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23 pages, 6131 KB  
Article
Integration of Snowmelt Runoff Model (SRM) with GIS and Remote Sensing for Operational Forecasting in the Kırkgöze Watershed, Turkey
by Serkan Şenocak and Reşat Acar
Water 2026, 18(3), 335; https://doi.org/10.3390/w18030335 - 29 Jan 2026
Abstract
Accurate snowmelt runoff prediction is critical for water resource management in mountainous regions where seasonal snowpack constitutes the dominant water supply. This study demonstrates operational application of the degree-day-based Snowmelt Runoff Model (SRM) integrated with Geographic Information Systems (GIS) and multi-platform remote sensing [...] Read more.
Accurate snowmelt runoff prediction is critical for water resource management in mountainous regions where seasonal snowpack constitutes the dominant water supply. This study demonstrates operational application of the degree-day-based Snowmelt Runoff Model (SRM) integrated with Geographic Information Systems (GIS) and multi-platform remote sensing for discharge forecasting in the Kirkgoze Basin (242.7 km2, 1823–3140 m elevation), Eastern Anatolia, Turkey. Three automatic weather stations spanning 872 m elevation gradient provided meteorological forcing, while MODIS MOD10A2 8-day composite products supplied operational snow cover observations validated against Landsat-5/7 (30 m resolution, 87.3% agreement, Kappa = 0.73) and synthetic aperture radar imagery (RADARSAT-1 C-band, ALOS-PALSAR L-band). Uncalibrated model performance was modest (R2 = 0.384, volumetric difference = 29.78%), demonstrating necessity of site-specific calibration. Systematic adjustment of snowmelt and rainfall runoff coefficients yielded excellent calibrated performance for 2009 melt season: R2 = 0.8606, correlation coefficient R = 0.927, Nash–Sutcliffe efficiency = 0.854, and volumetric difference = 3.35%. Enhanced temperature lapse rate (0.75 °C/100 m vs. standard 0.65 °C/100 m) reflected severe continental climate. Multiple linear regression analysis identified temperature, snow-covered area, snow water equivalent, and calibrated runoff coefficients as significant discharge predictors (R2 = 0.881). Results confirm SRM’s operational feasibility for seasonal forecasting and flood warning in data-scarce snow-dominated basins, with modest requirements (daily temperature, precipitation, and satellite snow cover) aligning with operational monitoring capabilities. The methodology provides a transferable framework for regional water resource management in climatically vulnerable mountain environments where snowmelt supports agriculture, hydropower, and municipal supply. Full article
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40 pages, 9833 KB  
Article
Decision-Level Fusion of PS-InSAR and Optical Data for Landslide Susceptibility Mapping Using Wavelet Transform and MAMBA
by Hongyi Guo, Antonio M. Martínez-Graña, Leticia Merchán, Agustina Fernández and Manuel Casado
Land 2026, 15(2), 211; https://doi.org/10.3390/land15020211 - 26 Jan 2026
Viewed by 94
Abstract
Landslides remain a critical geohazard in mountainous regions, where intensified extreme rainfall and rapid land-use changes exacerbate slope instability, challenging the reliability of traditional single-sensor susceptibility assessments. To overcome the limitations of data heterogeneity and noise, this study presents a decision-level fusion strategy [...] Read more.
Landslides remain a critical geohazard in mountainous regions, where intensified extreme rainfall and rapid land-use changes exacerbate slope instability, challenging the reliability of traditional single-sensor susceptibility assessments. To overcome the limitations of data heterogeneity and noise, this study presents a decision-level fusion strategy integrating Permanent Scatterer InSAR (PS-InSAR) deformation dynamics with multi-source optical remote sensing indicators via a Wavelet Transform (WT) enhanced Multi-source Additive Model Based on Bayesian Analysis (MAMBA). San Martín del Castañar (Spain), a region characterized by rugged terrain and active deformation, served as the study area. We utilized Sentinel-1A C-band datasets (January 2020–February 2025) as the primary source for continuous monitoring, complemented by L-band ALOS-2 observations to ensure coherence in vegetated zones, yielding 24,102 high-quality persistent scatterers. The WT-based multi-scale enhancement improved the signal-to-noise ratio by 23.5% and increased deformation anomaly detection by 18.7% across 24,102 validated persistent scatterers. Bayesian fusion within MAMBA produced high-resolution susceptibility maps, indicating that very-high and high susceptibility zones occupy 24.0% of the study area while capturing 84.5% of the inventoried landslides. Quantitative validation against 1247 landslide events (2020–2025) achieved an AUC of 0.912, an overall accuracy of 87.3%, and a recall of 84.5%, outperforming Random Forest, Logistic Regression, and Frequency Ratio models by 6.8%, 10.8%, and 14.3%, respectively (p < 0.001). Statistical analysis further demonstrates a strong geo-ecological coupling, with landslide susceptibility significantly correlated with ecological vulnerability (r = 0.72, p < 0.01), while SHapley Additive exPlanations identify land-use type, rainfall, and slope as the dominant controlling factors. Full article
(This article belongs to the Special Issue Ground Deformation Monitoring via Remote Sensing Time Series Data)
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13 pages, 248 KB  
Article
Factors Affecting Recovery from Post-Traumatic Amnesia During Inpatient Brain Injury Rehabilitation: A Retrospective Cohort Study
by Rathi Ratha Krishnan, Yuhan Yang, Emily Yee and Karen Sui Geok Chua
Life 2026, 16(2), 203; https://doi.org/10.3390/life16020203 - 26 Jan 2026
Viewed by 125
Abstract
Background: Longer post-traumatic amnesia (PTA) durations in traumatic brain injury (TBI) are associated with worse functional outcomes, poorer cognition, and persistent disability. A retrospective cohort study was conducted to evaluate factors affecting PTA duration and emergence. Methods: Data extraction of discharged records of [...] Read more.
