CD147 and Cyclooxygenase Expression in Feline Oral Squamous Cell Carcinoma
AbstractFeline oral squamous cell carcinoma (OSCC) is a highly invasive form of cancer in cats. In human OSCC, cluster of differentiation 147 (CD147) contributes to inflammation and tumor invasiveness. CD147 is a potential therapeutic target, but the expression of CD147 in feline OSCC has not been examined. Immunohistochemistry was used to determine if cyclooxygenase 2 (COX-2) and CD147 expression in feline OSCC biopsies was coordinated. Tumor cells were more likely to express COX-2 (22/43 cases or 51%) compared to stroma (8/43 or 19%) and adjacent oral epithelium (9/31 cases or 29%) (p < 0.05). CD147 was also more likely to occur in tumor cells compared to stroma and adjacent mucosa, with 21/43 (49%) of cases having >50% tumor cells with mild or moderate CD147 expression, compared to 9/28 (32%) in adjacent epithelium and only 5/43 (12%) in adjacent stroma (p < 0.05). In feline OSCC cell lines (SCCF1, SCCF2, and SCCF3), CD147 gene expression was more consistently expressed compared to COX-2, which was 60-fold higher in SCCF2 cells compared to SCCF1 cells (p < 0.05). CD147 expression did not correlate with COX-2 expression and prostaglandin E2 (PGE2) secretion, indicating that they may be independently regulated. CD147 potentially represents a novel therapeutic target for the treatment of feline OSCC and further study of CD147 is warranted. View Full-Text
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Nasry, W.H.S.; Wang, H.; Jones, K.; Dirksen, W.P.; Rosol, T.J.; Rodriguez-Lecompte, J.C.; Martin, C.K. CD147 and Cyclooxygenase Expression in Feline Oral Squamous Cell Carcinoma. Vet. Sci. 2018, 5, 72.
Nasry WHS, Wang H, Jones K, Dirksen WP, Rosol TJ, Rodriguez-Lecompte JC, Martin CK. CD147 and Cyclooxygenase Expression in Feline Oral Squamous Cell Carcinoma. Veterinary Sciences. 2018; 5(3):72.Chicago/Turabian Style
Nasry, Walaa H.S.; Wang, Haili; Jones, Kathleen; Dirksen, Wessel P.; Rosol, Thomas J.; Rodriguez-Lecompte, Juan C.; Martin, Chelsea K. 2018. "CD147 and Cyclooxygenase Expression in Feline Oral Squamous Cell Carcinoma." Vet. Sci. 5, no. 3: 72.
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