursement was insufficient to cover the cost of the tax. In this paper, we consider the recent actions of two Canadian provinces, Saskatchewan and Nova Scotia, embroiled in the federal carbon pricing system debate due to the removal of the carbon tax on fuel oil for space heating. The objective of this paper is to identify how some of the reasons, including global post-pandemic inflation and other challenges facing Canadians, such as those cited in third-party polls, have contributed to a rise in the system’s unpopularity. Our method estimates and compares the impacts of the carbon tax on the household energy services for space and water heating, lighting and appliances, and private (i.e., household) transportation for different types of housing (apartment, single-attached, and single-detached) and number of occupants (two, three, and four) in Saskatchewan and Nova Scotia. The results of this work show that while Saskatchewan households have higher energy intensities than those in Nova Scotia, the impact of the carbon tax on Nova Scotians using fuel oil for heating was greater than in Saskatchewan. In Saskatchewan and Nova Scotia, natural gas and electricity, respectively, are used for heating. This paper concludes with a summary of our findings and potential options for improving perceptions of the system. Full article

Postural imbalance is a leading cause of injury in older adults. Our study investigated the effectiveness of virtual reality (VR)-based interventions on balance ability in this population. Here, we examined 21 older, healthy adults (75.8 ± 5.2 years old). Participants performed 6 weeks of balance training, twice per week for 30 min; the experimental group donned an Oculus VR headset during the training while control participants did not. To assess balance ability, a force platform measured displacement of the center of pressure (COP) during quiet standing in double-leg, tandem, and single-leg stances with eyes closed pre- and post-assessment. COP measurements included mediolateral (ML) and anterior–posterior (AP) directions for root mean square (RMS), peak-to-peak displacement (MAXD), total excursion (TE), and 95% confidence area ellipse (AE) parameters. Post-training assessments showed improvements (significant decreases) in the COP parameters. Control group COP parameters improved in various stances ranging from a 3% to 40% decrease on average. The VR group improved MAXD, TE, and 95% AE ranging from a 5% to 47% decrease, on average, across various stances post- compared to pre-training. VR-based exercise training programs may encourage older adults to engage in mobility exercises, leading to a reduced risk of falls or injuries. Full article

Colorectal cancer (CRC) is a frequent, worldwide tumor described for its huge complexity, including inter-/intra-heterogeneity and tumor microenvironment (TME) variability. Intra-tumor heterogeneity and its connections with metabolic reprogramming and epithelial–mesenchymal transition (EMT) were investigated with explorative shotgun proteomics complemented by a Random Forest (RF) machine-learning approach. Deep and superficial tumor regions and distant-site non-tumor samples from the same patients (n = 16) were analyzed. Among the 2009 proteins analyzed, 91 proteins, including 23 novel potential CRC hallmarks, showed significant quantitative changes. In addition, a 98.4% accurate classification of the three analyzed tissues was obtained by RF using a set of 21 proteins. Subunit E1 of 2-oxoglutarate dehydrogenase (OGDH-E1) was the best classifying factor for the superficial tumor region, while sorting nexin-18 and coatomer-beta protein (beta-COP), implicated in protein trafficking, classified the deep region. Down- and up-regulations of metabolic checkpoints involved different proteins in superficial and deep tumors. Analogously to immune checkpoints affecting the TME, cytoskeleton and extracellular matrix (ECM) dynamics were crucial for EMT. Galectin-3, basigin, S100A9, and fibronectin involved in TME–CRC–ECM crosstalk were found to be differently variated in both tumor regions. Different metabolic strategies appeared to be adopted by the two CRC regions to uncouple the Krebs cycle and cytosolic glucose metabolism, promote lipogenesis, promote amino acid synthesis, down-regulate bioenergetics in mitochondria, and up-regulate oxidative stress. Finally, correlations with the Dukes stage and budding supported the finding of novel potential CRC hallmarks and therapeutic targets. Full article