Background: Longer post-traumatic amnesia (PTA) durations in traumatic brain injury (TBI) are associated with worse functional outcomes, poorer cognition, and persistent disability. A retrospective cohort study was conducted to evaluate factors affecting PTA duration and emergence. Methods: Data extraction of discharged records of adult TBI was performed between 1 April 2022 and 4 May 2023. Independent variables collected include socio-demographic, acute TBI, and rehabilitation characteristics. Admission/discharge Functional Independence Measure (FIM) was the main rehabilitation outcome measure charted. Dependent variables included PTA duration ≤ 30 days, >30 days, and PTA emergence. Results: A total of 189 datasets were analysed. Median age (IQR) 64 years (26), 145 males (76.7%), and 64.6% >55 years. PTA ≥ 30 days were correlated with the following factors: older age (66 years vs. 59.5 years, p = 0.017), presence of ICU admission (75.2% vs. 61.4%, p = 0.029), longer ICU stays (5 days vs. 3 days, p = 0.001), and longer duration of inpatient hospitalization (acute length of stay, ALOS 23 days vs. ALOS 14 days, p < 0.001). Age ≥ 55 years were 5.6 times as likely (p = 0.011) to be in prolonged PTA, an additional day’s stay in the acute hospital increased the odds by 1.15 (p < 0.001), and every score lost in the total admission FIM from 40 and below increased the odds of prolonged PTA by 3.35 times (p = 0.014). Conclusions: This study demonstrated that older age at TBI onset and longer ALOS significantly increased the risk of prolonged PTA duration. Conversely, higher admission FIM score, lower age at admission, and shorter ALOS were associated with lower PTA duration. Full article
27 pages, 16408 KB  
Article
A SNR-Based Adaptive Goldstein Filter for Ionospheric Faraday Rotation Estimation Using Spaceborne Full-Polarimetric SAR Data
by Zelin Wang, Xun Wang, Dong Li and Yunhua Zhang
Remote Sens. 2026, 18(2), 378; https://doi.org/10.3390/rs18020378 - 22 Jan 2026
Viewed by 100
Abstract
The spaceborne full-polarimetric (FP) synthetic aperture radar (SAR) is an advanced sensor for high-resolution Earth observation. However, FP data acquired by such a system are prone to distortions induced by ionospheric Faraday rotation (FR). From the perspective of exploiting these distortions, this enables [...] Read more.
