Search Results (347)

Phosphogypsum (PG) is the main by-product of the wet processing of phosphate rock for phosphoric acid production and is generated worldwide in hundreds of millions of tons per year. With an increasing demand for gypsum-based materials for industrial and agricultural applications and the predictable gypsum shortage in the coming years, PG can be considered a valuable replacement. However, the presence of fluorine in PG can limit its use, given the negative effects it can have on human health and the environment. In this work, it is presented a new methodology which determines with high sensitivity the fluorine concentrations in PG by a combination of Ion Beam Analytical (IBA) techniques, with a focus on PIGE (Particle Induced $\gamma$-ray Emission). Seventeen PG samples were analyzed, fifteen of which originated from processing experiments. Fluorine was detected in concentrations ranging from 0.003 to 0.691 wt.%. The upper end of this range is comparable to or higher than typical values reported for PG and may require treatment depending on the intended end use and environmental compliance criteria. Full article

We investigate the correlations between IceCube high-energy neutrinos and Fermi-LAT $\gamma$-ray sources using an unbinned likelihood analysis. In previous analyses of the same IceCube public dataset, only the spatial information of neutrino events was utilized, while the energy term in the probability density functions (PDFs) was neglected, limiting the achievable sensitivity. In this work, we incorporate both spatial and energy terms into the likelihood, with the energy PDFs constructed from the effective areas and smearing matrices. We focus on the Third Catalog of Hard Fermi-LAT Sources (3FHL) and the Fourth LAT AGN Catalog (4LAC-DR2). To account for the significant difference in IceCube’s sensitivity between the two hemispheres, we perform stacking analyses for the all-sky, Northern hemisphere, and Southern hemisphere source subsets separately, under both equal weighting and flux weighting schemes. No statistically significant neutrino excess is found in any configuration. We therefore derive 95% confidence level upper limits on the total neutrino flux contributed by these source populations. For a spectral index of $\Gamma =-2.5$, the all-sky stacking analysis indicates that the 3FHL and 4LAC-DR2 populations contribute at most 3.12% and 2.83% (equal weighting), and 4.45% and 3.49% (flux weighting) of the IceCube diffuse neutrino flux, respectively. Compared to the spatial-only analysis, the inclusion of the energy term improves the constraints on hard-spectrum emission by over one order of magnitude. Our results further demonstrate that the 3FHL and 4LAC-DR2 sources are subdominant contributors to the diffuse astrophysical neutrino flux observed by IceCube. Full article

Purpose: To develop an accelerator neutron source suitable for boron neutron capture therapy—a new promising method for treating malignant tumors—and to develop dosimetry tools and methods. Methods: Research into the transport and acceleration of a beam of charged particles, development and manufacture of an accelerator neutron source, study of the radiation generated, and development and implementation of dosimetry tools and methods. Results: A facility called VITA has been created, which includes a tandem electrostatic accelerator of an original design for producing a 2.3 MeV 10 mA proton beam, a lithium target for generating neutrons in the ⁷Li(p,n)⁷Be reaction, and a beam shaping assembly for forming a therapeutic neutron beam. The facility at the institute is used for scientific research, the facility in Xiamen (China) is used for clinical trials, and the facility in Moscow (Russia) will soon be used for clinical trials. Also, new tools and methods for measuring the boron dose, γ-ray dose, and sum of the fast neutron dose and the nitrogen dose have been proposed and implemented. The conducted studies demonstrated the high efficiency of the VITA^® facility, the first possibility of implementing prompt γ-ray spectroscopy for boron imaging, and the first possibility of implementing lithium neutron capture therapy, which has advantages over BNCT, and also presented the results of the development of new tools and methods for measuring the boron dose, γ-ray dose, and the sum of the fast neutron dose and the nitrogen dose. Conclusions: The authors strongly recommend using prompt γ-ray spectroscopy in treatment and developing lithium neutron capture therapy, including in combination with BNCT, and note the high efficiency, reliability and compactness of the VITA^® facility. Full article