This work aims to define a strategy for maintaining a vertical posture of the human body under conditions of conflicting sensory stimuli using a method of trend change analysis. The investigations involved 28 healthy individuals (13 females, 15 males, average age = 21, SD = 1.3 years). Measurements were conducted with eyes opened and closed and in the virtual environment with two sceneries oscillating at two frequencies. Values in the time domain were calculated—the mean center of pressure (COP) velocity and movement range in the AP direction—as well as values based on the moving average convergence divergence (MACD) computational algorithm—the trend change index (TCI), MACD_dT, MACD_dS, and MACD_dV. After dividing the analysis into distinct time periods, an increase in TCI values was identified in the oscillating scenery at 0.7 and 1.4 Hz during the 0.5–1 and 0.2–0.5 s time periods, respectively. Statistically significant differences were observed between measurements with an oscillation frequency of 0.7 Hz and those with an oscillation frequency of 1.4 Hz during the 0.2–0.5 s and 0.5–1 s periods. The use of stock exchange indices in the assessment of the ability to keep a stable body posture supplements and extends standard analyses in the time and frequency domains. Full article

Due to the impact of global warming and climate change, more and more people are starting to have a clearer understanding and vigilance about greenhouse gases. To prevent further deterioration of the global environment, this study examines the coefficients of performance of 21 currently available refrigerants with very low global-warming potential and zero ozone-depleting potential under evaporation temperatures of 10, −20, −40, and −60 °C and condensation temperatures of 30, 40, and 50 °C, respectively. It is found that the use of pure refrigerant in a two-stage refrigeration system to replace the single-stage refrigeration system, in addition to mixing it into an appropriate mixture, can effectively improve the performance coefficient of the refrigeration system. For single-stage vapor compression refrigeration systems, R1234ze(Z), R601, and R1233zd(E) have the best refrigeration performances among the environmentally friendly refrigerants studied, while R441A performs the worst for T_eva = 10 °C and −20 °C. Moreover, RE170 has the highest COP of the refrigeration system for T_eva = −40 °C and −60 °C. However, R1234yf performs worse in COP when the evaporation temperature is lower, and it ranks last for T_eva = −60 °C. When a double-stage vapor compression refrigeration system is employed instead, the percentage increase in the COP of the system using R1234yf becomes the largest for T_eva = −40 °C and −60 °C. However, the growth rate of R717 ranks last for T_eva = −60 °C. For an R717/R1234yf mixture at an optimum mass fraction of 0.25, the COP of the refrigeration system can be increased up to 25.8% despite an increase of 15.2% in operating pressure compared to R1234yf. The discharge temperature may rise; however, there will be no overheating problem for the compressor. Full article

The composition of food baskets can significantly influence the water consumption rate and society’s environmental impact. This study evaluates the sustainability of Iran’s food and nutrition security by evaluating five food baskets using water and carbon-footprint indices. These food baskets are the common Iranian food basket (CIFB), the vegetarian food basket (VFB), the Ministry of Health desired food basket (MHDFB), the Swiss Society for Nutrition food basket (SSNFB), and the Mediterranean food basket (MFB). This study also examines the role of Iran’s agricultural sector under the Paris Climate Change Agreement (COP21). The TOPSIS multi-criteria decision-making method was used to identify the most desirable food basket. The results of this study show that the VFB could be the most desirable alternative to the CIFB. Replacing the CIFB with the VFB causes a 10% and 21% lower water and carbon footprint, respectively. From a 30-year perspective (around 2050), choosing the VFB would reduce the blue water footprint by 19.7 BCM and the gray water footprint by 3.6 BCM compared to the CIFB. According to the provisions of COP21 regarding Iran’s voluntary program to reduce greenhouse gas emissions, the agricultural sector will be one of the sources of greenhouse gas emissions that will face an upward trend. Hence, to adhere to this voluntary commitment, these emissions should be reduced by changing the CIFB to the VFB or reducing emissions in other sectors, such as industry. Choosing the VFB can reduce 10.7 million tons of CO₂ emissions, which can be a significant step for the agricultural sector in Iran in reducing greenhouse gas emissions. Overall, considering the characteristics of farm products (water and carbon footprints) in Iran, a country located in a semi-arid climate, the VFB is recommended. Full article