The spaceborne full-polarimetric (FP) synthetic aperture radar (SAR) is an advanced sensor for high-resolution Earth observation. However, FP data acquired by such a system are prone to distortions induced by ionospheric Faraday rotation (FR). From the perspective of exploiting these distortions, this enables the estimation of the ionospheric FR angle (FRA), and consequently the total electron content, across most global regions (including the extensive ocean areas) using spaceborne FP SAR measurements. The accuracy of FRA estimation, however, is highly sensitive to noise interference. This study addresses denoising in FRA retrieval based on the Bickel–Bates estimator, with a specific focus on noise reduction methods built upon the adaptive Goldstein filter (AGF) that was originally designed for radar interferometric processing. For the first time, three signal-to-noise ratio (SNR)-based AGFs suitable for FRA estimation are investigated. A key feature of these filters is that their SNRs are all defined using the amplitude of the Bickel–Bates estimator signal rather than the FRA estimates themselves. Accordingly, these AGFs are applied to the estimator signal instead of the estimated FRAs. Two of the three AGFs are developed by adopting the mathematical forms of SNRs and filter parameters consistent with the existing SNR-based AGFs for interferogram. The third AGF is newly proposed by utilizing more general mathematical forms of SNR and filter parameter that differ from the first two. Specifically, its SNR definition aligns with that widely used in image processing, and its filter parameter is derived as a function of the defined SNR plus an additionally introduced adjustable factor. The three SNR-based AGFs tailored for FRA estimation are tested and evaluated against existing AGF variants and classical image denoising methods using three sets of FP SAR Datasets acquired by the L-band ALOS PALSAR sensor, encompassing an ocean-only scene, a plain land–ocean combined scene, and a more complex land–ocean combined scene. Experimental results demonstrate that all three filters can effectively mitigate noise, with the newly proposed AGF achieving the best performance among all denoising methods included in the comparison. Full article
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44 pages, 16501 KB  
Article
Morphotectonic Analysis of Upper Guajira Region, Colombia Using Multi-Resolution DEMs, Landsat-8, and WGM-12 Data
by Juan David Solano-Acosta, Jillian Pearse and Ana Ibis Despaigne-Diaz
Geosciences 2026, 16(1), 52; https://doi.org/10.3390/geosciences16010052 - 22 Jan 2026
Viewed by 141
Abstract
This study utilizes Digital Elevation Models (DEMs) with different spatial resolutions (SRTM 90 m, ASTER DEM 30 m, and ALOS PALSAR 12.5 m), Landsat-8 satellite imagery, and the Bouguer WGM-12 gravity model to analyze morphotectonic features in the Upper Guajira region of Colombia, [...] Read more.
This study utilizes Digital Elevation Models (DEMs) with different spatial resolutions (SRTM 90 m, ASTER DEM 30 m, and ALOS PALSAR 12.5 m), Landsat-8 satellite imagery, and the Bouguer WGM-12 gravity model to analyze morphotectonic features in the Upper Guajira region of Colombia, a desert area in northern South America, area that is composed by low-relief serranías of Cabo de la Vela, Carpintero, Cosinas, Simarua, Jarara, and Macuira. Three DEMs were used to extract and map morphotectonic lineaments, drainage networks, and morphological features. Lineaments were characterised by azimuth frequency, length, density, lithological distributions, and geological timeframes, with support from a digitized geological map from the Colombian Geological Service (SGC). The analysis of the east–west (E-W) Cuisa fault, using the Riedel shear model, suggests a transtensional/transpressional tectonic regime influenced by the Caribbean and South American plates, characterised by NE-SW and E-W fault orientations. Lineaments were grouped into five geochronological categories based on the geological map, revealing a shift from NE-SW to E-W orientations from the Cretaceous period onward, reflecting the ongoing movement of the Caribbean plate. Folds and faults from this tectonic activity were enhanced using Landsat-8 band combinations. The WGM-12 model was separated into regional and residual signals, with the latter highlighting the serranías subregions. Residual gravity analysis revealed significant negative anomalies, suggesting lower-density lithologies surrounded by higher-density blocks. This pattern aligns with the regional geological framework and may reflect a crustal root or terrain dragging linked to the tectonic processes that shaped the serranías. Derivative residual gravity data also revealed lineaments oriented NE–SW, whose distribution extends beyond the morphometric boundaries of the subregions. The study found a strong correlation between structural and drainage patterns, demonstrating structural control over geomorphology. This study establishes a solid morphotectonic and geophysical framework for the Upper Guajira region, demonstrating how multi-resolution DEM analysis combined with gravity data can resolve regional deformation patterns, crustal architecture, and tectonic development along the Caribbean–South American plate boundary. Full article
(This article belongs to the Section Structural Geology and Tectonics)
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24 pages, 5216 KB  
Article
Characterizing L-Band Backscatter in Inundated and Non-Inundated Rice Paddies for Water Management Monitoring
by Go Segami, Kei Oyoshi, Shinichi Sobue and Wataru Takeuchi
Remote Sens. 2026, 18(2), 370; https://doi.org/10.3390/rs18020370 - 22 Jan 2026
Viewed by 106
Abstract
Methane emissions from rice paddies account for over 11% of global atmospheric CH4, making water management practices such as Alternate Wetting and Drying (AWD) critical for climate change mitigation. Remote sensing offers an objective approach to monitoring AWD implementation and improving [...] Read more.
