Genes, Lifestyle and Non-communicable Diseases

Dear Colleagues,

The completion of human genome sequencing and the introduction of high-throughout ‘omic’ technologies have allowed a better understanding of lifestyle–gene interactions, which vary between genotypes, with the ultimate goal of developing personalised nutrition strategies for optimal health and disease prevention.

Humans are affected by both lifestyle and genetic factors; both factors must be considered equally to maintain the normal health condition of an individual. Previous studies were mostly directed at either the effects of lifestyle factors alone or solely genes; none have focused on both together. Recently, gene–nutrient and gene–physical activity interactions have been investigated. Nutrition and physical activity may impact health outcomes by directly affecting gene expression in critical metabolic pathways. Improved health outcomes can be achieved if nutritional requirements are individually tailored, taking into consideration the genetic make-up, life stage, dietary preferences, physical activity levels, and health status of an individual. This area of scientific research necessitates a better understanding of the mechanisms of nutrient-dependent interactions at the genetic, molecular, protein, and metabolic profile levels.

This Topic, “Genes, Lifestyle and Non-Communicable Diseases”, welcomes manuscripts detailing human and animal studies focused on the roles of lifestyle (diet and physical activity) and genetic factors in non-communicable diseases, such as cardiovascular disease, diabetes, and obesity, as well as in vitro studies aimed at elucidating the potential molecular mechanisms of genetic associations and lifestyle–gene interactions. Experimental papers, up-to-date review articles, and commentaries will all be considered.

Prof. Dr. Karani S. S Vimaleswaran
Topic Editor