Production Mechanisms and Biosynthesis of Aflatoxin
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Mycotoxins".
Deadline for manuscript submissions: closed (30 November 2019) | Viewed by 15627
Special Issue Editor
Interests: mycology; the comprehension of biotic and abiotic mechanisms leading to mycotoxin production; strategies that can be used to limit food contamination; identification of natural compounds able to specifically block toxin production; identification of natural compounds that could be used as alternatives to pesticides in the development of sustainable strategies to improve food safety; the emergence of new mycotoxins (Aflatoxin B1, stachybotriotoxins) in Europe due to climate change
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mycotoxins are frequent contaminants of foods and feeds around the world. Among the hundreds of known mycotoxins, aflatoxins are probably the most important due to their toxic effects (carcinogenic in human), their wide and increasing distribution due to climate changes, as well as their economic consequences (withdrawal of food batches due to international regulations). The biosynthesis of aflatoxins is complex, involving a cluster of 30 genes including two internal regulators. Moreover, the activation of this biosynthetic pathway interacts with many other genes and cellular pathways that are, to date, only partially known and understood. Deciphering the mechanisms underlying the synthesis and control of aflatoxin production could help to identify new strategies to control the contamination of foods and feeds. Indeed, understanding the interconnection between fungal cell biology and signaling and aflatoxin synthesis could lead to the identification of new targets to specifically control toxin production. Such new strategies could represent sustainable and ecologically friendly ways to ensure food safety and preserve biodiversity.
The focus of this Special Issue of Toxins is on the understanding of the biosynthetic pathways leading to aflatoxin production at both the cellular and molecular levels, as well as ways to control this production by interfering with biosynthetic processes.
Prof. Dr. Jean-Denis Bailly
Guest Editor
Manuscript Submission Information
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Keywords
- aflatoxins
- biosynthesis
- mechanism
- control
- cluster
- fungal biology
