Special Issue "10th Anniversary of Pathogens—T Cells in Pathogenic Infections"

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Immunological Responses and Immune Defense Mechanisms".

Deadline for manuscript submissions: 30 November 2022 | Viewed by 181

Special Issue Editor

Prof. Dr. Jianxun Song
E-Mail Website
Guest Editor
Microbial Pathogenesis and Immunology Department, College of Medicine Faculty, Texas A&M University Health Science Center, Bryan, TX 77807-3260, USA
Interests: adaptive immunity and immunotherapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The year 2022 marks the 10th anniversary of the publication of Pathogens. We would like to express our sincerest thanks to our readers, innumerable authors, anonymous peer reviewers, editors, and all the people working in one way or another for the journal, who have made substantial contributions over the years. We are delighted and proud to celebrate this milestone with a series of Special Issues and events.

To mark this important milestone, a Special Issue entitled “10th Anniversary of Pathogens—T Cells in Pathogenic Infections” will be launched as a part of this celebration.

T cells play a central role in the immune response against pathogenic infections, and T cell-based therapy has shown significant potential as a more powerful approach for treating various pathogenic diseases by harnessing the body's immune system. It is anticipated that responses initiated by immunotherapeutic interventions would explicitly uncover a revenue of discerningly suppressing the individual disease while maintaining the rest of the immune system functionally active. Increasing knowledge in cellular immunology and the host immune response has led to the exciting development of diverse immunotherapeutic modalities, including blockade of immune checkpoints, induction of activation of CD8+ cytotoxic T lymphocytes (CTLs) or CD4+ regulatory T cells (Tregs), the use of non-specific immunosuppressive drugs with associated side effects (e.g., anti-CD3, CD20, or CD52 antibody), adoptive T-cell transfer (ACT)-based therapy, and modulation of local environment, including the tumor microenvironment (TME) and inflammatory microenvironment (IME) to facilitate T cell immunity (e.g., low-dose IL-2 treatment). However, despite enormous advances in the T cell-based therapy, the clinical efficacy and benefits remain less satisfactory due to a variety of factors that lessen antiviral immunity, which include ex vivo T cell production, limited in vivo T cell expansion and persistence, auto antigen identification, generation of antigen-specific T cells, off-target complications, local environment, T cell trafficking to the local sites, etc. Effective strategies for bypassing these barriers should significantly improve T cell-based immunotherapy for pathogenic diseases, and thus are urgently needed.

Prof. Dr. Jianxun Song
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • pathogen
  • T cell
  • immunotherapy
  • persistence
  • cell metabolism
  • immunomodulation
  • exhaustion
  • memory
  • animal model

Published Papers

This special issue is now open for submission.
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