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Metabolites
Volume 15
Issue 8
10.3390/metabo15080527
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Article

Differences in the Profile of Aromatic Metabolites in the Corresponding Blood Serum and Cerebrospinal Fluid Samples of Patients with Secondary Bacterial Meningitis

by
Alisa K. Pautova
1,*,
Peter A. Meinarovich
1,
Vladislav E. Zakharchenko
1,
Pavel D. Sobolev
2,
Natalia A. Burnakova
2 and
Natalia V. Beloborodova
1
1
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Petrovka Street, 25-2, 107031 Moscow, Russia
2
Exacte Labs Bioanalytical Laboratory, 20-2 Nauchny proezd, 117246 Moscow, Russia
*
Author to whom correspondence should be addressed.
Metabolites 2025, 15(8), 527; https://doi.org/10.3390/metabo15080527 (registering DOI)
Submission received: 13 May 2025 / Revised: 8 July 2025 / Accepted: 31 July 2025 / Published: 3 August 2025
(This article belongs to the Special Issue Advances in Metabolomics for Precision Medicine: From Biomarker Discovery to Clinical Applications)
Review Reports Versions Notes

Abstract

Background: Secondary (nosocomial) bacterial meningitis remains a serious problem in patients with severe brain damage. The aim of this study was to assess the differences in the aromatic metabolites of tryptophan, phenylalanine, and tyrosine, in serum and cerebrospinal fluid (CSF) samples collected simultaneously from patients with long-term sequelae of severe brain damage with suspected secondary bacterial meningitis. Methods: Group I included 16 paired serum and CSF samples from patients (N = 11) without secondary bacterial meningitis; group II included 13 paired serum and CSF samples from patients (N = 4) with secondary bacterial meningitis. Results: The median concentrations of serum 5-hydroxyindole-3-acetic, CSF 4-hydroxyphenyllactic (p-HPhLA), CSF 4-hydroxyphenylacetic, CSF phenyllactic, and indole-3-lactic acids in serum and CSF were statistically higher in group II compared to group I (p-value ≤ 0.03), while 4-hydroxyphenylpropionic and indole-3-acetic in serum were lower in group II compared to group I (p-value = 0.04). In group I, p-HPhLA serum concentrations were greater than or equal to its CSF concentrations in 14 paired samples; in group II, p-HPhLA concentrations in serum were lower than in CSF in all paired samples. Conclusions: The obtained results demonstrate the differences in the profile of aromatic metabolites in serum and CSF and may confirm the hypothesis of the p-HPhLA microbial origin in the CSF of patients with secondary bacterial meningitis.
Keywords: 4-hydroxyphenyllactic acid; phenyllactic acid; indole-3-lactic acid; phenylpropionic acid; indole-3-propionic acid; nosocomial meningitis 4-hydroxyphenyllactic acid; phenyllactic acid; indole-3-lactic acid; phenylpropionic acid; indole-3-propionic acid; nosocomial meningitis

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MDPI and ACS Style

Pautova, A.K.; Meinarovich, P.A.; Zakharchenko, V.E.; Sobolev, P.D.; Burnakova, N.A.; Beloborodova, N.V. Differences in the Profile of Aromatic Metabolites in the Corresponding Blood Serum and Cerebrospinal Fluid Samples of Patients with Secondary Bacterial Meningitis. Metabolites 2025, 15, 527. https://doi.org/10.3390/metabo15080527

AMA Style

Pautova AK, Meinarovich PA, Zakharchenko VE, Sobolev PD, Burnakova NA, Beloborodova NV. Differences in the Profile of Aromatic Metabolites in the Corresponding Blood Serum and Cerebrospinal Fluid Samples of Patients with Secondary Bacterial Meningitis. Metabolites. 2025; 15(8):527. https://doi.org/10.3390/metabo15080527

Chicago/Turabian Style

Pautova, Alisa K., Peter A. Meinarovich, Vladislav E. Zakharchenko, Pavel D. Sobolev, Natalia A. Burnakova, and Natalia V. Beloborodova. 2025. "Differences in the Profile of Aromatic Metabolites in the Corresponding Blood Serum and Cerebrospinal Fluid Samples of Patients with Secondary Bacterial Meningitis" Metabolites 15, no. 8: 527. https://doi.org/10.3390/metabo15080527

APA Style

Pautova, A. K., Meinarovich, P. A., Zakharchenko, V. E., Sobolev, P. D., Burnakova, N. A., & Beloborodova, N. V. (2025). Differences in the Profile of Aromatic Metabolites in the Corresponding Blood Serum and Cerebrospinal Fluid Samples of Patients with Secondary Bacterial Meningitis. Metabolites, 15(8), 527. https://doi.org/10.3390/metabo15080527

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