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24 pages, 4301 KiB  
Article
Estimation of the Kinetic Coefficient of Friction of Asphalt Pavements Using the Top Topography Surface Roughness Power Spectrum
by Bo Sun, Haoyuan Luo, Yibo Rong and Yanqin Yang
Materials 2025, 18(15), 3643; https://doi.org/10.3390/ma18153643 (registering DOI) - 2 Aug 2025
Abstract
This study proposes a method for estimating the kinetic coefficient of friction (COF) for asphalt pavements by improving and applying Persson’s friction theory. The method utilizes the power spectral density (PSD) of the top surface topography instead of the full PSD to better [...] Read more.
This study proposes a method for estimating the kinetic coefficient of friction (COF) for asphalt pavements by improving and applying Persson’s friction theory. The method utilizes the power spectral density (PSD) of the top surface topography instead of the full PSD to better reflect the actual contact conditions. This approach avoids including deeper roughness components that do not contribute to real rubber–pavement contact due to surface skewness. The key aspect of the method is determining an appropriate cutting plane to isolate the top surface. Four cutting strategies were evaluated. Results show that the cutting plane defined at 0.5 times the root mean square (RMS) height exhibits the highest robustness across all pavement types, with the estimated COF closely matching the measured values for all four tested surfaces. This study presents an improved method for estimating the kinetic coefficient of friction (COF) of asphalt pavements by employing the power spectral density (PSD) of the top surface roughness, rather than the total surface profile. This refinement is based on Persson’s friction theory and aims to exclude the influence of deep surface irregularities that do not make actual contact with the rubber interface. The core of the method lies in defining an appropriate cutting plane to isolate the topographical features that contribute most to frictional interactions. Four cutting strategies were investigated. Among them, the cutting plane positioned at 0.5 times the root mean square (RMS) height demonstrated the best overall applicability. COF estimates derived from this method showed strong consistency with experimentally measured values across all four tested asphalt pavement surfaces, indicating its robustness and practical potential. Full article
(This article belongs to the Section Construction and Building Materials)
19 pages, 2574 KiB  
Article
The Neuroregenerative Effects of IncobotulinumtoxinA (Inco/A) in a Nerve Lesion Model of the Rat
by Oscar Sánchez-Carranza, Wojciech Danysz, Klaus Fink, Maarten Ruitenberg, Andreas Gravius and Jens Nagel
Int. J. Mol. Sci. 2025, 26(15), 7482; https://doi.org/10.3390/ijms26157482 (registering DOI) - 2 Aug 2025
Abstract
The use of Botulinum Neurotoxin A (BoNT/A) to treat peripheral neuropathic pain from nerve injury has garnered interest for its long-lasting effects and safety. This study examined the effects of IncobotulinumtoxinA (Inco/A), a BoNT/A variant without accessory proteins, on nerve regeneration in rats [...] Read more.
The use of Botulinum Neurotoxin A (BoNT/A) to treat peripheral neuropathic pain from nerve injury has garnered interest for its long-lasting effects and safety. This study examined the effects of IncobotulinumtoxinA (Inco/A), a BoNT/A variant without accessory proteins, on nerve regeneration in rats using the chronic constriction injury (CCI) model. Inco/A was administered perineurally at two time points: on days 0 and 21 post CCI. Functional and histological assessments were conducted to evaluate the effect of Inco/A on nerve regeneration. Sciatic Functional Index (SFI) measurements and Compound Muscle Action Potential (CMAP) recordings were conducted at different time points following CCI. Inco/A-treated animals exhibited a 65% improved SFI and 22% reduction in CMAP onset latencies compared to the vehicle-treated group, suggesting accelerated functional nerve recovery. Tissue analysis revealed enhanced remyelination in Inco/A-treated animals and 60% reduction in CGRP and double S100β signal expression compared to controls. Strikingly, 30% reduced immune cell influx into the injury site was observed following Inco/A treatment, suggesting that its anti-inflammatory effect contributes to nerve regeneration. These findings show that two injections of Inco/A promote functional recovery by enhancing neuroregeneration and modulating inflammatory processes, supporting the hypothesis that Inco/A has a neuroprotective and restorative role in nerve injury conditions. Full article
(This article belongs to the Section Molecular Neurobiology)
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20 pages, 4847 KiB  
Article
FCA-STNet: Spatiotemporal Growth Prediction and Phenotype Extraction from Image Sequences for Cotton Seedlings
by Yiping Wan, Bo Han, Pengyu Chu, Qiang Guo and Jingjing Zhang
Plants 2025, 14(15), 2394; https://doi.org/10.3390/plants14152394 (registering DOI) - 2 Aug 2025
Abstract
To address the limitations of the existing cotton seedling growth prediction methods in field environments, specifically, poor representation of spatiotemporal features and low visual fidelity in texture rendering, this paper proposes an algorithm for the prediction of cotton seedling growth from images based [...] Read more.
