Special Issue "Advances in Allergy Immunotherapy and Vaccination"

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Clinical Immunology".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 169

Special Issue Editor

INSERM, Immunology-Immunopathology-Immunotherapy (i3), Sorbonne Université, F-75005 Paris, France
Interests: vaccine; allergy immunotherapy

Special Issue Information

Dear Colleagues,

Allergic diseases are becoming increasingly detrimental to global health and economics. Classical allergic inflammation is caused by elevated allergen-specific IgE responses that promote basophil and mast cell degranulation upon encountering allergens. The only established disease-modifying treatment for allergic diseases—allergen-specific immunotherapy (AIT or SIT)—is not available for all types of allergies and still requires optimization from an efficacy/safety standpoint, as it currently requires a multitude of allergen extract injections over long time periods. Mechanistically, AIT aims to shift the type 2 inflammatory immune response towards a tolerant outcome. Though the detailed mechanisms of AIT are still not completely understood, interesting hallmarks that are associated with successful AIT include the expansion of regulatory T and B cells, as well as an increase in IgG4/IgE ratios. A major problem of AIT is the risk of anaphylaxis upon allergen extract administration due to the activation of basophils or mast cells. Current AIT optimization approaches include the evaluation of injection routes for allergen extracts and the modification of allergens in a way that reduces basophil/mast cell activation while maintaining allergen immunogenicity.

This Special Issue aims to improve our understanding of:

  1. The mechanisms that drive and suppress allergic sensitization and inflammation;
  2. The mechanisms by which allergic immune responses could be shifted towards tolerance by therapeutic vaccination and/or adjuvantation strategies;
  3. How the ability of allergens/vaccines to trigger the degranulation of mast  cells and basophils could be reduced without losing their immunogenicity and their disease-modifying properties.

Dr. Paul Engeroff
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • allergy
  • allergens
  • type 2 immune responses
  • immunotherapy
  • vaccine
  • mast cells
  • basophils

Published Papers

There is no accepted submissions to this special issue at this moment.
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