Cholesterol present in food of animal origin is a precursor of oxysterols (COPs), whose high intake through diet can be associated with health implications. Evaluation of the content of these contaminants in food is associated with many analytical problems. This work presents a GC-TOF/MS method for the simultaneous determination of squalene, cholesterol and seven COPs (7-ketocholesterol, 7α-hydroxycholesterol, 7β-hydroxycholesterol, 25-hydroxycholesterol, 5,6α-epoxycholesterol, 5,6β-epoxycholesterol, cholestanetriol). The sample preparation procedure includes such steps as saponification, extraction and silylation. The method is characterized by high sensitivity (limit of quantification, 0.02–0.25 ng mL⁻¹ for instrument, 30–375 μg kg of sample), repeatability (RSD 2.3–6.2%) and a wide linearity range for each tested compound. The method has been tested on eight different animal-origin products. The COP to cholesterol content ratio in most products is about 1%, but the profile of cholesterol derivatives differs widely (α = 0.01). In all the samples, 7-ketocholesterol is the dominant oxysterol, accounting for 31–67% of the total COPs level. The levels of the other COPs range between 0% and 21%. In none of the examined products are cholestanetriol and 25-hydroxycholesterol present. The amount of squalene, which potentially may inhibit the formation of COPs in food, ranges from 2 to 57 mg kg⁻¹. Full article

The sugarcane supply chain is one of the main contributors to economic development in many countries. However, it is necessary to consider the relationship of this supply chain with the environment in order to reduce/mitigate adverse environmental impacts. Life cycle assessment (LCA) supports improving the relationship between production systems and the environment, increasing process efficiency, and reducing costs. The main objective of this research was to identify the extent to which the sugarcane supply chain impacts environmental and human health aspects as well as the use of resources through LCA. This analysis focused on a supply chain in Brazil’s Midwest region, considering the stages of cultivation, transportation, and production. The results indicated that using fertilizers and pesticides and burning crops during harvest severely threaten the sustainability of this supply chain. Also, using crude oil, natural gas, coal, and other chemical products in ethanol production is a critical threat to the sustainability of the sugarcane supply chain. The obtained results cooperate with the decarbonization goals assumed by Brazil at the United Nations Climate Change Conference 2015 (COP 21). A multidimensional approach is necessary to assess the sugarcane production chain results, and the LCA method is appropriate for performing this analysis. Full article

Immersive Virtual Reality (VR) systems are expanding as sensorimotor readaptation tools for older adults. However, this purpose may be challenged by cybersickness occurrences possibly caused by sensory conflicts. This study aims to analyze the effects of aging and multisensory data fusion processes in the brain on cybersickness and the adaptation of postural responses when exposed to immersive VR. Methods: We repeatedly exposed 75 participants, aged 21 to 86, to immersive VR while recording the trajectory of their Center of Pressure (CoP). Participants rated their cybersickness after the first and fifth exposure. Results: The repeated exposures increased cybersickness and allowed for a decrease in postural responses from the second repetition, i.e., increased stability. We did not find any significant correlation between biological age and cybersickness scores. On the contrary, even if some postural responses are age-dependent, a significant postural adaptation occurred independently of age. The CoP trajectory length in the anteroposterior axis and mean velocity were the postural parameters the most affected by age and repetition. Conclusions: This study suggests that cybersickness and postural adaptation to immersive VR are not age-dependent and that cybersickness is unrelated to a deficit in postural adaptation or age. Age does not seem to influence the properties of multisensory data fusion. Full article

With the 2015 publication of his encyclical letter Laudato Si’: On Care for Our Common Home, Pope Francis emerged as a leading religious voice (alongside Patriarch Bartholomew) advocating for ecological justice and environmental sustainability. This remarkable exercise of global leadership has demonstrably influenced subsequent discourse, activism and deliberations on the environment, including the Paris Agreement of the United Nations Climate Change Conference (COP 21) in December 2015. In order to advance the collective understanding of the diagnosis of the environmental crisis and the prescriptions for change presented by Pope Francis in this teaching document, this essay examines key terms, claims and conceptual tools presented in its pages. This essay opens with a pointed analysis of the historical context within which this particular religious contribution to environmental justice proceeds. It closes by tracing certain key outcomes and ongoing impacts of the contribution of Pope Francis to this area of social concern. Full article

To reduce CO${}_2$ emissions in the industrial sector, high-temperature heat pumps are a key technology. This work presents an approach to design such an industrial heat pump system capable of supplying 200 ${}^{°}$C sink temperature and a capacity of approximately 1 MW. Today’s market-available heat pumps using displacement compressors are not suitable for reaching that high sink temperatures as they need lubricating oil, which is not temperature resistant enough. As a consequence, in this study a transcritical heat pump cycle using a two-stage oil-free radial compressor is investigated. Based on preliminary studies, R1233zd(E) is chosen as a refrigerant. The procedure couples 1D thermodynamic cycle simulations with a radial compressor mean-line design model. A preliminary geometry for a compressor with and without inlet guide vanes is presented, and compressor maps including the compressors behaviour in off-design are calculated. The compressor design is then imported into a 1D simulation to analysis the performance of the heat pump in the whole operating range. In the analysis, the application of a fixed inlet is evaluated, and an improvement of approximately 21% and 16% of the isentropic efficiency is achieved. The thermodynamic simulations showed a maximum COP of approximately 2.8 and a possible operating range of 0.5 to 1.3 MW thermal power. Furthermore, a techno-economical analysis by means of a deep-fryer use case showed reasonable payback times of between 2 and 10 years, depending on the electricity to gas price ratio. Full article