Methane emissions from rice paddies account for over 11% of global atmospheric CH4, making water management practices such as Alternate Wetting and Drying (AWD) critical for climate change mitigation. Remote sensing offers an objective approach to monitoring AWD implementation and improving greenhouse gas estimation accuracy. This study investigates the backscattering mechanisms of L-band SAR for inundation/non-inundation classification in paddy fields using full-polarimetric ALOS-2 PALSAR-2 data. Field surveys and satellite observations were conducted in Ryugasaki (Ibaraki) and Sekikawa (Niigata), Japan, collecting 1360 ground samples during the 2024 growing season. Freeman–Durden decomposition was applied, and relationships with plant height and water level were analyzed. The results indicate that plant height strongly influences backscatter, with backscattering contributions from the surface decreasing beyond 70 cm, reducing classification accuracy. Random forest models can classify inundated and non-inundated fields with up to 88% accuracy when plant height is below 70 cm. However, when using this method, it is necessary to know the plant height. Volume scattering proved robust to incidence angle and observation direction, suggesting its potential for phenological monitoring. These findings highlight the effectiveness of L-band SAR for water management monitoring and the need for integrating crop height estimation and regional adaptation to enhance classification performance. Full article
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22 pages, 3491 KB  
Article
Synergistic Effects and Differential Roles of Dual-Frequency and Multi-Dimensional SAR Features in Forest Aboveground Biomass and Component Estimation
by Yifan Hu, Yonghui Nie, Haoyuan Du and Wenyi Fan
Remote Sens. 2026, 18(2), 366; https://doi.org/10.3390/rs18020366 - 21 Jan 2026
Viewed by 90
Abstract
Accurate quantification of forest aboveground biomass (AGB) is essential for monitoring terrestrial carbon stocks. While total AGB estimation is widely practiced, resolving component biomass such as canopy, branches, leaves, and trunks enhances the precision of carbon sink assessments and provides critical structural parameters [...] Read more.
Accurate quantification of forest aboveground biomass (AGB) is essential for monitoring terrestrial carbon stocks. While total AGB estimation is widely practiced, resolving component biomass such as canopy, branches, leaves, and trunks enhances the precision of carbon sink assessments and provides critical structural parameters for ecosystem modeling. Most studies rely on a single SAR sensor or a limited range of SAR features, which restricts their ability to represent vegetation structural complexity and reduces biomass estimation accuracy. Here, we propose a phased fusion strategy that integrates backscatter intensity, interferometric coherence, texture measures, and polarimetric decomposition parameters derived from dual-frequency ALOS-2, GF-3, and Sentinel-1A SAR data. These complementary multi-dimensional SAR features are incorporated into a Random Forest model optimized using an Adaptive Genetic Algorithm (RF-AGA) to estimate forest total and component estimation. The results show that the progressive incorporation of coherence and texture features markedly improved model performance, increasing the accuracy of total AGB to R2 = 0.88 and canopy biomass to R2 = 0.78 under leave-one-out cross-validation. Feature contribution analysis indicates strong complementarity among SAR parameters. Polarimetric decomposition yielded the largest overall contribution, while L-band volume scattering was the primary driver of trunk and canopy estimation. Coherence-enhanced trunk prediction increased R2 by 13 percent, and texture improved canopy representation by capturing structural heterogeneity and reducing saturation effects. This study confirms that integrating coherence and texture information within the RF-AGA framework enhances AGB estimation, and that the differential contributions of multi-dimensional SAR parameters across total and component biomass estimation originate from their distinct structural characteristics. The proposed framework provides a robust foundation for regional carbon monitoring and highlights the value of integrating complementary SAR features with ensemble learning to achieve high-precision forest carbon assessment. Full article
(This article belongs to the Special Issue Advances in Multi-Sensor Remote Sensing for Vegetation Monitoring)
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16 pages, 3884 KB  
Article
Cobalt Diffusion Treatment in Topaz: Process and Mechanism of Color Modification
by Xiaoxu Yan, Suwei Yue, Zida Tong, Yuzhi Zhang and Yun Wu
Minerals 2026, 16(1), 94; https://doi.org/10.3390/min16010094 - 19 Jan 2026
Viewed by 226
Abstract
Topaz is one of the most economically important fluorine-rich nesosilicates, which are predominantly colorless in natural crystals. Hence, the trade relies almost entirely on irradiated blue topaz with an unstable color center, which has been shown to fade over time. The cobalt (Co) [...] Read more.
