Search Results (22)

The effectiveness of an innovative retrofit scheme using near-surface-mounted (NSM) X-shaped CFRP ropes for the strengthening of substandard RC beam–column joints was investigated experimentally. Three large-scale beam–column joint subassemblages were constructed with poor reinforcement details. One specimen was subjected to cyclic lateral loading, exhibited shear failure of the joint region and was used as the control specimen. The other specimens were retrofitted and subsequently subjected to the same history of incremental lateral displacement amplitudes with the control subassemblage. The retrofitting was characterized by low labor demands and included wrapping of NSM CFPR-ropes in the two diagonal directions on both lateral sides of the joint as shear reinforcement. Single or double wrapping of the joint was performed, while weights were suspended to prevent the loose placement of the ropes in the grooves. A significant improvement in the seismic performance of the retrofitted specimens was observed with respect to the control specimen, regarding strength and ductility. The proposed innovative scheme effectively prevented shear failure of the joint by shifting the damage in the beam, and the retrofitted specimens showed a more dissipating hysteresis behavior without significant loss of lateral strength and axial load-bearing capacity. The cumulative energy dissipation capacity of the strengthened specimens increased by 105.38% and 122.23% with respect to the control specimen. Full article

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (ANCA-vasculitis) is an autoimmune disease characterized by inflammation and necrosis of small or medium vessels. In the past, the role of the complement in the pathogenesis of ANCA-vasculitis has been underestimated, due to the paucity of the complement at sites of injured glomeruli. Following evidence from animal models of the major role of the complement in pathogenesis of ANCA-vasculitis, the complement has again attracted interest. Immunohistology analysis of pauci-immune glomerulonephritis—ANCA glomerulonephritis (ANCA-GN)—reveals the presence of complement products and membrane attack complex, suggesting their involvement in the disease process. Researchers emphasize the complement classical or lectin pathway as a contributor to the development of ANCA-vasculitis. The era of targeted therapies to suspend the complement activation as a therapy for ANCA-vasculitis has arrived, and thus, the comprehension of its role is very important. This review summarizes recent insights on the important role of complement activation in the development of ANCA-vasculitis as well as the emerging therapeutic possibilities that target complement components for the treatment of this condition. Full article

Arctic coastlines are the most vulnerable regions of the Earth, and local communities in those areas are being affected by rising sea levels and temperature. Therefore, Earth Observation combined with up-to-date geoinformation tools offers a dependable, cost-effective, and time-efficient approach to understanding the socioeconomic impact of climate changes in Arctic coastal areas. A promising approach is the Coastal Vulnerability Index (CVI), which takes into account different factors such as geomorphology, sea factors, and shoreline retreat or advance, to estimate the grade of vulnerability of a coastal area. Notwithstanding its potential, its application in the Arctic is still challenging. This study targets to estimate CVI to value the vulnerability of the coastal areas of Norway located in the Arctic. For the application of CVI and specifically for geomorphological and sea factors, data were acquired from international and national institutes. After the collection of all the necessary parameters for CVI was completed, all datasets were imported into a GIS software program (ArcGIS Pro) where the vulnerability classes of CVI were estimated. The results show that most of the coast of Northern Norway is characterized by a low to high degree of vulnerability, while in the island of Tromsø the vulnerability is mainly high and very high. Full article

Knowledge on the spatiotemporal patterns of surface energy balance parameters is crucial for understanding climate system processes. To this end, the assimilation of Earth Observation data with land biosphere models has shown promising results, but they are still hampered by several limitations related to the spatiotemporal resolution of EO sensors and cloud contamination. With the recent developments on Unmanned Aerial Vehicles (UAVs), there is a great opportunity to overcome these challenges and gain knowledge of surface energy balance parameters at unprecedented resolutions. The present study examines, for the first time, the ability of an inversion-modeling scheme, the so-called “analytical triangle” method, to retrieve estimates of surface energy fluxes and soil surface moisture (SSM) at high spatial resolution using UAV data. A further aim of our study was to examine the representativeness of the SSM estimates for the SM measurements taken at different depths. The selected experimental site is an agricultural site of citrus trees located near the city of Palermo on 30 July 2019. The results of comparisons showed that the sensible and latent heat fluxes from UAV were consistent with those measured from the ground, with absolute differences in comparison to ground measurements being 5.00 Wm⁻² for the latent heat (LE) flux and 65.02 Wm⁻² for H flux, whereas for the daytime fluxes H/Rn and LE/Rn were 0.161 and 0.012, respectively. When comparing analytical triangle SSM estimates with SM measurements made at different depths, it was found that there was a gradual increase in underestimation with increasing measurement depth. All in all, this study’s results provide a credible demonstration of the significant potential of the technique investigated herein as a cost-effective and rapid solution for estimating key parameters characterizing land surface processes. As those parameters are required by a wide range of disciplines and applications, utilization of the investigated technique in research and practical applications is expected to be seen in the future. Full article