In this work, we report the fabrication and characterization of single-film and double-film composite epitaxial garnet structures based on single-crystalline films (SCFs) and bulk single-crystal (SC) scintillators for enhanced α–γ discrimination in mixed radiation fields. These composite scintillators consist of TbAG:Ce and YAG:Ce SCFs grown by liquid-phase epitaxy (LPE) on Czochralski-grown Gd₃Ga_2.5Al_2.5O₁₂ (GAGG:Ce) bulk SC substrates. Single- and double-film architectures were designed to optimize the energy absorption and pulse-shape discrimination (PSD) performance for low-penetrating α-particles and high-energy γ-rays. Energy calibration was performed using different γ-ray sources (⁵⁷Co, ⁵¹Cr, and ¹³⁷Cs), enabling the conversion of detector signals to a calibrated electron-equivalent energy scale (keVee). Integration gates were systematically optimized, yielding maximum figures of merit (FOM) of 1.4 for the GAGG:Ce SC substrate, 1.9 for the single-film composite, and 5.0 for the double-film composite, demonstrating a progressive improvement in α–γ discrimination with increasing structural complexity. Two-dimensional PSD density maps reveal well-separated α and γ events, with the highest separation observed for the double-film composite. These results indicate that the engineering of LPE-grown composites provides tunable scintillation decay profiles, enhanced temporal separation, and increased light yields, making them promising candidates for applications such as mixed radiation field detection, dosimetry, and radiation monitoring. Full article

Data collected by sensors plays a critical role in system decision-making. Microphone arrays enable distance measurement and fault localization, which is particularly critical in the radiation environments of nuclear facilities. Acoustic localization based on microphone arrays can effectively fulfill this requirement. This study experimentally evaluates the Total Ionizing Dose (TID) effects of ⁶⁰Co γ-ray radiation on commercial MEMS (micro-electro-mechanical systems) silicon microphones. Five identical microphone units were simultaneously irradiated at a dose rate of 0.0342 Gy(Si)/s while continuously monitoring operating current and spectral response. Experimental results show that the commercial MEMS silicon microphones exhibit an average TID failure threshold of 932.6 ± 62.8 Gy(Si), with a 95% confidence interval of [875.5, 989.7] Gy(Si). Three degradation/failure levels are clearly defined: channel degradation, channel failure, and full system failure. Radiation exposure causes a progressive increase in operating current (up to 6.7 times the initial value), severe spectral distortion, and ultimately complete loss of localization function. This indicated that standard commercial MEMS silicon microphones possess a certain degree of tolerance to TID radiation. Subsequently, an annealing test was performed. However, Post-irradiation annealing restored the operating current but not the acoustic performance, indicating irreversible radiation-induced damage. Full article

Advanced Doppler-shift methods for the calculation of the γ-ray lineshape registered in recoil-distance Doppler-shift and Doppler-shift attenuation methods are presented, emphasizing the case using a gate set on the shifted part of a direct feeding transition. For the precise description of the γ-ray lineshape, the process of evaporation of light particles from the compound nucleus has to be taken into account in the case of heavy ion-induced fusion-evaporation reactions. In addition, the impact of different approaches for calculating stopping powers is investigated in the process of the lifetime determinations. In the RDDS experiments, the γ-emission during the slowing down in the stopper is discussed in detail. Applications of the new procedures are demonstrated in two experiments: the first one is a plunger experiment performed in order to check for chirality in the ¹³⁴Pr nucleus and the second one is a DSAM experiment conducted to test the isospin symmetry in ³¹P and ³¹S mirror nuclei. Full article