Topaz is one of the most economically important fluorine-rich nesosilicates, which are predominantly colorless in natural crystals. Hence, the trade relies almost entirely on irradiated blue topaz with an unstable color center, which has been shown to fade over time. The cobalt (Co) diffusion treatment is a stable alternative process for converting colorless topaz to blue by a solid-state diffusion mechanism. To investigate the potential role of Co2+ substitution in the formation of the blue layer and the coupled behavior of F/OH dehydroxylation in facilitating this process, systematic diffusion treatments have been successfully conducted and compared. In this study, gem-quality topazes were annealed in air at 1000 °C for 20–40 h (hr) along with CoO, Fe2O3, Cr2O3, and CuO powders. The diffused products were characterized using Scanning Electron Microscope (SEM), Ultraviolet-Visible absorption spectroscopy (UV-Vis), Near-Mid Infrared spectroscopy (NMIR), and X-ray photoelectron spectroscopy (XPS). Parallel runs with CuO, Fe2O3, or Cr2O3 alone confirmed that none of these oxides produces a stable blue layer, underscoring the unique role of Co. The Co-diffused sample displays an intense blue layer characterized by a Co2+ octahedral isomorphism triplet at 540, 580, and 630 nm, which are absent from both untreated and heat-only controls. XPS analysis reveals the emergence of Co2+ (binding energy: 780.63 eV) and a concomitant depletion in F, along with the disappearance of the OH overtone absorption at 7123 cm−1. These observations confirm that defluorination generates octahedral vacancies accommodated by the coupled substitution: CoF2 (solid reactant) + (AlO2) (fragment of topaz structure) → AlOF (solid product) + (CoOF) (fragment of topaz structure). Prolonged annealing leads to decreased relative atomic percentages of K+ and F ions, consistent with volatilization losses during the high-temperature process, thereby directly correlating color intensity with cobalt valence state, which transfers from Co2+ to Co3+. These findings establish a Co-incorporation chronometer for F–rich aluminosilicate systems, with an optimal annealing time of approximately 20 hr at 1000 °C. Furthermore, the above results demonstrate that the color mechanism in nesosilicate gems is simultaneously governed by volatile release and cation availability. Full article
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23 pages, 40663 KB  
Article
Time Series Analysis of Fucheng-1 Interferometric SAR for Potential Landslide Monitoring and Synergistic Evaluation with Sentinel-1 and ALOS-2
by Guangmin Tang, Keren Dai, Feng Yang, Weijia Ren, Yakun Han, Chenwen Guo, Tianxiang Liu, Shumin Feng, Chen Liu, Hao Wang, Chenwei Zhang and Rui Zhang
Remote Sens. 2026, 18(2), 304; https://doi.org/10.3390/rs18020304 - 16 Jan 2026
Viewed by 135
Abstract
Fucheng-1 is China’s first commercial synthetic aperture radar (SAR) satellite equipped with interferometric capabilities. Since its launch in 2023, it has demonstrated strong potential across a range of application domains. However, a comprehensive and systematic evaluation of its overall performance, including its time-series [...] Read more.
Fucheng-1 is China’s first commercial synthetic aperture radar (SAR) satellite equipped with interferometric capabilities. Since its launch in 2023, it has demonstrated strong potential across a range of application domains. However, a comprehensive and systematic evaluation of its overall performance, including its time-series monitoring capability, is still lacking. This study applies the Small Baseline Subset (SBAS-InSAR) method to conduct the first systematic processing and evaluation of 22 Fucheng-1 images acquired between 2023 and 2024. A total of 45 potential landslides were identified and subsequently validated through field investigations and UAV-based LiDAR data. Comparative analysis with Sentinel-1 and ALOS-2 indicates that Fucheng-1 demonstrates superior performance in small-scale deformation identification, temporal-variation characterization, and maintaining a high density of coherent pixels. Specifically, in the time-series InSAR-based potential landslide identification, Fucheng-1 identified 13 small-scale potential landslides, whereas Sentinel-1 identified none; the number of identifications is approximately 2.17 times that of ALOS-2. For time-series subsidence monitoring, the deformation magnitudes retrieved from Fucheng-1 are generally larger than those from Sentinel-1, mainly attributable to finer spatial sampling enabled by its higher spatial resolution and a higher maximum detectable deformation gradient. Moreover, as landslide size decreases, the advantages of Fucheng-1 in deformation identification and subsidence estimation become increasingly evident. Interferometric results further show that the number of high-coherence pixels for Fucheng-1 is 7–8 times that of co-temporal Sentinel-1 and 1.1–1.4 times that of ALOS-2, providing more high-quality observations for time-series inversion and thereby supporting a more detailed and spatially continuous reconstruction of deformation fields. Meanwhile, the orbital stability of Fucheng-1 is comparable to that of Sentinel-1, and its maximum detectable deformation gradient in mountainous terrain reaches twice that of Sentinel-1. Overall, this study provides the first systematic validation of the time-series InSAR capability of Fucheng-1 under complex terrain conditions, offering essential support and a solid foundation for the operational deployment of InSAR technologies based on China’s domestic SAR satellite constellation. Full article
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23 pages, 12387 KB  
Article
Behavioral, Histopathological, and Biochemical Implications of Aloe Emodin in Copper-Aβ-Induced Alzheimer’s Disease-like Model Rats
by Xitong Zhao, Jianing Yin, Baojian Du, Wenqian Fan, Yang Chen, Yazhu Yang, Fang Fang and Jun Guan
Curr. Issues Mol. Biol. 2026, 48(1), 86; https://doi.org/10.3390/cimb48010086 - 15 Jan 2026
Viewed by 178
Abstract
Simultaneously inhibiting beta-amyloid protein (Aβ) aggregation and reducing metal ion overload in the brain is a promising strategy for treating Alzheimer’s disease (AD). Aloe emodin (AE) is one of the major components of the traditional Chinese medicine rhubarb. Based on its reported pharmacological [...] Read more.