Land use/land cover (LULC) is a fundamental concept of the Earth’s system intimately connected to many phases of the human and physical environment. LULC mappings has been recently revolutionized by the use of high-resolution imagery from unmanned aerial vehicles (UAVs). The present study proposes an innovative approach for obtaining LULC maps using consumer-grade UAV imagery combined with two machine learning classification techniques, namely RF and SVM. The methodology presented herein is tested at a Mediterranean agricultural site located in Greece. The emphasis has been placed on the use of a commercially available, low-cost RGB camera which is a typical consumer’s option available today almost worldwide. The results evidenced the capability of the SVM when combined with low-cost UAV data in obtaining LULC maps at very high spatial resolution. Such information can be of practical value to both farmers and decision-makers in reaching the most appropriate decisions in this regard. Full article

Four exterior reinforced concrete beam–column joint subassemblages with poor reinforcement details and low-quality materials were constructed and subjected to cyclic lateral deformations under constant axial loading of the columns. The longitudinal rebars at the top of the beams were well-anchored in the joint region with a 90° hook and transversely welded to prevent premature slippage. The same was true for the longitudinal rebars at the bottom of the beam of the first specimen. Contrarily, the anchorage of the rebars at the bottom of the beam of the other three subassemblages was straight and of insufficient length. One of these specimens (the second) also had deficient lap splices of the column reinforcement, while the other three specimens had continuous column rebars. The third and the fourth subassemblage were designed with different joint aspect ratio and beam shear span/depth ratio values. The overall seismic performance of the specimens was evaluated and compared. The failure mode of the subassemblages was accurately predicted by the proposed analytical model. It was clearly demonstrated that the anchorage of the rebars, the length of the lap splices, the joint aspect ratio and the shear span/depth of the beam ratio value crucially affect the cyclic response of beam–column joints and, hence, may cause a severe detrimental impact to the overall structural integrity. Full article

Sentinel-2 data are crucial in mapping flooded areas as they provide high spatial and spectral resolution but under cloud-free weather conditions. In the present study, we aimed to devise a method for mapping a flooded area using multispectral Sentinel-2 data from optical sensors and Geographical Information Systems (GISs). As a case study, we selected a site located in Northern Italy that was heavily affected by flooding events on 3 October 2020, when the Sesia River in the Piedmont region was hit by severe weather disturbance, heavy rainfall, and strong winds. The method developed for mapping the flooded area was a thresholding technique through spectral water indices. More specifically, the Normalized Difference Water Index (NDWI) and the Modified Normalized Difference Water Index (MNDWI) were chosen as they are among the most widely used methods with applications across various environments, including urban, agricultural, and natural landscapes. The corresponding flooded area product from the Copernicus Emergency Management Service (EMS) was used to evaluate the flooded area predicted by our method. The results showed that both indices captured the flooded area with a satisfactory level of detail. The NDWI demonstrated a slightly higher accuracy, where it also appeared to be more sensitive to the separation of water from soil and areas with vegetation cover. The study findings may be useful in disaster management linked to flooded-area mapping and area rehabilitation mapping following a flood event, and they can also valuably assist decision and policy making towards a more sustainable environment. Full article

This study involved an investigation of the long-term seasonal rainfall patterns in central India at the district level during the period from 1991 to 2020, including various aspects such as the spatiotemporal seasonal trend of rainfall patterns, rainfall variability, trends of rainy days with different intensities, decadal percentage deviation in long-term rainfall patterns, and decadal percentage deviation in rainfall events along with their respective intensities. The central region of India was meticulously divided into distinct subparts, namely, Gujarat, Daman and Diu, Maharashtra, Goa, Dadra and Nagar Haveli, Madhya Pradesh, Chhattisgarh, and Odisha. The experimental outcomes represented the disparities in rainfall distribution across different districts of central India with the spatial distribution of mean rainfall ranges during winter (2.08 mm over Dadra and Nagar Haveli with an average of 24.19 mm over Odisha), premonsoon (6.65 mm over Gujarat to 132.89 mm over Odisha), monsoon (845.46 mm over Gujarat to 3188.21 mm over Goa), and post-monsoon (30.35 mm over Gujarat to 213.87 mm over Goa), respectively. Almost all the districts of central India displayed an uneven pattern in the percentage deviation of seasonal rainfall in all three decades for all seasons, which indicates the seasonal rainfall variability over the last 30 years. A noticeable variation in the percentage deviation of seasonal rainfall patterns has been observed in the following districts: Rewa, Puri, Anuppur, Ahmadabad, Navsari, Chhindwara, Devbhumi Dwarka, Amreli, Panch Mahals, Kolhapur, Kandhamal, Ratnagiri, Porbandar, Bametara, and Sabar Kantha. In addition, a larger number of rainy days of various categories occurred in the monsoon season in comparison to other seasons. A higher contribution of trace rainfall events was found in the winter season. The highest contributions of very light, light rainfall, moderate, rather high, and high events were found in the monsoon season in central India. The percentage of various categories of rainfall events has decreased over the last two decades (2001–2020) in comparison to the third decade (1991–2000), according to the mean number of rainfall events in the last 30 years. This spatiotemporal analysis provides valuable insights into the rainfall trends in central India, which represent regional disparities and the potential challenges impacted by climate patterns. This study contributes to our understanding of the changing rainfall dynamics and offers crucial information for effective water resource management in the region. Full article