To address the limitations of the existing cotton seedling growth prediction methods in field environments, specifically, poor representation of spatiotemporal features and low visual fidelity in texture rendering, this paper proposes an algorithm for the prediction of cotton seedling growth from images based on FCA-STNet. The model leverages historical sequences of cotton seedling RGB images to generate an image of the predicted growth at time t + 1 and extracts 37 phenotypic traits from the predicted image. A novel STNet structure is designed to enhance the representation of spatiotemporal dependencies, while an Adaptive Fine-Grained Channel Attention (FCA) module is integrated to capture both global and local feature information. This attention mechanism focuses on individual cotton plants and their textural characteristics, effectively reducing the interference from common field-related challenges such as insufficient lighting, leaf fluttering, and wind disturbances. The experimental results demonstrate that the predicted images achieved an MSE of 0.0086, MAE of 0.0321, SSIM of 0.8339, and PSNR of 20.7011 on the test set, representing improvements of 2.27%, 0.31%, 4.73%, and 11.20%, respectively, over the baseline STNet. The method outperforms several mainstream spatiotemporal prediction models. Furthermore, the majority of the predicted phenotypic traits exhibited correlations with actual measurements with coefficients above 0.8, indicating high prediction accuracy. The proposed FCA-STNet model enables visually realistic prediction of cotton seedling growth in open-field conditions, offering a new perspective for research in growth prediction. Full article
(This article belongs to the Special Issue Advances in Artificial Intelligence for Plant Research)
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18 pages, 921 KiB  
Article
Occurrence and Transfer by Conjugation of Linezolid- Resistance Among Non-Enterococcus faecalis and Enterococcus faecium in Intensive Pig Farms
by Giorgia Piccioni, Andrea Di Cesare, Raffaella Sabatino, Gianluca Corno, Gianmarco Mangiaterra, Daniela Marchis and Barbara Citterio
Microbiol. Res. 2025, 16(8), 180; https://doi.org/10.3390/microbiolres16080180 (registering DOI) - 2 Aug 2025
Abstract
Enterococcus spp. are opportunistic and nosocomial pathogens. Intensive pig farms have been recently described as important hotspots for antibiotic resistance and reservoirs of potentially pathogenic enterococci, including other species than the most known E. faecalis and E. faecium. Here, we identified Linezolid-resistant [...] Read more.
Enterococcus spp. are opportunistic and nosocomial pathogens. Intensive pig farms have been recently described as important hotspots for antibiotic resistance and reservoirs of potentially pathogenic enterococci, including other species than the most known E. faecalis and E. faecium. Here, we identified Linezolid-resistant non-E. faecalis and E. faecium (NFF) Enterococcus strains isolated from different production stages (suckling piglets, weaning pigs, and fatteners) across six intensive pig farms. The transferability of the linezolid-resistance determinants was assessed by bacterial conjugation and strains were also characterized for biofilm production, hemolytic and gelatinase activity. Among 64 identified NFF Enterococcus strains, 27 were resistant to at least three different antibiotic classes and 8/27 specifically to Linezolid. E. gallinarum and E. casseliflavus both transferred their Linezolid resistance determinants to the main pathogenic species E. faecium. Remarkably, this is the first report of the optrA gene transfer from E. casseliflavus to E. faecium by conjugation, which can greatly contribute to the spread of antibiotic resistance genes among pathogenic enterococcal species. The “weaning pigs” stage exhibited a significantly higher number of antibiotic-resistant enterococci than the “fatteners”. These findings highlight the importance of monitoring pig farms as hotspots for the spread of antibiotic-resistant enterococci, especially in the early stages of production. Furthermore, they underscore the significant role of NFF Enterococcus species as carriers of antibiotic resistance genes, even to last-resort antibiotics, which may be transferable to the major enterococcal species. Full article
(This article belongs to the Special Issue Zoonotic Bacteria: Infection, Pathogenesis and Drugs—Second Edition)
22 pages, 2498 KiB  
Article
SceEmoNet: A Sentiment Analysis Model with Scene Construction Capability
by Yi Liang, Dongfang Han, Zhenzhen He, Bo Kong and Shuanglin Wen
Appl. Sci. 2025, 15(15), 8588; https://doi.org/10.3390/app15158588 (registering DOI) - 2 Aug 2025
Abstract
How do humans analyze the sentiments embedded in text? When attempting to analyze a text, humans construct a “scene” in their minds through imagination based on the text, generating a vague image. They then synthesize the text and the mental image to derive [...] Read more.
