Cancer Immunotherapy and Vaccination: Mechanistic Insights into Lymphocyte-Mediated Immune Modulation
A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Cancer Vaccines and Immunotherapy".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 6215
Special Issue Editor
Special Issue Information
Dear Colleagues,
Cancer remains a major public health and economic issue with an ever-increasing burden. The advancement of cancer vaccines and immunotherapies, including checkpoint inhibitors and oncolytic virotherapy, that are able to amplify the body’s immune system against cancer has shown great promise. However, many human cancers fail to respond to these regimens due to the body’s own immunosuppressive tumor-promoting mechanisms that represent critical barriers to effective anti-tumor immunotherapies and vaccination. These mechanisms include the presence of immunosuppressive cells, e.g., regulatory T-cells, and dysfunctional effector cells that fail to exert anti-tumor activity in the tumor microenvironment. Moreover, some tumors even lack significant infiltration of anti-tumor effector cells, particularly cytotoxic T-cells and natural killer (NK) cells, rendering them resistant to immunotherapy. In addition to the required induction of anti-tumor cellular responses, recent studies have also begun to appreciate the necessity to enhance B-cell-mediated humoral antibody responses and to induce the formation of tertiary lymphoid structure in the tumor in order to improve the overall efficacy of cancer vaccines and immunotherapeutic approaches.
This Special Issue aims to provide a platform to all scientists working in these fields to discuss the currently known and any new mechanisms underlying the immune modulation induced by any developed or new cancer vaccines and immunotherapeutic approaches, with a focus on the immune responses driven by lymphocytes, including T-cells, B-cells, NK and innate lymphoid cells (ILC).
I look forward to receiving your contributions.
Dr. Jianmei Leavenworth
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- tumor immunology
- cancer immunotherapy
- cancer vaccines
- tumor microenvironment
- CD4+ T-cells
- regulatory T-cells
- CD8+ T-cells
- NK cells
- innate lymphoid cells
- cellular response
- humoral response
- tertiary lymphoid structure
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
