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  • Article
  • Open Access
7 Citations
5,870 Views
24 Pages

5-Hydroxyindole-Based EZH2 Inhibitors Assembled via TCCA-Catalyzed Condensation and Nenitzescu Reactions

  • Fangyu Du,
  • Qifan Zhou,
  • Wenjiao Sun,
  • Cheng Yang,
  • Chunfu Wu,
  • Lihui Wang and
  • Guoliang Chen

28 April 2020

5-Hydroxyindole derivatives have various demonstrated biological activities. Herein, we used 5-hydroxyindole as a synthetic starting point for structural alterations in a combinatorial process to synthesize 22 different compounds with EZH2 inhibitor...

  • Article
  • Open Access
3 Citations
2,950 Views
16 Pages

Association of Tumor Hydroxyindole O-Methyltransferase and Serum 5-Methoxytryptophan with Long-Term Survival of Hepatocellular Carcinoma

  • Bor-Sheng Ko,
  • Shu-Man Liang,
  • Tzu-Ching Chang,
  • Jing-Yiing Wu,
  • Po-Hsun Lee,
  • Yu-Juei Hsu,
  • Cheng-Chin Kuo,
  • Jun-Yang Liou and
  • Kenneth K. Wu

22 October 2021

5-methoxytryptophan (5-MTP) is a recently discovered tryptophan (Trp) metabolite with anti-inflammatory and tumor-suppressing actions. Its synthesis is catalyzed by hydroxyindole O-methyltransferase (HIOMT). HIOMT levels were reported to be decreased...

  • Article
  • Open Access
2 Citations
3,463 Views
18 Pages

7 April 2023

The Nenitzescu reaction is a condensation reaction between an enamine and a quinone, which can give rise to a wide variety of reaction products depending on the nature of the starting material and the reaction conditions. The most commonly observed p...

  • Article
  • Open Access
5 Citations
3,495 Views
11 Pages

31 October 2019

The enantioselective transformations of indoles preferentially take place in the more-reactive azole ring. However, the methods for the enantioselective functionalization of the indole benzene ring are scarce. In this paper, a series of bifunctional...

  • Article
  • Open Access
2 Citations
2,533 Views
14 Pages

19 December 2023

The rapid analysis and characterization of compounds using mass spectrometry (MS) may overlook trace compounds. Although targeted analysis methods can significantly improve detection sensitivity, it is hard to discover novel scaffold compounds in the...

  • Article
  • Open Access
3 Citations
2,552 Views
17 Pages

Syntheses of New Multisubstituted 1-Acyloxyindole Compounds

  • Ye Eun Kim,
  • Yoo Jin Lim,
  • Chorong Kim,
  • Yu Ra Jeong,
  • Hyunsung Cho and
  • Sang Hyup Lee

10 October 2022

The syntheses of novel 1-acyloxyindole compounds 1 and the investigations on reaction pathways are presented. Nitro ketoester substrate 2, obtained in a two-step synthetic process, underwent reduction, intramolecular addition, nucleophilic 1,5-additi...

  • Article
  • Open Access
11 Citations
3,843 Views
17 Pages

14 August 2019

The aim of this study was to characterize the embryonic ontogeny of 5-hydroxyindoles and 5-methoxyindoles synthesis pathways in the goose pineal organ. The study was performed on embryos aged 14–28 days, which have been incubated under a 12L:12...

  • Article
  • Open Access
11 Citations
2,684 Views
10 Pages

Specific Urinary Metabolites in Malignant Melanoma

  • Marcela Valko-Rokytovská,
  • Beáta Hubková,
  • Anna Birková,
  • Jana Mašlanková,
  • Marek Stupák,
  • Marianna Zábavníková,
  • Beáta Čižmárová and
  • Mária Mareková

Background and objectives: Melanin, which has a confirmed role in melanoma cell behaviour, is formed in the process of melanogenesis and is synthesized from tryptophan, L-tyrosine and their metabolites. All these metabolites are easily detectable by...