How do humans analyze the sentiments embedded in text? When attempting to analyze a text, humans construct a “scene” in their minds through imagination based on the text, generating a vague image. They then synthesize the text and the mental image to derive the final analysis result. However, current sentiment analysis models lack such imagination; they can only analyze based on existing information in the text, which limits their classification accuracy. To address this issue, we propose the SceEmoNet model. This model endows text classification models with imagination through Stable diffusion, enabling the model to generate corresponding visual scenes from input text, thus introducing a new modality of visual information. We then use the Contrastive Language-Image Pre-training (CLIP) model, a multimodal feature extraction model, to extract aligned features from different modalities, preventing significant feature differences caused by data heterogeneity. Finally, we fuse information from different modalities using late fusion to obtain the final classification result. Experiments on six datasets with different classification tasks show improvements of 9.57%, 3.87%, 3.63%, 3.14%, 0.77%, and 0.28%, respectively. Additionally, we set up experiments to deeply analyze the model’s advantages and limitations, providing a new technical path for follow-up research. Full article
(This article belongs to the Special Issue Advanced Technologies and Applications of Emotion Recognition)
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19 pages, 1797 KiB  
Article
Predicting Adsorption Performance Based on the Properties of Activated Carbon: A Case Study of Shenqi Fuzheng System
by Zhilong Tang, Bo Chen, Wenhua Huang, Xuehua Liu, Xinyu Wang and Xingchu Gong
Chemosensors 2025, 13(8), 279; https://doi.org/10.3390/chemosensors13080279 (registering DOI) - 1 Aug 2025
Abstract
This work aims to solve the problem of product quality fluctuations caused by batch-to-batch variations in the adsorption capacity of activated carbon during the production of traditional Chinese medicine (TCM) injections. In this work, Shenqi Fuzheng injection was selected as an example. Diluted [...] Read more.
This work aims to solve the problem of product quality fluctuations caused by batch-to-batch variations in the adsorption capacity of activated carbon during the production of traditional Chinese medicine (TCM) injections. In this work, Shenqi Fuzheng injection was selected as an example. Diluted Shenqi Extract (DSE), an intermediate in the production process of Shenqi Fuzheng injection, was adsorbed with different batches of activated carbon. The adsorption capacities of adenine, adenosine, calycosin-7-glucoside, and astragaloside IV in DSE were selected as evaluation indices for activated carbon absorption. Characterization methods such as nitrogen adsorption, X-ray photoelectron spectrum (XPS), and Fourier transform infrared (FTIR) were chosen to explore the quantitative relationships between the properties of activated carbon (i.e., specific surface area, pore volume, surface elements, and spectrum) and the adsorption capacities of these four components. It was found that the characteristic wavelengths from FTIR characterization, i.e., 1560 cm−1, 2325 cm−1, 3050 cm−1, and 3442 cm−1, etc., showed the strongest correlation with the adsorption capacities of these four components. Prediction models based on the transmittance at characteristic wavelengths were successfully established via multiple linear regression. In validation experiments of models, the relative errors of predicted adsorption capacities of activated carbon were mostly within 5%, indicating good predictive ability of the models. The results of this work suggest that the prediction method of adsorption capacity based on the mid-infrared spectrum can provide a new way for the quality control of activated carbon. Full article
(This article belongs to the Section Analytical Methods, Instrumentation and Miniaturization)
23 pages, 1480 KiB  
Article
Operator Newton Method for Large-Scale Coupled Riccati Equations Arising from Jump Systems
by Bo Yu, Yiwen Liu and Ning Dong
Axioms 2025, 14(8), 601; https://doi.org/10.3390/axioms14080601 (registering DOI) - 1 Aug 2025
Abstract
Consider a class of coupled discrete-time Riccati equations arising from jump systems. To compute their solutions when systems reach a steady state, we propose an operator Newton method and correspondingly establish its quadratic convergence under suitable assumptions. The advantage of the proposed method [...] Read more.