Simultaneously inhibiting beta-amyloid protein (Aβ) aggregation and reducing metal ion overload in the brain is a promising strategy for treating Alzheimer’s disease (AD). Aloe emodin (AE) is one of the major components of the traditional Chinese medicine rhubarb. Based on its reported pharmacological effects and its structural affinity for metal ions, this study aims to explore the potential of AE in improving AD pathology. Through the injection of Aβ or copper-Aβ complex in the bilateral hippocampus of rats, we constructed two kinds of nontransgenic animal models. Behavioral tests were used to evaluate cognitive impairment, and the effects of AE on neuronal damage and Aβ deposition were measured via Nissl staining and immunohistochemistry. Furthermore, we detected copper content in the serum and brain tissues as well as some biochemical indexes of Aβ cascade pathology in the brain tissues of model rats to explore the mechanism of action. AE treatment decreased copper accumulation and regulated Aβ metabolism in the brain of model rats, thereby improving Aβ deposition, memory impairment, hippocampal nerve cell damage, and related biochemical indicators. AE ameliorated the AD pathology of the model rats by targeting copper-induced Aβ toxicity, revealing a mechanism of action by which AE may exhibit good clinical efficacy in treating AD. Full article
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11 pages, 696 KB  
Article
Clinical Benefits of Aloe vera Gel in 0.3% Hyaluronate Eyedrops in Glaucoma Therapy-Related Ocular Surface Disease
by Luca Agnifili, Davide Celani, Alessandro Sferra, Maria Ludovica Ruggeri, Rodolfo Mastropasqua, Michele Figus and Matteo Sacchi
Biomedicines 2026, 14(1), 186; https://doi.org/10.3390/biomedicines14010186 - 15 Jan 2026
Viewed by 308
Abstract
Background: Aloe vera gel in 0.3% hyaluronate (AV/HA) could mitigate glaucoma therapy-related ocular surface disease (GTOSD). Methods: Thirty-nine patients diagnosed with GTOSD and receiving AV/HA or HA underwent ocular surface disease index (OSDI), Symptom Assessment iN Dry Eye (SANDE), National Eye [...] Read more.
Background: Aloe vera gel in 0.3% hyaluronate (AV/HA) could mitigate glaucoma therapy-related ocular surface disease (GTOSD). Methods: Thirty-nine patients diagnosed with GTOSD and receiving AV/HA or HA underwent ocular surface disease index (OSDI), Symptom Assessment iN Dry Eye (SANDE), National Eye Institute Visual Function Questionnaire (NEI VFQ)-25 questionnaires, and tear matrix metalloproteinase-9 (MMP-9), break-up time (BUT), corneal fluorescein staining (CFS), Schirmer test I (STI), and bulbar conjunctival hyperemia (BCH) determination. Results: After one month, AV/HA increased BUT (5 (7–4.5) to 7 (8–5.5)) and STI (12 (19.5–8) to 13.5 (20–10)), while it decreased BCH (2.2 (2.3–1.3) to 2.1 (2.2–1.2)) and CFS (3 (4–2) to 2 (3.0–1.5)) (p < 0.001). SANDE and OSDI scores were reduced from 36.18 (38.5–20.5) to 22.91 (31.5–17.21), and 29.5 (32.5–19.5) to 20 (26.5–18) (p < 0.001). HA reduced BCH from 2.75 (3.20–2.15) to 2.25 (2.30–1.90) (p = 0.014) and CFS from 3.5 (5–2.75) to 2.5 (4–2) (p = 0.014), while it increased BUT (p = 0.036). The SANDE score decreased from 28.95 (47.6–20.9) to 26.86 (36.41–19.90) (p = 0.009), whereas the OSDI decreased from 40 (49–19.5) to 29 (42–19.75) (p = 0.005). Any significant change in NEI VFQ-25 was collected. A trend for an MMP-9 immunoassay positivity reduction was observed in AV/HA (0.073). Conclusions: These findings invite considering lubricants enriched with natural anti-inflammatory agents, such as Aloe vera, as a potential adjunctive option to improve the ocular surface in glaucoma. Full article
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17 pages, 2793 KB  
Article
Exploring the Anti-Inflammatory Effects of Aloe vera Flower (AVF) and Its Active Ingredients in a Skin Inflammation Model Induced by Glyoxal-Derived Advanced Glycation End Products (GO-AGEs)
by Eun Yoo Lee, Seong-Min Hong, Sun Yeou Kim and Razia Sultana
Pharmaceuticals 2026, 19(1), 121; https://doi.org/10.3390/ph19010121 - 9 Jan 2026
Viewed by 569
Abstract
Objective: Advanced glycation end-products (AGEs) contribute to oxidative stress and inflammation, leading to various disorders, including skin inflammation. Here, we investigated the anti-inflammatory effects of Aloe vera flower (AVF) extract and its active constituents, vitexin (V) and isovitexin (IV), in a glyoxal-derived [...] Read more.