  • Article
  • Open Access
16 Citations
3,123 Views
19 Pages

Heterologous Expression of the Melatonin-Related Gene HIOMT Improves Salt Tolerance in Malus domestica

  • Kexin Tan,
  • Jiangzhu Zheng,
  • Cheng Liu,
  • Xianghan Liu,
  • Xiaomin Liu,
  • Tengteng Gao,
  • Xinyang Song,
  • Zhiwei Wei,
  • Fengwang Ma and
  • Chao Li

17 November 2021

Melatonin, a widely known indoleamine molecule that mediates various animal and plant physiological processes, is formed from N-acetyl serotonin via N-acetylserotonin methyltransferase (ASMT). ASMT is an enzyme that catalyzes melatonin synthesis in p...

  • Article
  • Open Access
24 Citations
4,498 Views
15 Pages

17 July 2020

Indole-containing acids—tryptophan metabolites—found in serum and cerebrospinal fluid (CSF) samples of patients with diseases of the central nervous system (CNS) were determined with the use of microextraction by packed sorbent (MEPS) fol...

  • Article
  • Open Access
9 Citations
3,237 Views
15 Pages

3 November 2023

The profile of and dynamic concentration changes in tyrosine, phenylalanine, and tryptophan metabolites in blood are of great interest since they could be considered potential biomarkers of different disorders. Some aromatic metabolites, such as 4-hy...

  • Article
  • Open Access
25 Citations
8,443 Views
17 Pages

Tryptophan: Its Metabolism along the Kynurenine, Serotonin, and Indole Pathway in Malignant Melanoma

  • Beáta Hubková,
  • Marcela Valko-Rokytovská,
  • Beáta Čižmárová,
  • Marianna Zábavníková,
  • Mária Mareková and
  • Anna Birková

15 August 2022

(1) Background: Tryptophan metabolism is known to be one of the important mechanisms used by cancer to evade immune surveillance. Altered tryptophan metabolism was studied in patients with pigmented malignant melanoma confirmed histologically by the...

  • Communication
  • Open Access
1 Citations
2,251 Views
14 Pages

27 July 2023

A novel double Friedel–Crafts reaction of acylsilanes in water is described. This strategy enables synthesis of bis(indolyl)methane derivatives with 1-hydroxy or 1-silyl substituents in moderate to high yield. Compared to the 1-silyl-bis(indoly...

  • Feature Paper
  • Article
  • Open Access
5 Citations
3,400 Views
19 Pages

Fluorescent Pyranoindole Congeners: Synthesis and Photophysical Properties of Pyrano[3,2-f], [2,3-g], [2,3-f], and [2,3-e]Indoles

  • Ainur D. Sharapov,
  • Ramil F. Fatykhov,
  • Igor A. Khalymbadzha,
  • Maria I. Valieva,
  • Igor L. Nikonov,
  • Olga S. Taniya,
  • Dmitry S. Kopchuk,
  • Grigory V. Zyryanov,
  • Anastasya P. Potapova and
  • Oleg N. Chupakhin
  • + 2 authors

13 December 2022

This paper reports the synthesis of four types of annulated pyranoindole congeners: pyrano[3,2-f]indole, pyrano[2,3-g]indole, pyrano[2,3-f]indole, and pyrano[2,3-e]indole and photophysical studies in this series. The synthesis of pyrano[3,2-f], [2,3-...

  • Article
  • Open Access
2 Citations
1,696 Views
14 Pages

Tryptophan Promotes the Production of Xanthophyll Compounds in Yellow Abdominal Fat through HAAO

  • Xiaojing Liu,
  • Lilin Men,
  • Yanji Chen,
  • Yongli Wang,
  • Yanke Wang,
  • Xu Zhang,
  • Huanxian Cui,
  • Yuming Guo and
  • Jie Wen

24 May 2024

Abdominal fat, which in the past was often regarded as waste and discarded, has in recent years been used as a fat source to produce meat by-products. Yellow abdominal fat has higher economic value. Therefore, improving the color of abdominal fat pla...