Consider a class of coupled discrete-time Riccati equations arising from jump systems. To compute their solutions when systems reach a steady state, we propose an operator Newton method and correspondingly establish its quadratic convergence under suitable assumptions. The advantage of the proposed method lies in the fact that its subproblems are solved using the operator Smith method, which allows it to maintain quadratic convergence in both the inner and outer iterations. Moreover, it does not require the constant term matrix of the equation to be invertible, making it more broadly applicable than existing inverse-free iterative methods. For large-scale problems, we develop a low-rank variant by incorporating truncation and compression techniques into the operator Newton framework. A complexity analysis is also provided to assess its scalability. Numerical experiments demonstrate that the presented low-rank operator Newton method is highly effective in approximating solutions to large-scale structured coupled Riccati equations. Full article
(This article belongs to the Special Issue Advances in Linear Algebra with Applications, 2nd Edition)
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16 pages, 2028 KiB  
Article
A Hybrid Algorithm for PMLSM Force Ripple Suppression Based on Mechanism Model and Data Model
by Yunlong Yi, Sheng Ma, Bo Zhang and Wei Feng
Energies 2025, 18(15), 4101; https://doi.org/10.3390/en18154101 (registering DOI) - 1 Aug 2025
Abstract
The force ripple of a permanent magnet synchronous linear motor (PMSLM) caused by multi-source disturbances in practical applications seriously restricts its high-precision motion control performance. The traditional single-mechanism model has difficulty fully characterizing the nonlinear disturbance factors, while the data-driven method has real-time [...] Read more.
The force ripple of a permanent magnet synchronous linear motor (PMSLM) caused by multi-source disturbances in practical applications seriously restricts its high-precision motion control performance. The traditional single-mechanism model has difficulty fully characterizing the nonlinear disturbance factors, while the data-driven method has real-time limitations. Therefore, this paper proposes a hybrid modeling framework that integrates the physical mechanism and measured data and realizes the dynamic compensation of the force ripple by constructing a collaborative suppression algorithm. At the mechanistic level, based on electromagnetic field theory and the virtual displacement principle, an analytical model of the core disturbance terms such as the cogging effect and the end effect is established. At the data level, the acceleration sensor is used to collect the dynamic response signal in real time, and the data-driven ripple residual model is constructed by combining frequency domain analysis and parameter fitting. In order to verify the effectiveness of the algorithm, a hardware and software experimental platform including a multi-core processor, high-precision current loop controller, real-time data acquisition module, and motion control unit is built to realize the online calculation and closed-loop injection of the hybrid compensation current. Experiments show that the hybrid framework effectively compensates the unmodeled disturbance through the data model while maintaining the physical interpretability of the mechanistic model, which provides a new idea for motor performance optimization under complex working conditions. Full article
23 pages, 3467 KiB  
Article
Resampling Multi-Resolution Signals Using the Bag of Functions Framework: Addressing Variable Sampling Rates in Time Series Data
by David Orlando Salazar Torres, Diyar Altinses and Andreas Schwung
Sensors 2025, 25(15), 4759; https://doi.org/10.3390/s25154759 (registering DOI) - 1 Aug 2025
Abstract
In time series analysis, the ability to effectively handle data with varying sampling rates is crucial for accurate modeling and analysis. This paper presents the MR-BoF (Multi-Resolution Bag of Functions) framework, which leverages sampling-rate-independent techniques to decompose time series data while accommodating signals [...] Read more.
