Next Article in Journal
Crosstalk between Autophagy and Type I Interferon Responses in Innate Antiviral Immunity
Next Article in Special Issue
Cytomegalovirus-Driven Adaption of Natural Killer Cells in NKG2Cnull Human Immunodeficiency Virus-Infected Individuals
Previous Article in Journal
The Influence of Envelope C-Terminus Amino Acid Composition on the Ratio of Cell-Free to Cell-Cell Transmission for Bovine Foamy Virus
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview
Viruses 2019, 11(2), 131;

Control of Acute Arboviral Infection by Natural Killer Cells

Sorbonne Université, UPMC Univ Paris 06, Inserm U1135, CNRS ERL8255, Centre d’Immunologie et des Maladies Infectieuses (CIMI-Paris), 75013 Paris, France
Institut Gustave Roussy, CNRS UMR9196, Unité Physiologie et Pathologie Moléculaires des Rétrovirus Endogènes et Infectieux, 94800 Villejuif, France
Author to whom correspondence should be addressed.
Received: 14 December 2018 / Revised: 28 January 2019 / Accepted: 31 January 2019 / Published: 31 January 2019
(This article belongs to the Special Issue The Role of NK Cells in Antiviral Innate Immunity)
Full-Text   |   PDF [1035 KB, uploaded 31 January 2019]   |  
  |   Review Reports


The recent explosive pandemic of chikungunya virus (CHIKV) followed by Zika (ZIKV) virus infections occurring throughout many countries represents the most unexpected arrival of arthropod-borne viral diseases in the past 20 years. Transmitted through the bite of Aedes mosquitoes, the clinical picture associated with these acute arbovirus infections, including Dengue (DENV), CHIKV and ZIKV, ranges from classical febrile illness to life-threatening disease. Whereas ZIKV and CHIKV-mediated infections have previously been recognized as relatively benign diseases, in contrast to Dengue fever, recent epidemic events have brought waves of increased morbidity and mortality leading to a serious public health problem. Although the host immune response plays a crucial role in controlling infections, it may also promote viral spread and immunopathology. Here, we review recent developments in our understanding of the immune response, with an emphasis on the early antiviral immune response mediated by natural killer cells and emphasize their Janus-faced effects in the control of arbovirus infection and pathogenesis. Improving our understanding knowledge on of the mechanisms that control viral infection is crucial in the current race against the globalization of arbovirus epidemics. View Full-Text
Keywords: natural killer cells; arboviruses; interferon-γ; cytotoxicity natural killer cells; arboviruses; interferon-γ; cytotoxicity

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Maucourant, C.; Petitdemange, C.; Yssel, H.; Vieillard, V. Control of Acute Arboviral Infection by Natural Killer Cells. Viruses 2019, 11, 131.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top