The increasing concentration of anthropogenic CO₂ in the air is one of the main causes of global warming. The Paris Agreement at COP 21 aims to reach the global peak of greenhouse gas emissions in the second half of this century, with CO₂ conversion towards valuable added compounds being one of the main strategies, especially in the field of heterogeneous catalysis. In the current search for new catalysts, the deposition of metallic nanoparticles (NPs) supported on metal oxides and metal carbide surfaces paves the way to new catalytic solutions. This review provides a comprehensive description and analysis of the relevant literature on the utilization of metal-supported NPs as catalysts for CO₂ conversion to useful chemicals and propose that the next catalysts generation can be led by single-metal-atom deposition, since in general, small metal particles enhance the catalytic activity. Among the range of potential indicators of catalytic activity and selectivity, the relevance of NPs’ size, the strong metal–support interactions, and the formation of vacancies on the support are exhaustively discussed from experimental and computational perspective. Full article

Despite the climate commitments made by countries in the Paris Climate Agreement adopted in 2015 and reinforced during COP 21 and with notably less success during COP 22, world carbon emissions increased in both 2021 and 2022. It is increasingly unlikely that the world will achieve the targeted 50% carbon reduction by 2030, the reduction approximately needed for reducing global temperature rise since the beginning of the Industrial Revolution to less than 1.5 deg. C. At the same time, there remain nearly 2 billion people in the world who have no or highly unreliable access to power. In developed countries, access to both clean energy and energy efficiency investment in residences within low to moderate income communities has also lagged. This paper provides a review of the “Productive Use of Energy (PUE)”, which is a means to add value to solar energy mini- and micro-grids to ensure investment worthiness and add more value to the communities being served. In this context, it posits an opportunity to leverage Bitcoin mining as a common PUE strategy applicable to new solar installations. Several actual pilot cases are described to demonstrate this potential throughout the world and at multiple scales. These include: (i) existing micro-grids with significant stranded energy to generate income that could be used to reduce the cost per kWh for the community; (ii) new solar micro-grids optimized to meet community load and mining operations; (iii) dedicated solar-powered Bitcoin mining mini-grids developed solely to create a funding stream for self-investment by communities for their benefit; and (iv) a low-income residential solar-powered Bitcoin miner to reduce the energy cost burden for residents. Several of these scenarios show significant potential to aid investment worthiness. Full article

Background: Understanding balance ability and assessing the risk of possible falls are very important for elderly rehabilitation. The Mini-Balanced Evaluation System Test (Mini-BESTest) is an important survey for older adults to evaluate subject balance, but it is not easy to complete due to various limitations of physical activities, including occasional fear of injury. A center of pressure (CoP) signal can be extracted from a force pressure plate with a short recording time, and it is relatively achievable to ask subjects to stand on a force pressure plate in a clinical environment. The goal of this study is to estimate the cutoff score of Mini-BESTest scores from CoP data. Methods: CoP signals from a human balance evaluation database with data from 75 people were used. Time domain, frequency domain, and nonlinear domain parameters of 60 s CoP signals were extracted to classify different cutoff point scores for both linear regression and a decision tree algorithm. Classification performances were evaluated by accuracy and area under a receiver operating characteristic curve. Results: The correlation coefficient between real and estimated Mini-BESTest scores by linear regression is 0.16. Instead of linear regression, binary classification accuracy above or below a cutoff point score was developed to examine the CoP classification performance for Mini-BESTest scores. The decision tree algorithm is superior to regression analysis among scores from 16 to 20. The highest area under the curve is 0.76 at a cutoff point score of 21 for the CoP measurement condition of eyes opened on the foam, and the corresponding classification accuracy is 76.15%. Conclusions: CoP measurement is a potential tool to estimate corresponding balance and fall survey scores for elderly rehabilitation and is useful for clinical users. Full article