Objective: Advanced glycation end-products (AGEs) contribute to oxidative stress and inflammation, leading to various disorders, including skin inflammation. Here, we investigated the anti-inflammatory effects of Aloe vera flower (AVF) extract and its active constituents, vitexin (V) and isovitexin (IV), in a glyoxal-derived AGE (GO-AGE)-induced skin inflammaging model. Methods: We evaluated the effects of AVF, V, and IV in epidermal keratinocytes (HaCaT cells) using enzyme-linked immunosorbent assay, Western blotting, quantitative real-time polymerase chain reaction, and in silico molecular docking. Results: Treatment of HaCaT cells with AVF, V, or IV significantly suppressed the secretion and expression of interleukins (IL-6 and IL-8) at both the mRNA and protein level, and reduced the expression of key inflammatory proteins, including kappa-light-chain-enhancer of activated B cells (NF-κB) and cyclooxygenase-2 (COX-2), and phosphorylation of mitogen-activated protein kinase (MAPK) pathway proteins. Notably, the inhibitory effects of V and IV on COX-2 expression were more comparable to or exceeded those of the positive control (Epigallocatechin gallate), even at a lower concentration. Conversely, the expression of sirtuin 1 (SIRT1) was upregulated by AVF, V, and IV, with IV showing 1.5-fold upregulation. Molecular docking analyses supported these findings, with IV displaying a particularly high binding affinity for COX-2 (−11.0 kcal/mol). Conclusions: These findings highlight the potential of AVF, V, and IV as novel therapeutic agents for managing skin inflammaging by modulating inflammatory pathways. Full article
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22 pages, 18075 KB  
Article
Geodynamic Characterization of Hydraulic Structures in Seismically Active Almaty Using Lineament Analysis
by Dinara Talgarbayeva, Andrey Vilayev, Tatyana Dedova, Oxana Kuznetsova, Larissa Balakay and Aibek Merekeyev
GeoHazards 2026, 7(1), 11; https://doi.org/10.3390/geohazards7010011 - 9 Jan 2026
Viewed by 256
Abstract
Monitoring the stability of hydraulic structures such as dams and reservoirs in seismically active regions is essential for ensuring their safety and operational reliability. This study presents a comprehensive geospatial approach combining lineament analysis and geodynamic zoning to assess the structural stability of [...] Read more.
Monitoring the stability of hydraulic structures such as dams and reservoirs in seismically active regions is essential for ensuring their safety and operational reliability. This study presents a comprehensive geospatial approach combining lineament analysis and geodynamic zoning to assess the structural stability of the Voroshilov and Priyut reservoirs located in the Almaty region, Kazakhstan. A regional lineament map was generated using ASTER GDEM data, while ALOS PALSAR data were used for detailed local analysis. Lineaments were extracted and analyzed through automated processing in PCI Geomatica. Lineament density maps and azimuthal rose diagrams were constructed to identify zones of tectonic weakness and assess regional structural patterns. Integration of lineament density, GPS velocity fields, InSAR deformation data, and probabilistic seismic hazard maps enabled the development of a detailed geodynamic zoning model. Results show that the studied sites are located within zones of low local geodynamic activity, with lineament densities of 0.8–1.2 km/km2, significantly lower than regional averages of 3–4 km/km2. GPS velocities in the area do not exceed 4 mm/year, and InSAR analysis indicates minimal surface deformation (<5 mm/year). Despite this apparent local stability, the 2024 Voroshilov Dam failure highlights the cumulative effect of regional seismic stresses (PGA up to 0.9 g) and localized filtration along fracture zones as critical risk factors. The proposed geodynamic zoning correctly identified the site as structurally stable under normal conditions but indicates that even low-activity zones are vulnerable under cumulative seismic loading. This demonstrates that an integrated approach combining remote sensing, geodetic, and seismic data can provide quantitative assessments for dam safety, predict potential high-risk zones, and support preventive monitoring in tectonically active regions. Full article
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23 pages, 1396 KB  
Article
Physicochemical and Sensory Evaluation of Dark Chocolate Enriched with Aloe vera-Derived Polysaccharide
by Veronika Kotrcová, Ekambaranellore Prakash, Marcela Sluková, Jana Čopíková and Natália Palugová
Polysaccharides 2026, 7(1), 6; https://doi.org/10.3390/polysaccharides7010006 - 9 Jan 2026
Viewed by 339
Abstract
The demand for clean-label functional foods has increased interest in natural polysaccharides with health benefits. Acemannan, an O-acetylated glucomannan from Aloe vera, possesses antioxidant, immunomodulatory, and prebiotic activities, but its performance in fat-based systems is not well understood. This study examined the [...] Read more.