In time series analysis, the ability to effectively handle data with varying sampling rates is crucial for accurate modeling and analysis. This paper presents the MR-BoF (Multi-Resolution Bag of Functions) framework, which leverages sampling-rate-independent techniques to decompose time series data while accommodating signals with differing resolutions. Unlike traditional methods that require uniform sampling frequencies, the BoF framework employs a flexible encoding approach, allowing for the integration of multi-resolution time series. Through a series of experiments, we demonstrate that the BoF framework ensures the precise reconstruction of the original data while enhancing resampling capabilities by utilizing decomposed components. The results show that this method offers significant advantages in scenarios involving irregular sampling rates and heterogeneous acquisition systems, making it a valuable tool for applications in fields such as finance, healthcare, industrial monitoring, IoT networks, and sensor networks. Full article
(This article belongs to the Section Intelligent Sensors)
19 pages, 481 KiB  
Article
Trust the Machine or Trust Yourself: How AI Usage Reshapes Employee Self-Efficacy and Willingness to Take Risks
by Zhiyong Han, Guoqing Song, Yanlong Zhang and Bo Li
Behav. Sci. 2025, 15(8), 1046; https://doi.org/10.3390/bs15081046 (registering DOI) - 1 Aug 2025
Abstract
As artificial intelligence (AI) technology becomes increasingly widespread in organizations, its impact on individual employees’ psychology and behavior has garnered growing attention. Existing research primarily focuses on AI’s effects on organizational performance and job design, with limited exploration of its mechanisms influencing individual [...] Read more.
As artificial intelligence (AI) technology becomes increasingly widespread in organizations, its impact on individual employees’ psychology and behavior has garnered growing attention. Existing research primarily focuses on AI’s effects on organizational performance and job design, with limited exploration of its mechanisms influencing individual employees, particularly in the critical area of risk-taking behavior, which is essential to organizational innovation. This research develops a moderated mediation model grounded in social cognitive theory (SCT) to explore how AI usage affects the willingness to take risks. A three-wave longitudinal study collected and statistically analyzed data from 442 participants. The findings reveal that (1) AI usage significantly enhances employees’ willingness to take risks; (2) self-efficacy serves as a partial mediator in the connection between AI usage and the willingness to take risks; and (3) learning goal orientation moderates both the relationship between AI usage and self-efficacy, as well as the mediating effect. This research enhances our understanding of AI’s impact on organizational behavior and provides valuable insights for human resource management in the AI era. Full article
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25 pages, 916 KiB  
Article
Technology-Enabled Cross-Platform Disposal of Idle Clothing in Social and E-Commerce Synergy: An Integrated TPB-TCV Framework
by Xingjun Ru, Ziyi Li, Qian Shang, Le Liu and Bo Gong
J. Theor. Appl. Electron. Commer. Res. 2025, 20(3), 189; https://doi.org/10.3390/jtaer20030189 - 1 Aug 2025
Abstract
This study integrates the Theory of Planned Behavior and the Theory of Consumption Values through a mixed-methods approach (structured interview and structural equation model) to investigate cross-platform disposal behaviors for idle clothing on social media and second-hand platform ecosystems. The study reconstructs traditional [...] Read more.
This study integrates the Theory of Planned Behavior and the Theory of Consumption Values through a mixed-methods approach (structured interview and structural equation model) to investigate cross-platform disposal behaviors for idle clothing on social media and second-hand platform ecosystems. The study reconstructs traditional theoretical variables: psychological motivation dimension (platform-enabled green attitude, social circle environmental demonstration, and cross-platform behavioral control) and perceived value dimension (functional integration value perception, socialized emotional empowerment, and community identity value). Key findings: Cross-platform behavioral control is the strongest predictor of behavioral intention. In the value dimension, emotional value has the strongest direct impact on disposal intentions, functional integration is key to enhancing behavioral control, and community identity value most significantly impacts the platform-enabled green attitude and the social circle environmental demonstration. Finally, proposing a governance framework of “technological empowerment–emotional resonance–identity motivation”, offering theoretical foundations for optimizing platform interoperability and formulating digital environmental policies. Full article
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14 pages, 2052 KiB  
Article
Study on the Shear Strength and Durability of Ionic Soil Stabilizer-Modified Soft Soil in Acid Alkali Environments
by Zhifeng Ren, Shijie Lin, Siyu Liu, Bo Li, Jiankun Liu, Liang Chen, Lideng Fan, Ziling Xie and Lingjie Wu
Eng 2025, 6(8), 178; https://doi.org/10.3390/eng6080178 - 1 Aug 2025
Abstract
Soft soils, characterized by high compressibility, low shear strength, and high water sensitivity, pose serious challenges to geotechnical engineering in infrastructure projects. Traditional stabilization methods such as lime and cement face limitations, including environmental concerns and poor durability under chemical or cyclic loading. [...] Read more.
