Canine Cancer Immunotherapeutics
A special issue of Veterinary Sciences (ISSN 2306-7381).
Deadline for manuscript submissions: closed (30 September 2018) | Viewed by 27886
Special Issue Editor
Interests: molecular pathogenesis of feline immunodeficiency virus infection; vaccine development in animal models for HIV-1 AIDS; use of cytokines and TLR ligands as vaccine adjuvants; tumor immunology in companion animal cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Recent studies have revealed the power of immunotherapeutics for human cancer. In particular, agents that activate the immune system by blocking specific anti-inflammatory check points, as well as engineered T cells have proven to be effective in certain human patient populations. However, important issues relating to these therapies must be addressed and include significant toxicities and selection of patients who will most likely respond to these therapeutics. Furthermore, delivery technologies for these drugs warrant further optimization to limit off-target toxicities. Canine cancer patients are likely to benefit from these promising immunotherapeutic modalities, and may also provide a powerful model for testing of new generations of immunotherapeutics. Recent reports within veterinary research describe canine-specific antibodies with potential as checkpoint inhibitors, as well therapeutic canine cancer vaccines with some efficacy. Together these therapeutic modalities may significantly impact therapeutic protocols for certain canine cancers in the future and therefore present a potent area of focus for clinical canine cancer research.
Original manuscripts that address development and testing of cancer immunotherapeutics for canine cancers are solicited for this Special Issue. Studies that use innovative or novel technologies to identify specific cancers or canine patient populations more likely to respond to immunotherapeutics, are also encouraged for submission.
Dr. Ellen E. Sparger
Guest Editor
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Keywords
- canine cancer
- cancer immunotherapeutics
- animal models
- checkpoint inhibitors
- engineered T cells
- cancer vaccines
- immune system targets
- immune modulation in cancer
- immunotherapy toxicities
- One Health
- One Medicine
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