  • Article
  • Open Access
52 Citations
8,290 Views
16 Pages

12 August 2020

The optimal ranges of protein for healthy adult dogs are not known. This study evaluated the impact of long-term consumption of foods containing low, medium, and high levels of protein on serum, urine, and fecal metabolites, and gut microbiome in bea...

  • Feature Paper
  • Article
  • Open Access
5 Citations
2,870 Views
23 Pages

22 September 2021

The dihydropyranoindole structures were previously identified as promising scaffolds for improving the anti-cancer activity of histone deacetylase inhibitors. This work describes the synthesis of related furoindoles and their ability to synergize wit...

  • Article
  • Open Access
6 Citations
3,994 Views
18 Pages

Synthesis and Biological Evaluation of New Glycoconjugated LDH Inhibitors as Anticancer Agents

  • Felicia D’Andrea,
  • Giulia Vagelli,
  • Carlotta Granchi,
  • Lorenzo Guazzelli,
  • Tiziano Tuccinardi,
  • Giulio Poli,
  • Dalila Iacopini,
  • Filippo Minutolo and
  • Valeria Di Bussolo

28 September 2019

Conjugation of known biologically active molecules to carbohydrate frameworks represents a valuable option for the preparation of hybrid, structurally-related families of compounds with the aim of modulating their biological response. Therefore, we p...

  • Article
  • Open Access
3 Citations
1,676 Views
11 Pages

Maternal Obesity and Differences in Child Urine Metabolome

  • Ellen C. Francis,
  • Kelly J. Hunt,
  • William A. Grobman,
  • Daniel W. Skupski,
  • Ashika Mani and
  • Stefanie N. Hinkle

25 October 2024

Background/objective: Approximately one-third of pregnant individuals in the U.S. are affected by obesity, which can adversely impact the in utero environment and offspring. This study aimed to investigate the differences in urine metabolomics betwee...

  • Article
  • Open Access
3 Citations
2,127 Views
17 Pages

6 August 2024

This study aimed to evaluate the effects of Clostridium butyricum (C. butyricum) on the prevention of the diarrhea rates and growth performances of weaned piglets induced by Escherichia coli K88 (E. coli K88). Twenty-four weaned piglets (6.92 ±...

  • Article
  • Open Access
18 Citations
4,729 Views
17 Pages

UPLC-HRMS-Based Plasma Metabolomic Profiling of Novel Biomarkers by Treatment with KDZI in Cerebral Ischemia Reperfusion Rats

  • Chunguo Wang,
  • Chenyue Liu,
  • Min Wang,
  • Quantao Ma,
  • Yaqi Li,
  • Ting Wang and
  • Baosheng Zhao

Kudiezi injection (KDZI), also known as Diemailing injection, is a traditional Chinese medicine injection of the composite plant Ixeris sonchifolia Hance (also known as Kudiezi), and has been widely used to treat coronary heart disease, angina pector...

  • Article
  • Open Access
17 Citations
6,025 Views
15 Pages

A Comparative Genomic and Transcriptomic Survey Provides Novel Insights into N-Acetylserotonin Methyltransferase (ASMT) in Fish

  • Kai Zhang,
  • Zhiqiang Ruan,
  • Jia Li,
  • Chao Bian,
  • Xinxin You,
  • Steven L. Coon and
  • Qiong Shi

2 October 2017

Melatonin is a multifunctional bioactive molecule that plays comprehensive physiological roles in all living organisms. N-acetylserotonin methyltransferase (ASMT, also known as hydroxyindole O-methyltransferase or HIOMT) is the final enzyme for biosy...