Soft soils, characterized by high compressibility, low shear strength, and high water sensitivity, pose serious challenges to geotechnical engineering in infrastructure projects. Traditional stabilization methods such as lime and cement face limitations, including environmental concerns and poor durability under chemical or cyclic loading. Ionic soil stabilizers (ISSs), which operate through electrochemical mechanisms, offer a promising alternative. However, their long-term performance—particularly under environmental stressors such as acid/alkali exposure and cyclic wetting–drying—remains insufficiently explored. This study evaluates the strength and durability of ISS-modified soil through a comprehensive experimental program, including direct shear tests, permeability tests, and cyclic wetting–drying experiments under neutral, acidic (pH = 4), and alkaline (pH = 10) environments. The results demonstrate that ISS treatment increases soil cohesion by up to 75.24% and internal friction angle by 9.50%, particularly under lower moisture conditions (24%). Permeability decreased by 88.4% following stabilization, resulting in only a 10–15% strength loss after water infiltration, compared to 40–50% in untreated soils. Under three cycles of wetting–drying, ISS-treated soils retained high shear strength, especially under acidic conditions, where degradation was minimal. In contrast, alkaline conditions caused a cohesion reduction of approximately 26.53%. These findings confirm the efficacy of ISSs in significantly improving both the mechanical performance and environmental durability of soft soils, offering a sustainable and effective solution for soil stabilization in chemically aggressive environments. Full article
(This article belongs to the Section Chemical, Civil and Environmental Engineering)
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20 pages, 15301 KiB  
Article
Application of CH241 Stainless Steel with High Concentration of Mn and Mo: Microstructure, Mechanical Properties, and Tensile Fatigue Life
by Ping-Yu Hsieh, Bo-Ding Wu and Fei-Yi Hung
Metals 2025, 15(8), 863; https://doi.org/10.3390/met15080863 (registering DOI) - 1 Aug 2025
Abstract
A novel stainless steel with high Mn and Mo content (much higher than traditional stainless steel), designated CH241SS, was developed as a potential replacement for Cr-Mo-V alloy steel in the cold forging applications of precision industry. Through carbon reduction in an environmentally friendly [...] Read more.
A novel stainless steel with high Mn and Mo content (much higher than traditional stainless steel), designated CH241SS, was developed as a potential replacement for Cr-Mo-V alloy steel in the cold forging applications of precision industry. Through carbon reduction in an environmentally friendly manner and a two-stage heat treatment process, the hardness of as-cast CH241 was tailored from HRC 37 to HRC 29, thereby meeting the industrial specifications of cold-forged steel (≤HRC 30). X-ray diffraction analysis of the as-cast microstructure revealed the presence of a small amount of ferrite, martensite, austenite, and alloy carbides. After heat treatment, CH241 exhibited a dual-phase microstructure consisting of ferrite and martensite with dispersed Cr(Ni-Mo) alloy carbides. The CH241 alloy demonstrated excellent high-temperature stability. No noticeable softening occurred after 72 h for the second-stage heat treatment. Based on the mechanical and room-temperature tensile fatigue properties of CH241-F (forging material) and CH241-ST (soft-tough heat treatment), it was demonstrated that the CH241 stainless steel was superior to the traditional stainless steel 4xx in terms of strength and fatigue life. Therefore, CH241 stainless steel can be introduced into cold forging and can be used in precision fatigue application. The relevant data include composition design and heat treatment properties. This study is an important milestone in assisting the upgrading of the vehicle and aerospace industries. Full article
(This article belongs to the Special Issue Advanced High Strength Steels: Properties and Applications)
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68 pages, 2838 KiB  
Review
Unravelling the Viral Hypothesis of Schizophrenia: A Comprehensive Review of Mechanisms and Evidence
by Mădălina Georgeta Sighencea and Simona Corina Trifu
Int. J. Mol. Sci. 2025, 26(15), 7429; https://doi.org/10.3390/ijms26157429 (registering DOI) - 1 Aug 2025
Abstract
Schizophrenia is a challenging multifactorial neuropsychiatric disease that involves interactions between genetic susceptibility and environmental insults. Increasing evidence implicates viral infections as significant environmental contributors, particularly during sensitive neurodevelopmental periods. This review synthesises current findings on the viral hypothesis of schizophrenia, encompassing a [...] Read more.