Wildfires are a pervasive natural phenomenon in Mediterranean forest ecosystems, causing significant ecological imbalances that demand immediate restoration efforts. The intricacy of reinstating the ecological balance necessitates a proactive approach to identifying and assessing suitable restoration sites. The assessment and investigation of the most suitable restoration sites is of particular importance both for the relevant authorities and for planning and decision making by the state. This study proposes the development of a user-friendly model for evaluating and identifying the most suitable restoration sites immediately after a fire, using geoinformation technologies. For the purposes of demonstrating the method’s applicability, the 2016 fire of “Prinos”, Thasos, Greece, an area that has been repeatedly affected by forest fires, was chosen as a case study. The methodology evaluation was carried out by applying the weighted multicriteria decision analysis method (MCDAM) and was based on a number of variables. The analysis, processing and extraction of the results were performed using primarily remote sensing datasets in a geographical information system (GIS) environment. The methodology proposed herein includes the classification of the individual criteria and their synthesis based on different weighting factors. In the final results, the restoration suitability maps are presented in five suitability zones based on two different scenarios. Based on this study, the integration of geospatial and remote sensing data offers a valuable and cost-effective means for promptly assessing post-fire landscapes, with the aim of identifying suitable restoration sites. Full article

IgA Nephropathy (IgAN) is the most common cause of primary glomerulonephritis worldwide. Despite the histopathologic hallmark of mesangial IgA deposition, IgAN is a heterogenous autoimmune disease not only in terms of clinical presentation but also in long-term disease progression. The pathogenesis of the disease is complex and includes the generation of circulating IgA immune complexes with chemical and biological characteristics that favor mesangial deposition and reaction to mesangial under-glycosylated IgA1 accumulation, which leads to tissue injury with glomerulosclerosis and interstitial fibrosis. Patients with proteinuria over 1 g, hypertension, and impaired renal function at diagnosis are considered to be at high risk for disease progression and end-stage kidney disease (ESKD). Glucocorticoids have been the mainstay of treatment for these patients for years, but without long-term benefit for renal function and accompanied by several adverse events. A better understanding of the pathophysiology of IgAN in recent years has led to the development of several new therapeutic agents. In this review, we summarize the current therapeutic approach for patients with IgAN as well as all novel investigational agents. Full article

This study examined the effects of a Pleurotus eryngii mushroom snack on metabolically unhealthy patients. After harvest, mushrooms were baked and subjected to UV-B irradiation to enhance vitamin D₂ content. A randomized controlled trial was conducted for three months with two arms. Both groups received conventional nutritional counseling for metabolic disorders, while the intervention group had to consume the snack daily as well. We collected blood samples at the beginning and the end of the study to determine biochemical measurements and serum 25(OH)D2 and to evaluate inflammation and oxidative stress. One hundred patients consented and were randomized. Comparatively to the control group, snack consumption regulated glucose levels and reduced body weight, fat, waist and hip circumferences. In addition, 25(OH)D2 increased significantly in the intervention group. The levels of LDL and SGOT were lower only in the intervention group. Levels of IL-6 and ox-LDL decreased in the mushroom group, while the overall physical health increased. These findings suggest potential antidiabetic, antiobesity, anti-inflammatory and antioxidant health benefits of the snack to metabolically unhealthy individuals. Full article

