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Open AccessArticle

Function of crzA in Fungal Development and Aflatoxin Production in Aspergillus flavus

School of Food Science and Biotechnology, Institute of Agricultural Science and Technology, Kyungpook National University, Daegu 41566, Korea
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Toxins 2019, 11(10), 567; https://doi.org/10.3390/toxins11100567
Received: 27 August 2019 / Revised: 26 September 2019 / Accepted: 27 September 2019 / Published: 27 September 2019
(This article belongs to the Special Issue Production Mechanisms and Biosynthesis of Aflatoxin)
The calcineurin pathway is an important signaling cascade for growth, sexual development, stress response, and pathogenicity in fungi. In this study, we investigated the function of CrzA, a key transcription factor of the calcineurin pathway, in an aflatoxin-producing fungus Aspergillus flavus (A. flavus). To examine the role of the crzA gene, crzA deletion mutant strains in A. flavus were constructed and their phenotypes, including fungal growth, spore formation, and sclerotial formation, were examined. Absence of crzA results in decreased colony growth, the number of conidia, and sclerocia production. The crzA-deficient mutant strains were more susceptible to osmotic pressure and cell wall stress than control or complemented strains. Moreover, deletion of crzA results in a reduction in aflatoxin production. Taken together, these results demonstrate that CrzA is important for differentiation and mycotoxin production in A. flavus. View Full-Text
Keywords: CrzA; Calcineurin; aflatoxin; Aspergillus flavus; Asexual development CrzA; Calcineurin; aflatoxin; Aspergillus flavus; Asexual development
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Lim, S.-Y.; Son, Y.-E.; Lee, D.-H.; Eom, T.-J.; Kim, M.-J.; Park, H.-S. Function of crzA in Fungal Development and Aflatoxin Production in Aspergillus flavus. Toxins 2019, 11, 567.

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