T Cells in Viral Infections
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".
Deadline for manuscript submissions: closed (15 October 2022) | Viewed by 10170
Special Issue Editor
Interests: adaptive immunity and immunotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
T cell-based therapy has shown great potential as a more powerful approach to treating numerous diseases, including cancers and infectious and autoimmune disorders by harnessing the body's immune system. It is anticipated that responses initiated by immunotherapeutic interventions would explicitly uncover a venue of discerningly suppressing the individual disease while maintaining the rest of the immune system functionally active. Increasing knowledge in cellular immunology and the host immune response has led to the exciting development of diverse immunotherapeutic modalities, including the blockade of immune checkpoints, induction of activation of CD8+ cytotoxic T lymphocytes (CTLs) or CD4+ regulatory T cells (Tregs), the use of non-specific immunosuppressive drugs with associated side effects (e.g., anti-CD3, CD20 or CD52 antibody), adoptive T-cell transfer (ACT)-based therapy, and modulation of the local environment including the tumor microenvironment (TME) and inflammatory microenvironment (IME) to facilitate T cell immunity (e.g., low-dose IL-2 treatment). Nevertheless, despite enormous advances in T cell-based therapy, the clinical efficacy and benefits remain less satisfactory due to a variety of factors that lessen anti-disease immunity, which include ex vivo T cell production, limited in vivo T cell expansion and persistence, auto antigen identification, generation of antigen-specific T cells, off-target complications, local environment, T cell trafficking to the local sites, etc. Effective strategies to bypassing these barriers should significantly improve T cell-based immunotherapy for various diseases and are thus urgently needed.
Prof. Dr. Song Jianxun
Guest Editor
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Keywords
- virus
- T cell
- animal model
- immunotherapy
- viral latency
- cell metabolism
- immunomodulation
- exhaustion
- memory
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