The landscape of human immunodeficiency virus (HIV) epidemiology and treatment is ever-changing, with the widespread and evolving use of antiretroviral therapy (ART). With timely ART, people living with HIV (PLWH) are nearing the life expectancies and the functionality of the general population; nevertheless, the effects of HIV and ART on cardiovascular health remain under investigation. The pathophysiology of HIV-related cardiomyopathy and heart failure (HF) have historically been attributed to systemic inflammation and changes in cardiometabolic function and cardiovascular architecture. Importantly, newer evidence suggests that ART also plays a role in modulating the process of HIV-related cardiomyopathy and HF. In the short term, newer highly active ART (HAART) seems to have cardioprotective effects; however, emerging data on the long-term cardiovascular outcomes of certain HAART medications, i.e., protease inhibitors, raise concerns about the potential adverse effects of these drugs in the clinical course of HIV-related HF. As such, the traditional phenotypes of dilated cardiomyopathy and left ventricular systolic failure that are associated with HIV-related heart disease are incrementally being replaced with increasing rates of diastolic dysfunction and ischemic heart disease. Moreover, recent studies have found important links between HIV-related HF and other clinical and biochemical entities, including depression, which further complicate cardiac care for PLWH. Considering these trends in the era of ART, the traditional paradigms of HIV-related cardiomyopathy and HF are being called into question, as is the therapeutic role of interventions such as ventricular assist devices and heart transplantation. In all, the mechanisms of HIV-related myocardial damage and the optimal approaches to the prevention and the treatment of cardiomyopathy and HF in PLWH remain under investigation. Full article

The use of the innovative material of Carbon Fiber-Reinforced (C-FRP) ropes as external near surface mounted reinforcement for the strengthening of reinforced concrete beam-column joints is studied. The ropes are diagonally applied forming external X-type reinforcements on both sides of the joint body. The efficiency of the technique is mainly based on the assumption that the confinement of the joint body due to the applied X-shaped ropes and the contribution of the ropes as shear reinforcement are efficient enough to reduce the shear deformations observed in the joint core during the seismic excitation. Thereof the experimental measurements of the shear deformations of nine full scale beam-column joints tested in cyclic deformations are elaborated and presented herein. The specimens are sorted in two groups. Specimens of group A have been designed in the way that damage is mainly expected in the beam. On the other hand, in order to investigate the efficacy of the use of the ropes for substandard joints the group B specimens have been designed in the way that cracks and some damages are expected to develop in the joint body. Systematic and extended comparative presentations for specimens with and without ropes proved in all the examined cases that the externally mounted C-FRP ropes kept the joint body intact and substantially reduced the shear deformations especially in high drifts. Moreover, the influence of the externally mounted X-shaped C-FRP ropes on the seismic behaviour of these specimens is also examined in terms of the developing principal tensile stresses inside the joint body. From the comparisons of the principal stresses developing in specimens with and without X-form C-FRP ropes it became quite obvious that the ropes kept the joint body intact and allowed the development of higher values of principal stresses comparing with the stresses developing in specimens without ropes. Full article

High-strength steel fiber-reinforced concrete (HSFC) and ultra-high strength steel fiber-reinforced concrete (UHSFC) jackets have been proved experimentally to be much more effective with respect to other strengthening schemes in improving the hysteresis performance of existing substandard reinforced concrete (RC) structural members. In this paper, an existing analytical model for the prediction of the shear capacity of RC beam-column joints strengthened with a HSFC or UHSFC jacket is extended to provide design formulation of these innovative HSFC and UHSFC jackets. An authoritative validation of the proposed formulation is also achieved by comparisons of experimental results of 50 beam-column joint specimens with the analytical predictions of the model. Test data used for verification have been collected from the literature based on experimental studies of the authors and other researchers. The merits of the HSFC and UHSFC jacketing technique are also highlighted in the state of practice. Design and application of the proposed fiber-reinforced concrete jackets in deficient existing RC beam-column joints provides a sustainable strengthening technique by contributing to the reduction in the cost and to labor-intensive procedures of common jackets by completely replacing the installation of reinforcement. Full article

An analytical and experimental investigation was conducted herein to examine the cyclic load behavior of beam–column joint subassemblages, typical of both the modern reinforced concrete (RC) structures and of the pre-1960s–1970s existing ones. Seven exterior RC beam–column joint subassemblages were constructed and subjected to earthquake-type loading. Three specimens were designed according to the requirements of the Eurocode (EC) for ductility class medium (DCM), while the other three specimens possessed poor seismic details, conforming to past building codes. The hysteresis behavior of the subassemblages was evaluated. An analytical model was used to calculate the ultimate shear capacity of the beam–column joint area, while also predicting accurately the failure mode of the specimens. It was clearly demonstrated experimentally and analytically that it is possible for excessive seismic damage of the beam–column joint region to occur when designing according to the current European building codes. In addition, the proposed analytical model was found to be very satisfactory in accurately predicting seismic behavior and in preventing the premature brittle shear failure of the joints. The seventh subassemblage, constructed with steel fiber RC and significantly less transverse reinforcement than that required according to the EC, exhibited satisfactory ductile seismic performance, demonstrating the effectiveness of the proposed design solution. Full article