The demand for clean-label functional foods has increased interest in natural polysaccharides with health benefits. Acemannan, an O-acetylated glucomannan from Aloe vera, possesses antioxidant, immunomodulatory, and prebiotic activities, but its performance in fat-based systems is not well understood. This study examined the incorporation of acemannan into dark chocolate at 1% and 5% (w/w) and its effects on physicochemical, rheological, antioxidant, and sensory properties. Particle size distribution remained within acceptable limits, though the 5% sample showed a larger mean size and broader span. Rheological tests confirmed shear-thinning behavior, with the higher concentration increasing viscosity at low shear and reducing it at high shear. Antioxidant activity measured by the DPPH assay showed modest improvement in enriched samples. Consumer tests with 30 panelists indicated a strong preference (89%) for the 1% formulation, which maintained a smooth mouthfeel and balanced sensory characteristics, while the 5% sample displayed more fruity and earthy notes with lower acceptance. GC–MS analysis revealed altered volatile profiles, and FTIR spectroscopy confirmed acemannan stability in the chocolate matrix. These findings demonstrate that acemannan can be incorporated into dark chocolate up to 1% as a multifunctional, structurally stable polysaccharide ingredient without compromising product quality. Full article
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20 pages, 7991 KB  
Article
Future Coastal Inundation Risk Map for Iraq by the Application of GIS and Remote Sensing
by Hamzah Tahir, Ami Hassan Md Din and Thulfiqar S. Hussein
Earth 2026, 7(1), 8; https://doi.org/10.3390/earth7010008 - 8 Jan 2026
Cited by 1 | Viewed by 335
Abstract
The Iraqi coastline in the northern Persian Gulf is highly vulnerable to the impacts of future sea level rise. This study introduces a novel approach in the Arc Geographic Information System (ArcGIS) for inundation risk of the 58 km Iraqi coast of the [...] Read more.
The Iraqi coastline in the northern Persian Gulf is highly vulnerable to the impacts of future sea level rise. This study introduces a novel approach in the Arc Geographic Information System (ArcGIS) for inundation risk of the 58 km Iraqi coast of the northern Persian Gulf through a combination of multi-data sources, machine-learning predictions, and hydrological connectivity by Landsat. The Prophet/Neural Prophet time-series framework was used to extrapolate future sea level rise with 11 satellite altimetry missions that span 1993–2023. The coastline was obtained by using the Landsat-8 Operational Land Imager (OLI) imagery based on the Normalised Difference Water Index (NDWI), and topography was obtained by using the ALOS World 3D 30 m DEM. Global Land Use and Land Cover (LULC) projections (2020–2100) and population projections (2020–2100) were used as future inundation values. Two scenarios were compared, one based on an altimeter-based projection of sea level rise (SLR) and the other based on the National Aeronautics and Space Administration (NASA) high-emission scenario, Representative Concentration Pathway 8.5 (RCP8.5). It is found that, by the IPCC AR6 end-of-century projection horizon (relative to 1995–2014), 154,000 people under the altimeter case and 181,000 people under RCP8.5 will have a risk of being inundated. The highest flooded area is the barren area (25,523–46,489 hectares), then the urban land (5303–5743 hectares), and finally the cropland land (434–561 hectares). Critical infrastructure includes 275–406 km of road, 71–99 km of electricity lines, and 73–82 km of pipelines. The study provides the first hydrologically verified Digital Elevation Model (DEM)-refined inundation maps of Iraq that offer a baseline, in the form of a comprehensive and quantitative base, to the coastal adaptation and climate resilience planning. Full article
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