  • Article
  • Open Access
5 Citations
2,376 Views
18 Pages

GnRH Immunocastration in Male Xizang Sheep: Impacts on Rumen Microbiome and Metabolite Profiles for Enhanced Health and Productivity

  • Xiaoming Zhang,
  • Tianzeng Song,
  • Guiqiong Liu,
  • Jing Wu,
  • Yangzong Zhaxi,
  • Shehr Bano Mustafa,
  • Khuram Shahzad,
  • Xiaoying Chen,
  • Wangsheng Zhao and
  • Xunping Jiang

11 October 2024

Castration is a prevalent and indispensable practice in sheep husbandry, aiding in enhancing meat quality, mitigating aggressive behavior, and managing unwanted reproduction. Nevertheless, the conventional surgical castration procedure poses several...

  • Article
  • Open Access
4 Citations
3,389 Views
19 Pages

One-Pot Synthesis of Novel Multisubstituted 1-Alkoxyindoles

  • Ye Eun Kim,
  • Hyunsung Cho,
  • Yoo Jin Lim,
  • Chorong Kim and
  • Sang Hyup Lee

Studies on a one-pot synthesis of novel multisubstituted 1-alkoxyindoles 1 and their mechanistic investigations are presented. The synthesis of 1 was successfully achieved through consecutive four step reactions from substrates 2. The substrates 2, p...

  • Article
  • Open Access
5 Citations
3,628 Views
13 Pages

Indolyl Septanoside Synthesis for In Vivo Screening of Bacterial Septanoside Hydrolases

  • Aditya R. Pote,
  • Sergi Pascual,
  • Antoni Planas and
  • Mark W. Peczuh

Building-up and breaking-down of carbohydrates are processes common to all forms of life. Glycoside hydrolases are a broad class of enzymes that play a central role in the cleavage of glycosidic bonds, which is fundamental to carbohydrate degradation...

  • Review
  • Open Access
80 Citations
23,842 Views
22 Pages

Neurotransmitter Dysfunction in Irritable Bowel Syndrome: Emerging Approaches for Management

  • Mónica Gros,
  • Belén Gros,
  • José Emilio Mesonero and
  • Eva Latorre

31 July 2021

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder whose aetiology is still unknown. Most hypotheses point out the gut-brain axis as a key factor for IBS. The axis is composed of different anatomic and functional structures inte...

  • Article
  • Open Access
17 Citations
5,630 Views
9 Pages

13 February 2018

The biochemical potential of pathogenic bacteria may cause alteration in the neurophysiological environment; consequently, neuroendocrine and immune responses of the host are modulated by endogenously produced metabolic products of neuropathogenic ba...

  • Communication
  • Open Access
4 Citations
2,303 Views
8 Pages

A Multiomic Analysis of Chicken Serum Revealed the Modulation of Host Factors Due to Campylobacter jejuni Colonization and In-Water Supplementation of Eugenol Nanoemulsion

  • Basanta R. Wagle,
  • Austin Quach,
  • Seungjun Yeo,
  • Anna L. F. V. Assumpcao,
  • Komala Arsi,
  • Annie M. Donoghue and
  • Palmy R. R. Jesudhasan

5 February 2023

Campylobacter jejuni is a foodborne pathogen that causes campylobacteriosis globally, affecting ~95 million people worldwide. Most C. jejuni infections involve consuming and/or handling improperly cooked poultry meat. To better understand chicken hos...

  • Article
  • Open Access
4 Citations
2,201 Views
13 Pages

21 October 2023

Glucosinolates (GSLs) in different plant parts of broccoli (Brassica oleracea var. italic) and rocket (Eruca vesicaria) were analyzed qualitatively and quantitatively before and after treatment with sodium selenate (2 and 5 mM), by their desulfo-coun...

  • Article
  • Open Access
19 Citations
9,104 Views
27 Pages

Diurnal Profiles of Melatonin Synthesis-Related Indoles, Catecholamines and Their Metabolites in the Duck Pineal Organ

  • Bogdan Lewczuk,
  • Natalia Ziółkowska,
  • Magdalena Prusik and
  • Barbara Przybylska-Gornowicz

16 July 2014

This study characterizes the diurnal profiles of ten melatonin synthesis-related indoles, the quantitative relations between these compounds, and daily variations in the contents of catecholamines and their metabolites in the domestic duck pineal org...

