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Viruses 2019, 11(2), 131; https://doi.org/10.3390/v11020131

Control of Acute Arboviral Infection by Natural Killer Cells

1
Sorbonne Université, UPMC Univ Paris 06, Inserm U1135, CNRS ERL8255, Centre d’Immunologie et des Maladies Infectieuses (CIMI-Paris), 75013 Paris, France
2
Institut Gustave Roussy, CNRS UMR9196, Unité Physiologie et Pathologie Moléculaires des Rétrovirus Endogènes et Infectieux, 94800 Villejuif, France
*
Author to whom correspondence should be addressed.
Received: 14 December 2018 / Revised: 28 January 2019 / Accepted: 31 January 2019 / Published: 31 January 2019
(This article belongs to the Special Issue The Role of NK Cells in Antiviral Innate Immunity)
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Abstract

The recent explosive pandemic of chikungunya virus (CHIKV) followed by Zika (ZIKV) virus infections occurring throughout many countries represents the most unexpected arrival of arthropod-borne viral diseases in the past 20 years. Transmitted through the bite of Aedes mosquitoes, the clinical picture associated with these acute arbovirus infections, including Dengue (DENV), CHIKV and ZIKV, ranges from classical febrile illness to life-threatening disease. Whereas ZIKV and CHIKV-mediated infections have previously been recognized as relatively benign diseases, in contrast to Dengue fever, recent epidemic events have brought waves of increased morbidity and mortality leading to a serious public health problem. Although the host immune response plays a crucial role in controlling infections, it may also promote viral spread and immunopathology. Here, we review recent developments in our understanding of the immune response, with an emphasis on the early antiviral immune response mediated by natural killer cells and emphasize their Janus-faced effects in the control of arbovirus infection and pathogenesis. Improving our understanding knowledge on of the mechanisms that control viral infection is crucial in the current race against the globalization of arbovirus epidemics. View Full-Text
Keywords: natural killer cells; arboviruses; interferon-γ; cytotoxicity natural killer cells; arboviruses; interferon-γ; cytotoxicity
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Maucourant, C.; Petitdemange, C.; Yssel, H.; Vieillard, V. Control of Acute Arboviral Infection by Natural Killer Cells. Viruses 2019, 11, 131.

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