Humoral Immune Responses to Cytomegalovirus
A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Pathogens-host Immune Interface".
Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 329
Special Issue Editor
Special Issue Information
Summary: Despite extensive research efforts to develop a human cytomegalovirus (CMV) vaccine candidate for congenital disease and transplant-related complications, there is no CMV vaccine approved for routine clinical use. While the stimulation of antibodies is thought to be important for developing of a CMV vaccine strategy, the precise antibody responses that provide protection against CMV infection in pregnant women or transplant recipients are not well understood.
In this special issue we invite you to submit an original article or a review article about CMV-specific humoral immune responses with the goal to obtain a better understanding for the feasibility to develop an effective CMV vaccine candidate or novel antibody-based therapies. This may include novel data or a discussion about the protective capacity of antibodies to prevent CMV infection and disease in pregnant women or transplant recipients, the problematic of the imperfect protection by naturally-acquired immunity in the context of CMV vaccine development, the primary glycoprotein and epitope targets of potentially protective CMV-specific antibodies, the importance of specific antibody functions and antibody potency to protect against CMV, the need to target different glycoprotein complexes to effectively interfere with CMV infection, immune evasion strategies to escape antibody recognition, the relation of in vitro antibody function and potency and the protective capacity of specific antibodies in vivo, and antibody-mediated protection in animal models to optimize and guide the development of novel CMV-specific vaccine approaches and therapies. We ask you to form a final opinion in a conclusive paragraph about the importance of antibodies and antibody function, potency and epitope specificity in the protection against CMV infection.
Prof. Felix Wussow
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cytomegalovirus
- congenital infection
- transplant recipients
- immunity
- antibody
- protection
- glycoprotein
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