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Article

4 Citations

3,987 Views

14 Pages

Alpha2-Adrenoblockers Regulate Development of Oxidative Stress and Cognitive Behaviour of Rats under Chronic Acoustic Stress Conditions

Magdalina Melkonyan,
Ashkhen Manukyan,
Lilit Hunanyan,
Artem Grigoryan,
Hayk Harutyunyan,
Lilit Sukiasyan,
Lusine Danielyan and
Konstantin Yenkoyan

Pharmaceuticals2021, 14(6), 529;https://doi.org/10.3390/ph14060529

2 June 2021

Noise is a wide-spread stress factor in modern life produced by urbanization, traffic, and an industrialized environment. Noise stress causes dysfunction and neurotransmission impairment in the central nervous system, as well as changes in hormone le...

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Article

14 Citations

4,957 Views

11 Pages

Pharmacologic Evaluation of Antidepressant Activity and Synthesis of 2-Morpholino-5-phenyl-6H-1,3,4-thiadiazine Hydrobromide

Alexey P. Sarapultsev,
Oleg N. Chupakhin,
Petr A. Sarapultsev,
Larisa P. Sidorova and
Tatiana A. Tseitler

Pharmaceuticals2016, 9(2), 27;https://doi.org/10.3390/ph9020027

19 May 2016

Substituted thiadiazines exert a reliable therapeutic effect in treating stress, and a schematic description of their ability to influence all aspects of a stress response has been depicted. This study was conducted to pharmacologically evaluate comp...

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Article

14 Citations

5,997 Views

13 Pages

α2-Adrenergic Receptor in Liver Fibrosis: Implications for the Adrenoblocker Mesedin

Ute A. Schwinghammer,
Magda M. Melkonyan,
Lilit Hunanyan,
Roman Tremmel,
Ralf Weiskirchen,
Erawan Borkham-Kamphorst,
Elke Schaeffeler,
Torgom Seferyan,
Wolfgang Mikulits and
Konstantin Yenkoyan
+ 2 authors

Cells2020, 9(2), 456;https://doi.org/10.3390/cells9020456

18 February 2020

The noradrenergic system is proposed to play a prominent role in the pathogenesis of liver fibrosis. While α1- and β-adrenergic receptors (ARs) are suggested to be involved in a multitude of profibrogenic actions, little is known about &al...

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Article

14 Citations

5,749 Views

18 Pages

Neuroprotective, Neurogenic, and Amyloid Beta Reducing Effect of a Novel Alpha 2-Adrenoblocker, Mesedin, on Astroglia and Neuronal Progenitors upon Hypoxia and Glutamate Exposure

Magda M. Melkonyan,
Lilit Hunanyan,
Ali Lourhmati,
Nikolas Layer,
Sandra Beer-Hammer,
Konstantin Yenkoyan,
Matthias Schwab and
Lusine Danielyan

Int. J. Mol. Sci.2018, 19(1), 9;https://doi.org/10.3390/ijms19010009

21 December 2017

Locus coeruleus-noradrenergic system dysfunction is known to contribute to the progression of Alzheimer’s disease (AD). Besides a variety of reports showing the involvement of norepinephrine and its receptor systems in cognition, amyloid β (Aβ) metab...

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