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Special Issue "Viruses and the Unfolded Protein Response"
Deadline for manuscript submissions: 1 December 2019.
Interests: influenza A virus; Kaposi’s sarcoma-associated herpesvirus; viral oncogenes; mRNA turnover and translation; stress granules; p-bodies; autophagy; unfolded protein response; inflammation; host shutoff
Special Issues and Collections in MDPI journals
Special Issue in Viruses: CSV2018: The 2nd symposium of the Canadian Society for Virology (CSV)
Special Issue in Viruses: The Role of NK Cells in Antiviral Innate Immunity
Viruses use host cell translation machinery to synthesize viral proteins, and the endoplasmic reticulum (ER) to ensure proper folding, post-translational modification, and trafficking of transmembrane and secreted viral proteins. Overloading the ER’s folding capacity activates the unfolded protein response (UPR), whereby the ER stress sensors PERK, IRE1, and ATF6 initiate signals that transiently attenuate translation and stimulate the production of stress-mitigating transcription factors. UPR transcription increases production of ER protein folding machinery, expands the ER’s surface area, and increases degradation of misfolded proteins by ER-associated degradation (ERAD). The UPR also plays important roles in cell fate decisions and immune responses. At present, relatively little is known about how viruses manipulate the UPR and the functional consequences of these interactions.
For this Special Issue of Viruses, we hope to assemble a collection of research papers and reviews that provide a comprehensive view of this emerging field of virus research. Topics of interest include, but are not limited to:
- viral protein synthesis and interplay with the UPR and/or the integrated stress response;
- viral modulation of UPR sensors;
- viral modulation of UPR transcription;
- viral control of ERAD;
- effects of viral infection on UPR-dependent cell differentiation and cell fate;
- the UPR and viral pathogenesis; and
- therapeutic targeting of the UPR during viral infection.
We hope that this Special Issue will serve as a valuable resource to new and established researchers in the field, and frame important unanswered questions to focus future research efforts.
Dr. Craig McCormick
Dr. Carolina Arias
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- endoplasmic reticulum
- unfolded protein response