Cancer Immunotherapy and Vaccination: Mechanistic Insights into Lymphocyte-Mediated Immune Modulation
A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Cancer Vaccines and Immunotherapy".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 5220
Special Issue Editor
Special Issue Information
Dear Colleagues,
Cancer remains a major public health and economic issue with an ever-increasing burden. The advancement of cancer vaccines and immunotherapies, including checkpoint inhibitors and oncolytic virotherapy, that are able to amplify the body’s immune system against cancer has shown great promise. However, many human cancers fail to respond to these regimens due to the body’s own immunosuppressive tumor-promoting mechanisms that represent critical barriers to effective anti-tumor immunotherapies and vaccination. These mechanisms include the presence of immunosuppressive cells, e.g., regulatory T-cells, and dysfunctional effector cells that fail to exert anti-tumor activity in the tumor microenvironment. Moreover, some tumors even lack significant infiltration of anti-tumor effector cells, particularly cytotoxic T-cells and natural killer (NK) cells, rendering them resistant to immunotherapy. In addition to the required induction of anti-tumor cellular responses, recent studies have also begun to appreciate the necessity to enhance B-cell-mediated humoral antibody responses and to induce the formation of tertiary lymphoid structure in the tumor in order to improve the overall efficacy of cancer vaccines and immunotherapeutic approaches.
This Special Issue aims to provide a platform to all scientists working in these fields to discuss the currently known and any new mechanisms underlying the immune modulation induced by any developed or new cancer vaccines and immunotherapeutic approaches, with a focus on the immune responses driven by lymphocytes, including T-cells, B-cells, NK and innate lymphoid cells (ILC).
I look forward to receiving your contributions.
Dr. Jianmei Leavenworth
Guest Editor
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Keywords
- tumor immunology
- cancer immunotherapy
- cancer vaccines
- tumor microenvironment
- CD4+ T-cells
- regulatory T-cells
- CD8+ T-cells
- NK cells
- innate lymphoid cells
- cellular response
- humoral response
- tertiary lymphoid structure
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