Special Issue "Viral Strategies of Immune Evasion"

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editors

Dr. Alessandro Sinigaglia
E-Mail Website
Guest Editor
Department of Molecular Medicine, University of Padova. 35122 Padua, Italy.
Interests: Mechanisms of viral infection and immunity; development of new assays for the diagnosis of infectious diseases; microRNAs in infectious diseases
Prof. Dr. Luisa Barzon
E-Mail Website
Guest Editor
Department of Molecular Medicine, University of Padova, 35121 Padova, Italy
Interests: surveillance, diagnosis, and pathogenesis of emerging vector-borne viral infections; pathogenesis, diagnosis, and prevention of human papillomavirus-related diseases; investigation of virus–host interactions; development of patient-specific models of human susceptibility to viral infections; application of innovative molecular methods in infectious disease diagnosis
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The coordinated activation of innate and adaptive immune responses are crucial for host protection against viral diseases. However, several viruses have evolved sophisticated strategies to evade or actively suppress host immunity, which represent important components of viral pathogenesis. Mechanisms of immune evasion include, for example, escape from recognition by intracellular sensors, suppression of IFN-α/β production and signaling, subversion of immune cell function, overstimulation or suppression of inflammatory responses, modulation of autophagy and cell death mechanisms, selection of genetic variants that escape from neutralizing antibodies.

In this Special Issue, we aim for research papers and review articles that contribute to an improved understanding of the mechanisms evolved by viral pathogens to evade host innate and adaptive immunity.  

Dr. Alessandro Sinigaglia
Prof. Luisa Barzon
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • adaptive immune response
  • apoptosis
  • autophagy
  • inflammasome
  • inflammatory cell death
  • innate immune response
  • interferon
  • interferon pathway
  • microRNAs
  • natural killer cells
  • neutralizing antibodies
  • pattern recognition receptors
  • T cells
  • viral entry
  • viral evolution
  • viral proteins
  • viral replication

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

Review
Immune Evasion of SARS-CoV-2 Emerging Variants: What Have We Learnt So Far?
Viruses 2021, 13(7), 1192; https://doi.org/10.3390/v13071192 - 22 Jun 2021
Cited by 4 | Viewed by 3961
Abstract
Despite the slow evolutionary rate of SARS-CoV-2 relative to other RNA viruses, its massive and rapid transmission during the COVID-19 pandemic has enabled it to acquire significant genetic diversity since it first entered the human population. This led to the emergence of numerous [...] Read more.
Despite the slow evolutionary rate of SARS-CoV-2 relative to other RNA viruses, its massive and rapid transmission during the COVID-19 pandemic has enabled it to acquire significant genetic diversity since it first entered the human population. This led to the emergence of numerous variants, some of them recently being labeled “variants of concern” (VOC), due to their potential impact on transmission, morbidity/mortality, and the evasion of neutralization by antibodies elicited by infection, vaccination, or therapeutic application. The potential to evade neutralization is the result of diversity of the target epitopes generated by the accumulation of mutations in the spike protein. While three globally recognized VOCs (Alpha or B.1.1.7, Beta or B.1.351, and Gamma or P.1) remain sensitive to neutralization albeit at reduced levels by the sera of convalescent individuals and recipients of several anti-COVID19 vaccines, the effect of spike variability is much more evident on the neutralization capacity of monoclonal antibodies. The newly recognized VOC Delta or lineage B.1.617.2, as well as locally accepted VOCs (Epsilon or B.1.427/29-US and B1.1.7 with the E484K-UK) are indicating the necessity of close monitoring of new variants on a global level. The VOCs characteristics, their mutational patterns, and the role mutations play in immune evasion are summarized in this review. Full article
(This article belongs to the Special Issue Viral Strategies of Immune Evasion)
Show Figures

Figure 1

Back to TopTop