Special Issue "Toxicity of Plant Derived Substances"

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Plant Toxins".

Deadline for manuscript submissions: 28 February 2022.

Special Issue Editor

Prof. Kateřina Macáková
E-Mail Website
Guest Editor
Department of Pharmacognosy, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
Interests: (Poly)phenolic substances, transition metals, oxidative stress, platelet aggregation, pharmacognosy

Special Issue Information

The plant kingdom is an almost inexhaustible source of various substances that can have both positive and negative effects on the human body. Many natural substances used in the therapy of various diseases come from toxic plant species. These include, for example, cytostatic agents, cardiac glycosides, or anti-Alzheimer´s disease drugs. On the other hand, there are a lot of substances isolated from plants that are commonly used, and whose negative effects or even toxicity is not so obvious (e.g., these effects can occur after prolonged use or is idiosyncratic, etc.). In addition, these substances, although under certain circumstances toxic, may also have significant importance in the search for potential drugs.

This Special Issue aims to collect novel data on toxic or potentially toxic natural substances derived from plant organisms that could a) have negative or toxic effects on human beings and/or b) find application in the treatment of various diseases. Original papers, short communications, reviews, or mini-reviews are welcome for publication.

Prof. Kateřina Macáková
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Natural Substance
  • Plant
  • Toxic
  • Potentially Toxic
  • Potential Drug

Published Papers (1 paper)

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Review

Review
Overview of Pharmacokinetics and Liver Toxicities of Radix Polygoni Multiflori
Toxins 2020, 12(11), 729; https://doi.org/10.3390/toxins12110729 - 21 Nov 2020
Viewed by 793
Abstract
Radix Polygoni Multiflori (RPM), a traditional Chinese medicine, has been used as a tonic and an anti-aging remedy for centuries. However, its safe and effective application in clinical practice could be hindered by its liver injury potential and lack of investigations on its [...] Read more.
Radix Polygoni Multiflori (RPM), a traditional Chinese medicine, has been used as a tonic and an anti-aging remedy for centuries. However, its safe and effective application in clinical practice could be hindered by its liver injury potential and lack of investigations on its hepatotoxicity mechanism. Our current review aims to provide a comprehensive overview and a critical assessment of the absorption, distribution, metabolism, excretion of RPM, and their relationships with its induced liver injury. Based on the well-reported intrinsic liver toxicity of emodin, one of the major components in RPM, it is concluded that its plasma and liver concentrations could attribute to RPM induced liver injury via metabolic enzymes alteration, hepatocyte apoptosis, bile acids homeostasis disruption, and inflammatory damage. Co-administered 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucopyranoside in RPM and other drugs/herbs could further aggravate the hepatotoxicity of emodin via enhancing its absorption and inhibiting its metabolism. To ensure the safe clinical use of RPM, a better understanding of the toxicokinetics and effect of its co-occurring components or other co-administered drugs/herbs on the pharmacokinetics of emodin is warranted. Full article
(This article belongs to the Special Issue Toxicity of Plant Derived Substances)
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