Background/Objectives: Terbium-161 is an interesting and promising theranostic radionuclide, thanks to its decay characteristics (T_1/2 = 6.95 d, E(β)_max = 593 keV, E(β)_av = 154 keV, E(γ) = 74.6 keV (10.2%)). Having similar chemical properties, it is considered as an alternative to currently used ¹⁷⁷Lu. In addition, ¹⁶¹Tb emits a significant amount of conversion and Auger electrons, which contribute to the enhancement of localised therapeutic effect. The aim of this paper is to describe the preparation of ¹⁶¹Tb in quantity and quality relevant for preclinical and early clinical studies and to provide practical notes on the preparation. Methods: No-carrier-added ¹⁶¹Tb has been repeatedly prepared by neutron irradiation of highly enriched ¹⁶⁰Gd targets (up to 98 mg of ¹⁶⁰Gd₂O₃) at nuclear reactor LVR-15 (CV Řež, Czech Republic) in four different irradiation positions. The separation and purification process of ¹⁶¹Tb from the bulk of ¹⁶⁰Gd target was performed by cation exchange chromatography with Dowex 50 W × 8 (H⁺ cycle, 200–400 mesh). Terbium-161 was obtained in ¹⁶¹TbCl₃ form and formulated into 0.1 M HCl solution. The γ-ray spectrometry was used for radionuclide identification and radionuclidic purity and the ICP-MS method for chemical purity measurements and specific activity determination. The DOTA labelling assay was performed, as described by Gracheva et al., providing an assessment of the apparent molar activity of the preparation in terms of its competitive interaction with stable daughter nuclide ¹⁶¹Dy. Results: Irradiations (59.2 h to 421.52 h) of enriched ¹⁶⁰Gd targets with mass ranging from 43.4 to 144.0 mg for ¹⁶⁰Gd(NO₃)₃ and from 12.5 to 98.3 mg for ¹⁶⁰Gd₂O₃ yielded 1.3–23.7 GBq of ¹⁶¹Tb. The separation yields of purified ¹⁶¹Tb varied from 85 to 99%, with the activities of 9.9–22.1 GBq and the highest achieved specific activity of the final product was 4.1 GBq/μg (of Tb). The DOTA chelator was radiolabelled with ¹⁶¹Tb at time points from 2 to 14 days after the end of separation (EOS). Conclusions: Based on our results, we describe practical aspects of terbium production at the laboratory scale with a particular focus on practical aspects and issues arising during the process that may surprise even experienced radiochemists, as lanthanoid separation is not always straightforward, even though it is well-known and has been extensively studied. The preparation of ¹⁶¹Tb in a n.c.a. form proceeds, according to the reported data, with high reproducibility and achieves significant activity levels suitable for both preclinical and clinical investigations by irradiation of highly enriched ¹⁶⁰Gd targets in LVR-15 reactor with subsequent separation and purification of ¹⁶¹Tb on cation exchange resin Dowex 50 W × 8(H⁺). The produced [¹⁶¹Tb]TbCl₃ is employed in subsequent experimental research and development for the labelling of preparations intended for preclinical applications. Full article

This study investigates the development of a high-density W-Ni-Fe alloy using liquid-phase sintering and examines its microstructure and mechanical properties. Critical parameters, including sintering time and heating rate, were optimized to achieve enhanced density, microhardness, tensile strength, and γ-ray shielding properties. The results show that optimal sintering conditions (45 min at a heating rate of 30 K/min and a sintering temperature of 1753 K) lead to a uniform dispersion of tungsten particles, with a high-volume fraction of tungsten in the matrix and enhanced bonding within the γ(Ni-Fe) matrix. The alloy achieved a density of 16.99 g/cm³ and exhibited superior mechanical performance, with a tensile strength of 846.66 MPa and an elongation of 10.5%, as well as excellent γ-ray attenuation capabilities. These results demonstrate its suitability for nuclear applications. Full article

Concerns about radiation exposure following the Fukushima Nuclear Power Plant accident continue to grow, and health risks associated with medical radiation have also become an important issue. Therefore, identifying agents that can mitigate radiation-related health effects is necessary. We focused on the antioxidant 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (tempol) and investigated its radioprotective mechanisms. HeLa and TIG-3 cells were irradiated with X-rays, γ-rays, or heavy-ion beams. The effect of tempol on reactive oxygen species (ROS) production was evaluated using fluorescence-activated cell sorting (FACS) analysis. DNA double-strand break (DSB) formation was assessed by γ-H2AX immunofluorescence staining. In mice, γ-H2AX formation in the thymus and duodenum were evaluated after acute or chronic γ-ray exposure. Inflammatory responses were analyzed through macrophage infiltration and TNF mRNA expression, while apoptosis was measured using Annexin V staining. Tempol suppressed ROS production and γ-H2AX foci formation following irradiation. It also reduced γ-H2AX induction in mouse tissues. Activated macrophage infiltration and TNF expression in the duodenum tended to decrease in tempol-treated mice, whereas apoptotic levels showed no significant differences. Notably, tempol more effectively inhibited γ-H2AX formation during chronic irradiation than acute exposure. These findings suggest that tempol mitigates radiation-induced inflammation and reduces DNA damage, supporting its potential as a radioprotective agent. Full article