  • Article
  • Open Access
9 Citations
3,748 Views
9 Pages

Serotonin-Secreting Neuroendocrine Tumours of the Pancreas

  • Anna Caterina Milanetto,
  • Matteo Fassan,
  • Alina David and
  • Claudio Pasquali

Background: Serotonin-secreting pancreatic neuroendocrine tumours (5-HT-secreting pNETs) are very rare, and characterised by high urinary 5-hydroxyindole-acetic acid (5-HIAA) levels (or high serum 5-HT levels). Methods: Patients with 5-HT-secreting p...

  • Article
  • Open Access
1 Citations
1,118 Views
22 Pages

Differences in the Profile of Aromatic Metabolites in the Corresponding Blood Serum and Cerebrospinal Fluid Samples of Patients with Secondary Bacterial Meningitis

  • Alisa K. Pautova,
  • Peter A. Meinarovich,
  • Vladislav E. Zakharchenko,
  • Pavel D. Sobolev,
  • Natalia A. Burnakova and
  • Natalia V. Beloborodova

3 August 2025

Background: Secondary (nosocomial) bacterial meningitis remains a serious problem in patients with severe brain damage. The aim of this study was to assess the differences in the aromatic metabolites of tryptophan, phenylalanine, and tyrosine, in ser...

  • Review
  • Open Access
18 Citations
5,003 Views
14 Pages

Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression

  • Xiao Qiu,
  • Pengcheng Lu,
  • Xinyu Zeng,
  • Shengjie Jin and
  • Xianghe Chen

The mechanism behind the onset of depression has been the focus of current research in the neuroscience field. Silent information regulator 1 (SIRT1) is a key player in regulating energy metabolism, and it can regulate depression by mediating the inf...

  • Article
  • Open Access
8 Citations
3,441 Views
16 Pages

20 February 2023

Background and Objectives: Disturbance of tryptophan (Trp) and fatty acid (FA) metabolism plays a role in the pathogenesis of psychiatric disorders. However, quantitative analysis and comparison of plasma Trp metabolites and medium- and long-chain fa...

  • Article
  • Open Access
32 Citations
4,704 Views
20 Pages

17 June 2021

Diarrhea is an adverse effect of antimicrobial therapy in horses. This matched, case-controlled study compared the fecal microbiome and metabolome of horses on antibiotics that developed diarrhea (AAD, n = 17) to those that did not develop diarrhea (...

  • Article
  • Open Access
775 Views
14 Pages

Associations Between Gut Microbiota and Mitochondrial Metabolites, with Growth Differentiation Factor-15 as a Marker of Oxidative Stress in Heart Failure vs. Healthy Ageing

  • Konstantinos Prokopidis,
  • Adam Burke,
  • Beyza Gulsah Altinpinar,
  • Sima Jalali Farahani,
  • Omid Khaiyat,
  • Gregory Y. H. Lip,
  • Rajiv Sankaranarayanan,
  • Vanja Pekovic-Vaughan,
  • Howbeer Muhamadali and
  • Masoud Isanejad

2 February 2026

Growth differentiation factor-15 (GDF-15) is an established marker of oxidative stress and a general stress-response mitokines. In this study, we aim to investigate the association of GDF-15 with the metabolic signature of gut and mitochondrial activ...

  • Article
  • Open Access
8 Citations
3,808 Views
15 Pages

Effects of Streptozotocin-Induced Diabetes on the Pineal Gland in the Domestic Pig

  • Bogdan Lewczuk,
  • Magdalena Prusik,
  • Natalia Ziółkowska,
  • Michał Dąbrowski,
  • Kamila Martniuk,
  • Maria Hanuszewska and
  • Łukasz Zielonka

9 October 2018

Several observations from experiments in rodents and human patients suggest that diabetes affects pineal gland function, including melatonin secretion; however, the accumulated data are not consistent. The aim of the present study was to determine th...

