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Article

20 Citations

4,139 Views

17 Pages

The ECM Modulator ITIH5 Affects Cell Adhesion, Motility and Chemotherapeutic Response of Basal/Squamous-Like (BASQ) Bladder Cancer Cells

Michael Rose,
Erik Noetzel,
Jennifer Kistermann,
Julian Eschenbruch,
Sandra Rushrush,
Lin Gan,
Ruth Knüchel,
Nadine T. Gaisa and
Edgar Dahl

Cells2021, 10(5), 1038;https://doi.org/10.3390/cells10051038

28 April 2021

This study aims at characterizing the role of the putative tumor suppressor ITIH5 in basal-type bladder cancers (BLCA). By sub-classifying TCGA BLCA data, we revealed predominant loss of ITIH5 expression in the basal/squamous-like (BASQ) subtype. ITI...

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Article

40 Citations

4,001 Views

13 Pages

Immunohistochemistry-Based Taxonomical Classification of Bladder Cancer Predicts Response to Neoadjuvant Chemotherapy

Albert Font,
Montserrat Domènech,
Raquel Benítez,
Marta Rava,
Miriam Marqués,
José L. Ramírez,
Silvia Pineda,
Sara Domínguez-Rodríguez,
José L. Gago and
Francisco X. Real
+ 6 authors

Cancers2020, 12(7), 1784;https://doi.org/10.3390/cancers12071784

3 July 2020

Background: Platinum-based neoadjuvant chemotherapy (NAC) increases the survival of patients with organ-confined urothelial bladder cancer (UBC). In retrospective studies, patients with basal/squamous (BASQ)-like tumors present with more advanced dis...

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Article

2 Citations

1,602 Views

23 Pages

SOX2 Regulates Growth, Expression of Basal/Luminal Markers, and Chemotherapy Response in Urothelial Carcinoma

Nelofar Nargis,
Abigail Lind,
Adam Sczepanski,
Randi Herndon,
Olivia Smiley,
Seema Somji,
Donald A. Sens and
Aaron A. Mehus

Cells2025, 14(13), 949;https://doi.org/10.3390/cells14130949

20 June 2025

Urothelial carcinoma (UC) is a common genitourinary malignancy. Smoking, exposure to arsenic in drinking water, and age can increase the risk of developing UC. Neoadjuvant cisplatin-based chemotherapy prior to radical cystectomy is the standard treat...

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Article

3 Citations

2,686 Views

15 Pages

Distinct Infiltration of T Cell Populations in Bladder Cancer Molecular Subtypes

Viktor Sincic,
Ken F. Arlenhold,
Sarah Richtmann,
Henrik Lilljebjörn,
Pontus Eriksson,
Gottfrid Sjödahl,
Mats Wokander,
Karin Hägerbrand,
Peter Ellmark and
Kristina Lundberg
+ 3 authors

Cells2024, 13(11), 926;https://doi.org/10.3390/cells13110926

28 May 2024

Bladder cancer is a heterogenous disease, and molecular subtyping is a promising method to capture this variability. Currently, the immune compartment in relation to subtypes is poorly characterized. Here, we analyzed the immune compartment in bladde...

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