Schizophrenia is a challenging multifactorial neuropsychiatric disease that involves interactions between genetic susceptibility and environmental insults. Increasing evidence implicates viral infections as significant environmental contributors, particularly during sensitive neurodevelopmental periods. This review synthesises current findings on the viral hypothesis of schizophrenia, encompassing a wide array of neurotropic viruses, including influenza viruses, herpesviruses (HSV-1 and 2, CMV, VZV, EBV, HHV-6 and 8), hepatitis B and C viruses, HIV, HERVs, HTLV, Zika virus, BoDV, coronaviruses (including SARS-CoV-2), and others. These pathogens can contribute to schizophrenia through mechanisms such as direct microinvasion, persistent central nervous system infection, immune-mediated neuroinflammation, molecular mimicry, and the disturbance of the blood–brain barrier. Prenatal exposure to viral infections can trigger maternal immune activation, resulting in cytokine-mediated alterations in the neurological development of the foetus that persist into adulthood. Genetic studies highlight the role of immune-related loci, including major histocompatibility complex polymorphisms, in modulating susceptibility to infection and neurodevelopmental outcomes. Clinical data also support the “mild encephalitis” hypothesis, suggesting that a subset of schizophrenia cases involve low-grade chronic neuroinflammation. Although antipsychotics have some immunomodulatory effects, adjunctive anti-inflammatory therapies show promise, particularly in treatment-resistant cases. Despite compelling associations, pathogen-specific links remain inconsistent, emphasising the need for longitudinal studies and integrative approaches such as viromics to unravel causal relationships. This review supports a “multi-hit” model in which viral infections interfere with hereditary and immunological susceptibilities, enhancing schizophrenia risk. Elucidating these virus–immune–brain interactions may facilitate the discovery of biomarkers, targeted prevention, and novel therapeutic strategies for schizophrenia. Full article
(This article belongs to the Special Issue Schizophrenia: From Molecular Mechanism to Therapy)
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20 pages, 4765 KiB  
Article
Ultrasonic EDM for External Cylindrical Surface Machining with Graphite Electrodes: Horn Design and Hybrid NSGA-II–AHP Optimization of MRR and Ra
by Van-Thanh Dinh, Thu-Quy Le, Duc-Binh Vu, Ngoc-Pi Vu and Tat-Loi Mai
Machines 2025, 13(8), 675; https://doi.org/10.3390/machines13080675 (registering DOI) - 1 Aug 2025
Abstract
This study presents the first investigation into the application of ultrasonic vibration-assisted electrical discharge machining (UV-EDM) using graphite electrodes for external cylindrical surface machining—an essential surface in the production of tablet punches and sheet metal-forming dies. A custom ultrasonic horn was designed and [...] Read more.
This study presents the first investigation into the application of ultrasonic vibration-assisted electrical discharge machining (UV-EDM) using graphite electrodes for external cylindrical surface machining—an essential surface in the production of tablet punches and sheet metal-forming dies. A custom ultrasonic horn was designed and fabricated using 90CrSi material to operate effectively at a resonant frequency of 20 kHz, ensuring stable vibration transmission throughout the machining process. A Box–Behnken experimental design was employed to explore the effects of five process parameters—vibration amplitude (A), pulse-on time (Ton), pulse-off time (Toff), discharge current (Ip), and servo voltage (SV)—on two key performance indicators: material removal rate (MRR) and surface roughness (Ra). The optimization process was conducted in two stages: single-objective analysis to maximize MRR while ensuring Ra < 4 µm, followed by a hybrid multi-objective approach combining NSGA-II and the Analytic Hierarchy Process (AHP). The optimal solution achieved a high MRR of 9.28 g/h while maintaining Ra below the critical surface finish threshold, thus meeting the practical requirements for punch surface quality. The findings confirm the effectiveness of the proposed horn design and hybrid optimization strategy, offering a new direction for enhancing productivity and surface integrity in cylindrical EDM applications using graphite electrodes. Full article
(This article belongs to the Section Advanced Manufacturing)
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