  • Article
  • Open Access
7 Citations
6,233 Views
13 Pages

Tetrodotoxin (TTX) inhibits neurotransmission in animals, and there is no specific antidote. In clinical practice in China, Althaea rosea (A. rosea flower) extract has been used to treat TTX poisoning. In this work, the efficacy of the ethyl acetate...

  • Article
  • Open Access
1 Citations
1,736 Views
12 Pages

Metabolomic Profiling of Disease Progression Following Radiotherapy for Breast Cancer

  • Alexandra N. McMahon,
  • Isildinha M. Reis,
  • Cristiane Takita,
  • Jean L. Wright and
  • Jennifer J. Hu

5 March 2025

Background: This study aims to explore metabolic biomarkers and pathways in breast cancer prognosis. Methods: We performed a global post-radiotherapy (RT) urinary metabolomic analysis of 120 breast cancer patients: 60 progression-free (PF) patients a...

  • Systematic Review
  • Open Access
12 Citations
11,698 Views
21 Pages

Pharmacokinetics of Psilocybin: A Systematic Review

  • Shakila Meshkat,
  • Huda Al-Shamali,
  • Argyrios Perivolaris,
  • Trusha Tullu,
  • Richard J. Zeifman,
  • Yanbo Zhang,
  • Lisa Burback,
  • Olga Winkler,
  • Andrew Greenshaw and
  • Venkat Bhat
  • + 6 authors

Background: Psilocybin has shown promise in therapeutic applications for mental disorders. Understanding the pharmacokinetics of psilocybin and its active metabolite psilocin is crucial for optimizing its clinical use and minimizing adverse effects....

  • Article
  • Open Access
30 Citations
5,010 Views
19 Pages

Study on the Mechanism of Mesaconitine-Induced Hepatotoxicity in Rats Based on Metabonomics and Toxicology Network

  • Qian Chen,
  • Kai Zhang,
  • Mingjie Jiao,
  • Jiakang Jiao,
  • Dongling Chen,
  • Yihui Yin,
  • Jia Zhang and
  • Fei Li

14 July 2022

Mesaconitine (MA), one of the main diterpenoid alkaloids in Aconitum, has a variety of pharmacological effects, such as analgesia, anti-inflammation and relaxation of rat aorta. However, MA is a highly toxic ingredient. At present, studies on its tox...

  • Article
  • Open Access
15 Citations
3,711 Views
18 Pages

12/15-Lipoxygenase Regulation of Diabetic Cognitive Dysfunction Is Determined by Interfering with Inflammation and Cell Apoptosis

  • Qi Chen,
  • Qixue Zheng,
  • Yang Yang,
  • Ying Luo,
  • Hong Wang,
  • Huan Li,
  • Lu Yang,
  • Congli Hu,
  • Jiahua Zhang and
  • Junqing Yang
  • + 5 authors

12 August 2022

This study aimed to discuss the role of 12/15-lipoxygenase (12/15-LOX) regulation involved in diabetes cognitive dysfunction. First, Mini Mental State Examination (MMSE) test was used to evaluate cognitive ability in diabetic patients and normal cont...

  • Review
  • Open Access
24 Citations
5,938 Views
11 Pages

Cytoguardin was identified in the conditioned medium of fibroblasts as a tryptophan metabolite, 5-methoxytryptophan (5-MTP). It is synthesized via two enzymatic steps: tryptophan hydroxylase (TPH) and hydroxyindole O-methyltransferase (HIOMT). A trun...