The biological activities of fucoidan from brown algae have attracted considerable attention. Degradation to low-molecular-weight fucoidan reduces viscosity and improves bioavailability, enhancing antioxidant and anti-inflammatory effects. Fucoidan was degraded using acetic acid combined with ⁶⁰Co γ-ray irradiation and fractionated by Bio-Gel P10 chromatography to obtain four fractions (AIF1–AIF4). The fractions were structurally characterized and assessed for in vitro radical-scavenging activity and modulation of oxidative stress markers in H₂O₂-induced RAW264.7 macrophages. Compared with the model group, all fractions significantly increased catalase (CAT) and superoxide dismutase (SOD) activities, with the highest increase of approximately 1.33 U/mgprot for CAT and 20.32 U/mgprot for SOD, while decreasing malondialdehyde (MDA) and intracellular reactive oxygen species (ROS) levels. Among the four fractions, AIF4, with the lowest molecular weight, exhibited the highest antioxidant activity. LMWF treatment also upregulated the mRNA expression of antioxidant-related genes (HO-1, SOD1, SOD2) and signaling molecules (PI3K and Akt), accompanied by increased protein levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and PI3K/Akt pathway components. These findings indicate that LMWF is closely associated with the regulation of the PI3K/Akt–Nrf2 signaling axis under oxidative conditions and support its potential application as a dietary antioxidant ingredient. Full article

Recent measurements performed by the LUNA(Laboratory for Underground Nuclear Astrophysics) collaboration between 2019 and 2024 have provided the most precise direct determinations to date of several key reaction rates in the NeNa cycle, specifically the ²⁰Ne(p,γ)²¹Na and the ²²Ne(p,γ)²³Na reactions, as well as its bridge to the MgAl cycle, i.e., the ²³Na(p,γ)²⁴Mg reaction. Despite their improved accuracy, these updated rates are not yet consistently incorporated into widely used nuclear reaction network compilations. We explore the astrophysical impact of adopting the new LUNA rates by performing nucleosynthesis calculations, focusing on the case of ²⁶Al nucleosynthesis and considering four different stellar environments: low-mass AGB stars, massive stars, very massive stars and core-collapse supernovae. Our results show substantial sensitivity of ²⁶Al production to the revised rates. In the AGB model, the surface ²⁶Al abundance decreases by up to 30%, while in the massive star model, the ²⁶Al abundance in the C-burning shell increases by 51%. In contrast, the impact on both the ²⁶Al yields ejected by very massive stars and on the explosive nucleosynthesis in the supernova model is negligible. These findings have direct implications for galactic chemical evolution, the global budget of ²⁶Al, and theoretical predictions of the ⁶⁰Fe/²⁶Al ratio, which will be critically tested by forthcoming γ-ray observations from missions such as the Compton Spectrometer and Imager (COSI). Full article

The impact of pretreatment methods on the fermentation quality and nutritional profile of bamboo silage was assessed to determine the optimal ensiling strategy. Tender bamboo underwent microwave, ultrasound, alkali, and irradiation pretreatments. Subsequently, a four-factor, three-level L9 (3⁴) orthogonal experiment was employed, utilizing pretreated bamboo as the substrate. The experiment evaluated the effects of silage time (30, 45, 60 days), moisture content (55%, 60%, 65%), cellulase addition [2, 4, and 6 mg/g FM (Fresh weight)], and silage inoculant addition (0.5, 5, 50 mg/g FM). Results indicated that γ-ray irradiation pretreatment effectively reduced lignin and cellulose content while increasing reducing sugars levels approximately fourfold compared to the control group. Six out of the nine treatment groups exhibited superior comprehensive fermentation quality scores, with silage time demonstrating the most significant influence on the fermentation quality of tender bamboo silage. The order of influence was silage time > silage inoculant level > moisture content > cellulase, with a silage time of 30 days, a silage inoculant level of 0.5 mg/g FM, a moisture content of 65%, and a cellulase level of 2 mg/g FM, all contributing to enhanced fermentation quality. Regarding nutritional composition, silage time significantly impacted crude protein and soluble sugar levels, with optimal levels observed at 30 and 60 days, respectively. Moisture content primarily affected soluble sugar levels, followed by neutral detergent fiber, with an optimal level of 55%. Other factors showed minimal effects. Based on fermentation quality and nutritional component analysis, and prioritizing fermentation quality while considering cost-effectiveness, the optimal ensiling conditions for bamboo were determined to be a silage time of 30 days, a moisture content of 65%, an addition of 2 mg/g FM of cellulase, and an addition of 0.5 mg/g FM of silage inoculant. Full article

