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Vaccines
Special Issues
Vaccines and Immunotherapy for Inflammatory Disease
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Vaccines and Immunotherapy for Inflammatory Disease

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Vaccines, Clinical Advancement, and Associated Immunology".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 1285

Special Issue Editor

Dr. Pui-Ying Leong

E-Mail Website
Guest Editor
Department of Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan
Interests: immunology; vaccine development; inflammatory pathways; autoimmune diseases; cytokine signaling; immunotherapy

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the role of vaccines and immunotherapeutic strategies in preventing and treating inflammatory diseases. Inflammation is a crucial factor in the development of various chronic conditions, including autoimmune disorders, metabolic syndromes, and certain types of cancer. As our understanding of immune regulation improves, new therapeutic vaccines and targeted immunotherapies have emerged as promising tools to address abnormal inflammatory responses.

We invite original research articles, reviews, and clinical studies that examine vaccine-based interventions, immune modulation strategies, biomarkers for vaccine efficacy, and the potential application of immunotherapies in inflammatory disease contexts. We particularly encourage contributions that connect basic immunology with clinical applications.

Dr. Pui-Ying Leong
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vaccines
  • immunotherapy
  • inflammation
  • autoimmune disease
  • cytokines
  • immune modulation
  • chronic inflammatory diseases
  • immune response
  • vaccine development
  • translational immunology

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

14 pages, 612 KB  
Article
COVID-19 Vaccination Reduces Lower Limb Amputation Rates and Mortality Rate in Patients with Pre-Existing Peripheral Vascular Disease Based on TriNetX Database
by Shiuan-Tzuen Su, Yu-Hsuan Huang, Jing-Yang Huang and James C.-C. Wei
Vaccines 2025, 13(9), 969; https://doi.org/10.3390/vaccines13090969 - 12 Sep 2025
Viewed by 646
Abstract
Background: Unvaccinated individuals with peripheral arterial occlusive disease (PAOD) are more likely to develop acute limb ischemia (ALI) following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We assessed the protective effect of the COVID-19 vaccine in preventing ALI in PAOD patients with [...] Read more.
Background: Unvaccinated individuals with peripheral arterial occlusive disease (PAOD) are more likely to develop acute limb ischemia (ALI) following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We assessed the protective effect of the COVID-19 vaccine in preventing ALI in PAOD patients with SARS-CoV-2 infection. Methods: This retrospective cohort study was conducted using the United States TriNetX (Cambridge, MA, USA), using patients with PAOD who were diagnosed with SARS-CoV-2 infection between 1 November 2020 and 31 December 2023. Propensity score matching was performed to adjust for demographic variables, lifestyle factors, medical utilization, and comorbidities. Cox proportional hazards models were used to compare the two matched cohorts. Kaplan–Meier analysis estimated the 3-year cumulative probability of lower limb amputation incidence. We selected 12,948 PAOD patients who received the COVID-19 vaccine and 44,064 PAOD patients who were unvaccinated against COVID-19. Results: A total of 11,822 pairs of COVID-19 vaccinated PAOD patients and unvaccinated individuals were compared. The mean (SD) age was 66.5 (14.1) years; there were 4849 male patients (41%) and 6569 female (55.6%) compared to unvaccinated PAOD patients, and those who received the COVID-19 vaccine had a significantly lower risk of 3-year all-cause mortality (log-rank test, p < 0.001; hazard ratio (HR) was 0.857; 95% CI, 0.796–0.922) and lower limb amputation (log-rank test, p = 0.001, HR = 0.716; 95% CI, 0.587–0.873), though there was no significant difference in ischemic stroke (log-rank test, p = 0.174; HR = 0.958; 95% CI, 0.902–1.019). Conclusions: This study found that patients who received the COVID-19 vaccine had a significantly lower risk of 3-year all-cause mortality and lower limb amputation, though there was no significant difference in ischemic stroke. Full article
(This article belongs to the Special Issue Vaccines and Immunotherapy for Inflammatory Disease)
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