  • Article
  • Open Access
2 Citations
3,512 Views
20 Pages

A Novel RP-UHPLC-MS/MS Approach for the Determination of Tryptophan Metabolites Derivatized with 2-Bromo-4′-Nitroacetophenone

  • Timotej Jankech,
  • Ivana Gerhardtova,
  • Petra Majerova,
  • Juraj Piestansky,
  • Lubica Fialova,
  • Josef Jampilek and
  • Andrej Kovac

Many biologically active metabolites of the essential amino acid L-tryptophan (Trp) are associated with different neurodegenerative diseases and neurological disorders. Precise and reliable methods for their determination are needed. Variability in t...

  • Article
  • Open Access
6 Citations
9,796 Views
13 Pages

Does Melatonin Homeostasis Play a Role in Continuous Epigastric Pain Syndrome?

  • Cezary Chojnacki,
  • Tomasz Poplawski,
  • Janusz Blasiak,
  • Jan Chojnacki and
  • Grazyna Klupinska

14 June 2013

Two clinical forms of functional dyspepsia (FD) are listed in the Rome III criteria: postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS), differing in the recurrence of ailments depending on the diet. Continuous EPS (CEPS) is obse...

  • Article
  • Open Access
32 Citations
6,335 Views
18 Pages

Determination and Application of Nineteen Monoamines in the Gut Microbiota Targeting Phenylalanine, Tryptophan, and Glutamic Acid Metabolic Pathways

  • Shu-Rong Ma,
  • Jin-Bo Yu,
  • Jie Fu,
  • Li-Bin Pan,
  • Hang Yu,
  • Pei Han,
  • Zheng-Wei Zhang,
  • Ran Peng,
  • Hui Xu and
  • Yan Wang

It has been reported that monoamine neurotransmitters can be produced by gut microbiota, and that several related metabolites of amino acids in these pathways are associated with nervous system (NVS) diseases. Herein, we focused on three pathways, na...

  • Article
  • Open Access
4 Citations
9,621 Views
20 Pages

Taurine Supplementation Alleviates Blood Pressure via Gut–Brain Communication in Spontaneously Hypertensive Rats

  • Qing Su,
  • Xiong-Feng Pan,
  • Hong-Bao Li,
  • Ling-Xiao Xiong,
  • Juan Bai,
  • Xiao-Min Wang,
  • Xiao-Ying Qu,
  • Ning-Rui Zhang,
  • Guo-Quan Zou and
  • Meng-Lu Xu
  • + 4 authors

27 November 2024

Objects: Taurine exhibits protective effects in the context of cardiovascular pathophysiology. A range of evidence suggests that hypertension activates inflammatory responses and oxidative stress in the paraventricular nucleus (PVN), elevating the ar...

  • Article
  • Open Access
2 Citations
1,764 Views
17 Pages

ANAC042 Regulates the Biosynthesis of Conserved- and Lineage-Specific Phytoalexins in Arabidopsis

  • Ivan Monsalvo,
  • Leonardo Parasecolo,
  • Sarah Pullano,
  • Jie Lin,
  • Aida Shahabi,
  • Melissa Ly,
  • Hyejung Kwon,
  • Khushi Mathur,
  • Karl Angelo M. Rodrillo and
  • Nik Kovinich
  • + 1 author

Phytoalexins are specialized metabolites that are synthesized by plants in response to pathogens. A paradigm in transcription factor (TF) biology is that conserved TFs have dedicated roles across plant lineages in regulating specific branches of spec...

  • Article
  • Open Access
2 Citations
2,841 Views
23 Pages

21 October 2025

Background: Modulation of the gut–brain axis using probiotics present a promising approach for enhancing cognitive function in mild cognitive impairment (MCI). In prior non-clinical research, Lactobacillus delbrueckii subsp. lactis CKDB001 (LL)...

  • Article
  • Open Access
15 Citations
4,479 Views
18 Pages

11 July 2022

Lactobacillus delbrueckii subsp. bulgaricus (LDB) is an approved feed additive on the Chinese ‘Approved Feed Additives’ list. However, the possibility of LDB as an antibiotic replacement remains unclear. Particularly, the effect of LDB on...