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Veterinary Sciences
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Research on Microbiome and Bioactive Substances in Human and Animal...
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Research on Microbiome and Bioactive Substances in Human and Animal Health: Antibiotic Resistance, Database, Metabolism, Methodology, and Vaccine Design

A Special Issue of Veterinary Sciences (ISSN 2306-7381) belonging to the section "Veterinary Microbiology, Parasitology and Immunology".

Deadline for manuscript submissions: 15 March 2027 | Viewed by 1127

Editors

Dr. Zheng Li

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Guest Editor
Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Interests: microbiome; 16S rDNA; metagenome; methodology
Dr. Shulei Jia

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Guest Editor
School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
Interests: microbiomics; antibiotic resistance and epidemics; vaccine design; gut microbiome; model development and methodology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The microbiome and microbiome-derived bioactive substances play essential roles in maintaining health and shaping disease processes in both humans and animals, and growing evidence demonstrates their involvement in key biological and clinical areas, including antimicrobial resistance, metabolic regulation, immune modulation, and host responses to therapeutic and preventive interventions. Rapid advances in sequencing technologies, bioinformatics, and multi-omics approaches have greatly enhanced our ability to characterize microbial communities, resistomes, and host–microbe interactions, while supporting translational applications across human and veterinary medicine.

With this context in mind, this Special Issue aims to provide a multidisciplinary platform for original research articles, high-quality reviews, and short communications addressing both fundamental mechanisms and applied perspectives. Topics of interest include, but are not limited to, zoonosis, microbiome from humans, companion or livestock animals, resistant genes, antibiotic resistance gene (ARG) dissemination, microbiome-associated metabolism, bioactive compounds, database construction and data integration, methodological innovations, and microbiome-informed strategies for disease prevention and vaccine design. Contributions from experimental, clinical, veterinary, and computational studies that support One Health approaches and advance the translational impact of microbiome research are particularly encouraged.

Dr. Zheng Li
Dr. Shulei Jia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial resistance
  • genomic database
  • metagenomics
  • epidemiology and public health
  • zoonotic diseases
  • companion animals gut microbiota
  • bioactive substances and human health
  • one health
  • human gut microbiota
  • clinical methodology and vaccine design

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Published Papers (2 papers)

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Research

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18 pages, 3757 KB  
Article
Diversity and Spatiotemporal Atlas of Ticks in the Beijing–Tianjin–Hebei Urban Agglomeration Based on the MaxEnt Model
by Lingling Chen, Wanying Gao, Yang Song, Zihao Huang, Jialing Long, Jiaqi Nie, Zengliang Wang and Shulei Jia
Vet. Sci. 2026, 13(7), 651; https://doi.org/10.3390/vetsci13070651 - 3 Jul 2026
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Abstract
Background: This study aims to delineate the present and projected suitable habitats for four dominant tick species in the Beijing–Tianjin–Hebei (BTH) region, providing a spatial basis for targeted tick-borne disease surveillance. Methods: We systematically reviewed the published literature and the Global Biodiversity Information [...] Read more.
Background: This study aims to delineate the present and projected suitable habitats for four dominant tick species in the Beijing–Tianjin–Hebei (BTH) region, providing a spatial basis for targeted tick-borne disease surveillance. Methods: We systematically reviewed the published literature and the Global Biodiversity Information Facility (GBIF) to compile tick occurrence records in the BTH region. A total of 167 geo-referenced occurrence records with verified coordinates were obtained for four dominant species: Haemaphysalis longicornis, Haemaphysalis concinna, Dermacentor silvarum, and Ixodes persulcatus. The MaxEnt model was applied with bioclimatic variables (WorldClim, 2.5 arc-min), elevation, slope, aspect, and NDVI. Model performance was evaluated using the area under the receiver operating characteristic curve (AUC) for within-species comparisons, complemented by the True Skill Statistic (TSS), Cohen’s kappa, and omission rate. Future projections (2021–2040, 2041–2060, 2061–2080, 2081–2100) were made under the SSP245 scenario using only climate variables, as the NDVI and topographic variables cannot be reliably forecast. Results: The four dominant tick species showed distinct distribution patterns: Hae. longicornis was widely distributed across the BTH region, whereas Hae. concinna, D. silvarum, and I. persulcatus were mainly found in the northern and northwestern mountainous areas. The primary environmental drivers were temperature, elevation, and the NDVI. MaxEnt models achieved good predictive performance (test AUC: 0.86–0.91; TSS: 0.72–0.88). Under future climate scenarios, suitable habitat centroids were projected to shift northwestward for Hae. longicornis (~57.6 km), D. silvarum (~71.1 km), and I. persulcatus (~50.0 km), and northeastward for Hae. concinna (~63.0 km) by 2081–2100. Conclusions: In this study, we identified current and future high-risk areas for four dominant tick species in the BTH region, providing a reproducible foundation for surveillance. Future projections should be interpreted with caution as they only account for climatic changes. Full article
(This article belongs to the Special Issue Research on Microbiome and Bioactive Substances in Human and Animal Health: Antibiotic Resistance, Database, Metabolism, Methodology, and Vaccine Design)
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Review

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16 pages, 1449 KB  
Review
Improving the Quality of Lyophilized Animal Vaccines: A Review of Optimization Strategies for Freeze-Drying Processes
by Fangjing Huang, Jiajie Jiao, Zexi Wang, Hongying Jie, Jiahao He, Xiaoxin Zuo, Yanhong Zhao, Yu Lu, Jianhong Gu and Fang Lyu
Vet. Sci. 2026, 13(9), 972; https://doi.org/10.3390/vetsci13090972 - 16 Sep 2026
Abstract
Vacuum freeze-drying, commonly referred to as lyophilization, is one of the primary processes in vaccine industrial manufacturing. It offers significant advantages, including a marked extension of the shelf-life of dried products, effective preservation of biological activity, and user convenience. However, in the production [...] Read more.
Vacuum freeze-drying, commonly referred to as lyophilization, is one of the primary processes in vaccine industrial manufacturing. It offers significant advantages, including a marked extension of the shelf-life of dried products, effective preservation of biological activity, and user convenience. However, in the production of animal freeze-dried vaccines, the diverse nature of antigens, the complexity of heat-stable protectant formulations, and variations in manufacturing equipment pose substantial challenges to process design for animal freeze-dried vaccines. Commercially available animal freeze-dried vaccines commonly suffer from antigen potency loss, insufficient product stability, low production efficiency and high manufacturing costs. Freeze-drying process optimization can markedly improve the quality of freeze-dried vaccines, with key evaluation indicators including vaccine stability, shelf-life, sample morphology, and residual moisture content. Focusing on multiple types of animal vaccines, this review summarizes research advances in improving the quality of animal freeze-dried vaccines from the perspectives of modifying material properties, enhancing freezing-stage regulation, increasing the specific surface area for drying, and optimizing heat conduction. Finally, future research strategies for animal freeze-dried vaccines are prospected. Although numerous approaches have been proposed to enhance the quality of animal freeze-dried vaccines, comprehensive considerations from multiple dimensions are still required to provide more holistic theoretical support for cost reduction and efficiency improvement in the production of animal freeze-dried vaccines. Full article
(This article belongs to the Special Issue Research on Microbiome and Bioactive Substances in Human and Animal Health: Antibiotic Resistance, Database, Metabolism, Methodology, and Vaccine Design)
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