Developing safe and effective hemostatic materials is critical for rapid bleeding control and wound management. However, traditional hemostatic materials using chemical crosslinking often fall short in hemostatic efficiency and carry risks of secondary injury from reagent residues. This study introduced an irradiation-fabricated composite collagen sponge based on fish skin collagen, chitosan, and soluble starch. The sponge was prepared via material solution blending, followed by cobalt-60 gamma irradiation at various doses, with casting and freeze-drying. Its functionality and safety were systematically evaluated. The results show that low-dose gamma irradiation (1–3 kGy) applied to a precursor solution prior to freeze-drying promoted intermolecular crosslinking, improving mechanical strength, elongation, and biostability, while higher doses (6 kGy) slightly reduced crosslinking due to the partial degradation of collagen, chitosan, and starch. With low-dose irradiation, the proposed hemostatic sponges show enhanced water absorption, blood cell adsorption, swelling, and antibacterial properties, indicating effective hemostatic performance. Spectroscopic characterization confirmed chemical bond modifications with no loss of crystallinity. Cytotoxicity and in vivo tests demonstrated biocompatibility and effective hemostatic performance. Compared with the commercial HSD sponge, the irradiated sponges exhibited superior hemostatic efficacy. This study presents that a collagen-based synergistic matrix prepared by gamma-ray irradiation can produce a hemostatic sponge with enhanced absorbency, bioactivity, and antibacterial properties, highlighting its great potential in rapid hemostasis and wound care applications. Full article

In this study, we extract a 7-day binned $\gamma$-ray light curve from 2008 August to 2019 March in the energy range 0.1–300 GeV and identify four outburst periods with peak flux of >8.0$\times {10}^{-7}$ ph ${\mathrm{cm}}^{-2}{\mathrm{s}}^{-1}$. Four active states in the optical are also marked during this period. The fastest variability timescale suggests the emission region radius is R ∼ 2.4$\times {10}^{16}$ cm, and the observed emission region lies within <0.7 pc distance from the central engine. The majority of short-timescale flares exhibit a symmetric temporal profile, implying that the rise and decay timescales are dominated by disturbances caused by dense plasma blobs passing through the standing shock front in the jet region. To understand the properties of the source jets, we employ a standard one-zone leptonic scenario to model the broadband spectral energy distributions (SEDs) of flaring periods and determine that the $\gamma$-ray spectrum is better reproduced when the dissipation region of the jet is located within the molecular torus (MT). The $\gamma$-ray spectra from the outburst phases show an obvious spectral break with a break energy between 3.00 and 7.08 GeV, which may be attributed to an intrinsic break in the energy distribution of radiating particles. The studies of the survival time of a sheet before being destroyed by the turbulent motions of plasma (${\tau }_{cs}\sim 2.9\times {10}^4$ s), the shock acceleration time ($t_{acc}\sim$$4.3\times {10}^4$ s), and the minimum interaction height ($Z_{min}$ ≈ 2.57–4.55$\times {10}^{17}$ cm > $R_{BLR}$ ∼ 1.0$\times {10}^{17}$ cm) suggest that the $\gamma$-ray flaring event maybe caused by a magnetic reconnection mechanism, but we cannot completely rule out the shock-in-jet model. Full article

This work presents a simulation study of a Timepix3 telescope composed of nine detectors for use as a Compton scatter polarimeter in the energy range of 35–100 keV. Four detectors carry 1 mm thick silicon (Si) sensors and five detectors carry 1 mm thick cadmium telluride (CdTe) sensors. The modulation factor for 100% linearly polarized X-ray beams was found to be ${\mu }_{100}>70\%$ in the energy range of 55–80 keV. The quality factor of the polarimeter has its maximum 12.8% at the energy 75 keV. The comparison of quality factors and the calculations of a hypothetical observation of the Crab nebula show that this multilayer Timepix3 approach is competitive with contemporary X-ray polarimeters. Full article