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Vet. Sci. 2018, 5(3), 72; https://doi.org/10.3390/vetsci5030072

CD147 and Cyclooxygenase Expression in Feline Oral Squamous Cell Carcinoma

1
Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE C1A 4P3, Canada
2
Diagnostic Services, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE C1A 4P3, Canada
3
Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
4
Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA
*
Author to whom correspondence should be addressed.
Received: 16 July 2018 / Revised: 2 August 2018 / Accepted: 9 August 2018 / Published: 13 August 2018
(This article belongs to the Special Issue Canine Cancer Immunotherapeutics)
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Abstract

Feline oral squamous cell carcinoma (OSCC) is a highly invasive form of cancer in cats. In human OSCC, cluster of differentiation 147 (CD147) contributes to inflammation and tumor invasiveness. CD147 is a potential therapeutic target, but the expression of CD147 in feline OSCC has not been examined. Immunohistochemistry was used to determine if cyclooxygenase 2 (COX-2) and CD147 expression in feline OSCC biopsies was coordinated. Tumor cells were more likely to express COX-2 (22/43 cases or 51%) compared to stroma (8/43 or 19%) and adjacent oral epithelium (9/31 cases or 29%) (p < 0.05). CD147 was also more likely to occur in tumor cells compared to stroma and adjacent mucosa, with 21/43 (49%) of cases having >50% tumor cells with mild or moderate CD147 expression, compared to 9/28 (32%) in adjacent epithelium and only 5/43 (12%) in adjacent stroma (p < 0.05). In feline OSCC cell lines (SCCF1, SCCF2, and SCCF3), CD147 gene expression was more consistently expressed compared to COX-2, which was 60-fold higher in SCCF2 cells compared to SCCF1 cells (p < 0.05). CD147 expression did not correlate with COX-2 expression and prostaglandin E2 (PGE2) secretion, indicating that they may be independently regulated. CD147 potentially represents a novel therapeutic target for the treatment of feline OSCC and further study of CD147 is warranted. View Full-Text
Keywords: feline; oral squamous cell carcinoma; CD147; EMMPRIN; Basigin; COX-1; COX-2; PGE2; inflammation; invasion feline; oral squamous cell carcinoma; CD147; EMMPRIN; Basigin; COX-1; COX-2; PGE2; inflammation; invasion
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Nasry, W.H.S.; Wang, H.; Jones, K.; Dirksen, W.P.; Rosol, T.J.; Rodriguez-Lecompte, J.C.; Martin, C.K. CD147 and Cyclooxygenase Expression in Feline Oral Squamous Cell Carcinoma. Vet. Sci. 2018, 5, 72.

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